Oxymatrine protects articular chondrocytes from IL-1 β-induced damage through autophagy activation via AKT/mTOR signaling pathway inhibition
Osteoarthritis (OA) is a common degenerative joint disease characterized by persistent articular cartilage degeneration and synovitis. Oxymatrine (OMT) is a quinzolazine alkaloid extracted from the traditional... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 11, 2024 Category: Orthopaedics Authors: Jinying Lu, Jiang Bian, Yutong Wang, Yan Zhao, Xinmin Zhao, Gao Wang and Jing Yang Tags: Correspondence Source Type: research

Geniposide alleviates cholesterol-induced endoplasmic reticulum stress and apoptosis in osteoblasts by mediating the GLP-1R/ABCA1 pathway
Cholesterol (CHO) is an essential component of the body. However, high CHO levels in the body can damage bone mass and promote osteoporosis. CHO accumulation can cause osteoblast apoptosis, which has a negativ... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 11, 2024 Category: Orthopaedics Authors: Mingliang Zhong, Zhenyu Wu, Zhixi Chen, Longhuo Wu and Jianguo Zhou Tags: Correspondence Source Type: research

Application and evaluation of artificial intelligence 3D preoperative planning software in developmental dysplasia of the hip
Accurate preoperative planning is crucial for successful total hip arthroplasty (THA) for developmental dysplasia of the hip (DDH). The aim of this study was to compare the accuracy of an artificial intelligen... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 8, 2024 Category: Orthopaedics Authors: Hongbin Xie, Jiafeng Yi, Yijian Huang, Renwen Guo, Yubo Liu, Xiangpeng Kong and Wei Chai Tags: Research article Source Type: research

Efficacy and immune-inflammatory mechanism of acupuncture-related therapy in animal models of knee osteoarthritis: a preclinical systematic review and network meta-analysis
Many KOA patients have not reached indications for surgery, thus we need to find effective non-surgical treatments. Acupuncture is thought to have the potential to modulate inflammation and cytokines in KOA th... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 8, 2024 Category: Orthopaedics Authors: Yingjie Huang, Hai Huang, Qiqi Chen, Yantong Luo, Jieni Feng, Yuexia Deng, Guangyao Li, Min Li and Jian Sun Tags: Systematic Review Source Type: research

A biodegradable PVA coating constructed on the surface of the implant for preventing bacterial colonization and biofilm formation
Bone implant infections pose a critical challenge in orthopedic surgery, often leading to implant failure. The potential of implant coatings to deter infections by hindering biofilm formation is promising. How... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 8, 2024 Category: Orthopaedics Authors: Zhonghua Lei, Haifeng Liang, Wei Sun, Yan Chen, Zhi Huang and Bo Yu Tags: Research article Source Type: research

Comparison of outcomes after anterior cervical discectomy and fusion with and without a cervical collar: a systematic review and meta-analysis
The clinical outcomes of patients who received a cervical collar after anterior cervical decompression and fusion were evaluated by comparison with those of patients who did not receive a cervical collar. (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 7, 2024 Category: Orthopaedics Authors: Tingxin Zhang, Gang Gao, Yanhong Li, Feng Gao, Wupeng Yang, Yongjiang Wang and Nana Guo Tags: Systematic Review Source Type: research

Dyslipidemia may impact initial recovery following arthroscopic rotator cuff repair: a retrospective study
The current literature shows that dyslipidemia can lead to a higher incidence of rotator cuff tears (RCTs) and an increased retear rate after repair. We aimed to evaluate the influence of preoperative dyslipid... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 7, 2024 Category: Orthopaedics Authors: Lei Yao, Xiumei Zhao, Lu Mei, Yinghao Li, Long Pang, Chunsen Zhang, Jian Li and Xin Tang Tags: Research article Source Type: research

Obstetric-related lower back pain: the effect of number of pregnancy on development of chronic lower back pain, worsening of lumbar disc degeneration and alteration of lumbar sagittal balance
This study aims to determine whether the number of pregnancies contributes to the development of chronic lower back pain, worsening the lumbar disc degeneration and altering the normal lumbar sagittal balance. (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 7, 2024 Category: Orthopaedics Authors: Erdal G üngör and Zeynep Karakuzu Güngör Tags: Correspondence Source Type: research

Effects of ultrasound-guided lumbar plexus and sacral plexus block combined with general anesthesia on the anesthetic efficacy and surgical outcomes in elderly patients undergoing intertrochanteric fracture surgery: a randomized controlled trial
Surgery for intertrochanteric fractures in elderly patients is challenging due to the risk of severe pain and significant stress responses. We investigated the effects of a combined approach of ultrasound-guid... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 7, 2024 Category: Orthopaedics Authors: Ji Feng, Guangyan Tang, Yunhua Shui, Jilin Xiang and Zhijun Qin Tags: Research article Source Type: research

Modified gastro-soleus turn-down flap for chronic or neglected achilles tendon ruptures
Achilles ’ tendon chronic rupture is a common entity that is usually misdiagnosed or mistreated. Hence, she was presented to us later or with complications affecting her gait. Surgical resection is needed to ei... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 6, 2024 Category: Orthopaedics Authors: Mohamed A. A. Ibrahim, Mohamed G. Abdelkader, Samir A. Nematallah, Gamal A. Elsawy, Sameh A. Alghandour and Lotfy M. Shwitter Tags: Research article Source Type: research

Investigating the in vitro antibacterial efficacy of composite bone cement incorporating natural product-based monomers and gentamicin
The objective of this study is to investigate the impact of four natural product extracts, namely, aloe-emodin, quercetin, curcumin, and tannic acid, on the in vitro bacteriostatic properties and biocompatibil... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 6, 2024 Category: Orthopaedics Authors: Yu-Chen Kan, Rui Guo, Yang Xu, Lu-Yang Han, Wen-Han Bu, Long-Xu Han and Jian-Jun Chu Tags: Research article Source Type: research

Comparison of outcomes after total hip arthroplasty between patients with osteonecrosis of the femoral head in Association Research Circulation Osseous stage III and stage IV: a five-year follow-up study
This study aimed to compare the surgical outcomes of ONFH patients who underwent THA in ARCO stage II... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 6, 2024 Category: Orthopaedics Authors: Tianyu Wang, Dongwei Wu, Chengsi Li, Xinqun Cheng, Zhenbang Yang, Yingze Zhang and Yanbin Zhu Tags: Research article Source Type: research

Biomechanical characteristics of Sanders type II and III calcaneal fractures fixed by open reduction and internal fixation and percutaneous minimally invasive fixation
This work investigated the differences in the biomechanical properties of open reduction and internal fixation (ORIF) and percutaneous minimally invasive fixation (PMIF) for the fixation of calcaneal fractures... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 5, 2024 Category: Orthopaedics Authors: Wu Ren, Kailu Zhang, Ziya Zhao, Xueling Zhang, Fei Lin, Yawei Li, Ke Bao, Jun Yang, Jinlong Chang and Jia Li Tags: Research article Source Type: research

Clinical effects of arthroscopic-assisted uni-portal spinal surgery and unilateral bi-portal endoscopy on unilateral laminotomy for bilateral decompression in patients with lumbar spinal stenosis: a retrospective cohort study
To investigate the clinical effectiveness of Arthroscopic-assisted Uni-portal Spinal Surgery (AUSS) in the treatment of lumbar spinal stenosis. (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 5, 2024 Category: Orthopaedics Authors: Fang Wang, Rui Wang, Chengyi Zhang, En Song and Fengtao Li Tags: Research article Source Type: research

Management of rotator cuff injuries using allogenic platelet-rich plasma
Rotator cuff injuries are a major cause of shoulder pain, affecting the quality of life and producing a significant burden on healthcare systems. Conservative management modalities are prioritized, resorting t... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 4, 2024 Category: Orthopaedics Authors: Ashim Gupta, Filippo Migliorini and Nicola Maffulli Tags: Research article Source Type: research