Silencing p75NTR regulates osteogenic differentiation and angiogenesis of BMSCs to enhance bone healing in fractured rats
Fractures heal through a process that involves angiogenesis and osteogenesis but may also lead to non-union or delayed healing. Bone marrow mesenchymal stem cells (BMSCs) have been reported to play a pivotal r... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 20, 2024 Category: Orthopaedics Authors: Zhifeng Wu, Yongming Yang and Ming Wang Tags: Research article Source Type: research

The latissimus dorsi creates a dynamic track for the inferior angle of the scapula during arm abduction in humans
The importance of several scapulothoracic muscles, including trapezius and serratus anterior, in maintaining physiological scapula kinematics has been highlighted in the past. However, the relationship between... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 20, 2024 Category: Orthopaedics Authors: Alp Paksoy, Doruk Akg ün, Henry Gebauer, Daniel Karczewski, Lucca Lacheta, John M. Tokish, Aaron Chamberlain and Philipp Moroder Tags: Research article Source Type: research

mir-150-5p inhibits the osteogenic differentiation of bone marrow-derived mesenchymal stem cells by targeting irisin to regulate the p38/MAPK signaling pathway
To study the effect of miR-150-5p on the osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs), and further explore the relationship between its regulatory mechanism and irisin. (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 18, 2024 Category: Orthopaedics Authors: Jia-long Qi, Zhi-dong Zhang, Zhou Dong, Tao Shan and Zong-sheng Yin Tags: Research article Source Type: research

Bone cement reinforcement improves the therapeutic effects of screws in elderly patients with pelvic fragility factures
Pelvic fragility fractures in elderly individuals present significant challenges in orthopedic and geriatric medicine due to reduced bone density and increased frailty associated with aging. (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 18, 2024 Category: Orthopaedics Authors: Lecai Gao and Baorui Xing Tags: Research article Source Type: research

Glaucocalyxin A delays the progression of OA by inhibiting NF- κB and MAPK signaling pathways
Osteoarthritis (OA) is a common degenerative joint condition marked by inflammation and cartilage breakdown. Currently, there is a dearth of treatment medications that can clearly slow the course of OA. Glauco... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 18, 2024 Category: Orthopaedics Authors: Xin Hong, Xuqiang Liu, Bo Li, Shoujie Shi, Kai Xiao, Tiantian Xu, Yaoyang Nie, Min Dai and Meisong Zhu Tags: Research article Source Type: research

High flexion femoral side remnant preservation positioning technique: a new method for positioning the femoral tunnel in anterior cruciate ligament reconstruction
The aim of this study is to find a new method for femoral side preservation positioning in anterior cruciate ligament (ACL) reconstruction and test the accuracy and precision of this method. (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 18, 2024 Category: Orthopaedics Authors: Xiaobo Li, Jiajun Lu, JIxian Su, Hanlin Li, Xiaoying Liu and Ran Ding Tags: Research article Source Type: research

Exosomes derived from umbilical cord-mesenchymal stem cells inhibit the NF- κB/MAPK signaling pathway and reduce the inflammatory response to promote recovery from spinal cord injury
Spinal cord injury (SCI) is a serious traumatic disease of the central nervous system and leads to incomplete or complete loss of the body ’s autonomous motor and sensory functions, seriously endangering human ... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 16, 2024 Category: Orthopaedics Authors: Zhiwei Luan, Jingsong Liu, Mi Li, Yangyang Wang and Yansong Wang Tags: Research article Source Type: research

Navigation versus fluoroscopy in minimalinvasive iliosacral screw placement
When needed operative treatment of sacral fractures is mostly performed with percutaneous iliosacral screw fixation. The advantage of navigation in insertion of pedicle screws already could be shown by former ... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 16, 2024 Category: Orthopaedics Authors: Max Prost, Roman Taday, Carl Christoph Paul Beyersdorf, David Latz, Joachim Windolf, Max Joseph Scheyerer and Markus Rafael Konieczny Tags: Research article Source Type: research

A retrospective study: exploring preoperative hyponatremia in elderly patients with hip fractures
This study aims to provide valuable insights into... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 16, 2024 Category: Orthopaedics Authors: Li-Tao Shi, Zhen Feng and Cui-Min Zhu Tags: Research article Source Type: research

The influence of anterior cervical discectomy and fusion surgery on cervical muscles and the correlation between related muscle changes and surgical efficacy
This study is to evaluate the changes of cervical muscles after ACDF and analyze the ... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 16, 2024 Category: Orthopaedics Authors: Chong Sun, Hongfei Xiang, Xiaolin Wu, Bohua Chen and Zhu Guo Tags: Research article Source Type: research

Validity and reliability of the Modified Four Square Step Test in individuals with ankle sprain
Postural instability and gait abnormalities are frequently observed after an ankle sprain. A modified Four Square Step Test (mFSST) was developed to assess dynamic balance during gait. The aim of this study wa... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 15, 2024 Category: Orthopaedics Authors: Mehmet Yeti ş, Hikmet Kocaman, Mehmet Canli, Halil Alkan, Hasan Yildirim, Nazim Tolgahan Yildiz and Şafak Kuzu Tags: Research article Source Type: research

m6A methylation modification and immune infiltration analysis in osteonecrosis of the femoral head
Osteonecrosis of the femoral head (ONFH) is a elaborate hip disease characterized by collapse of femoral head and osteoarthritis. RNA N6-methyladenosine (m6A) plays a crucial role in a lot of biological proces... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 15, 2024 Category: Orthopaedics Authors: Weihua Fang, Peng Peng, Kun Lin, Fangjun Xiao, Wei He, Mincong He and Qiushi Wei Tags: Research Source Type: research

Duloxetine reduces opioid consumption and pain after total hip or knee arthroplasty: a meta-analysis of randomized controlled trials
There is no consensus in the current literature on the analgesic role of duloxetine after total hip arthroplasty (THA) or total knee arthroplasty (TKA). Thus, we designed this meta-analysis to reveal the analg... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 13, 2024 Category: Orthopaedics Authors: Yicai Lin, Mingyang Jiang, Chun Liao, Qingjian Wu and Jinmin Zhao Tags: Correspondence Source Type: research

Time-elapsed microstructural imaging of failure of the reverse shoulder implant
Reverse Shoulder Arthroplasties (RSA) have become a primary choice for improving shoulder function and pain. However, the biomechanical failure mechanism of the humeral component is still unclear. The present ... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 12, 2024 Category: Orthopaedics Authors: Saulo Martelli, Egon Perilli, Xiaolong Fan, Sophie Rapagna and Ashish Gupta Tags: Methodology Source Type: research

Oxymatrine protects articular chondrocytes from IL-1 β-induced damage through autophagy activation via AKT/mTOR signaling pathway inhibition
Osteoarthritis (OA) is a common degenerative joint disease characterized by persistent articular cartilage degeneration and synovitis. Oxymatrine (OMT) is a quinzolazine alkaloid extracted from the traditional... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 11, 2024 Category: Orthopaedics Authors: Jinying Lu, Jiang Bian, Yutong Wang, Yan Zhao, Xinmin Zhao, Gao Wang and Jing Yang Tags: Correspondence Source Type: research