Core needle biopsy versus fine needle aspiration cytology in bone and soft tissue tumors
Bharat RekhiJournal of Cytology 2019 36(2):118-123
Fine needle aspiration cytology (FNAC) for diagnosis of musculoskeletal tumors is well discussed and debated. The current evidence restricts its application in recurrent and metastatic lesions, with core needle biopsy as the acceptable technique/gold standard for the primary diagnosis of these challenging tumors. However, there are several studies showing reasonable sensitivity and specificity in primary diagnosis of bone and soft tissue tumors, especially in differentiating benign from malignant tumors. There is an acceptable limitation in the exact subtyping of soft tis...
Source: Journal of Cytology - March 7, 2019 Category: Cytology Authors: Bharat Rekhi Source Type: research
DNA extraction and polymerase chain reaction
Nalini GuptaJournal of Cytology 2019 36(2):116-117
DNA extraction and polymerase chain reaction (PCR) are the basic techniques employed in the molecular laboratory. This short overview covers various physical and chemical methods used for DNA extraction so as to obtain a good-quality DNA in sufficient quantity. DNA can be amplified with the help of PCR. The basic principle and different variants of PCR are discussed. (Source: Journal of Cytology)
Source: Journal of Cytology - March 7, 2019 Category: Cytology Authors: Nalini Gupta Source Type: research
Utility of DNA-specific stains in micronuclei assay as a marker of genotoxicity in oral potentially malignant disorders and oral squamous cell carcinoma
Conclusion: Malignant transformation is accompanied by loss of cell capacity to evolve to death in situations of DNA damage. These findings indicate that nuclear anomalies may be misinterpreted as MN with nonspecific DNA stains and lead to false-positive results in studies with cells of epithelial origin. (Source: Journal of Cytology)
Source: Journal of Cytology - March 7, 2019 Category: Cytology Authors: Saurabh Juneja Sonal Katyal Ajit Singh Rathore Devi Charan Shetty Ankita Tandon Pankaj Jain Source Type: research
Image-guided fine needle aspiration cytology of intrathoracic lesions
Conclusion: Image-guided TTFNAC of intrathoracic lesions is a safe method when done by well-trained medical personnel with lesser rate of complications. An early accurate diagnosis of malignancy can be made based on the cytological features; however, further subtyping of the malignancy may sometimes be difficult due to overlapping cytological features. TTFNAC can be a diagnostic tool for identifying nonneoplastic lesion such as TB. Hence, image-guided FNAC aids in early diagnosis and management of patients with intrathoracic lesions. (Source: Journal of Cytology)
Source: Journal of Cytology - March 7, 2019 Category: Cytology Authors: Annie E Abraham Pooja K Suresh HB Sridevi Kausalya K Sahu Deepa Adiga Jessica Minal Santosh Rai Vishak Acharya Source Type: research
Diagnostic efficacy of ultrasound-guided fine needle aspiration combined with the bethesda system of reporting
Conclusion: The study showed that The Bethesda System of Reporting Thyroid Cytology provides effective communication between clinician and pathologists thereby enabling clear management strategies. We also concluded that US-guided FNACs offer better results compared with palpation-guided FNACs. (Source: Journal of Cytology)
Source: Journal of Cytology - March 7, 2019 Category: Cytology Authors: K Ajitha Kumari Poonam D Jadhav Chaya Prasad NV Smitha Annie Jojo VD Manjula Source Type: research
Hormone receptors and human epidermal growth factor (HER2) expression in fine-needle aspirates from metastatic breast carcinoma & #8211; Role in patient management
Conclusion: ER, PR, and HER2 by IHC in cell blocks of metastatic lymphnodes are reliable. Change in receptor (34.2%) and HER2 status (21.9%) was documented, which is of clinical significance as these patients warrant a change of management. (Source: Journal of Cytology)
Source: Journal of Cytology - March 7, 2019 Category: Cytology Authors: Issam M Francis Rabeah Abbas Altemaimi Bushra Al-Ayadhy Preeta Alath Mohammed Jaragh Fatma Jasem Mothafar Kusum Kapila Source Type: research
Comparative analysis of liquid based and conventional cytology smears in fine needle aspirates from breast lesions
Conclusion: LBC is a promising technique in the field of cytology. It has the potential to decrease the number of slides screened per case and decrease the turn-around-time. (Source: Journal of Cytology)
Source: Journal of Cytology - March 7, 2019 Category: Cytology Authors: Vasundhara Sharma Veena Gupta Padam Parmar Promil Jain Deepak Thakran Rajeev Sen Source Type: research
Clinical and cyto-morphological characterization of triple negative breast cancer
Conclusion: FNAC can be helpful in making diagnosis of TNBC and along with ER, PR, HER2 characterization, helpful in planning treatment strategy, saving time, manpower, and resources in the patient management. (Source: Journal of Cytology)
Source: Journal of Cytology - March 7, 2019 Category: Cytology Authors: Chayanika Kala Mohd Athar Sanjay Kala Lubna Khan Ramendra K Jauhari Amitabh Satsangi Source Type: research
Cytology microarray on cell block preparation: A novel diagnostic approach in fluid cytology
Conclusions: IHC on CMA blocks of effusion fluids is a very effective technique that can significantly reduce the cost of testing by >70%. (Source: Journal of Cytology)
Source: Journal of Cytology - March 7, 2019 Category: Cytology Authors: Arghya Bandyopadhyay Soumi Bhattacharyya Shreosee Roy Kaushik Majumdar Kaushik Bose Anup K Boler Source Type: research
A comparative study for selectivity of micronuclei in cervical exfoliated cells on chronic boron effects
Conclusion: These findings suggest that MGG and PAP staining gives similar results with regard to MN count. On the other hand, it has been shown again that HPV induces MN and causes genomic instability. (Source: Journal of Cytology)
Source: Journal of Cytology - March 7, 2019 Category: Cytology Authors: Hatice Y & #305;ld & #305;r & #305;m Asl & #305; G & #246;ker H & #252;lya Demirci Tevfik G & #252;venal Mehmet Korkmaz Source Type: research
Sebaceous carcinoma of upper eyelid presenting as submandibular lymphadenopathy
Mona A Agnihotri, Kanchan S Kothari, Leena P NaikJournal of Cytology 2019 36(1):73-74 (Source: Journal of Cytology)
Source: Journal of Cytology - January 17, 2019 Category: Cytology Authors: Mona A Agnihotri Kanchan S Kothari Leena P Naik Source Type: research
Primary mucinous eccrine adenocarcinoma: A rare skin adnexal tumor at an unusual site
Rachna Goyal, Nadeem Tanveer, Usha R SinghJournal of Cytology 2019 36(1):71-72 (Source: Journal of Cytology)
Source: Journal of Cytology - January 17, 2019 Category: Cytology Authors: Rachna Goyal Nadeem Tanveer Usha R Singh Source Type: research
Endobronchial ultrasound-guided transbronchial needle aspiration: Techniques and challenges
Valliappan Muthu, Inderpaul Singh Sehgal, Sahajal Dhooria, Kuruswamy T Prasad, Nalini Gupta, Ashutosh N Aggarwal, Ritesh AgarwalJournal of Cytology 2019 36(1):65-70
Intrathoracic lymphadenopathy is a common problem encountered in clinical practice and is caused by a wide variety of diseases. Traditionally, the mediastinal lymph nodes were sampled using conventional transbronchial needle aspiration (TBNA), or surgical methods such as mediastinoscopy, and thoracotomy (open or video-assisted thoracoscopy). However, surgical modalities including mediastinoscopy are invasive, expensive, and not universally available. Moreover,...
Source: Journal of Cytology - January 17, 2019 Category: Cytology Authors: Valliappan Muthu Inderpaul Singh Sehgal Sahajal Dhooria Kuruswamy T Prasad Nalini Gupta Ashutosh N Aggarwal Ritesh Agarwal Source Type: research
Role of EBUS TBNA in staging of lung cancer: A clinician & #39;s perspective
Inderpaul Singh Sehgal, Ritesh Agarwal, Sahajal Dhooria, Kuruswamy Thurai Prasad, Ashutosh N AggarwalJournal of Cytology 2019 36(1):61-64
The treatment of non-small cell lung cancer (NSCLC) includes surgical resection with curative intent in early-stage disease and chemoradiation in the advanced stage disease. Therefore, an accurate preoperative mediastinal lymph node staging is required not only to offer the appropriate treatment but also to avoid unnecessary invasive procedures including thoracotomy. The mediastinal lymph nodes can be sampled using several techniques including mediastinoscopy, surgery (open or video-ass...
Source: Journal of Cytology - January 17, 2019 Category: Cytology Authors: Inderpaul Singh Sehgal Ritesh Agarwal Sahajal Dhooria Kuruswamy Thurai Prasad Ashutosh N Aggarwal Source Type: research
EBUS-TBNA for diagnosis of extrapulmonary lesions
Deepali JainJournal of Cytology 2019 36(1):59-60
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has recently emerged as a minimally invasive and safe modality for the evaluation of mediastinal lymphadenopathy, particularly in staging of lung carcinoma patients. In high tuberculosis endemic countries, EBUS-TBNA is useful in obtaining tissue diagnosis of granulomatous inflammation. Role of EBUS-TBNA in workup of extrapulmonary malignancies is not widely described. Herein, a brief overview of importance of EBUS-TBNA in investigation of extrapulmonary lesions/malignancies is presented. (Source: Journal of Cytology)
Source: Journal of Cytology - January 17, 2019 Category: Cytology Authors: Deepali Jain Source Type: research
