Real-world assessment of treatment inertia in the management of patients treated for major depressive disorder in the USA
Conclusion: Effective symptom management is critical for optimal outcomes in MDD. Results demonstrate that treatment inertia is common in MDD despite guidelines recommending treatment modification in patients not reaching remission.PMID:37987716 | DOI:10.57264/cer-2023-0091 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - November 21, 2023 Category: General Medicine Authors: John J Sheehan Chris LaVallee Keshia Maughn Santosh Balakrishnan Jacqueline A Pesa Kruti Joshi Craig Nelson Source Type: research

Gastrointestinal manifestations in pediatric and adult patients with Rett syndrome: an analysis of US claims and physician survey data
Conclusion: Patients with RTT experience a high burden of GI manifestations, which translate to considerable medical costs. Importantly, the prevalence of GI manifestations was likely underestimated in this study, as only those symptoms which resulted in a healthcare encounter were captured.PMID:37971297 | DOI:10.57264/cer-2023-0054 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - November 16, 2023 Category: General Medicine Authors: Damian M May Jeffrey Neul Jes ús Eric Piña-Garza Kal é Kponee-Shovein Ambika Satija Malena Mahendran Nathaniel Downes Kristy Sheng Neema Lema Andra Boca Patrick Lefebvre Victor Abler James M Youakim Wendy Y Cheng Source Type: research

Once-nightly sodium oxybate (FT218) improved symptoms of disrupted nighttime sleep in people with narcolepsy: a plain language summary
This study showed that people who took ON-SXB had better nighttime sleep even if they were taking alerting agents during the day. The most common side effects of ON-SXB included dizziness, nausea (feeling sick to your stomach), vomiting, headache, and bedwetting.WHAT DO THE RESULTS MEAN?: A once-nightly bedtime dose of ON-SXB is a narcolepsy treatment option for people without the need for a middle-of-the-night dose of sodium oxybate.PMID:37971303 | DOI:10.57264/cer-2023-0133 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - November 16, 2023 Category: General Medicine Authors: Thomas Roth Michael J Thorpy Clete A Kushida Matthew Horsnell Jennifer Gudeman Source Type: research

Gastrointestinal manifestations in pediatric and adult patients with Rett syndrome: an analysis of US claims and physician survey data
Conclusion: Patients with RTT experience a high burden of GI manifestations, which translate to considerable medical costs. Importantly, the prevalence of GI manifestations was likely underestimated in this study, as only those symptoms which resulted in a healthcare encounter were captured.PMID:37971297 | DOI:10.57264/cer-2023-0054 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - November 16, 2023 Category: General Medicine Authors: Damian M May Jeffrey Neul Jes ús Eric Piña-Garza Kal é Kponee-Shovein Ambika Satija Malena Mahendran Nathaniel Downes Kristy Sheng Neema Lema Andra Boca Patrick Lefebvre Victor Abler James M Youakim Wendy Y Cheng Source Type: research

Once-nightly sodium oxybate (FT218) improved symptoms of disrupted nighttime sleep in people with narcolepsy: a plain language summary
This study showed that people who took ON-SXB had better nighttime sleep even if they were taking alerting agents during the day. The most common side effects of ON-SXB included dizziness, nausea (feeling sick to your stomach), vomiting, headache, and bedwetting.WHAT DO THE RESULTS MEAN?: A once-nightly bedtime dose of ON-SXB is a narcolepsy treatment option for people without the need for a middle-of-the-night dose of sodium oxybate.PMID:37971303 | DOI:10.57264/cer-2023-0133 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - November 16, 2023 Category: General Medicine Authors: Thomas Roth Michael J Thorpy Clete A Kushida Matthew Horsnell Jennifer Gudeman Source Type: research

Gastrointestinal manifestations in pediatric and adult patients with Rett syndrome: an analysis of US claims and physician survey data
Conclusion: Patients with RTT experience a high burden of GI manifestations, which translate to considerable medical costs. Importantly, the prevalence of GI manifestations was likely underestimated in this study, as only those symptoms which resulted in a healthcare encounter were captured.PMID:37971297 | DOI:10.57264/cer-2023-0054 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - November 16, 2023 Category: General Medicine Authors: Damian M May Jeffrey Neul Jes ús Eric Piña-Garza Kal é Kponee-Shovein Ambika Satija Malena Mahendran Nathaniel Downes Kristy Sheng Neema Lema Andra Boca Patrick Lefebvre Victor Abler James M Youakim Wendy Y Cheng Source Type: research

Once-nightly sodium oxybate (FT218) improved symptoms of disrupted nighttime sleep in people with narcolepsy: a plain language summary
This study showed that people who took ON-SXB had better nighttime sleep even if they were taking alerting agents during the day. The most common side effects of ON-SXB included dizziness, nausea (feeling sick to your stomach), vomiting, headache, and bedwetting.WHAT DO THE RESULTS MEAN?: A once-nightly bedtime dose of ON-SXB is a narcolepsy treatment option for people without the need for a middle-of-the-night dose of sodium oxybate.PMID:37971303 | DOI:10.57264/cer-2023-0133 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - November 16, 2023 Category: General Medicine Authors: Thomas Roth Michael J Thorpy Clete A Kushida Matthew Horsnell Jennifer Gudeman Source Type: research

Gastrointestinal manifestations in pediatric and adult patients with Rett syndrome: an analysis of US claims and physician survey data
Conclusion: Patients with RTT experience a high burden of GI manifestations, which translate to considerable medical costs. Importantly, the prevalence of GI manifestations was likely underestimated in this study, as only those symptoms which resulted in a healthcare encounter were captured.PMID:37971297 | DOI:10.57264/cer-2023-0054 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - November 16, 2023 Category: General Medicine Authors: Damian M May Jeffrey Neul Jes ús Eric Piña-Garza Kal é Kponee-Shovein Ambika Satija Malena Mahendran Nathaniel Downes Kristy Sheng Neema Lema Andra Boca Patrick Lefebvre Victor Abler James M Youakim Wendy Y Cheng Source Type: research

Once-nightly sodium oxybate (FT218) improved symptoms of disrupted nighttime sleep in people with narcolepsy: a plain language summary
This study showed that people who took ON-SXB had better nighttime sleep even if they were taking alerting agents during the day. The most common side effects of ON-SXB included dizziness, nausea (feeling sick to your stomach), vomiting, headache, and bedwetting.WHAT DO THE RESULTS MEAN?: A once-nightly bedtime dose of ON-SXB is a narcolepsy treatment option for people without the need for a middle-of-the-night dose of sodium oxybate.PMID:37971303 | DOI:10.57264/cer-2023-0133 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - November 16, 2023 Category: General Medicine Authors: Thomas Roth Michael J Thorpy Clete A Kushida Matthew Horsnell Jennifer Gudeman Source Type: research

Institute for Clinical and Economic Review -  Peterson Health Technology Institute value assessment framework for digital health technologies
J Comp Eff Res. 2023 Nov 15:e230154. doi: 10.57264/cer-2023-0154. Online ahead of print.ABSTRACTDigital health technologies (DHTs) are a broad and rapidly innovating class of interventions with distinctive pathways for development, regulatory approval, uptake and reimbursement. Given the unique nature of DHTs, existing value assessment frameworks and evidence standards for health technologies such as drugs and devices are not directly applicable. The value assessment framework presented here describes a conceptual model and associated methods to guide assessments of DHTs. The framework seeks to accomplish two goals: to set...
Source: Journal of Comparative Effectiveness Research - November 15, 2023 Category: General Medicine Authors: Steven D Pearson Prabhjot Singh Francesca Beaudoin Jon Campbell Lindsey Schapiro Sarah K Emond Caroline Pearson Source Type: research

Implementation of electronic patient-reported outcomes for symptom monitoring during cancer treatment: the importance of getting it right
J Comp Eff Res. 2023 Oct 14:CER. doi: 10.57264/cer-2023-0157. Online ahead of print.NO ABSTRACTPMID:37961992 | DOI:10.57264/cer-2023-0157 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - November 14, 2023 Category: General Medicine Authors: Ethan Basch Kathryn Hudson Gabrielle Rocque Source Type: research