Reduced expression of semaphorin 3A in osteoclasts causes lymphatic expansion in a Gorham-Stout disease (GSD) mouse model
In this study, by comparing the RNA expression profile of osteoclasts (OCs) with that of OC precursors (OCPs) by RNA sequencing, we identified a new factor, semaphorin 3A (Sema3A), which is an osteoprotective factor involved in the lymphatic expansion of GSD. Compared to OCPs, OCs enhanced the growth, migration, and tube formation of lymphatic endothelial cells (LECs), in which the expression of Sema3A is low compared to that in OCPs. In the presence of recombinant Sema3A, the growth, migration, and tube formation of LECs were inhibited, further confirming the inhibitory effect of Sema3A on LECs in vitro. Using an LEC-indu...
Source: J Zhejiang Univ Sci ... - January 1, 2024 Category: Science Authors: Dongfang Zhang Hao Xu Chi Qin Kangming Cai Jing Zhang Xinqiu Xia Jingwen Bi Li Zhang Lianping Xing Qianqian Liang Wensheng Wang Source Type: research
Mass spectrometry analysis of intact protein < em > N < /em > -glycosylation signatures of cells and sera in pancreatic adenocarcinomas
J Zhejiang Univ Sci B. 2024 Jan 15;25(1):51-64. doi: 10.1631/jzus.B2200652.ABSTRACTPancreatic cancer is among the most malignant cancers, and thus early intervention is the key to better survival outcomes. However, no methods have been derived that can reliably identify early precursors of development into malignancy. Therefore, it is urgent to discover early molecular changes during pancreatic tumorigenesis. As aberrant glycosylation is closely associated with cancer progression, numerous efforts have been made to mine glycosylation changes as biomarkers for diagnosis; however, detailed glycoproteomic information, especia...
Source: J Zhejiang Univ Sci ... - January 1, 2024 Category: Science Authors: Mingming Xu Zhaoliang Liu Wenhua Hu Ying Han Zhen Wu Sufeng Chen Peng Xia Jing DU Xumin Zhang Piliang Hao Jun Xia Shuang Yang Source Type: research
Bioceramic scaffolds with two-step internal/external modification of copper-containing polydopamine enhance antibacterial and alveolar bone regeneration capability
J Zhejiang Univ Sci B. 2024 Jan 15;25(1):65-82. doi: 10.1631/jzus.B23d0004.ABSTRACTMagnesium-doped calcium silicate (CS) bioceramic scaffolds have unique advantages in mandibular defect repair; however, they lack antibacterial properties to cope with the complex oral microbiome. Herein, for the first time, the CS scaffold was functionally modified with a novel copper-containing polydopamine (PDA(Cu2+)) rapid deposition method, to construct internally modified (*P), externally modified (@PDA), and dually modified (*P@PDA) scaffolds. The morphology, degradation behavior, and mechanical properties of the obtained scaffolds...
Source: J Zhejiang Univ Sci ... - January 1, 2024 Category: Science Authors: Xiaojian Jiang Lihong Lei Weilian Sun Yingming Wei Jiayin Han Shuaiqi Zhong Xianyan Yang Zhongru Gou Lili Chen Source Type: research
Deep learning-based radiomics allows for a more accurate assessment of sarcopenia as a prognostic factor in hepatocellular carcinoma
J Zhejiang Univ Sci B. 2024 Jan 15;25(1):83-90. doi: 10.1631/jzus.B2300363.ABSTRACTHepatocellular carcinoma (HCC) is one of the most common malignancies and is a major cause of cancer-related mortalities worldwide (Forner et al., 2018; He et al., 2023). Sarcopenia is a syndrome characterized by an accelerated loss of skeletal muscle (SM) mass that may be age-related or the result of malnutrition in cancer patients (Cruz-Jentoft and Sayer, 2019). Preoperative sarcopenia in HCC patients treated with hepatectomy or liver transplantation is an independent risk factor for poor survival (Voron et al., 2015; van Vugt et al., 2016...
Source: J Zhejiang Univ Sci ... - January 1, 2024 Category: Science Authors: Zhikun Liu Yichao Wu Abid Ali Khan L U Lun Jianguo Wang Jun Chen Ningyang Jia Shusen Zheng Xiao Xu Source Type: research
Targeting ferroptosis and ferritinophagy: new targets for cardiovascular diseases
J Zhejiang Univ Sci B. 2024 Jan 15;25(1):1-22. doi: 10.1631/jzus.B2300097.ABSTRACTCardiovascular diseases (CVDs) are a leading factor driving mortality worldwide. Iron, an essential trace mineral, is important in numerous biological processes, and its role in CVDs has raised broad discussion for decades. Iron-mediated cell death, namely ferroptosis, has attracted much attention due to its critical role in cardiomyocyte damage and CVDs. Furthermore, ferritinophagy is the upstream mechanism that induces ferroptosis, and is closely related to CVDs. This review aims to delineate the processes and mechanisms of ferroptosis and ...
Source: J Zhejiang Univ Sci ... - January 1, 2024 Category: Science Authors: Yi Luan Yang Yang Ying Luan Hui Liu Han Xing Jinyan Pei Hengdao Liu Bo Qin Kaidi Ren Source Type: research
