Utilization of 3D printing technology in hepatopancreatobiliary surgery
J Zhejiang Univ Sci B. 2024 Feb 15;25(2):123-134. doi: 10.1631/jzus.B2300175.ABSTRACTThe technology of three-dimensional (3D) printing emerged in the late 1970s and has since undergone considerable development to find numerous applications in mechanical engineering, industrial design, and biomedicine. In biomedical science, several studies have initially found that 3D printing technology can play an important role in the treatment of diseases in hepatopancreatobiliary surgery. For example, 3D printing technology has been applied to create detailed anatomical models of disease organs for preoperative personalized surgical s...
Source: J Zhejiang Univ Sci ... - February 2, 2024 Category: Science Authors: Wujiang Shi Jiangang Wang Jianjun Gao Xinlei Zou Qingfu Dong Ziyue Huang Jialin Sheng Canghai Guan Yi Xu Yunfu Cui Xiangyu Zhong Source Type: research
Therapeutic advances in atrial fibrillation based on animal models
J Zhejiang Univ Sci B. 2024 Feb 15;25(2):135-152. doi: 10.1631/jzus.B2300285.ABSTRACTAtrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia among humans, with its incidence increasing significantly with age. Despite the high frequency of AF in clinical practice, its etiology and management remain elusive. To develop effective treatment strategies, it is imperative to comprehend the underlying mechanisms of AF; therefore, the establishment of animal models of AF is vital to explore its pathogenesis. While spontaneous AF is rare in most animal species, several large animal models, particularly those of p...
Source: J Zhejiang Univ Sci ... - February 2, 2024 Category: Science Authors: Qian Gong Xuan LE Pengcheng Yu Lenan Zhuang Source Type: research
Flexible neural probes: a review of the current advantages, drawbacks, and future demands
J Zhejiang Univ Sci B. 2024 Feb 15;25(2):153-167. doi: 10.1631/jzus.B2300337.ABSTRACTBrain diseases affect millions of people and have a huge social and economic impact. The use of neural probes for studies in animals has been the main approach to increasing knowledge about neural network functioning. Ultimately, neuroscientists are trying to develop new and more effective therapeutic approaches to treating neurological disorders. The implementation of neural probes with multifunctionalities (electrical, optical, and fluidic interactions) has been increasing in the last few years, leading to the creation of devices with hi...
Source: J Zhejiang Univ Sci ... - February 2, 2024 Category: Science Authors: Sara Pimenta Joo R Freitas Jos H Correia Source Type: research
A proton birdcage coil integrated with interchangeable single loops for multi-nuclear MRI/MRS
J Zhejiang Univ Sci B. 2024 Feb 15;25(2):168-180. doi: 10.1631/jzus.B2300587.ABSTRACTEnergy metabolism is fundamental for life. It encompasses the utilization of carbohydrates, lipids, and proteins for internal processes, while aberrant energy metabolism is implicated in many diseases. In the present study, using three-dimensional (3D) printing from polycarbonate via fused deposition modeling, we propose a multi-nuclear radiofrequency (RF) coil design with integrated 1H birdcage and interchangeable X-nuclei (2H, 13C, 23Na, and 31P) single-loop coils for magnetic resonance imaging (MRI)/magnetic resonance spectroscopy (MRS)...
Source: J Zhejiang Univ Sci ... - February 2, 2024 Category: Science Authors: Yi Zhang Zhiyan Quan Feiyang Lou Yujiao Fang Garth J Thompson Gao Chen Xiaotong Zhang Source Type: research
Advances in the research and application of neurokinin-1 receptor antagonists
J Zhejiang Univ Sci B. 2024 Feb 15;25(2):91-105. doi: 10.1631/jzus.B2300455.ABSTRACTRecently, the substance P (SP)/neurokinin-1 receptor (NK-1R) system has been found to be involved in various human pathophysiological disorders including the symptoms of coronavirus disease 2019 (COVID-19). Besides, studies in the oncological field have demonstrated an intricate correlation between the upregulation of NK-1R and the activation of SP/NK-1R system with the progression of multiple carcinoma types and poor clinical prognosis. These findings indicate that the modulation of SP/NK-1R system with NK-1R antagonists can be a potential...
Source: J Zhejiang Univ Sci ... - February 2, 2024 Category: Science Authors: Xiangyu Hong Junjie Ma Shanshan Zheng Guangyu Zhao Caiyun Fu Source Type: research
Recent advancements in the diagnosis and treatment of acral melanoma
J Zhejiang Univ Sci B. 2024 Feb 15;25(2):106-122. doi: 10.1631/jzus.B2300221.ABSTRACTAcral melanoma (AM) is the most common histologic subtype of melanoma in dark-skinned patients and is associated with a worse prognosis and a high mortality rate, largely due to the inconspicuous nature of early-stage lesions, which can lead to late diagnosis. Because of the overlapping clinical and histopathological features of AM with other forms of cutaneous melanomas, early detection of AM requires a multidisciplinary approach that integrates various diagnostic modalities, including clinical examination, dermoscopy, histopathology, mol...
Source: J Zhejiang Univ Sci ... - February 2, 2024 Category: Science Authors: Ahmad Alhaskawi Sohaib Hasan Abdullah Ezzi Yanzhao Dong Haiying Zhou Zewei Wang Jingtian Lai Chengjun Yao Vishnu Goutham Kota Mohamed Hasan Abdulla Hasan Abdulla Hui Lu Source Type: research
Utilization of 3D printing technology in hepatopancreatobiliary surgery
J Zhejiang Univ Sci B. 2024 Feb 15;25(2):123-134. doi: 10.1631/jzus.B2300175.ABSTRACTThe technology of three-dimensional (3D) printing emerged in the late 1970s and has since undergone considerable development to find numerous applications in mechanical engineering, industrial design, and biomedicine. In biomedical science, several studies have initially found that 3D printing technology can play an important role in the treatment of diseases in hepatopancreatobiliary surgery. For example, 3D printing technology has been applied to create detailed anatomical models of disease organs for preoperative personalized surgical s...
Source: J Zhejiang Univ Sci ... - February 2, 2024 Category: Science Authors: Wujiang Shi Jiangang Wang Jianjun Gao Xinlei Zou Qingfu Dong Ziyue Huang Jialin Sheng Canghai Guan Yi Xu Yunfu Cui Xiangyu Zhong Source Type: research
Therapeutic advances in atrial fibrillation based on animal models
J Zhejiang Univ Sci B. 2024 Feb 15;25(2):135-152. doi: 10.1631/jzus.B2300285.ABSTRACTAtrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia among humans, with its incidence increasing significantly with age. Despite the high frequency of AF in clinical practice, its etiology and management remain elusive. To develop effective treatment strategies, it is imperative to comprehend the underlying mechanisms of AF; therefore, the establishment of animal models of AF is vital to explore its pathogenesis. While spontaneous AF is rare in most animal species, several large animal models, particularly those of p...
Source: J Zhejiang Univ Sci ... - February 2, 2024 Category: Science Authors: Qian Gong Xuan LE Pengcheng Yu Lenan Zhuang Source Type: research
Flexible neural probes: a review of the current advantages, drawbacks, and future demands
J Zhejiang Univ Sci B. 2024 Feb 15;25(2):153-167. doi: 10.1631/jzus.B2300337.ABSTRACTBrain diseases affect millions of people and have a huge social and economic impact. The use of neural probes for studies in animals has been the main approach to increasing knowledge about neural network functioning. Ultimately, neuroscientists are trying to develop new and more effective therapeutic approaches to treating neurological disorders. The implementation of neural probes with multifunctionalities (electrical, optical, and fluidic interactions) has been increasing in the last few years, leading to the creation of devices with hi...
Source: J Zhejiang Univ Sci ... - February 2, 2024 Category: Science Authors: Sara Pimenta Joo R Freitas Jos H Correia Source Type: research
A proton birdcage coil integrated with interchangeable single loops for multi-nuclear MRI/MRS
J Zhejiang Univ Sci B. 2024 Feb 15;25(2):168-180. doi: 10.1631/jzus.B2300587.ABSTRACTEnergy metabolism is fundamental for life. It encompasses the utilization of carbohydrates, lipids, and proteins for internal processes, while aberrant energy metabolism is implicated in many diseases. In the present study, using three-dimensional (3D) printing from polycarbonate via fused deposition modeling, we propose a multi-nuclear radiofrequency (RF) coil design with integrated 1H birdcage and interchangeable X-nuclei (2H, 13C, 23Na, and 31P) single-loop coils for magnetic resonance imaging (MRI)/magnetic resonance spectroscopy (MRS)...
Source: J Zhejiang Univ Sci ... - February 2, 2024 Category: Science Authors: Yi Zhang Zhiyan Quan Feiyang Lou Yujiao Fang Garth J Thompson Gao Chen Xiaotong Zhang Source Type: research
Advances in the research and application of neurokinin-1 receptor antagonists
J Zhejiang Univ Sci B. 2024 Feb 15;25(2):91-105. doi: 10.1631/jzus.B2300455.ABSTRACTRecently, the substance P (SP)/neurokinin-1 receptor (NK-1R) system has been found to be involved in various human pathophysiological disorders including the symptoms of coronavirus disease 2019 (COVID-19). Besides, studies in the oncological field have demonstrated an intricate correlation between the upregulation of NK-1R and the activation of SP/NK-1R system with the progression of multiple carcinoma types and poor clinical prognosis. These findings indicate that the modulation of SP/NK-1R system with NK-1R antagonists can be a potential...
Source: J Zhejiang Univ Sci ... - February 2, 2024 Category: Science Authors: Xiangyu Hong Junjie Ma Shanshan Zheng Guangyu Zhao Caiyun Fu Source Type: research
Recent advancements in the diagnosis and treatment of acral melanoma
J Zhejiang Univ Sci B. 2024 Feb 15;25(2):106-122. doi: 10.1631/jzus.B2300221.ABSTRACTAcral melanoma (AM) is the most common histologic subtype of melanoma in dark-skinned patients and is associated with a worse prognosis and a high mortality rate, largely due to the inconspicuous nature of early-stage lesions, which can lead to late diagnosis. Because of the overlapping clinical and histopathological features of AM with other forms of cutaneous melanomas, early detection of AM requires a multidisciplinary approach that integrates various diagnostic modalities, including clinical examination, dermoscopy, histopathology, mol...
Source: J Zhejiang Univ Sci ... - February 2, 2024 Category: Science Authors: Ahmad Alhaskawi Sohaib Hasan Abdullah Ezzi Yanzhao Dong Haiying Zhou Zewei Wang Jingtian Lai Chengjun Yao Vishnu Goutham Kota Mohamed Hasan Abdulla Hasan Abdulla Hui Lu Source Type: research
Utilization of 3D printing technology in hepatopancreatobiliary surgery
J Zhejiang Univ Sci B. 2024 Feb 15;25(2):123-134. doi: 10.1631/jzus.B2300175.ABSTRACTThe technology of three-dimensional (3D) printing emerged in the late 1970s and has since undergone considerable development to find numerous applications in mechanical engineering, industrial design, and biomedicine. In biomedical science, several studies have initially found that 3D printing technology can play an important role in the treatment of diseases in hepatopancreatobiliary surgery. For example, 3D printing technology has been applied to create detailed anatomical models of disease organs for preoperative personalized surgical s...
Source: J Zhejiang Univ Sci ... - February 2, 2024 Category: Science Authors: Wujiang Shi Jiangang Wang Jianjun Gao Xinlei Zou Qingfu Dong Ziyue Huang Jialin Sheng Canghai Guan Yi Xu Yunfu Cui Xiangyu Zhong Source Type: research
Therapeutic advances in atrial fibrillation based on animal models
J Zhejiang Univ Sci B. 2024 Feb 15;25(2):135-152. doi: 10.1631/jzus.B2300285.ABSTRACTAtrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia among humans, with its incidence increasing significantly with age. Despite the high frequency of AF in clinical practice, its etiology and management remain elusive. To develop effective treatment strategies, it is imperative to comprehend the underlying mechanisms of AF; therefore, the establishment of animal models of AF is vital to explore its pathogenesis. While spontaneous AF is rare in most animal species, several large animal models, particularly those of p...
Source: J Zhejiang Univ Sci ... - February 2, 2024 Category: Science Authors: Qian Gong Xuan LE Pengcheng Yu Lenan Zhuang Source Type: research
Flexible neural probes: a review of the current advantages, drawbacks, and future demands
J Zhejiang Univ Sci B. 2024 Feb 15;25(2):153-167. doi: 10.1631/jzus.B2300337.ABSTRACTBrain diseases affect millions of people and have a huge social and economic impact. The use of neural probes for studies in animals has been the main approach to increasing knowledge about neural network functioning. Ultimately, neuroscientists are trying to develop new and more effective therapeutic approaches to treating neurological disorders. The implementation of neural probes with multifunctionalities (electrical, optical, and fluidic interactions) has been increasing in the last few years, leading to the creation of devices with hi...
Source: J Zhejiang Univ Sci ... - February 2, 2024 Category: Science Authors: Sara Pimenta Joo R Freitas Jos H Correia Source Type: research
