ELABELA-derived peptide ELA13 attenuates kidney fibrosis by inhibiting the Smad and ERK signaling pathways
In conclusion, ELA13 protected against kidney fibrosis through inhibiting the Smad and ERK signaling pathways and could thus be a promising candidate for anti-renal fibrosis treatment.PMID:38584095 | DOI:10.1631/jzus.B2300033 (Source: J Zhejiang Univ Sci ...)
Source: J Zhejiang Univ Sci ... - April 7, 2024 Category: Science Authors: Zhibin Yan Ying Shi Runling Yang Jijun Xue Caiyun Fu Source Type: research
Seizure as the main presenting manifestation of three patients with acute glufosinate-ammonium poisoning
J Zhejiang Univ Sci B. 2024 Apr 15;25(4):354-358. doi: 10.1631/jzus.B2300469.ABSTRACTGlufosinate-ammonium herbicides are the most widely used broad-spectrum, non-selective herbicides in the world. Glufosinate-ammonium is a structural analogue of glutamate (Glu) which can irreversibly inhibit the activity of glutamine synthetase (GS) and Glu decarboxylase in plants, thereby blocking the synthesis of glutamine (Gln) from Glu and ammonia (Hoerlein, 1994). This causes the plants to die because of the nitrogen metabolism disorder and subsequent intracellular accumulation of ammonia. In humans, the characteristic features of glu...
Source: J Zhejiang Univ Sci ... - April 7, 2024 Category: Science Authors: Ping Wang Congying Song Xuan Lu Yuanqiang Lu Source Type: research
Erratum to: Bioinformatic analysis for potential biological processes and key targets of heart failure-related stroke
J Zhejiang Univ Sci B. 2024 Apr 15;25(4):359. doi: 10.1631/jzus.B20e0544.ABSTRACTThe original version of this article (Liu et al., 2021) unfortunately contained a mistake: statement of equal contribution is missing. This correction article shows that Chiyu LIU and Sixu CHEN contributed equally to this work. The original article has been corrected.PMID:38584097 | DOI:10.1631/jzus.B20e0544 (Source: J Zhejiang Univ Sci ...)
Source: J Zhejiang Univ Sci ... - April 7, 2024 Category: Science Authors: Chiyu Liu Sixu Chen Haifeng Zhang Yangxin Chen Qingyuan Gao Zhiteng Chen Zhaoyu Liu Jingfeng Wang Source Type: research
Erratum to: Molecular dynamics simulation reveals DNA-specific recognition mechanism via c-Myb in pseudo-palindromic consensus of < em > mim-1 < /em > promoter
J Zhejiang Univ Sci B. 2024 Apr 15;25(4):360. doi: 10.1631/jzus.B22e0634.ABSTRACTThe original version of this article (Weng et al., 2023) unfortunately contained a mistake. In Acknowledgments, the number (No. 226-2022-00213) of the Fundamental Research Funds for the Central Universities is wrong. The correct number should be No. 2022FZZX01-33.PMID:38584098 | DOI:10.1631/jzus.B22e0634 (Source: J Zhejiang Univ Sci ...)
Source: J Zhejiang Univ Sci ... - April 7, 2024 Category: Science Authors: Jinru Weng Shuo Yang Jinkang Shen Hongsen Liu Yuzi Xu Dongyun Hao Shan Wang Source Type: research
Impacts of pancreatic exocrine insufficiency on gut microbiota
J Zhejiang Univ Sci B. 2024 Apr 15;25(4):271-279. doi: 10.1631/jzus.B2300070.ABSTRACTPancreatic exocrine insufficiency (PEI) can be induced by various kinds of diseases, including chronic pancreatitis, acute pancreatitis, and post-pancreatectomy. The main pathogenetic mechanism of PEI involves the decline of trypsin synthesis, disorder of pancreatic fluid flow, and imbalance of secretion feedback. Animal studies have shown that PEI could induce gut bacterial overgrowth and dysbiosis, with the abundance of Lactobacillus and Bifidobacterium increasing the most, which could be partially reversed by pancreatic enzyme replaceme...
Source: J Zhejiang Univ Sci ... - April 7, 2024 Category: Science Authors: Yulin Guo Feng Cao Fei Li Source Type: research
Emerging role of lncRNAs as mechanical signaling molecules in mechanotransduction and their association with Hippo-YAP signaling: a review
J Zhejiang Univ Sci B. 2024 Apr 15;25(4):280-292. doi: 10.1631/jzus.B2300497.ABSTRACTCells within tissues are subject to various mechanical forces, including hydrostatic pressure, shear stress, compression, and tension. These mechanical stimuli can be converted into biochemical signals through mechanoreceptors or cytoskeleton-dependent response processes, shaping the microenvironment and maintaining cellular physiological balance. Several studies have demonstrated the roles of Yes-associated protein (YAP) and its homolog transcriptional coactivator with PDZ-binding motif (TAZ) as mechanotransducers, exerting dynamic influe...
Source: J Zhejiang Univ Sci ... - April 7, 2024 Category: Science Authors: Siyi Lin Xinyu He Ying Wang Yu Chen Aifu Lin Source Type: research
Unlocking the growth potential: harnessing the power of synbiotics to enhance cultivation of < em > Pleurotus < /em > spp
J Zhejiang Univ Sci B. 2024 Apr 15;25(4):293-306. doi: 10.1631/jzus.B2300383.ABSTRACTThe oyster mushroom (Pleurotus spp.) is one of the most widely cultivated mushroom species globally. The present study investigated the effect of synbiotics on the growth and quality of Pleurotus ostreatus and Pleurotus pulmonarius. Different synbiotics formulations were applied by spraying mushroom samples daily and measuring their growth parameters, yield, biological efficiency, proximate composition, mineral content, total phenolic content (TPC), and diphenyl-1-picryl-hydrazyl (DPPH) radical scavenging activity. Results demonstrated tha...
Source: J Zhejiang Univ Sci ... - April 7, 2024 Category: Science Authors: Reshma Patil Aizi Nor Mazila Ramli Ang Shu Xuan Ng Zhi Xin Nur Izyan Wan Azelee Prakash Bhuyar Source Type: research
Nrf2-mediated ferroptosis of spermatogenic cells involved in male reproductive toxicity induced by polystyrene nanoplastics in mice
This study demonstrated that PS-NPs induce male reproductive dysfunction in mice by causing spermatogenic cell ferroptosis dependent on Nrf2.PMID:38584093 | DOI:10.1631/jzus.B2300138 (Source: J Zhejiang Univ Sci ...)
Source: J Zhejiang Univ Sci ... - April 7, 2024 Category: Science Authors: Xufeng Fu Hang Han Hong Yang Bo Xu Wenjie Dai Ling Liu Tiantian He Xing DU Xiuying Pei Source Type: research
Large-scale genome-wide SNP analysis reveals the rugged (and ragged) landscape of global ancestry, phylogeny, and demographic history in chicken breeds
This study was a large-scale genome-wide analysis of the landscape of the complex molecular architecture, genetic variability, and detailed structure among 49 populations. These populations represent a significant sample of the world's chicken breeds from Europe (Russia, Czech Republic, France, Spain, UK, etc.), Asia (China), North America (USA), and Oceania (Australia). Based on the results of breed genotyping using the Illumina 60K single nucleotide polymorphism (SNP) chip, a bioinformatic analysis was carried out. This included the calculation of heterozygosity/homozygosity statistics, inbreeding coefficients, and effec...
Source: J Zhejiang Univ Sci ... - April 7, 2024 Category: Science Authors: Natalia V Dementieva Yuri S Shcherbakov Olga I Stanishevskaya Anatoly B Vakhrameev Tatiana A Larkina Artem P Dysin Olga A Nikolaeva Anna E Ryabova Anastasiia I Azovtseva Olga V Mitrofanova Grigoriy K Peglivanyan Natalia R Reinbach Darren K Griffin Michael Source Type: research
ELABELA-derived peptide ELA13 attenuates kidney fibrosis by inhibiting the Smad and ERK signaling pathways
In conclusion, ELA13 protected against kidney fibrosis through inhibiting the Smad and ERK signaling pathways and could thus be a promising candidate for anti-renal fibrosis treatment.PMID:38584095 | DOI:10.1631/jzus.B2300033 (Source: J Zhejiang Univ Sci ...)
Source: J Zhejiang Univ Sci ... - April 7, 2024 Category: Science Authors: Zhibin Yan Ying Shi Runling Yang Jijun Xue Caiyun Fu Source Type: research
Seizure as the main presenting manifestation of three patients with acute glufosinate-ammonium poisoning
J Zhejiang Univ Sci B. 2024 Apr 15;25(4):354-358. doi: 10.1631/jzus.B2300469.ABSTRACTGlufosinate-ammonium herbicides are the most widely used broad-spectrum, non-selective herbicides in the world. Glufosinate-ammonium is a structural analogue of glutamate (Glu) which can irreversibly inhibit the activity of glutamine synthetase (GS) and Glu decarboxylase in plants, thereby blocking the synthesis of glutamine (Gln) from Glu and ammonia (Hoerlein, 1994). This causes the plants to die because of the nitrogen metabolism disorder and subsequent intracellular accumulation of ammonia. In humans, the characteristic features of glu...
Source: J Zhejiang Univ Sci ... - April 7, 2024 Category: Science Authors: Ping Wang Congying Song Xuan Lu Yuanqiang Lu Source Type: research
Erratum to: Bioinformatic analysis for potential biological processes and key targets of heart failure-related stroke
J Zhejiang Univ Sci B. 2024 Apr 15;25(4):359. doi: 10.1631/jzus.B20e0544.ABSTRACTThe original version of this article (Liu et al., 2021) unfortunately contained a mistake: statement of equal contribution is missing. This correction article shows that Chiyu LIU and Sixu CHEN contributed equally to this work. The original article has been corrected.PMID:38584097 | DOI:10.1631/jzus.B20e0544 (Source: J Zhejiang Univ Sci ...)
Source: J Zhejiang Univ Sci ... - April 7, 2024 Category: Science Authors: Chiyu Liu Sixu Chen Haifeng Zhang Yangxin Chen Qingyuan Gao Zhiteng Chen Zhaoyu Liu Jingfeng Wang Source Type: research
Erratum to: Molecular dynamics simulation reveals DNA-specific recognition mechanism via c-Myb in pseudo-palindromic consensus of < em > mim-1 < /em > promoter
J Zhejiang Univ Sci B. 2024 Apr 15;25(4):360. doi: 10.1631/jzus.B22e0634.ABSTRACTThe original version of this article (Weng et al., 2023) unfortunately contained a mistake. In Acknowledgments, the number (No. 226-2022-00213) of the Fundamental Research Funds for the Central Universities is wrong. The correct number should be No. 2022FZZX01-33.PMID:38584098 | DOI:10.1631/jzus.B22e0634 (Source: J Zhejiang Univ Sci ...)
Source: J Zhejiang Univ Sci ... - April 7, 2024 Category: Science Authors: Jinru Weng Shuo Yang Jinkang Shen Hongsen Liu Yuzi Xu Dongyun Hao Shan Wang Source Type: research
Defense and anti-defense mechanisms of bacteria and bacteriophages
J Zhejiang Univ Sci B. 2024 Feb 14;25(3):181-196. doi: 10.1631/jzus.B2300101.ABSTRACTIn the post-antibiotic era, the overuse of antimicrobials has led to a massive increase in antimicrobial resistance, leaving medical doctors few or no treatment options to fight infections caused by superbugs. The use of bacteriophages is a promising alternative to treat infections, supplementing or possibly even replacing antibiotics. Using phages for therapy is possible, since these bacterial viruses can kill bacteria specifically, causing no harm to the normal flora. However, bacteria have developed a multitude of sophisticated and comp...
Source: J Zhejiang Univ Sci ... - March 7, 2024 Category: Science Authors: Xiaoqing Wang Sebastian Leptihn Source Type: research
Advances in the study of mitophagy in osteoarthritis
J Zhejiang Univ Sci B. 2024 Mar 15;25(3):197-211. doi: 10.1631/jzus.B2300402.ABSTRACTOsteoarthritis (OA), characterized by cartilage degeneration, synovial inflammation, and subchondral bone remodeling, is among the most common musculoskeletal disorders globally in people over 60 years of age. The initiation and progression of OA involves the abnormal metabolism of chondrocytes as an important pathogenic process. Cartilage degeneration features mitochondrial dysfunction as one of the important causative factors of abnormal chondrocyte metabolism. Therefore, maintaining mitochondrial homeostasis is an important strategy to ...
Source: J Zhejiang Univ Sci ... - March 7, 2024 Category: Science Authors: Hong Cao Xuchang Zhou Bowen Xu Han Hu Jianming Guo Miao Wang Nan Li Zou Jun Source Type: research
