Dexamethasone for post-operative nausea and vomiting prophylaxis in cesarean delivery and a delayed diagnosis of neonatal congenital adrenal hyperplasia
Classical congenital adrenal hyperplasia (CAH) occurs in 1 in 10 000-20 000 births, with approximately 95% of the cases due to 21-hydroxylase deficiency.1 Congenital adrenal hyperplasia results in decreased glucocorticoid and mineralocorticoid production with excess adrenal sex steroids. Untreated, it can result in salt wasting, failure to thrive, and potentially fatal adrenal crisis. The 46,XX infants present with virilized genitalia, ranging from clitoromegaly and/or labial fusion to development of a full phallus, thus raising suspicion for CAH upon initial examination. (Source: International Journal of Obstetric Anesthesia)
Source: International Journal of Obstetric Anesthesia - December 12, 2023 Category: Anesthesiology Authors: A. Waselewski Tags: Case Report Source Type: research

Maldistribution of fluid in preeclampsia: a secondary kinetic analysis
Preeclampsia is a complication of pregnancy that is characterized by hypertension, proteinuria, hypovolemia, peripheral edema, and, in severe cases, by coagulopathy.1 The combination of hypovolemia and edema is challenging for the anesthetist who plans to manage fluid therapy. (Source: International Journal of Obstetric Anesthesia)
Source: International Journal of Obstetric Anesthesia - December 5, 2023 Category: Anesthesiology Authors: R.G. Hahn Tags: Original Article Source Type: research

Extensive epidural spread of cerebrospinal fluid displacing the spinal cord after an inadvertent dural puncture in an obstetric patient
A 24-year-old healthy primipara, body mass index (BMI) 34  kg/m2, had a difficult neuraxial labor analgesia insertion from a combined spinal-epidural (CSE) technique with an 18-gauge Tuohy needle and 27-gauge spinal needle. The first three attempts resulted in paresthesia in the thighs from the spinal needle before successful spinal needle insertion, ide ntification of the clear flow of cerebrospinal fluid (CSF) and intrathecal injection of fentanyl citrate (25 µg in a volume of 2 mL). Dural puncture with the epidural needle was not observed and the epidural catheter was expected to be in the epidural space. (Source...
Source: International Journal of Obstetric Anesthesia - December 5, 2023 Category: Anesthesiology Authors: S. Kaivola, J. Martola, A. V äänänen Tags: Case Report Source Type: research

Extensive epidural spread of cerebrospinal fluid displacingthespinal cord afteraninadvertent dural puncture inanobstetric patient
A 24-year-old healthy primipara, body mass index (BMI) 34 kg/m2, had a difficult neuraxial labor analgesia insertion from a combined spinal-epidural (CSE) technique with an 18-gauge Tuohy needle and 27-gauge spinal needle. The first three attempts resulted in paresthesia in the thighs from the spinal needle before successful spinal needle insertion, identification of the clear flow of cerebrospinal fluid (CSF) and intrathecal injection of fentanyl citrate (25 µg in a volume of 2 mL). Dural puncture with the epidural needle was not observed and the epidural catheter was expected to be in the epidural space. (Source: Intern...
Source: International Journal of Obstetric Anesthesia - December 5, 2023 Category: Anesthesiology Authors: S. Kaivola, J. Martola, A. V äänänen Tags: Case Report Source Type: research

Maldistribution of fluid in preeclampsia; a secondary kinetic analysis
Preeclampsia is a complication of pregnancy that is characterized by hypertension, proteinuria, hypovolemia, peripheral edema, and, in severe cases, by coagulopathy.1 The combination of hypovolemia and edema is challenging for the anesthetist who plans to perform fluid therapy. (Source: International Journal of Obstetric Anesthesia)
Source: International Journal of Obstetric Anesthesia - December 5, 2023 Category: Anesthesiology Authors: Robert G. Hahn Tags: Original Article Source Type: research

Pregnancy-related outcomes in obstetric patients with pulmonary hypertension: a single-center retrospective cohort study
The World Health Organization (WHO) classifies pulmonary hypertension (PH) among the highest risk cardiovascular conditions complicating pregnancy. Pregnancy-related mortality among patients with PH ranges from 4% to 56%.1 –4 Mortality within one year of delivery may be higher in patients with severe PH compared with mild PH (21% vs. 9%).1,5 Obstetricians are advised to counsel patients with PH against pregnancy or recommend termination of pregnancy due to this high risk of mortality.6 However, PH severity is not a factor considered in these recommendations. (Source: International Journal of Obstetric Anesthesia)
Source: International Journal of Obstetric Anesthesia - December 1, 2023 Category: Anesthesiology Authors: A.L. McNeil, N.K. Al-Shibli, M.E. Fuller, S.A. Goldstein, A.S. Habib, S.K. Dotters-Katz, S.H. Shah, M-L. Meng Tags: Original Article Source Type: research

The minimum effective dose (ED90) of prophylactic oxytocin infusion during cesarean delivery in patients with and without obesity: an up-down sequential allocation dose-response study
Postpartum hemorrhage (PPH) is a major cause of maternal morbidity and mortality, with uterine atony being the commonest reason.1 The dose, timing and duration of oxytocin, administered as first-line prophylaxis to prevent uterine atony during cesarean delivery, varies in current clinical practice.2 Irrespective of the oxytocin regimen, lower doses are currently used to minimize various maternal side effects reported with high-dose boluses or empirically-titrated infusions.3 –6 (Source: International Journal of Obstetric Anesthesia)
Source: International Journal of Obstetric Anesthesia - December 1, 2023 Category: Anesthesiology Authors: A. Tyagi, C. NigamC, R.K. Malhotra, P. Bodh, S. Deep, A. Singla Tags: Original Article Source Type: research

Pregnancy-related outcomes in obstetric patients with pulmonary hypertension: a single center retrospective cohort study
The World Health Organization (WHO) classifies pulmonary hypertension (PH) among the highest risk cardiovascular conditions complicating pregnancy. Pregnancy-related mortality among patients with PH ranges from 4% to 56%.1 –4 Mortality within one year of delivery may be higher in patients with severe PH compared with mild PH (21% vs. 9%).1,5 Obstetricians are advised to counsel patients with PH against pregnancy or recommend termination of pregnancy due to this high risk of mortality.6 However, PH severity is not a factor considered in these recommendations. (Source: International Journal of Obstetric Anesthesia)
Source: International Journal of Obstetric Anesthesia - December 1, 2023 Category: Anesthesiology Authors: A.L. McNeil, N.K. Al-Shibli, M.R. Fuller, S.A. Goldstein, A.S. Habib, S.K. Dotters-Katz, S.H. Shah, M-L. Meng Tags: Original Article Source Type: research

Acute Sheehan syndrome revealed by neuropsychiatric disorders
We report the case of a 37-year-old parturient whose Sheehan syndrome was diagnosed early because of neuropsychiatric symptoms. (Source: International Journal of Obstetric Anesthesia)
Source: International Journal of Obstetric Anesthesia - December 1, 2023 Category: Anesthesiology Authors: Emilie Occhiali Tags: Correspondence Source Type: research

Anesthetic management for emergency cesarean section in a patient with Townes-Brocks Syndrome
Townes –Brocks syndrome (TBS) is a rare genetic disorder with a prevalence of 1:250 000.[1] This condition, associated with a mutation in the SALL1 gene, is characterized by a triad of imperforate anus, dysplastic ears, and thumb malformations. However, TBS often presents with a broader range of clinical manifestations including hearing impairment, genito-urinary, heart and foot malformations, cleft lip/palate, hemifacial microsomia, iris coloboma, Duane anomaly, and Arnold-Chiari malformation type 1. (Source: International Journal of Obstetric Anesthesia)
Source: International Journal of Obstetric Anesthesia - December 1, 2023 Category: Anesthesiology Authors: S Bojic, S Mihajlovic Tags: Correspondence Source Type: research

An evaluation of a healthy participant laboratory model of epidural hyperthermia: a physiological study
Hyperthermia (a core temperature>37.5 °C) complicates labour in approximately 21% of women who receive epidural analglsia.1 Epidural-related maternal hyperthermia (ERMH) is associated with adverse maternal and neonatal outcomes, including sepsis evaluation, antibiotic therapy, operative delivery, and possibly, neonatal brain injury.1-3 The underlying mechanism is unclear but we propose, based on prior work, that ERMH is a consequence of cholinergic sympathetic blockade.4 (Source: International Journal of Obstetric Anesthesia)
Source: International Journal of Obstetric Anesthesia - November 30, 2023 Category: Anesthesiology Authors: G. Chang, H. Moiteiro Manteigas, P.H. Strutton, C.J. Mullington Tags: Original Article Source Type: research

The availability of short-handled videolaryngoscopes in obstetric anaesthesia
In their paper 'A National Survey of Videolaryngoscopy in the United Kingdom,' Cook and Kelly found that the availability of videolaryngoscopes was approximately 40% less in obstetric theatres compared with general theatres.1 Following this, Lucas and Vaughan wrote in a letter to the British Journal of Anaesthesia noting that these findings were consistent with their prior research into videolaryngoscope availability in obstetric theatres and that increasing availability should be a priority for obstetric anaesthesia. (Source: International Journal of Obstetric Anesthesia)
Source: International Journal of Obstetric Anesthesia - November 30, 2023 Category: Anesthesiology Authors: Ruaridh McCusker, Nicki Alexander, Kate Theodosiou Tags: Correspondence Source Type: research

Cesarean section under spinal anesthesia in a first-time gravida with Fabry disease
Fabry disease (FD) (also Fabry Syndrome) is an x-linked inherited lysosomal storage disease characterized by reduced or absent activity of the enzyme α-galactosidase A.1 This leads to accumulation of globotriaosylceramide (Gb3) in various organs such as skin, heart, kidneys, brain, eyes, vascular and nervous systems, with corresponding organ dysfunction.2 Initial symptoms are often nonspecific, such that FD is usually diagnosed late and after se vere symptoms such as stroke, heart or kidney failure are present. (Source: International Journal of Obstetric Anesthesia)
Source: International Journal of Obstetric Anesthesia - November 20, 2023 Category: Anesthesiology Authors: K. Politt, C. Gaik Tags: Correspondence Source Type: research

Predictive performance of Shock Index for postpartum hemorrhage during cesarean delivery
Postpartum hemorrhage (PPH) is a significant obstetric emergency responsible for approximately one in five cases of maternal mortality worldwide.1 Conventionally, PPH in cesarean delivery (CD) is defined as blood loss ≥1000 mL,2 and its prevalence differs greatly across studies, regions, and levels of maternity care facilities, ranging from 4.8% to 30%.3–5 With the growing prevalence of PPH due to an increase in high-risk pregnancies (e.g. advanced maternal age, pregnancy via assisted reproductive technology, multiple pregnancy, and placenta accreta spectrum disorders),6 reducing life-threatening maternal morbidities a...
Source: International Journal of Obstetric Anesthesia - November 20, 2023 Category: Anesthesiology Authors: H. Mizutani, T. Ushida, K. Ozeki, S. Tano, Y. Iitani, K. Imai, K. Nishiwaki, H. Kajiyama, T. Kotani Tags: Original Article Source Type: research

Caesarean section under spinal anesthesia in a first-time gravida with Fabry disease
Fabry disease is a rare lysosomal storage disorder characterized by reduced or absent activity of the enzyme α-galactosidase A. Since the fertility of affected patients is generally not impaired, and an enzyme replacement therapy, which is now available, can halt the progression of the disease, anesthesiologists in obstetrics may also be confronted with affected patients. The present case report describes the performance of spinal anesthesia without complications for an elective Caesarean section in a woman with known Fabry disease. (Source: International Journal of Obstetric Anesthesia)
Source: International Journal of Obstetric Anesthesia - November 20, 2023 Category: Anesthesiology Authors: Katharina Politt, Christine Gaik Tags: Correspondence Source Type: research