International Journal of Developmental Biology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Insights into the role of the Wnt signaling pathway in the regeneration of animal model systems
Int J Dev Biol. 2023;67(3):65-78. doi: 10.1387/ijdb.220144yl.ABSTRACTRegeneration enables the regrowth and restoration of missing body parts. It is a common phenomenon among animals. However, only some species exhibit remarkable regeneration capabilities and can regenerate organs such as limbs, lenses or hearts. Regeneration has been widely studied, thereby giving rise to new fields, such as regenerative medicine. Furthermore, regeneration has the potential to be applied to the human body. However, the molecular mechanisms governing this process should be elucidated first. Recent advancements in research methods have led t...
Source: International Journal of Developmental Biology - November 8, 2023 Category: Biology Authors: Katarzyna S Walczy ńska Ling Zhu Yujun Liang Source Type: research
Evaluation of changes of apelin and apelin receptor (APJ) expression in cervix-uterus and placental axis in an LPS-induced preterm labor model
Int J Dev Biol. 2023;67(3):91-100. doi: 10.1387/ijdb.230156sa.ABSTRACTAlthough preterm birth is among the preventable causes of maternal and infant death, its mechanism has not yet been clarified. When evaluated in terms of the results, the psycho-social burden of mother-infant losses and the costs of rehabilitation, care, and treatment for postpartum sequelae are high. When evaluated in terms of its causes, infection/inflammation has an important place. Therefore, it is essential to understand the role of pro- and anti-inflammatory proteins in the process. In our study, apelin and apelin receptor (APJ) expression in the c...
Source: International Journal of Developmental Biology - November 8, 2023 Category: Biology Authors: Sema Avci Ezgi Golal Nuray Acar Source Type: research
Valproic acid effects on human adipose-derived stem cell differentiation into oligodendrocytes and improved remyelination in a mouse model of Multiple Sclerosis
Int J Dev Biol. 2023;67(3):101-108. doi: 10.1387/ijdb.230154ng.ABSTRACTValproic acid (VPA), a neuroprotective agent and inhibitor of GSK3-β, along with human Adipose-Derived Stem Cells (hADSCs) have been proposed to be potential therapeutic agents for neurodegenerative disorders. In the present study, we have assessed the effects of VPA alone or in combination with hADSCs on oligodendrocyte differentiation, remyelination, and functional recovery in a mouse model of Multiple Sclerosis (MS). These MS-model mice were randomly divided into cuprizone, sham, VPA, hADSC, and VPA/hADSC groups, with 10 mice considered a control gr...
Source: International Journal of Developmental Biology - November 8, 2023 Category: Biology Authors: Sahar Ghosouri Mohammad Bakhtiari Soleimani Mitra Nazem Ghasemi Source Type: research
Insights into the role of the Wnt signaling pathway in the regeneration of animal model systems
Int J Dev Biol. 2023;67(3):65-78. doi: 10.1387/ijdb.220144yl.ABSTRACTRegeneration enables the regrowth and restoration of missing body parts. It is a common phenomenon among animals. However, only some species exhibit remarkable regeneration capabilities and can regenerate organs such as limbs, lenses or hearts. Regeneration has been widely studied, thereby giving rise to new fields, such as regenerative medicine. Furthermore, regeneration has the potential to be applied to the human body. However, the molecular mechanisms governing this process should be elucidated first. Recent advancements in research methods have led t...
Source: International Journal of Developmental Biology - November 8, 2023 Category: Biology Authors: Katarzyna S Walczy ńska Ling Zhu Yujun Liang Source Type: research
Evaluation of changes of apelin and apelin receptor (APJ) expression in cervix-uterus and placental axis in an LPS-induced preterm labor model
Int J Dev Biol. 2023;67(3):91-100. doi: 10.1387/ijdb.230156sa.ABSTRACTAlthough preterm birth is among the preventable causes of maternal and infant death, its mechanism has not yet been clarified. When evaluated in terms of the results, the psycho-social burden of mother-infant losses and the costs of rehabilitation, care, and treatment for postpartum sequelae are high. When evaluated in terms of its causes, infection/inflammation has an important place. Therefore, it is essential to understand the role of pro- and anti-inflammatory proteins in the process. In our study, apelin and apelin receptor (APJ) expression in the c...
Source: International Journal of Developmental Biology - November 8, 2023 Category: Biology Authors: Sema Avci Ezgi Golal Nuray Acar Source Type: research
Valproic acid effects on human adipose-derived stem cell differentiation into oligodendrocytes and improved remyelination in a mouse model of Multiple Sclerosis
Int J Dev Biol. 2023;67(3):101-108. doi: 10.1387/ijdb.230154ng.ABSTRACTValproic acid (VPA), a neuroprotective agent and inhibitor of GSK3-β, along with human Adipose-Derived Stem Cells (hADSCs) have been proposed to be potential therapeutic agents for neurodegenerative disorders. In the present study, we have assessed the effects of VPA alone or in combination with hADSCs on oligodendrocyte differentiation, remyelination, and functional recovery in a mouse model of Multiple Sclerosis (MS). These MS-model mice were randomly divided into cuprizone, sham, VPA, hADSC, and VPA/hADSC groups, with 10 mice considered a control gr...
Source: International Journal of Developmental Biology - November 8, 2023 Category: Biology Authors: Sahar Ghosouri Mohammad Bakhtiari Soleimani Mitra Nazem Ghasemi Source Type: research
Insights into the role of the Wnt signaling pathway in the regeneration of animal model systems
Int J Dev Biol. 2023;67(3):65-78. doi: 10.1387/ijdb.220144yl.ABSTRACTRegeneration enables the regrowth and restoration of missing body parts. It is a common phenomenon among animals. However, only some species exhibit remarkable regeneration capabilities and can regenerate organs such as limbs, lenses or hearts. Regeneration has been widely studied, thereby giving rise to new fields, such as regenerative medicine. Furthermore, regeneration has the potential to be applied to the human body. However, the molecular mechanisms governing this process should be elucidated first. Recent advancements in research methods have led t...
Source: International Journal of Developmental Biology - November 8, 2023 Category: Biology Authors: Katarzyna S Walczy ńska Ling Zhu Yujun Liang Source Type: research
Evaluation of changes of apelin and apelin receptor (APJ) expression in cervix-uterus and placental axis in an LPS-induced preterm labor model
Int J Dev Biol. 2023;67(3):91-100. doi: 10.1387/ijdb.230156sa.ABSTRACTAlthough preterm birth is among the preventable causes of maternal and infant death, its mechanism has not yet been clarified. When evaluated in terms of the results, the psycho-social burden of mother-infant losses and the costs of rehabilitation, care, and treatment for postpartum sequelae are high. When evaluated in terms of its causes, infection/inflammation has an important place. Therefore, it is essential to understand the role of pro- and anti-inflammatory proteins in the process. In our study, apelin and apelin receptor (APJ) expression in the c...
Source: International Journal of Developmental Biology - November 8, 2023 Category: Biology Authors: Sema Avci Ezgi Golal Nuray Acar Source Type: research
Valproic acid effects on human adipose-derived stem cell differentiation into oligodendrocytes and improved remyelination in a mouse model of Multiple Sclerosis
Int J Dev Biol. 2023;67(3):101-108. doi: 10.1387/ijdb.230154ng.ABSTRACTValproic acid (VPA), a neuroprotective agent and inhibitor of GSK3-β, along with human Adipose-Derived Stem Cells (hADSCs) have been proposed to be potential therapeutic agents for neurodegenerative disorders. In the present study, we have assessed the effects of VPA alone or in combination with hADSCs on oligodendrocyte differentiation, remyelination, and functional recovery in a mouse model of Multiple Sclerosis (MS). These MS-model mice were randomly divided into cuprizone, sham, VPA, hADSC, and VPA/hADSC groups, with 10 mice considered a control gr...
Source: International Journal of Developmental Biology - November 8, 2023 Category: Biology Authors: Sahar Ghosouri Mohammad Bakhtiari Soleimani Mitra Nazem Ghasemi Source Type: research
Insights into the role of the Wnt signaling pathway in the regeneration of animal model systems
Int J Dev Biol. 2023;67(3):65-78. doi: 10.1387/ijdb.220144yl.ABSTRACTRegeneration enables the regrowth and restoration of missing body parts. It is a common phenomenon among animals. However, only some species exhibit remarkable regeneration capabilities and can regenerate organs such as limbs, lenses or hearts. Regeneration has been widely studied, thereby giving rise to new fields, such as regenerative medicine. Furthermore, regeneration has the potential to be applied to the human body. However, the molecular mechanisms governing this process should be elucidated first. Recent advancements in research methods have led t...
Source: International Journal of Developmental Biology - November 8, 2023 Category: Biology Authors: Katarzyna S Walczy ńska Ling Zhu Yujun Liang Source Type: research
Evaluation of changes of apelin and apelin receptor (APJ) expression in cervix-uterus and placental axis in an LPS-induced preterm labor model
Int J Dev Biol. 2023;67(3):91-100. doi: 10.1387/ijdb.230156sa.ABSTRACTAlthough preterm birth is among the preventable causes of maternal and infant death, its mechanism has not yet been clarified. When evaluated in terms of the results, the psycho-social burden of mother-infant losses and the costs of rehabilitation, care, and treatment for postpartum sequelae are high. When evaluated in terms of its causes, infection/inflammation has an important place. Therefore, it is essential to understand the role of pro- and anti-inflammatory proteins in the process. In our study, apelin and apelin receptor (APJ) expression in the c...
Source: International Journal of Developmental Biology - November 8, 2023 Category: Biology Authors: Sema Avci Ezgi Golal Nuray Acar Source Type: research
Polarized contact behavior in directionally migrating < em > Xenopus < /em > gastrula mesendoderm
Int J Dev Biol. 2023;67(3):79-90. doi: 10.1387/ijdb.230123rw.ABSTRACTThe control of cell-cell adhesion and detachment is essential for collective migration and cell rearrangement. Here, we have used the contact behavior of Xenopus gastrula mesoderm explants migrating directionally on ectoderm conditioned substratum to study the regulation of active cell-cell detachment. When colliding laterally, explants repelled each other, whereas they fused front-to-back when aligned in the direction of migration. For this mesoderm polarization by the substratum, we identified three control modules. First, PDGF-A signaling normally supp...
Source: International Journal of Developmental Biology - September 21, 2023 Category: Biology Authors: Martina Nagel Rudolf Winklbauer Source Type: research
Polarized contact behavior in directionally migrating < em > Xenopus < /em > gastrula mesendoderm
Int J Dev Biol. 2023 Sep 18. doi: 10.1387/ijdb.230123rw. Online ahead of print.ABSTRACTThe control of cell-cell adhesion and detachment is essential for collective migration and cell rearrangement. Here, we have used the contact behavior of Xenopus gastrula mesoderm explants migrating directionally on ectoderm conditioned substratum to study the regulation of active cell-cell detachment. When colliding laterally, explants repelled each other, whereas they fused front-to-back when aligned in the direction of migration. For this mesoderm polarization by the substratum, we identified three control modules. First, PDGF-A signa...
Source: International Journal of Developmental Biology - September 21, 2023 Category: Biology Authors: Martina Nagel Rudolf Winklbauer Source Type: research
