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The stem cell transcription factor ZFP296 transforms NIH3T3 cells and promotes anchorage-independent growth of cancer cells
In this study, we investigated the possible role of zinc finger protein 296 (ZFP296), a transcription factor expressed in ES cells, in cancer development. First, we found that overexpression of Zfp296 in NIH3T3 mouse fibroblasts induced two phenomena indicative of cell transformation: enhanced proliferation under low-serum conditions and anchorage-independent growth. We also found that Zfp296 expression was upregulated in the tumor area of a mouse model of colon carcinogenesis. In addition, the expression levels of ZFP296 in various human cell lines were generally low in normal cells and relatively high in cancer cells. Fi...
Source: International Journal of Developmental Biology - February 9, 2024 Category: Biology Authors: Yumi Mizoue Tomomi Ikeda Takako Ikegami Oleksandra Riabets Yoshie Oishi Morikuni Tobita Hidenori Akutsu Koichi Hattori Beate Heissig Hiroshi Koide Source Type: research

Chick chorioallantoic membrane: a valuable 3D < em > in vivo < /em > model for screening nanoformulations for tumor antiangiogenic therapeutics
Int J Dev Biol. 2023;67(4):115-135. doi: 10.1387/ijdb.230198pb.ABSTRACTDrug discovery is an extensive process. From identifying lead compounds to approval for clinical application, it goes through a sequence of labor-intensive in vitro, in vivo preclinical screening and clinical trials. Among thousands of drugs screened only a few get approval for clinical trials. Furthermore, these approved drugs are often discontinued due to systemic toxicity and comorbidity at clinically administered dosages. To overcome these limitations, nanoformulations have emerged as the most sought-after strategy to safely and effectively deliver ...
Source: International Journal of Developmental Biology - February 9, 2024 Category: Biology Authors: Anna Senrung Tanya Tripathi Divya Janjua Sunita Kumari Yadav Arun Chhokar Nikita Aggarwal Joni Yadav Apoorva Chaudhary Udit Joshi Pallavi Sethi Alok Chandra Bharti Source Type: research

The stem cell transcription factor ZFP296 transforms NIH3T3 cells and promotes anchorage-independent growth of cancer cells
In this study, we investigated the possible role of zinc finger protein 296 (ZFP296), a transcription factor expressed in ES cells, in cancer development. First, we found that overexpression of Zfp296 in NIH3T3 mouse fibroblasts induced two phenomena indicative of cell transformation: enhanced proliferation under low-serum conditions and anchorage-independent growth. We also found that Zfp296 expression was upregulated in the tumor area of a mouse model of colon carcinogenesis. In addition, the expression levels of ZFP296 in various human cell lines were generally low in normal cells and relatively high in cancer cells. Fi...
Source: International Journal of Developmental Biology - February 9, 2024 Category: Biology Authors: Yumi Mizoue Tomomi Ikeda Takako Ikegami Oleksandra Riabets Yoshie Oishi Morikuni Tobita Hidenori Akutsu Koichi Hattori Beate Heissig Hiroshi Koide Source Type: research

Chick chorioallantoic membrane: a valuable 3D < em > in vivo < /em > model for screening nanoformulations for tumor antiangiogenic therapeutics
Int J Dev Biol. 2023;67(4):115-135. doi: 10.1387/ijdb.230198pb.ABSTRACTDrug discovery is an extensive process. From identifying lead compounds to approval for clinical application, it goes through a sequence of labor-intensive in vitro, in vivo preclinical screening and clinical trials. Among thousands of drugs screened only a few get approval for clinical trials. Furthermore, these approved drugs are often discontinued due to systemic toxicity and comorbidity at clinically administered dosages. To overcome these limitations, nanoformulations have emerged as the most sought-after strategy to safely and effectively deliver ...
Source: International Journal of Developmental Biology - February 9, 2024 Category: Biology Authors: Anna Senrung Tanya Tripathi Divya Janjua Sunita Kumari Yadav Arun Chhokar Nikita Aggarwal Joni Yadav Apoorva Chaudhary Udit Joshi Pallavi Sethi Alok Chandra Bharti Source Type: research

The stem cell transcription factor ZFP296 transforms NIH3T3 cells and promotes anchorage-independent growth of cancer cells
In this study, we investigated the possible role of zinc finger protein 296 (ZFP296), a transcription factor expressed in ES cells, in cancer development. First, we found that overexpression of Zfp296 in NIH3T3 mouse fibroblasts induced two phenomena indicative of cell transformation: enhanced proliferation under low-serum conditions and anchorage-independent growth. We also found that Zfp296 expression was upregulated in the tumor area of a mouse model of colon carcinogenesis. In addition, the expression levels of ZFP296 in various human cell lines were generally low in normal cells and relatively high in cancer cells. Fi...
Source: International Journal of Developmental Biology - February 9, 2024 Category: Biology Authors: Yumi Mizoue Tomomi Ikeda Takako Ikegami Oleksandra Riabets Yoshie Oishi Morikuni Tobita Hidenori Akutsu Koichi Hattori Beate Heissig Hiroshi Koide Source Type: research

Chick chorioallantoic membrane: a valuable 3D < em > in vivo < /em > model for screening nanoformulations for tumor antiangiogenic therapeutics
Int J Dev Biol. 2023;67(4):115-135. doi: 10.1387/ijdb.230198pb.ABSTRACTDrug discovery is an extensive process. From identifying lead compounds to approval for clinical application, it goes through a sequence of labor-intensive in vitro, in vivo preclinical screening and clinical trials. Among thousands of drugs screened only a few get approval for clinical trials. Furthermore, these approved drugs are often discontinued due to systemic toxicity and comorbidity at clinically administered dosages. To overcome these limitations, nanoformulations have emerged as the most sought-after strategy to safely and effectively deliver ...
Source: International Journal of Developmental Biology - February 9, 2024 Category: Biology Authors: Anna Senrung Tanya Tripathi Divya Janjua Sunita Kumari Yadav Arun Chhokar Nikita Aggarwal Joni Yadav Apoorva Chaudhary Udit Joshi Pallavi Sethi Alok Chandra Bharti Source Type: research

The stem cell transcription factor ZFP296 transforms NIH3T3 cells and promotes anchorage-independent growth of cancer cells
In this study, we investigated the possible role of zinc finger protein 296 (ZFP296), a transcription factor expressed in ES cells, in cancer development. First, we found that overexpression of Zfp296 in NIH3T3 mouse fibroblasts induced two phenomena indicative of cell transformation: enhanced proliferation under low-serum conditions and anchorage-independent growth. We also found that Zfp296 expression was upregulated in the tumor area of a mouse model of colon carcinogenesis. In addition, the expression levels of ZFP296 in various human cell lines were generally low in normal cells and relatively high in cancer cells. Fi...
Source: International Journal of Developmental Biology - February 9, 2024 Category: Biology Authors: Yumi Mizoue Tomomi Ikeda Takako Ikegami Oleksandra Riabets Yoshie Oishi Morikuni Tobita Hidenori Akutsu Koichi Hattori Beate Heissig Hiroshi Koide Source Type: research

Chick chorioallantoic membrane: a valuable 3D < em > in vivo < /em > model for screening nanoformulations for tumor antiangiogenic therapeutics
Int J Dev Biol. 2023;67(4):115-135. doi: 10.1387/ijdb.230198pb.ABSTRACTDrug discovery is an extensive process. From identifying lead compounds to approval for clinical application, it goes through a sequence of labor-intensive in vitro, in vivo preclinical screening and clinical trials. Among thousands of drugs screened only a few get approval for clinical trials. Furthermore, these approved drugs are often discontinued due to systemic toxicity and comorbidity at clinically administered dosages. To overcome these limitations, nanoformulations have emerged as the most sought-after strategy to safely and effectively deliver ...
Source: International Journal of Developmental Biology - February 9, 2024 Category: Biology Authors: Anna Senrung Tanya Tripathi Divya Janjua Sunita Kumari Yadav Arun Chhokar Nikita Aggarwal Joni Yadav Apoorva Chaudhary Udit Joshi Pallavi Sethi Alok Chandra Bharti Source Type: research

The stem cell transcription factor ZFP296 transforms NIH3T3 cells and promotes anchorage-independent growth of cancer cells
In this study, we investigated the possible role of zinc finger protein 296 (ZFP296), a transcription factor expressed in ES cells, in cancer development. First, we found that overexpression of Zfp296 in NIH3T3 mouse fibroblasts induced two phenomena indicative of cell transformation: enhanced proliferation under low-serum conditions and anchorage-independent growth. We also found that Zfp296 expression was upregulated in the tumor area of a mouse model of colon carcinogenesis. In addition, the expression levels of ZFP296 in various human cell lines were generally low in normal cells and relatively high in cancer cells. Fi...
Source: International Journal of Developmental Biology - February 9, 2024 Category: Biology Authors: Yumi Mizoue Tomomi Ikeda Takako Ikegami Oleksandra Riabets Yoshie Oishi Morikuni Tobita Hidenori Akutsu Koichi Hattori Beate Heissig Hiroshi Koide Source Type: research

Chick chorioallantoic membrane: a valuable 3D < em > in vivo < /em > model for screening nanoformulations for tumor antiangiogenic therapeutics
Int J Dev Biol. 2023;67(4):115-135. doi: 10.1387/ijdb.230198pb.ABSTRACTDrug discovery is an extensive process. From identifying lead compounds to approval for clinical application, it goes through a sequence of labor-intensive in vitro, in vivo preclinical screening and clinical trials. Among thousands of drugs screened only a few get approval for clinical trials. Furthermore, these approved drugs are often discontinued due to systemic toxicity and comorbidity at clinically administered dosages. To overcome these limitations, nanoformulations have emerged as the most sought-after strategy to safely and effectively deliver ...
Source: International Journal of Developmental Biology - February 9, 2024 Category: Biology Authors: Anna Senrung Tanya Tripathi Divya Janjua Sunita Kumari Yadav Arun Chhokar Nikita Aggarwal Joni Yadav Apoorva Chaudhary Udit Joshi Pallavi Sethi Alok Chandra Bharti Source Type: research

The stem cell transcription factor ZFP296 transforms NIH3T3 cells and promotes anchorage-independent growth of cancer cells
In this study, we investigated the possible role of zinc finger protein 296 (ZFP296), a transcription factor expressed in ES cells, in cancer development. First, we found that overexpression of Zfp296 in NIH3T3 mouse fibroblasts induced two phenomena indicative of cell transformation: enhanced proliferation under low-serum conditions and anchorage-independent growth. We also found that Zfp296 expression was upregulated in the tumor area of a mouse model of colon carcinogenesis. In addition, the expression levels of ZFP296 in various human cell lines were generally low in normal cells and relatively high in cancer cells. Fi...
Source: International Journal of Developmental Biology - February 9, 2024 Category: Biology Authors: Yumi Mizoue Tomomi Ikeda Takako Ikegami Oleksandra Riabets Yoshie Oishi Morikuni Tobita Hidenori Akutsu Koichi Hattori Beate Heissig Hiroshi Koide Source Type: research

Chick chorioallantoic membrane: a valuable 3D < em > in vivo < /em > model for screening nanoformulations for tumor antiangiogenic therapeutics
Int J Dev Biol. 2023;67(4):115-135. doi: 10.1387/ijdb.230198pb.ABSTRACTDrug discovery is an extensive process. From identifying lead compounds to approval for clinical application, it goes through a sequence of labor-intensive in vitro, in vivo preclinical screening and clinical trials. Among thousands of drugs screened only a few get approval for clinical trials. Furthermore, these approved drugs are often discontinued due to systemic toxicity and comorbidity at clinically administered dosages. To overcome these limitations, nanoformulations have emerged as the most sought-after strategy to safely and effectively deliver ...
Source: International Journal of Developmental Biology - February 9, 2024 Category: Biology Authors: Anna Senrung Tanya Tripathi Divya Janjua Sunita Kumari Yadav Arun Chhokar Nikita Aggarwal Joni Yadav Apoorva Chaudhary Udit Joshi Pallavi Sethi Alok Chandra Bharti Source Type: research

The stem cell transcription factor ZFP296 transforms NIH3T3 cells and promotes anchorage-independent growth of cancer cells
In this study, we investigated the possible role of zinc finger protein 296 (ZFP296), a transcription factor expressed in ES cells, in cancer development. First, we found that overexpression of Zfp296 in NIH3T3 mouse fibroblasts induced two phenomena indicative of cell transformation: enhanced proliferation under low-serum conditions and anchorage-independent growth. We also found that Zfp296 expression was upregulated in the tumor area of a mouse model of colon carcinogenesis. In addition, the expression levels of ZFP296 in various human cell lines were generally low in normal cells and relatively high in cancer cells. Fi...
Source: International Journal of Developmental Biology - February 9, 2024 Category: Biology Authors: Yumi Mizoue Tomomi Ikeda Takako Ikegami Oleksandra Riabets Yoshie Oishi Morikuni Tobita Hidenori Akutsu Koichi Hattori Beate Heissig Hiroshi Koide Source Type: research

Chick chorioallantoic membrane: a valuable 3D < em > in vivo < /em > model for screening nanoformulations for tumor antiangiogenic therapeutics
Int J Dev Biol. 2023;67(4):115-135. doi: 10.1387/ijdb.230198pb.ABSTRACTDrug discovery is an extensive process. From identifying lead compounds to approval for clinical application, it goes through a sequence of labor-intensive in vitro, in vivo preclinical screening and clinical trials. Among thousands of drugs screened only a few get approval for clinical trials. Furthermore, these approved drugs are often discontinued due to systemic toxicity and comorbidity at clinically administered dosages. To overcome these limitations, nanoformulations have emerged as the most sought-after strategy to safely and effectively deliver ...
Source: International Journal of Developmental Biology - February 9, 2024 Category: Biology Authors: Anna Senrung Tanya Tripathi Divya Janjua Sunita Kumari Yadav Arun Chhokar Nikita Aggarwal Joni Yadav Apoorva Chaudhary Udit Joshi Pallavi Sethi Alok Chandra Bharti Source Type: research

The stem cell transcription factor ZFP296 transforms NIH3T3 cells and promotes anchorage-independent growth of cancer cells
In this study, we investigated the possible role of zinc finger protein 296 (ZFP296), a transcription factor expressed in ES cells, in cancer development. First, we found that overexpression of Zfp296 in NIH3T3 mouse fibroblasts induced two phenomena indicative of cell transformation: enhanced proliferation under low-serum conditions and anchorage-independent growth. We also found that Zfp296 expression was upregulated in the tumor area of a mouse model of colon carcinogenesis. In addition, the expression levels of ZFP296 in various human cell lines were generally low in normal cells and relatively high in cancer cells. Fi...
Source: International Journal of Developmental Biology - February 9, 2024 Category: Biology Authors: Yumi Mizoue Tomomi Ikeda Takako Ikegami Oleksandra Riabets Yoshie Oishi Morikuni Tobita Hidenori Akutsu Koichi Hattori Beate Heissig Hiroshi Koide Source Type: research