Effects of dexmedetomidine compared to propofol in alcohol withdrawal
Lizotte RJ, Kappes JA, Bartel BJ, Hayes KM, Lesselyoung VL (Source: International Journal of COPD)
Source: International Journal of COPD - October 30, 2014 Category: Respiratory Medicine Source Type: research
The Parkinson & #39;s disease death rate: carbidopa and vitamin B6
(Source: International Journal of COPD)
Source: International Journal of COPD - October 21, 2014 Category: Respiratory Medicine Tags: Clinical Pharmacology: Advances and Applications Source Type: research
The Parkinson's disease death rate: carbidopa and vitamin B6
Marty Hinz,1 Alvin Stein,2 Ted Cole31Clinical Research, NeuroResearch Clinics, Inc., Cape Coral, FL, USA; 2Stein Orthopedic Associates, Plantation, FL, USA; 3Cole Center for Healing, Cincinnati, OH, USAAbstract: The only indication for carbidopa and benserazide is the management of L-3,4-dihydroxyphenylalanine (L-dopa)-induced nausea. Both drugs irreversibly bind to and permanently deactivate pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, and PLP-dependent enzymes. PLP is required for the function of over 300 enzymes and proteins. Virtually every major system in the body is impacted directly or indirectly...
Source: International Journal of COPD - October 21, 2014 Category: Respiratory Medicine Tags: Clinical Pharmacology: Advances and Applications Source Type: research
Parkinson's disease death rate
Hinz M, Stein A, Cole T (Source: International Journal of COPD)
Source: International Journal of COPD - October 20, 2014 Category: Respiratory Medicine Source Type: research
Lack of effect of ezogabine/retigabine on the pharmacokinetics of digoxin in healthy individuals: results from a drug–drug interaction study
Conclusion: Co-administration of EZG/RTG across the therapeutic range resulted in small, non-dose-dependent and non-clinically relevant increases in digoxin systemic exposure, suggesting that digoxin dose adjustment is not necessary. Keywords: digoxin, retigabine, ezogabine, drug–drug interactions (Source: International Journal of COPD)
Source: International Journal of COPD - October 12, 2014 Category: Respiratory Medicine Tags: Clinical Pharmacology: Advances and Applications Source Type: research
Effect of ezogabine retigabine on the PK of digoxin
Tompson DJ, Crean CS, Buraglio M, Arumugham T (Source: International Journal of COPD)
Source: International Journal of COPD - October 12, 2014 Category: Respiratory Medicine Source Type: research
Arbekacin: another novel agent for treating infections due to methicillin-resistant Staphylococcus aureus and multidrug-resistant Gram-negative pathogens
Tetsuya Matsumoto Department of Microbiology, Tokyo Medical University, Tokyo, Japan Abstract: Arbekacin sulfate (ABK), an aminoglycoside antibiotic, was discovered in 1972 and was derived from dibekacin to stabilize many common aminoglycoside modifying enzymes. ABK shows broad antimicrobial activities against not only Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) but also Gram-negative bacteria such as Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae. ABK has been approved as an injectable formulation in Japan since 1990, under the trade name Habekacin, for the tre...
Source: International Journal of COPD - September 26, 2014 Category: Respiratory Medicine Tags: Clinical Pharmacology: Advances and Applications Source Type: research
Arbekacin, a novel agent for treating infections
Matsumoto T (Source: International Journal of COPD)
Source: International Journal of COPD - September 25, 2014 Category: Respiratory Medicine Source Type: research
Melatonergic drugs in development
Alessia Carocci,1 Alessia Catalano,1 Maria Stefania Sinicropi2 1Department of Pharmacy–Drug Sciences, University of Bari Aldo Moro, Bari, 2Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Cosenza, Italy Abstract: Melatonin (N-acetyl-5-methoxytryptamine) is widely known as "the darkness hormone". It is a major chronobiological regulator involved in circadian phasing and sleep-wake cycle in humans. Numerous other functions, including cyto/neuroprotection, immune modulation, and energy metabolism have been ascribed to melatonin. A variety of studies have revealed a role for mel...
Source: International Journal of COPD - September 18, 2014 Category: Respiratory Medicine Tags: Clinical Pharmacology: Advances and Applications Source Type: research
Advances in melatonergic agents
Carocci A, Catalano A, Sinicropi MS (Source: International Journal of COPD)
Source: International Journal of COPD - September 17, 2014 Category: Respiratory Medicine Source Type: research
