CAVI in hypertensive patients
Kiuchi S, Hisatake S, Kawasaki M, Hirashima O, Kabuki T, Yamazaki J, Ikeda T (Source: International Journal of COPD)
Source: International Journal of COPD - October 7, 2015 Category: Respiratory Medicine Source Type: research
A clinical evaluation to determine the safety, pharmacokinetics, and pharmacodynamics of an inositol-stabilized arginine silicate dietary supplement in healthy adult males
Conclusion: The arginine silicate dietary supplement increases blood levels of arginine after a single dose within 30 minutes and blood levels of silicon for up to 1.5 hours. Blood levels of arginine, silicon, and NO (salivary nitrite) were elevated consistently after 14 days of use. The observed increase in baseline salivary nitrite is supporting information that there was some improvement in NO production. Further study on the effect of this supplement on NO production and the resulting physiological effect is warranted. Within the specific protocol of this study, the product was found to be safe. Keywords: arginine, ni...
Source: International Journal of COPD - October 7, 2015 Category: Respiratory Medicine Tags: Clinical Pharmacology: Advances and Applications Source Type: research
Pharmacokinetic characteristics of arginine silicate
Kalman DS, Feldman S, Samson A, Krieger DR (Source: International Journal of COPD)
Source: International Journal of COPD - October 6, 2015 Category: Respiratory Medicine Source Type: research
An exploratory, randomized, parallel-group, open-label, relative bioavailability study with an additional two-period crossover food-effect study exploring the pharmacokinetics of two novel formulations of pexmetinib (ARRY-614)
Conclusion: These results suggest that the LFC formulation of pexmetinib may achieve greater exposures with lower doses due to the greater bioavailability compared to the PIC, and remain unaffected by coadministration with food. Keywords: pexmetinib, myelodysplastic syndromes, liquid-filled capsule, bioavailability, food-effect, formulation (Source: International Journal of COPD)
Source: International Journal of COPD - September 30, 2015 Category: Respiratory Medicine Tags: Clinical Pharmacology: Advances and Applications Source Type: research
Pharmacokinetics of a liquid-filled capsule formulation of pexmetinib
Wollenberg LA, Corson DT, Nugent CA, Peterson FL, Ptaszynski AM, Arrigo A, Mannila CG, Litwiler KS, Bell SJ (Source: International Journal of COPD)
Source: International Journal of COPD - September 29, 2015 Category: Respiratory Medicine Source Type: research
Tizanidine-induced acute severe cystitis in a female taking famotidine
We report a case of a 26-year-old Asian female on famotidine who presented with acute severe urinary burning after taking tizanidine. Keywords: adverse drug reaction, cystitis, famotidine, tizanidine (Source: International Journal of COPD)
Source: International Journal of COPD - July 29, 2015 Category: Respiratory Medicine Tags: Clinical Pharmacology: Advances and Applications Source Type: research
Tizanidine-induced cystitis
Poudel RR, Kafle NK (Source: International Journal of COPD)
Source: International Journal of COPD - July 28, 2015 Category: Respiratory Medicine Source Type: research
Pharmacokinetics and skin-tissue penetration of daptomycin in rats
Conclusion: Daptomycin exhibited good penetration into skin tissue, supporting its use for the treatment of complicated skin and skin-structure infections. However, further studies are needed in infected patients in order to investigate the relationship between the antimicrobial efficacy of daptomycin and its drug concentrations in skin tissues. Keywords: daptomycin, pharmacokinetics, rat, skin-tissue penetration (Source: International Journal of COPD)
Source: International Journal of COPD - May 21, 2015 Category: Respiratory Medicine Tags: Clinical Pharmacology: Advances and Applications Source Type: research
Daptomycin pharmacokinetics and tissue penetration
Matsumoto K, Kitaoka M, Kuroda Y, Ikawa K, Morikawa N, Sasaki J, Iketani O, Iwata S, Horino T, Hori S, Kizu J (Source: International Journal of COPD)
Source: International Journal of COPD - May 20, 2015 Category: Respiratory Medicine Source Type: research
Pharmacodynamics and Pharmacokinetics
Persson PB (Source: International Journal of COPD)
Source: International Journal of COPD - May 10, 2015 Category: Respiratory Medicine Source Type: research
Pharmacokinetic equivalence study of two formulations of the anticonvulsant pregabalin
Conclusion: The study concluded that the two formulations of pregabalin capsules studied were bioequivalent.Keywords: antiepileptic, bioavailability, bioequivalence, generic product (Source: International Journal of COPD)
Source: International Journal of COPD - April 20, 2015 Category: Respiratory Medicine Tags: Clinical Pharmacology: Advances and Applications Source Type: research
Bioequivalence study of pregabalin
Tjandrawinata RR, Setiawati E, Putri RSI, Gunawan VA, Ong F, Susanto LW, Nofiarny D (Source: International Journal of COPD)
Source: International Journal of COPD - April 19, 2015 Category: Respiratory Medicine Source Type: research
