Expanding antitumor therapeutic windows by targeting cancer-specific nicotinamide adenine dinucleotide phosphate-biogenesis pathways
Gaurab Chakrabarti,1,2,4 David E Gerber,3,4 David A Boothman1,2,4 1Department of Pharmacology, 2Department of Radiation Oncology, 3Division of Hematology and Oncology, 4Harold C Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, USA Abstract: Nicotinamide adenine dinucleotide phosphate (NADPH) biogenesis is an essential mechanism by which both normal and cancer cells maintain redox balance. While antitumor approaches to treat cancers through elevated reactive oxygen species (ROS) are not new ideas, depleting specific NADPH-biogenesis pathways that control recovery and repair pathways are nove...
Source: International Journal of COPD - March 27, 2015 Category: Respiratory Medicine Tags: Clinical Pharmacology: Advances and Applications Source Type: research
Cancer-selective alterations in NADPH biogenesis
Chakrabarti G, Gerber DE, Boothman DA (Source: International Journal of COPD)
Source: International Journal of COPD - March 26, 2015 Category: Respiratory Medicine Source Type: research
Carbon monoxide: a critical quantitative analysis and review of the extent and limitations of its second messenger function
David G Levitt,1 Michael D Levitt2 1Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, USA; 2Research Service, Veterans Affairs Medical Center, Minneapolis, MN, USA Abstract: Endogenously produced carbon monoxide (CO) is commonly believed to be a ubiquitous second messenger involved in a wide range of physiological and pathological responses. The major evidence supporting this concept is that CO is produced endogenously via heme oxygenase-catalyzed breakdown of heme and that experimental exposure to CO alters tissue function. However, it remains to be conclusively demonstrated that...
Source: International Journal of COPD - February 25, 2015 Category: Respiratory Medicine Tags: Clinical Pharmacology: Advances and Applications Source Type: research
Carbon monoxide signaling
Levitt DG, Levitt MD (Source: International Journal of COPD)
Source: International Journal of COPD - February 25, 2015 Category: Respiratory Medicine Source Type: research
Severe iatrogenic bradycardia related to the combined use of beta-blocking agents and sodium channel blockers
Conclusion: Although wide QRS ventricular tachyarrhythmia is a better known proarrhythmic effect of Na channel blockers, life-threatening bradycardia may also occur in combination with beta-blockers in the elderly, even months after the start of medication, and at plasma concentrations that do not prolong QRS width. Keywords: proarrhythmia, elderly, QRS duration (Source: International Journal of COPD)
Source: International Journal of COPD - February 15, 2015 Category: Respiratory Medicine Tags: Clinical Pharmacology: Advances and Applications Source Type: research
Drug related serious bradycardia
Kawabata M, Yokoyama Y, Sasaki T, Tao S, Ihara K, Shirai Y, Sasano T, Goya M, Furukawa T, Isobe M, Hirao K (Source: International Journal of COPD)
Source: International Journal of COPD - February 15, 2015 Category: Respiratory Medicine Source Type: research
Heparin requirements for full anticoagulation are higher for patients on dabigatran than for those on warfarin – a model-based study
Conclusion: Patients on warfarin with an average INR of 1.5 or higher are more sensitive to heparin than patients not previously anticoagulated or patients who discontinued dabigatran 27 hours earlier (approximately two half-lives) warfarin. Keywords: atrial fibrillation, electrophysiology, NONMEM, PKPD model (Source: International Journal of COPD)
Source: International Journal of COPD - February 4, 2015 Category: Respiratory Medicine Tags: Clinical Pharmacology: Advances and Applications Source Type: research
Heparin requirements when on dabigatran
Edrich T, Frendl G, Michaud G, Paschalidis I Ch (Source: International Journal of COPD)
Source: International Journal of COPD - February 4, 2015 Category: Respiratory Medicine Source Type: research
Bioavailability of everolimus administered as a single 5 mg tablet versus five 1 mg tablets: a randomized, open-label, two-way crossover study of healthy volunteers
Conclusion: Although the extent of absorption was similar, the Cmax of five 1 mg tablets was higher than that of one 5 mg tablet, suggesting these formulations lead to different peak blood concentrations and are not interchangeable at the dose tested. Keywords: absorption kinetics, healthy volunteers (Source: International Journal of COPD)
Source: International Journal of COPD - January 22, 2015 Category: Respiratory Medicine Tags: Clinical Pharmacology: Advances and Applications Source Type: research
Bioavailability of one 5 mg versus five 1 mg everolimus tablets
Thudium K, Gallo J, Bouillaud E, Sachs C, Eddy S, Cheung W (Source: International Journal of COPD)
Source: International Journal of COPD - January 21, 2015 Category: Respiratory Medicine Source Type: research
