The variability and reproducibility of whole genome sequencing technology for detecting resistance to anti-tuberculous drugs
Conclusions: We have demonstrated high comparative reproducibility of two sequencing platforms, and high predictive ability of the TBProfiler mutation library and analytical pipeline, when profiling resistance to first- and second-line anti-tuberculosis drugs. However, platform-specific variability in coverage of some genome regions may have implications for predicting resistance to specific drugs. These findings may have implications for future clinical practice and thus deserve further scrutiny, set within larger studies and using updated mutation libraries. (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - December 21, 2016 Category: Psychiatry Authors: Jody Phelan Denise O ’Sullivan Diana Machado Jorge Ramos Alexandra Whale Justin O ’Grady Keertan Dheda Susana Campino Ruth McNerney Miguel Viveiros Jim Huggett Taane Clark Source Type: research

Risk factors for erectile dysfunction in end-stage renal disease patients with short- or long-term hemodialysis therapy
Background: The influence of prolongation of hemodialysis (HD) period for erectile dysfunction (ED) has not been well evaluated. We evaluated the effects of various factors including hemodialysis duration for ED in hemodialysis patients. Methods: One hundred seventy-eight HD patients including 50 patients who received HD more than 10   years were enrolled in this study. The questionnaire of the International Index of Erectile Function (IIEF)-5 in Japanese language was used for evaluation of ED status in this cohort. Various clinical factors of these patients were collected from review of medical records, and the relations...
Source: International Journal of Bipolar Disorders - December 21, 2016 Category: Psychiatry Authors: Hayato Nishida Atsushi Yamagishi Toshihiko Sakurai Tomohiro Shibasaki Hisashi Kawazoe Osamu Ichiyanagi Tomoyuki Kato Akira Nagaoka Yoshihiko Tomita Norihiko Tsuchiya Source Type: research

Unravelling the glass trade bead sequence from Magoro Hill, South Africa: separating pre-seventeenth-century Asian imports from later European counterparts
Excavations conducted between 2010 and 2012 at Magoro Hill, a site in South Africa ’ s Limpopo Province frequented or intermittently occupied by African farming communities since the first millennium AD, yielded a substantial glass bead assemblage. A selection of the beads was studied non-destructively by classifying them according to morphological attributes, supplemented by Raman analyses and XRF measurements. It became evident that a morphological classification of beads recovered from sites that include imports into Africa after the seventeenth century AD could be problematic due to apparent morphological similaritie...
Source: International Journal of Bipolar Disorders - December 21, 2016 Category: Psychiatry Authors: Farahnaz Koleini Linda Prinsloo Wim Biemond Philippe Colomban Anh-Tu Ngo Jan Boeyens Maria van der Ryst Koos van Brakel Source Type: research

Resistance training program for fatigue management in the workplace: exercise protocol in a cluster randomized controlled trial
This study aims to demonstrate a resistance exercise protocol that individuals will perform during the work schedule, and to evaluate the effectiveness of this exercises program for fatigue control.Methods/DesignThis is a cluster randomized controlled trial with two arms and is assessor blinded. A total of 352 workers of both sexes, aged 18 – 65 years, from a medium-sized dairy plant were enrolled in this study. Participants will be recruited from 13 production sectors according to the eligibility criteria and will be randomized by clusters to either the Progressive Resistance Exercise (PRE) intervention group or the Com...
Source: International Journal of Bipolar Disorders - December 21, 2016 Category: Psychiatry Authors: H élio Santos Luciana Chiavegato Daniela Valentim Patricia da Silva Rosimeire Padula Source Type: research

Ultrasound anatomy of the transversus abdominis plane region in pregnant women before and after cesarean delivery
Background: After cesarean delivery, analgesia is often incomplete and a multimodal approach to analgesia is necessary. Transverse abdominal plane (TAP) block has been advocated in this setting, yet no systematic description of the ultrasound anatomy in pregnant women exists in the literature. Therefore, we aimed to describe the sonographical features of relevant structures in pregnant women before and after elective cesarean. Methods: Sixty women at, or close to term scheduled for elective cesarean delivery underwent a standardized ultrasound examination before and after delivery. We assessed the visibility of the muscula...
Source: International Journal of Bipolar Disorders - December 21, 2016 Category: Psychiatry Authors: Nicholas Kiefer Stefanie Krahe Ulrich Gembruch Stefan Weber Source Type: research

Block network mapping approach to quantitative trait locus analysis
Conclusions: Block Network Mapping provides an alternative data-driven approach to mapping quantitative trait loci that leverages correlations in the sampled genotypes. The evaluation methodology can be combined with existing approaches such as Interval Mapping. Python scripts are available at http://lbm.niddk.nih.gov/vipulp/. Genotype data is available at http://churchill-lab.jax.org/website/GattiDOQTL. (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - December 21, 2016 Category: Psychiatry Authors: Zeina Shreif Daniel Gatti Vipul Periwal Source Type: research

Efficacy of therapeutic suggestions under general anesthesia: a systematic review and meta-analysis of randomized controlled trials
Conclusions: Even though effects were small, our results provide indications that intraoperative suggestions can have the potential to reduce the need for medication and enhance recovery. Further high quality trials are needed to strengthen the promising evidence on the efficacy of therapeutic suggestions under general anesthesia for patients undergoing surgery. (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - December 21, 2016 Category: Psychiatry Authors: Jenny Rosendahl Susan Koranyi Davina Jacob Nina Zech Ernil Hansen Source Type: research

Arabidopsis PRC1 core component AtRING1 regulates stem cell-determining carpel development mainly through repression of class I KNOX genes
Conclusions: Our study uncovers a novel mechanistic pathway through which AtRING1a and AtRING1b repress KNOX-I expression to terminate floral stem cell activities and establish carpel cell fate identities. (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - December 21, 2016 Category: Psychiatry Authors: Donghong Chen Anne Molitor Lin Xu Wen-Hui Shen Source Type: research

Stochastic modelling of infectious diseases for heterogeneous populations
Conclusion: We propose a stochastic model to study the dynamics of infectious disease spread in heterogeneous populations from temporal-spatial surveillance data. The proposed model is evaluated using both simulated data and the real data from the 2009 H1N1 epidemic in Hong Kong and achieves acceptable prediction accuracy. We believe that our model can provide valuable insights for public health authorities to predict the effect of disease spread and analyse its underlying factors and to guide new control efforts. (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - December 21, 2016 Category: Psychiatry Authors: Rui-Xing Ming Ji-Ming Liu William W. Cheung Xiang Wan Source Type: research

Lithium side effects and toxicity: prevalence and management strategies
Despite its virtually universal acceptance as the gold standard in treating bipolar disorder, prescription rates for lithium have been decreasing recently. Although this observation is multifactorial, one obvi... (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - December 17, 2016 Category: Psychiatry Authors: Michael Gitlin Source Type: research

Serum concentrations of mood stabilizers are associated with memory, but not other cognitive domains in psychosis spectrum disorders; explorative analyses in a naturalistic setting
Mood stabilizers like lithium and anticonvulsants are used in bipolar and related psychotic disorders. There is a lack of knowledge of the relationship of these medications and cognition in the psychosis spect... (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - December 9, 2016 Category: Psychiatry Authors: Nils Eiel Steen, Monica Aas, Carmen Simonsen, Ingrid Dieset, Martin Tesli, Mari Nerhus, Erlend Gardsjord, Ragni M ørch, Ingrid Agartz, Ingrid Melle, Anja Vaskinn, Olav Spigset and Ole A. Andreassen Source Type: research

Electronic monitoring of self-reported mood: the return of the subjective?
This narrative review describes recent developments in the use of technology for utilizing the self-monitoring of mood, provides some relevant background, and suggests some promising directions. Subjective exp... (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - November 29, 2016 Category: Psychiatry Authors: Abigail Ortiz and Paul Grof Source Type: research

Bipolar disorder in the digital age: new tools for the same illness
“Nothing is more difficult than to ascertain the length of time that a maniacal patient can exist without sleep.”—Dr. Sutherland (Br J Psychiatry 7(37):1–19, 1861). Dr. Sutherland’s patient was suffering from an ... (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - November 17, 2016 Category: Psychiatry Authors: John Torous, Paul Summergrad and S. Nassir Ghaemi Source Type: research

Bipolar disorder in children and adolescents: diagnostic inpatient rates from 2000 to 2013 in Germany
Despite growing consensus on nosology and epidemiology of bipolar disorder (BD) in minors, differences remain. We contribute to this discussion by measuring long-term trends in the inpatient discharge rates of... (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - November 11, 2016 Category: Psychiatry Authors: Pradeep Rao, Julie K. Moore, Richard Stewart, Kevin Runions, Natasha Bear, Janice W. Y. Wong, Martin Holtmann and Florian D. Zepf Source Type: research

Psychometric properties and validation of a four-item version of the Strauss –Carpenter scale in bipolar disorder
Bipolar disorder is a chronic illness that impairs functioning and affects the quality of life of patients. The onset of this illness usually occurs at an early age, and the risk of relapse remains high for de... (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - October 18, 2016 Category: Psychiatry Authors: Susana Alberich, Sara Barbeito, Itxaso Gonz ález-Ortega, Amaia Ugarte, Patricia Vega, Sonia Ruiz de Azúa, Purificación López, Iñaki Zorrilla and Ana González-Pinto Source Type: research