Epigenetic markers in inflammation-related genes associated with mood disorder: a cross-sectional and longitudinal study in high-risk offspring of bipolar parents
Bipolar disorder is highly heritable and typically onsets in late adolescence or early adulthood. Evidence suggests that immune activation may be a mediating pathway between genetic predisposition and onset of... (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - August 6, 2019 Category: Psychiatry Authors: Anne Duffy, Sarah M. Goodday, Charles Keown-Stoneman, Martina Scotti, Malosree Maitra, Corina Nagy, Julie Horrocks and Gustavo Turecki Tags: Short communication Source Type: research

Clinical use of lithium salts: guide for users and prescribers
Lithium has been used clinically for 70 years, mainly to treat bipolar disorder. Competing treatments and exaggerated impressions about complexity and risks of lithium treatment have led to its declining use i... (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - July 22, 2019 Category: Psychiatry Authors: Leonardo Tondo, Martin Alda, Michael Bauer, Veerle Bergink, Paul Grof, Tomas Hajek, Ute Lewitka, Rasmus W. Licht, Mirko Manchia, Bruno M üller-Oerlinghausen, René E. Nielsen, Marylou Selo, Christian Simhandl and Ross J. Baldessarini Tags: Review Source Type: research

Alec J. Coppen —A pioneering psychiatrist who discovered the pivotal role of serotonin in the pathogenesis of depression as well as the antisuicidal effect of lithium
(Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - July 2, 2019 Category: Psychiatry Authors: Bruno M üller-Oerlinghausen and Mohammed T. Abou-Saleh Tags: Editorial Source Type: research

Neuropsychological profiles of adult bipolar disorder patients with and without comorbid attention-deficit hyperactivity disorder
Comorbid attention-deficit/hyperactivity disorder (ADHD) is common in bipolar disorder and associated with worse outcomes. Cognitive testing might be a tool to identify this group. Here we compare the neuropsy... (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - June 28, 2019 Category: Psychiatry Authors: Sara Salarvan, Timea Sparding, Caitlin Clements, Eleonore Ryd én and Mikael Landén Tags: Research Source Type: research

Attenuated inflammatory response of monocyte-derived macrophage from patients with BD: a preliminary report
Innate immune system dysfunction has been recognized as an important element in the pathophysiology of bipolar disorder (BD). We aimed to investigate whether there are differences in the response of macrophage... (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - June 1, 2019 Category: Psychiatry Authors: Bruna M. Ascoli, Mariana M. Parisi, Giovana Bristot, B árbara Antqueviezc, Luiza P. Géa, Rafael Colombo, Flávio Kapczinski, Fátima Theresinha Costa Rodrigues Guma, Elisa Brietzke, Florencia M. Barbé-Tuana and Adriane R. Rosa Tags: Research Source Type: research

Why are somatic diseases in bipolar disorder insufficiently treated?
Somatic diseases, including cardiovascular, respiratory, and cancer diseases, are the main contributors to a shortened life expectancy of 10 –20 years in patients with bipolar disorder as compared to the genera... (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - May 5, 2019 Category: Psychiatry Authors: Ren é Ernst Nielsen, Pirathiv Kugathasan, Sune Straszek, Svend Eggert Jensen and Rasmus W. Licht Tags: Review Source Type: research

Electroconvulsive therapy electrode placement for bipolar state-related targeted engagement
Electroconvulsive therapy (ECT) is an effective treatment for all bipolar states. However, ECT remains underutilized, likely stemming from stigma and the risk of neurocognitive impairment. Neuroimaging researc... (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - May 4, 2019 Category: Psychiatry Authors: Christopher C. Abbott, Jeremy Miller, Megan Lloyd and Mauricio Tohen Tags: Review Source Type: research

Metabolic profile in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives
The prevalence of metabolic syndrome and insulin resistance is twice as high in patients with bipolar disorder compared with the general population, and possibly associated with a disabling illness trajectory ... (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - April 2, 2019 Category: Psychiatry Authors: Klara Coello, Maj Vinberg, Filip K. Knop, Bente K. Pedersen, Roger S. McIntyre, Lars V. Kessing and Klaus Munkholm Tags: Research Source Type: research

Intra-individual variability in animal models of bipolar disorder
(Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - April 2, 2019 Category: Psychiatry Authors: Emily R. Hawken, Elisa Brietzke and Claudio N. Soares Tags: Letter to the Editor Source Type: research

Controversies in bipolar disorder; role of second-generation antipsychotic for maintenance therapy
In this narrative review, we discuss use of second-generation antipsychotics (SGAs) in maintenance treatment of bipolar disorder. We compare their use to historically more established treatments (particularly ... (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - March 27, 2019 Category: Psychiatry Authors: Sameer Jauhar and Allan H. Young Tags: Review Source Type: research

“What if I get ill?” perinatal concerns and preparations in primi- and multiparous women with bipolar disorder
Women with bipolar disorder have a high risk of illness relapse postpartum, including psychosis. The aim of the study was to explore how perinatal women with bipolar disorder relate to the risk. What are their... (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - March 3, 2019 Category: Psychiatry Authors: Teija M. S. Anke, Kari Slinning and Dag Vegard Skjelstad Tags: Research Source Type: research

Mortality rate trends in patients diagnosed with schizophrenia or bipolar disorder: a nationwide study with 20 years of follow-up
Patients with severe mental illness (SMI) have a reduced life expectancy of one to two decades as compared to the general population, with most years of life lost due to somatic diseases. Most previous studies... (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - March 1, 2019 Category: Psychiatry Authors: Line Hosbond Lomholt, Diana Vincens Andersen, Christina Sejrsgaard-Jacobsen, Cagla Margit Øzdemir, Claus Graff, Ole Schjerning, Svend Eggert Jensen, Sune Puggard Vogt Straszek, Rasmus W. Licht, Simon Grøntved and René Ernst Nielsen Tags: Research Source Type: research

Genetic and environmental influences on circulating NK and T cells and their relation to bipolar disorder
In previous studies we found mild deficiencies of circulating T cells in patients with bipolar disorder (BD) and children at risk for BD, correlating to a higher inflammatory state. The genetic and environment... (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - February 10, 2019 Category: Psychiatry Authors: G. Snijders, R. Brouwer, S. Kemner, F. Bootsman, H. A. Drexhage and M. H. J. Hillegers Tags: Short Communication Source Type: research

Differences in mood instability in patients with bipolar disorder type I and II: a smartphone-based study
This study investigated differences in mood instability between patients with bipolar disorder type I and type II, which previously ha... (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - February 1, 2019 Category: Psychiatry Authors: Maria Faurholt-Jepsen, Mads Frost, Jonas Busk, Ellen Margrethe Christensen, Jakob E. Bardram, Maj Vinberg and Lars Vedel Kessing Tags: Research Source Type: research

Rumination related activity in brain networks mediating attentional switching in euthymic bipolar patients
Mood disorder patients have a tendency to be more internally oriented, with difficulties in switching attentional focus, which might result in the generation of negative thoughts, such as rumination. The prese... (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - January 12, 2019 Category: Psychiatry Authors: Kallia Apazoglou, Anne-Lise K üng, Paolo Cordera, Jean-Michel Aubry, Alexandre Dayer, Patrik Vuilleumier and Camille Piguet Tags: Research Source Type: research