Brachial artery stiffening in healthy primigravidas is associated with weight gain and increased cardiac output.
Authors: Niemczyk NA, Catov JM, Desai MM, McClure CK, Roberts JM, Sekikawa A, Tepper PG, Barinas-Mitchell E Abstract OBJECTIVE: To assess brachial artery distensibility and associated factors in healthy primigravidas. METHODS: We assessed brachial artery distensibility using the DynaPulse 5,000A in 37 women each trimester, and 6-8 weeks and 1-5 years postpartum. Associations with physical and cardiometabolic measures were considered. RESULTS: Mean (SE) brachial artery distensibility (%Δ/mmHg) decreased (stiffened) from 7.50 (0.20) 12-14 weeks to 6.93 (0.22) 36-38 weeks (p 
Source: Hypertension in Pregnancy - September 27, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Arterial stiffness during controlled ovarian hyperstimulation and early pregnancy in women exposed to assisted reproduction.
CONCLUSION: During COH for IVF treatment, DPA showed no changes in arterial stiffness during the follicular phase or in early pregnancy, but increased arterial stiffness in central and peripheral arteries in the early luteal phase. The result suggests a hormonal hemodynamic activation counteracting the effects of estrogen. PMID: 30238809 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - September 23, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Prognostic value of serum soluble FMS-like tyrosine kinase (sFlt-1) levels in pre-eclampsia and eclampsia; a prospective cohort study.
Authors: Abbas AM, Fikry EM, Mostafa TS, Shaltout AS, El-Baz MAH Abstract OBJECTIVE: To evaluate the levels of circulating sFlt-1 in pre-eclampsia (PE) and eclampsia patients and to assess its prognostic value in detection of PE complications. METHODS: The present study was a prospective cohort study conducted in tertiary hospital between January and December 2016. Included patients were divided into two groups; (Group I) severe PE group and (Group II) eclampsia group. Age-, parity-, and gestational age-matched women had approached to participate in the study as a control group (Group III). Serum sFlt-1 levels ...
Source: Hypertension in Pregnancy - July 25, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Association between hypertensive disorders complicating pregnancy and risk of placenta accreta: a meta-analysis and systematic review.
CONCLUSIONS: Our meta-analysis demonstrated that the risk of placenta accreta is reduced in women with hypertensive disorders complicating pregnancy. Further well-designed studies are warranted to testify the result and explored any potential mechanism association between hypertensive disorders complicating pregnancy and placenta accreta. PMID: 30040502 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - July 25, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

The value of the 24-h proteinuria in evaluating the severity of preeclampsia and predicting its adverse maternal outcomes.
Authors: Li B, Lin L, Yang H, Zhu Y, Wei Y, Li X, Chen D, Zhao X, Cui S, Ding H, Ding G, Meng H, Wei H, Sun X, Xin H Abstract BACKGROUND: To identify the 24-h proteinuria value with quantitative analysis and how it correlates with the severity of preeclampsia and subsequent adverse maternal outcomes in the Chinese population. STUDY DESIGN: Eleven hospitals in 10 provinces across China were chosen, in which 1,738 pregnant women complicated by hypertensive disorders of pregnancy (HDP) with the records of 24 h proteinuria were enrolled. They were allocated into four groups: patients with maximal quantified proteinuria
Source: Hypertension in Pregnancy - July 25, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Urinary clusterin and glutathione-s-transferase levels in HIV positive normotensive and preeclamptic pregnancies.
CONCLUSION: HIV infection affects the activity of urinary CLU protein in HIV positive preeclampsia. However, the cytoprotective role of these proteins neutralizes the oxidative radicals associated with preeclampsia development through complement response in HIV infection. PMID: 30024772 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - July 21, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Objective assessment of obstructive sleep apnea in normal pregnant and preeclamptic women.
Authors: Keshavarzi F, Mehdizadeh S, Khazaie H, Ghadami MR Abstract OBJECTIVE: Obstructive sleep apnea (OSA) is a risk factor for adverse pregnancy outcomes. The aim of this study was to evaluate the association between OSA and preeclampsia. METHODS: Between 30 and 39 weeks gestation, objective sleep apnea were evaluated in 38 normal pregnant and 40 preeclamptic women. Preeclampsia was defined by having a blood pressure (BP)> 140/90 mmHg on two occasions after the 20th week of pregnancy with excess protein in the urine (> 300 mg in 24 h) or 30 mg persistent proteinuria (...
Source: Hypertension in Pregnancy - July 21, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Uterine artery flow velocity waveforms before and after delivery in hypertensive disorders of pregnancy near term.
Authors: Duncan JR, Tobiasz AM, Bursac Z, Rios-Doria EV, Schenone MH, Mari G Abstract OBJECTIVE: To compare the uterine artery pulsatility index (UtAPI-AP) before labor and immediate postpartum (UtAPI-PP) in hypertensive disorders of pregnancy (HTNP) and normotensives near term. METHODS: Pregnancies ≥36 weeks admitted for labor induction in our institution from October 2015 to October 2017 were included. We excluded active labor, multiple gestations, fetal demise, and those with inadequate uterine artery sampling. Our primary outcome was to compare the UtAPI-AP and UtAPI-PP between subjects with HTNP (g...
Source: Hypertension in Pregnancy - July 19, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Serum magnesium level in the first trimester of pregnancy as a predictor of pre-eclampsia - a pilot study.
Authors: Čabarkapa V, Bogavac M, Jakovljević A, Pezo L, Nikolić A, Belopavlović Z, Mirjana D Abstract OBJECTIVES: The aim of this study was to evaluate the importance of serum concentration of magnesium (Mg) in the first trimester of pregnancy for predicting pre-eclampsia (PE). METHODS: This prospective study included 403 pregnant women over 18, with singleton pregnancy (from 11 to 14 weeks of pregnancy). The subjects were divided into a group who subsequently developed PE (PEKT) (n = 61), and a group of healthy pregnancies with no complications and with normal outcomes (TNT) (n = 3...
Source: Hypertension in Pregnancy - July 19, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

The association of hyperuricemia and immediate postpartum hypertension in women without a diagnosis of chronic hypertension.
Authors: Marrs CC, Rahman M, Dixon L, Olson G Abstract Our objective was to determine if elevated uric acid (UA) is associated with postpartum hypertension (PP HTN) in women without chronic hypertension. This is a secondary analysis of a randomized trial. We compared those with elevated UA to those with normal UA. Logistic regression was conducted to determine the association of elevated UA with PP HTN. Five hundred and fifty-six women met criteria. An UA level ≥ 5.2 mg/dL was associated with immediate PP HTN (adjusted odds ratio 2.44, 95% CI 1.63-3.64). The association was stronger among overweight an...
Source: Hypertension in Pregnancy - July 18, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

First versus second trimester mean platelet volume and uric acid for prediction of preeclampsia in women at moderate and low risk.
CONCLUSION: Second trimester MPV and serum uric acid alone or in combination could be used as a useful biochemical markers for prediction of PE based on their validity, simplicity, and availability. PMID: 29893156 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - June 14, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Morphological and structural changes of umbilical veins and clinical significance in preeclampsia.
CONCLUSIONS: These results indicate that umbilical vein of preeclampsia cases has a thickened tunica media from smooth muscle proliferation, which may be an adapted reaction to hypertension. Altogether, this study demonstrates that morphological changes in umbilical veins adversely affect fetal development in preeclampsia cases. PMID: 29733777 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - May 9, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Association between serum CA125 levels in preeclampsia and its severity among women in Lagos, South-West Nigeria.
This study was done to assess the relationship between serum concentration of CA125 in normal pregnancies and those complicated with preeclampsia. METHODS: A case-control study involving 70 women diagnosed with preeclampsia and 70 healthy controls matched for age, parity, and gestational age at enrollment. Venous samples were collected from each participant after informed consent was obtained. The preeclampsia group was further subdivided into mild and severe preeclampsia and all participants were followed up till delivery with records of delivery, maternal, and neonatal outcomes obtained thereafter. Serum CA125 levels...
Source: Hypertension in Pregnancy - May 3, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Association of angiotensin receptor 2 gene polymorphisms with pregnancy induced hypertension risk.
CONCLUSIONS: rs5193, rs1403543 and rs12710567 of AT2R gene might have no effect on PIH risk among Chinese Han women. PMID: 29714512 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - May 2, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Cardiovascular risk after preeclampsia: The effect of communicating risk factors on intended healthy behavior.
CONCLUSION: Communicating risk factors alone does not seem to be effective as an intervention to achieve lifestyle changes. PMID: 29694251 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - April 26, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Changes in endothelial function, arterial stiffness and blood pressure in pregnant women after consumption of high-flavanol and high-theobromine chocolate: a double blind randomized clinical trial.
Authors: Babar A, Bujold E, Leblanc V, Lavoie-Lebel É, Paquette J, Bazinet L, Lemieux S, Marc I, Abdous B, Dodin S Abstract OBJECTIVES: The aim of this 2-group, parallel, double blind single-centre RCT was to evaluate the acute and chronic impacts of high flavanol high theobromine (HFHT) chocolate consumption on endothelial function, arterial stiffness and blood pressure (BP) in women at risk of preeclampsia. METHODS: 131 pregnant women considered at risk of preeclampsia based on uterine artery Doppler ultrasound were divided into two groups (HFHT or low flavanol and theobromine chocolate (LFLT). Acute c...
Source: Hypertension in Pregnancy - April 18, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Relation of locus 1p13 rs646776 polymorphism with the risk of preeclampsia.
CONCLUSION: The rare C allele of rs646776 polymorphism in chromosomal locus 1p13.3 is associated with decreased risk of preeclampsia. PMID: 29575956 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - March 27, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Safety of a physical therapy protocol for women with preeclampsia: a randomized controlled feasibility trial.
CONCLUSION: The protocol applied in the intervention group is feasible and safe for both mother and fetus. Both groups showed clinical reduction in the levels of anxiety; whereas, pain was clinically reduced in the intervention group. PMID: 29495906 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - March 3, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Early pregnancy protein multiplex screening reflects circulating and urinary divergences associated with the development of preeclampsia.
Authors: Martinez-Fierro ML, Castruita-De La Rosa C, Garza-Veloz I, Cardiel-Hernandez RM, Espinoza-Juarez MA, Delgado-Enciso I, Castañeda-Lopez ME, Cardenas-Vargas E, Trejo-Vázquez F, Sotelo-Ham EI, Castañeda-Miranda R, Cid-Baez MA, Ortiz-Rodriguez JM, Solis-Sanchez LO, Aviles AG, Ortiz-Castro Y Abstract BACKGROUND: Preeclampsia, a pregnancy disorder characterized by hypertension and proteinuria, represents the leading cause of fetal and maternal morbidity and mortality in developing countries. The identification of novel and accurate biomarkers that are predictive of preeclampsia is necessary ...
Source: Hypertension in Pregnancy - January 9, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Associations of hypertensive disorders of pregnancy and outcomes of labor induction with prostaglandin vaginal inserts.
CONCLUSION: After adjustment for confounders, such as BMI, baseline modified Bishop score and gestational age, time-to-event outcomes for induction of labor using MVI or DVI in HTNsive women are not significantly different from non-HTNsive women. PMID: 29291357 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - January 2, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

The effect of magnesium sulfate on gene expression in maternal microvascular endothelial cells.
Authors: Lee DK, Sengupta A, Nevo O Abstract Preeclampsia is a severe complication of pregnancy associated with maternal and fetal morbidity and mortality. To date, magnesium sulfate remains the preferred method of treatment used to reduce the development of eclampsia. Our aim was to investigate the effects of magnesium sulfate on the expression of genes involved with endothelial function in maternal microvascular endothelial cells from both normal and preeclamptic pregnancies. Primary cells from normal pregnancies treated with 80 mg/L magnesium sulfate for 6 h revealed an overall trend of increased expre...
Source: Hypertension in Pregnancy - November 29, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Alteration in methylation level at differential methylated regions of MEST and DLK1 in fetus of preeclampsia.
Authors: Wang X, Wan L, Weng X, Xie J, Zhang A, Liu Y, Dong M Abstract OBJECTIVES: Offspring born to preeclamptic women are at high risk for metabolic diseases in later life, but the mechanisms are not known. The purposes of the current investigation were to clarify the changes in DNA methylation at MEST and DLK1 DMRs in fetus of preeclampsia and to explore the possible mechanisms behind the high risk of adult diseases in the offspring of preeclampsia. METHODS: Fetal lymphocytes were isolated from umbilical cord blood of 78 women with preeclampsia and 95 women with normal pregnancy. Genomic DNA was extracted an...
Source: Hypertension in Pregnancy - November 23, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Relation with postpartum maternal morbidity of different types of anesthesia in preeclamptic patients.
CONCLUSION: The need for antihypertensive medication is greater in patients with severe preeclampsia receiving general anesthesia. There is a need for comprehensive, prospective, and randomized controlled trials to establish the relationship between postpartum morbidity and the different types of anesthesia. PMID: 29157041 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - November 23, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

ADAMTS 1, 4, 12, and 13 levels in maternal blood, cord blood, and placenta in preeclampsia.
Authors: Namlı Kalem M, Kalem Z, Yüce T, Soylemez F Abstract The aim of this study is to compare ADAMTS (A Disintegrin and Metalloprotease Domains with Thrombospondins motifs) 1, 4, 12, and 13 levels in maternal and cord blood and placental tissue between preeclampsia and uncomplicated pregnancies. The enzyme-linked immunosorbent assay (ELISA) results showed that ADAMTS 1, 4, 12, and 13 levels in the maternal and cord blood were lower in the preeclampsia group than in the control group. Based on the immunohistochemistry (IHC) results, ADAMTS 1, 4, and 12 levels in placental tissues were higher in the preeclam...
Source: Hypertension in Pregnancy - November 16, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Preeclampsia knowledge among women in Utah.
CONCLUSIONS: Patient awareness is essential to the successful management of PE. The need for improved PE education in Utah was evident in this survey. As not all healthcare providers are diligent in instructing patients regarding PE, more research is needed to fully assess the knowledge of mothers and examine the practices of providers. An explanation of PE signs and symptoms should be given to all women at prenatal care visits to improve health outcomes. PMID: 29140734 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - November 16, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Editorial Board Page EOV.
Authors: PMID: 29131741 [PubMed - in process] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - November 15, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Type of obstetric anesthesia administered and complications in women with preeclampsia in low- and middle-income countries: A systematic review.
CONCLUSION: General anesthesia is associated with increased complications in women with preeclampsia undergoing cesarean section in LMIC. PMID: 29125378 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - November 12, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Circulating fetal and total cell-free DNA, and sHLA-G in black South African women with gestational hypertension and pre-eclampsia.
Authors: Eche S, Mackraj I, Moodley J Abstract OBJECTIVE: Quantification of circulating fetal and total cell-free DNA (cfDNA) and soluble human leucocyte antigen (HLAG) in gestational hypertension and pre-eclampsia. METHODS: Serum cfDNA were quantified in controls, pre-eclamptics, and gestational hypertensive patients using real-time qPCR. Soluble HLAG was measured by enzyme-linked immune-sorbent assay. RESULTS: Serum fetal and total cfDNA levels were higher in pre-eclampsia compared with the controls and gestational hypertensives (p 
Source: Hypertension in Pregnancy - November 10, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Association between the soluble epoxide hydrolase gene and preeclampsia.
In this study the association between K55R polymorphism, methylation level of the EPHX2 promoter region, and PE was investigated in 520 individuals including 260 PE patients and 260 healthy pregnant women. METHODS: K55R polymorphism and methylation level of the EPHX2 promoter were determined by the real-time PCR using double-dye hydrolysis probes and methylation-sensitive high-resolution melting analysis, respectively. RESULTS: The presence of the K55R polymorphism was significantly higher in cases (28.1%) than controls (17.3%), and was associated with increased risk of PE (OR: 1.86; 95% CI: 1.09-2.63). Methylation...
Source: Hypertension in Pregnancy - October 24, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Maternal serum autotaxin levels in early- and late-onset preeclampsia.
CONCLUSION: Autotaxin might be a promising marker for detecting early-onset preeclampsia. However, further studies are necessary to confirm this hypothesis. PMID: 29058512 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - October 24, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Role of kidney biomarkers [Kidney injury molecule-1, Calbindin, Interleukin-18 and Monocyte chemoattractant protein-1] in HIV associated pre-eclampsia.
CONCLUSION: Our results demonstrate an increase in the urinary level of kidney injury molecule-1 and calbindin in PE, implicating their possible value as biomarkers of kidney injury. We observed no differences in the levels of KIM-1, IL-18, MCP-1 and calbindin based on HIV status. We propose that studies with larger sample sizes using these markers be conducted to establish their use as markers of diagnosing kidney injury in PE. PMID: 29039974 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - October 20, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Maternal and cord blood cyclophilin A in severe preeclampsia and normal pregnancy and its correlation with vitamin D and zinc.
CONCLUSION: Cyclophilin A levels in severe preeclampsia is higher compared to normal pregnancy. There is no correlation between cyclophilin A, zinc, and vitamin D. PMID: 29039975 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - October 20, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

FN1, FOS, and ITGA5 induce preeclampsia: Abnormal expression and methylation.
CONCLUSION: FN1, FOS, and ITGA5 might promote the development of preeclampsia via modulating differentiation/apoptosis/invasion of human extravillous trophoblasts, as well as focal adhesion, VEGFR3 signaling, β1 integrin cell surface interactions, α9β1/α4β1 integrin signaling, AP-1/ATF-2/HIF-1α transcription factor networks, and Fc-epsilon receptor I signaling in mast cells. PMID: 29039998 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - October 20, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Systemic vascular resistance and endogenous inhibitors of nitric oxide synthesis in early- compared to late-onset preeclampsia: preliminary findings.
CONCLUSIONS: Early-onset and late-onset preeclampsia are both characterized by increased systemic vascular resistance and elevated levels of nitric oxide synthesis inhibitors. PMID: 28841341 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - August 27, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Association between the high soluble fms-like tyrosine kinase-1 to placental growth factor ratio and adverse outcomes in asymptomatic women with early-onset fetal growth restriction.
Authors: Shinohara S, Uchida Y, Kasai M, Sunami R Abstract OBJECTIVE: To assess whether the high soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) ratio is associated with adverse outcomes (e.g., HELLP syndrome [hemolysis, elevated liver enzymes, and low platelets], severe hypertension uncontrolled by medication, non-reassuring fetal status, placental abruption, pulmonary edema, growth arrest, maternal death, or fetal death) and a shorter duration to delivery in early-onset fetal growth restriction (FGR). METHODS: Thirty-four women with FGR diagnosed at
Source: Hypertension in Pregnancy - July 25, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

The pathology of eclampsia: An autopsy series.
CONCLUSION: Pathological changes in cases of eclampsia include widespread endothelial/vascular injury in vulnerable organ beds. PMID: 28678644 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - July 6, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Corrigendum.
Authors: PMID: 28635350 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - June 22, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Role of angiopoietin-2, endoglin, and placental growth factor in HIV-associated preeclampsia.
This study assessed their serum levels in HIV-negative and HIV-positive pregnant normotensive and pre-eclamptic women. METHODS: Participants were recruited at the antenatal clinic, serum samples were evaluated using the Bioplex Human Cancer Biomarker (panel 2). RESULTS: Ang-2 and Eng levels were higher, whilst PlGF levels were lower in the PE compared with the normotensive group. Pregnancy type had no significant effect on Ang-2 and showed a significant interaction with Eng (p
Source: Hypertension in Pregnancy - June 21, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Therapeutic benefit of mesenchymal stem cells in pregnant rats with angiotensin receptor agonistic autoantibody-induced hypertension: Implications for immunomodulation and cytoprotection.
This study aimed to investigate the biological function of human umbilical cord-derived mesenchymal stem cells (HU-MSCs) for the treatment of angiotensin receptor agonistic autoantibody (AT1-AA)-induced hypertension during pregnancy. HU-MSCs were isolated, cultured, and labeled in vitro. AT1-AA and HU-MSCs were administered to pregnant rats. Green fluorescent protein (GFP)-positive HU-MSCs infused in vivo were identified by immunofluorescence. Systolic blood pressure (SBP) was evaluated. The effects of HU-MSCs on fetal weight, kidney burden, and spiral artery remodeling, as well as on the expression of tumor necrosis facto...
Source: Hypertension in Pregnancy - June 16, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Serum levels of platelet endothelial cell adhesion molecule-1 (PECAM-1) and soluble vascular endothelial growth factor receptor (sVEGFR)-1 and -2 in HIV associated preeclampsia.
CONCLUSION: Irrespective of the HIV status, we report an upregulation of sVEGFR-1 with concomitant decline of PECAM-1 and sVEGFR-2 levels in PE compared to normotensive pregnancies. PMID: 28609170 [PubMed - in process] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - June 16, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Myocardial performance index in hypertensive disorders of pregnancy: The relationship between blood pressures and angiogenic factors.
Authors: Ramadan H, Rana S, Mueller A, Bajracharya S, Zhang D, Salahuddin S, Nasim R, Perdigao JL, Minhaj M, Tung A, Arany Z, Shahul S Abstract OBJECTIVE: To study the association between cardiac function measured by myocardial performance index (MPI), blood pressures and angiogenic factors measured at the time of echocardiography in patients with and without hypertensive disorders of pregnancy (HDP). METHODS: We prospectively studied 189 pregnant women and evaluated whether changes in cardiac function observed on echocardiography were correlated with higher blood pressures and whether higher blood pressures we...
Source: Hypertension in Pregnancy - June 16, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Placental expression of sFlt-1 and PlGF in early preeclampsia vs. early IUGR vs. age-matched healthy pregnancies.
CONCLUSION: High sFlt-1 concentrations may account for diminished maternal serum PlGF levels. PMID: 28609172 [PubMed - in process] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - June 16, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Assessment of relationships between novel inflammatory markers and presence and severity of preeclampsia: Epicardial fat thickness, pentraxin-3, and neutrophil-to-lymphocyte ratio.
In this study, a total of 100 consecutive pregnants with a diagnosis of preeclampsia and 40 healthy pregnants between October 2014 and April 2015 were included. Epicardial fat tissue was calculated by two-dimensional transthoracic echocardiography, and pentraxin-3 and neutrophil-to-lymphocyte ratio were measured by using an enzyme-linked immunosorbent assay method and routine blood count analysis, respectively. RESULTS: Epicardial fat thickness (p 
Source: Hypertension in Pregnancy - June 2, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Decreased frequency of peripheral blood CD8(+)CD25(+)FoxP3(+)regulatory T cells correlates with IL-33 levels in pre-eclampsia.
CONCLUSIONS: These findings suggest that the reduced CD8(+)CD25(+)Foxp3(+)Treg cells may play a role in the pathogenesis of PE. Abbreviations PE: pre-eclampsia; PBMCs: peripheral blood mononuclear cells; CTLA-4: cytotoxic T-lymphocyteantigen-4; APCs: antigen presenting cells; TGF-β: transforming growth factor-β; IL: interleukin; Treg: cells regulatory T cells; PBS: phosphate-buffered saline; Foxp3: forkhead Box protein 3; HELLPs: hemolysis, elevated liver enzyme and low platelet syndrome. PMID: 28541089 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - May 26, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Incidence of superimposed preeclampsia among pregnant Asian women with chronic hypertension.
CONCLUSION: Incidence of superimposed preeclampsia was 43.3% among pregnant women with chronic hypertension, with increased adverse neonatal outcomes. High MAP ≥105 mmHg during late second trimester might be an important predictor of the condition. PMID: 28541800 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - May 26, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Placental protein 13 (PP13)-induced vasodilation of resistance arteries from pregnant and nonpregnant rats occurs via endothelial-signaling pathways.
This study aims to evaluate PP13 effects on isolated uterine arteries from nonpregnant and mid-pregnant rats. Vessels were isolated, cannulated, and pressurized to 50 mmHg within an arteriograph, preconstricted and exposed to increasing PP13 concentrations (10(-13)-10(-8) M). PP13 elicited 38-50% arterial vasodilation with half-maximum response (EC50) = 1 pM. The relaxation was mediated by activating the endothelial-signaling pathways of prostaglandin and nitric oxide (NO). Accordingly, these results encourage evaluation of PP13 as a possible therapy for gestational diseases characterized by insufficient uteroplacental blo...
Source: Hypertension in Pregnancy - May 20, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Effect of vascular endothelial growth factors A, C, and D in HIV-associated pre-eclampsia.
Authors: Shange GP, Moodley J, Naicker T Abstract OBJECTIVE: To measure and correlate the level of vascular endothelial growth factors A, C, and D in HIV-associated pre-eclampsia. METHODS: VEGF-A, VEGF-C, and VEGF-D were measured in serum of 76 normotensive and pre-eclamptic pregnant women stratified by HIV status using Bio-Plex. RESULTS: No significant difference was shown between pre-eclamptic and normotensive and between HIV negative and positive women. A strong significant positive correlation was demonstrated between VEGF-A and VEGF-C, VEGF-A and VEGF-D, and VEGF-C and VEGF D (p
Source: Hypertension in Pregnancy - May 20, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Emergency department visits for postpartum hypertension.
CONCLUSION: Postpartum surveillance may not prevent readmission for hypertension; future focus should be in prevention interventions. PMID: 28524763 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - May 20, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Human endometrial stromal cell plasticity: Reversible sFlt1 expression negatively coincides with decidualization.
In this study, we seek to understand the dynamic regulation of sFlt1 production in primary human ESC as a result of hormone stimulation and withdrawal. To mimic a biphasic menstrual cycle, ESC were treated with cAMP to induce endometrial decidualization that occurs during the luteal secretory phase, followed by cAMP withdrawal reflecting the follicular proliferative phase. Here, we present data to show that (1) ESC produce detectable amounts of sFlt1, (2) sFlt1 expression is turned off during decidualization at both the protein and RNA level (3) ESC decidualization and resulting sFlt1 expression are reversible phenomenon, ...
Source: Hypertension in Pregnancy - May 13, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Increased placental sFlt-1 but unchanged PlGF expression in late-onset preeclampsia.
CONCLUSION: High sFlt-1 concentrations may account for diminished maternal serum PlGF levels. PMID: 28494189 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - May 13, 2017 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research