Travel distance to prenatal care and high blood pressure during pregnancy.
CONCLUSION: To our knowledge, no previous studies have examined the association between poor geographic accessibility to care and the possible harms of travel burdens for pregnant women. Future research that replicates these findings can assist in developing recommendations for pregnant women and health-care accessibility. PMID: 27835033 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - November 13, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

The effect of healthy pregnant plasma and preeclamptic plasma on the phagocytosis index of neutrophil granulocytes and monocytes of nonpregnant women.
CONCLUSION: The decreased phagocyte function of neutrophil granulocytes and that of monocytes in healthy pregnancy and the further decreased phagocyte function in preeclampsia is caused by factor(s) in the maternal circulation. PMID: 27835035 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - November 13, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Increased circulating Th22 cells correlated with Th17 cells in patients with severe preeclampsia.
CONCLUSIONS: Increased circulating Th22 cells, which were correlated with Th17 cells, were observed in patients with sPE. The immune imbalance between T helper (Th) cells may contribute to the pathogenesis of sPE. PMID: 27835036 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - November 13, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Developing a new algorithm for first and second trimester preeclampsia screening in twin pregnancies.
CONCLUSIONS: The algorithm effectively forecasted twin risk to develop PE. PMID: 27835040 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - November 13, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Identifying miRNA regulatory mechanisms in preeclampsia by systems biology approaches.
Authors: Biró O, Nagy B, Rigó J Abstract BACKGROUND: Preeclampsia (PE) is the major cause of maternal and fetal morbidity and mortality, affecting 3-8% of all pregnancies around the globe. miRNAs are small, noncoding RNA molecules, which negatively regulate gene expression. Abnormally expressed miRNAs contribute to pregnancy complications such as PE. The aim of our study was to find possible regulatory mechanisms by system biology approaches, which are connected to the pathogenesis of PE. METHODS: We integrated publicly available miRNA and gene expression profiles and created a network from the si...
Source: Hypertension in Pregnancy - November 13, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Furosemide in postpartum management of severe preeclampsia: A randomized controlled trial.
Conclusion: In conclusion, the use of a short course of furosemide along with nifedipine significantly reduces the need of additional antihypertensive in severe preeclamptic women with postpartum hypertension when compared to women who received nifedipine alone. PMID: 27835048 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - November 13, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Comparison of serum selenium levels among hypertensive and normotensive pregnant women.
Authors: da Silva AC, Martins-Costa SH, Valério EG, Lopes Ramos JG Abstract OBJECTIVE: To correlate serum selenium levels with hypertensive disorders of pregnancy (HDP) in a selected population and evaluate this mineral as a possible protective factor. METHODS: This case-control study included 32 normotensive, 20 hypertensive (chronic and gestational hypertension), and 38 preeclamptic pregnant women. All patients were recruited from antenatal or obstetric admissions of a tertiary hospital in Brazil. Serum selenium was measured at the time of inclusion. Patients were followed up until hospital discharge a...
Source: Hypertension in Pregnancy - November 13, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

The role of glutathione peroxidase maternal serum level in late onset of severe preeclampsia.
This study was done to investigate the association between maternal serum glutathione peroxidase (GP) and late onset of severe preeclampsia. METHODS: Cross-sectional study was undertaken comparing normal pregnancy and severe preeclampsia at 37-42 weeks of gestational age. Maternal venous blood was taken to assess the level of GP. RESULT: Twenty normal pregnancy and 20 severe preeclampsia patients were investigated. The median (max-min) of GP level for preeclampsia was 4.31 (0.03-327.41) mU/mL significantly lower than in normal pregnancy 318.90 (6.46-694.11) mU/mL (p
Source: Hypertension in Pregnancy - November 3, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Predictivity of mean platelet volume in severe preeclamptic women.
Authors: Özdemirci Ş, Başer E, Kasapoğlu T, Karahanoğlu E, Kahyaoglu I, Yalvaç S, Tapısız Ö Abstract INTRODUCTION: To evaluate the predictive and clinical utilization of the mean platelet volume (MPV) in severe preeclamptic women. MPV is known as platelet size and associated with platelet activation or new platelet synthesis. Platelet count is decreased by vascular endothelial damage in cases of severe preeclampsia. It leads to increased turnover of platelets. METHODS: The severe preeclamptic women with and without preeclampsia during pregnancy were divided into subgroups depending on the...
Source: Hypertension in Pregnancy - November 3, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Using Doppler ultrasound of the uterine and umbilical arteries and disordered angiogenesis markers (sFlt-1/PlGF) in unified monitoring of ischemic placental syndrome patients.
CONCLUSIONS: A unified method for monitoring the ischemic placental syndrome based on pathogenetic, biophysical (Doppler ultrasound), and biochemical (sFlt-1/PlGF) parameters is feasible and constitutes a valuable supplement to the existing standards, while the high correlations between Doppler ultrasound examinations and both sFlt-1 and PlGF point to a shared pathogenesis of the lesions. Intensity of Doppler changes is connected with time of testing and pregnancy duration. PMID: 27314436 [PubMed - in process] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - November 3, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Reduction of cardiovascular risk after preeclampsia: the role of framing and perceived probability in modifying behavior.
CONCLUSION: Perceived probability influences willingness to modify behavior to reduce cardiovascular risk after preeclampsia; framing and the interaction was not of influence. PMID: 27314519 [PubMed - in process] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - November 3, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Effect of folic acid supplementation during pregnancy on gestational hypertension/preeclampsia: A systematic review and meta-analysis.
CONCLUSION: Whether folic acid supplementation in pregnancy can prevent the occurrence of gestational hypertension/preeclampsia remains uncertain. PMID: 27315401 [PubMed - in process] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - November 3, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Correlations between complement system's activation factors and anti-angiogenesis factors in plasma of patients with early/late-onset severe preeclampsia.
Authors: He Y, Xu B, Song D, Yu F, Chen Q, Zhao M Abstract OBJECTIVE: To investigate the expression of complement system's activation factors in plasma of patients with severe preeclampsia and their correlations with anti-angiogenesis factors. METHODS: A case-control study was performed. The study group consisted of 30 cases of early-onset severe preeclampsia (EOSPE) and 30 cases of late-onset severe preeclampsia (LOSPE). Thirty cases were selected as the early-onset control group (E-control) and 30 as the late-onset control group (L-control), with the weeks of gestation matched. Enzyme-linked immunosorbent ass...
Source: Hypertension in Pregnancy - November 3, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Cardiovascular risk factors in women with inheritable thrombophilia a decade after single or recurrent hypertensive disorder of pregnancy.
CONCLUSION: Women with inheritable thrombophilia after single or recurrent HD have a high cardiovascular risk. PMID: 27322349 [PubMed - in process] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - November 3, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Preeclampsia and preterm delivery: A population-based case-control study.
CONCLUSION: Preeclampsia is an important contributor to preterm delivery in this setting and therefore a potentially useful condition to target in order to reduce preterm rates. PMID: 27322489 [PubMed - in process] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - November 3, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Hypertensive disorders in primigravid black South African women: A one-year descriptive analysis.
CONCLUSION: Hypertensive disorders of pregnancy developed in 12.5% (n = 731/5860) of primigravidae seen over a one-year period. Gestational hypertension comprised the commonest subcategory of the HDP and there were no perinatal deaths in this group. PMID: 27391770 [PubMed - in process] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - November 3, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Correlation between changes in liver stiffness and preeclampsia as shown by transient elastography.
Conclusions: Fibroscan results for fibrosis were significantly higher in postpartum preeclamptic women (although within the normal range). Further studies are required in order to evaluate the usefulness of Fibroscan as an additional test in the evaluation and management of preeclampsia. PMID: 27391875 [PubMed - in process] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - November 3, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Hypertensive disorders during monozygotic and dizygotic twin gestations: A population-based study.
CONCLUSION: Based on a large population-based dataset and on the best clinical estimate of twin zygosity, it appears that zygosity is not associated with hypertensive disorders in twin gestations. PMID: 27420020 [PubMed - in process] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - November 3, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Analgesic requirements and pain experience after caesarean section under neuraxial anesthesia in women with preeclampsia.
Authors: Dennis AT, Mulligan SM Abstract OBJECTIVE: We determined pain experience and analgesic usage in women with preeclampsia (PE) after caesarean section (CS). METHOD: We conducted a one-year retrospective case (PE), control (healthy pregnancy HP) study in women undergoing CS. RESULTS: Sixty-two women were included. Cases received more intrathecal bupivacaine (mean difference 0.4 mg) and in the first six hours postoperatively received (mean ± SD, % or median (interquartile range, IQR)), less oxycodone (11.5 ± 3.9 mg versus 14.3 ± 5.1 mg, p
Source: Hypertension in Pregnancy - November 3, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Fibrinolysis parameters in Sudanese women with severe preeclampsia.
Authors: Elzein HO, Muddathir AR, Rida M, Rayis DA, Elhassan EM, Adam I Abstract BACKGROUND: Although preeclampsia remains a major cause of maternal and fetal morbidity and mortality, its pathogenesis is not fully understood. Coagulation and fibrinolysis changes were suggested to have a role in the pathogenesis of preeclampsia. OBJECTIVES: A case-control study was conducted in Medani Hospital, Sudan, to investigate thrombin-activatable fibrinolysis inhibitor (TAFI) and plasminogen-activated inhibitor (PAI) in women with severe preeclampsia. Obstetrics and medical history was gathered using questionnaire. TAFI, ...
Source: Hypertension in Pregnancy - November 3, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

MoM cutoffs for variables, an important tool for multivariate analysis and accurate interpretation of preeclampsia risk in high-risk pregnancy at 11-13(+6) weeks gestation.
CONCLUSION: The study demonstrated 96.6% diagnostic accuracy of the multi-variable screening test to predict the risk of PE in the first trimester. The negative predictive value (>98%) reinforces the utility of cost-effective noninvasive screening test for the early detection of PE. ABBREVIATIONS: PLGF: Placental growth factor; PAPP-A: Pregnancy-associated plasma protein-A; free β-HCG: Free beta-human chorionic gonadotropin; BMI: Body mass index; MAP: Mean arterial blood pressure; Ut-PI: Mean uterine artery pressure (left and right uterine artery)-pulsatility index; MoM: Multiple of median; NICE: National Insti...
Source: Hypertension in Pregnancy - November 3, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Editorial Board EOV.
Authors: PMID: 27805867 [PubMed - in process] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - November 3, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Oral labetalol compared to oral nifedipine for postpartum hypertension: A randomized controlled trial.
CONCLUSIONS: Both labetalol and nifedipine were effective for control of persistent postpartum hypertension. However, labetalol achieved control significantly more often with the starting dose and had fewer side effects. CLINICAL TRIAL REGISTRATION: Oral nifedipine versus oral labetalol, NCT02168309. https://clinicaltrials.gov/ct2/show/NCT02168309?term=labetalol+versus+nifedipine&rank=2. PMID: 27786578 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - October 28, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

The effect of pre-eclampsia-like syndrome induced by L-NAME on learning and memory and hippocampal glucocorticoid receptor expression: A rat model.
CONCLUSION: Pre-eclampsia would impair cognitive and learning capabilities in adolescent offspring, and the upregulated expression of hippocampal GR may be involved in the underlying mechanisms. PMID: 27786581 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - October 28, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Genetic predisposition to elevated levels of C-reactive protein is associated with a decreased risk for preeclampsia.
CONCLUSION: Our data suggest an inverse, counterintuitive association between the genetic predisposition to elevated levels of CRP and a decreased risk of preeclampsia. This suggests that the blood CRP level is a marker of preeclampsia, but it does not appear to be a factor on the causal pathway. PMID: 27657194 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - September 23, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Expression of EGF, EGFR, and proliferation in placentas from pregnancies complicated with preeclampsia.
CONCLUSION: Higher DC and EVTB proliferation in PE could contribute to PE development. PMID: 27657362 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - September 23, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Association between COMT Val158Met polymorphism and preeclampsia in the Chinese Han population.
CONCLUSION: The COMT Val158Met polymorphism might not be associated with PE in Chinese women. PMID: 27646972 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - September 22, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Increased prenatal blood manganese may induce gestational blood pressure.
Authors: Vigeh M, Nishioka E, Yokoyama K, Ohtani K, Matsukawa T Abstract OBJECTIVE: Pregnancy hypertension is the most common gestational complication and poses a critical risk for mother and fetus. Whether environmental factors may play an important role in disease occurrence is not fully determined. METHODS: To investigate the effects of prenatal manganese (Mn) exposure on gestational blood pressure, 386 women were examined. RESULTS: Early pregnancy blood Mn was significantly (p
Source: Hypertension in Pregnancy - September 22, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Preeclampsia with and without intrauterine growth restriction-Two pathogenetically different entities?
The objective of this study is to determine the differences in histopathological features of basal decidua and placenta in cases of preeclampsia with or without fetal intrauterine growth restriction (IUGR). METHODS: A prospective case-control study included a study group consisting of 30 pregnant women with preeclampsia completed by cesarean section (CS), in 19 of whom preeclampsia was associated with IUGR, and in 11 it was not. The control group consisted of 20 healthy pregnant women delivered by elective CS. Placentas and samples of placental bed obtained during CS were histopathologically (HP) analyzed after hematox...
Source: Hypertension in Pregnancy - September 15, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Fibrinolysis parameters in Sudanese women with severe preeclampsia.
Authors: Elzein HO, Muddathir AR, Rida M, Rayis DA, Elhassan EM, Adam I Abstract BACKGROUND: Although preeclampsia remains a major cause of maternal and fetal morbidity and mortality, its pathogenesis is not fully understood. Coagulation and fibrinolysis changes were suggested to have a role in the pathogenesis of preeclampsia. OBJECTIVES: A case-control study was conducted in Medani Hospital, Sudan, to investigate thrombin-activatable fibrinolysis inhibitor (TAFI) and plasminogen-activated inhibitor (PAI) in women with severe preeclampsia. Obstetrics and medical history was gathered using questionnaire. TAFI, ...
Source: Hypertension in Pregnancy - September 8, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

MoM cutoffs for variables, an important tool for multivariate analysis and accurate interpretation of preeclampsia risk in high-risk pregnancy at 11-13(+6) weeks gestation.
CONCLUSION: The study demonstrated 96.6% diagnostic accuracy of the multi-variable screening test to predict the risk of PE in the first trimester. The negative predictive value (>98%) reinforces the utility of cost-effective noninvasive screening test for the early detection of PE. PMID: 27599037 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - September 8, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study.
Authors: Abheiden CN, Blomjous BS, Kroese SJ, Bultink IE, Fritsch-Stork RD, Lely AT, de Boer MA, de Vries JI Abstract OBJECTIVE: To relate anticoagulant use to pregnancy complications in women with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS). METHODS: All ongoing pregnancies, 184, in two Dutch tertiary centers between 2000 and 2015. RESULTS: LMWH and aspirin was prescribed in 15/109 SLE women without antiphospholipid antibodies (aPL), 5/14 with aPL, 11/13 with APS, 45/48 with primary APS. Main complications in the four treatment groups (no anticoagulant treatment, aspirin,...
Source: Hypertension in Pregnancy - September 8, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Hemolysis, elevated liver enzymes, and low platelet syndrome: Outcomes for patients admitted to intensive care at a tertiary referral hospital.
Authors: Gedik E, Yücel N, Sahin T, Koca E, Colak YZ, Togal T Abstract PURPOSE: The aim was to assess outcomes for pregnancies in which hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome develops and the patient requires transfer for critical care. MATERIALS AND METHODS: The cases of women with HELLP syndrome who delivered at our tertiary center or surrounding hospitals and were admitted to the intensive care between January 2007 and July 2012 were retrospectively analyzed. Results were compared for the surviving and non-surviving patients. RESULTS: Among the 77 women with HELLP syndr...
Source: Hypertension in Pregnancy - September 8, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Analgesic requirements and pain experience after caesarean section under neuraxial anesthesia in women with preeclampsia.
Authors: Dennis AT, Mulligan SM Abstract OBJECTIVE: We determined pain experience and analgesic usage in women with preeclampsia (PE) after caesarean section (CS). METHOD: We conducted a one-year retrospective case (PE), control (healthy pregnancy HP) study in women undergoing CS. RESULTS: Sixty-two women were included. Cases received more intrathecal bupivacaine (mean difference 0.4 mg) and in the first six hours postoperatively received (mean ± SD, % or median (interquartile range, IQR)), less oxycodone (11.5 ± 3.9 mg versus 14.3 ± 5.1 mg, p
Source: Hypertension in Pregnancy - July 31, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Hypertensive disorders during monozygotic and dizygotic twin gestations: A population-based study.
CONCLUSION: Based on a large population-based dataset and on the best clinical estimate of twin zygosity, it appears that zygosity is not associated with hypertensive disorders in twin gestations. PMID: 27420020 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - July 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Maternal and perinatal outcomes in women with and without hypertensive syndromes submitted to induction of labor with misoprostol.
Authors: de Paiva Marques RM, Souza AS, de Lucena Feitosa FE, Costa AA, Amorim MM Abstract OBJECTIVES: To determine maternal and perinatal outcomes according to the mode of delivery in normotensive and hypertensive women bearing a live, full-term fetus, who were submitted to labor induction with misoprostol. METHODS: Retrospective cohort study. The endpoints were tachysystole, uterine hyperstimulation, indications for cesarean section, severe maternal morbidity, side effects, maternal death, 1st/5th minute Apgar, neonatal death, requirement for neonatal intensive care, and birth weight (grams). The chi-square o...
Source: Hypertension in Pregnancy - July 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Hypertensive disorders in primigravid black South African women: A one-year descriptive analysis.
CONCLUSION: Hypertensive disorders of pregnancy developed in 12.5% (n = 731/5860) of primigravidae seen over a one-year period. Gestational hypertension comprised the commonest subcategory of the HDP and there were no perinatal deaths in this group. PMID: 27391770 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - July 9, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Correlation between changes in liver stiffness and preeclampsia as shown by transient elastography.
Conclusions: Fibroscan results for fibrosis were significantly higher in postpartum preeclamptic women (although within the normal range). Further studies are required in order to evaluate the usefulness of Fibroscan as an additional test in the evaluation and management of preeclampsia. PMID: 27391875 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - July 9, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Time-specific placental growth factor (PlGF) across pregnancy and infant birth weight in women with preexisting diabetes.
Authors: James-Todd T, Cohen A, Wenger J, Brown F Abstract OBJECTIVE: Determine the independent association between time-specific placental growth factor (PIGF)-a marker of placental vasculature-and infant birth weight in offspring of mothers with preexisting type 1 and 2 diabetes. METHODS: A total of 150 women were recruited from Joslin Diabetes Center's/Beth Israel Deaconess Medical Center's Diabetes in Pregnancy Program. PlGF was measured up to four times during pregnancy. Infant birth weight and covariate data were collected from medical records. Hemoglobin A1c was assessed from drawn blood samples. We used...
Source: Hypertension in Pregnancy - June 25, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Cardiovascular risk factors in women with inheritable thrombophilia a decade after single or recurrent hypertensive disorder of pregnancy.
CONCLUSION: Women with inheritable thrombophilia after single or recurrent HD have a high cardiovascular risk. PMID: 27322349 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - June 22, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Preeclampsia and preterm delivery: A population-based case-control study.
CONCLUSION: Preeclampsia is an important contributor to preterm delivery in this setting and therefore a potentially useful condition to target in order to reduce preterm rates. PMID: 27322489 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - June 22, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

The role of glutathione peroxidase maternal serum level in late onset of severe preeclampsia.
This study was done to investigate the association between maternal serum glutathione peroxidase (GP) and late onset of severe preeclampsia. METHODS: Cross-sectional study was undertaken comparing normal pregnancy and severe preeclampsia at 37-42 weeks of gestational age. Maternal venous blood was taken to assess the level of GP. RESULT: Twenty normal pregnancy and 20 severe preeclampsia patients were investigated. The median (max-min) of GP level for preeclampsia was 4.31 (0.03-327.41) mU/mL significantly lower than in normal pregnancy 318.90 (6.46-694.11) mU/mL (p
Source: Hypertension in Pregnancy - June 19, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Predictivity of mean platelet volume in severe preeclamptic women.
Authors: Özdemirci Ş, Başer E, Kasapoğlu T, Karahanoğlu E, Kahyaoglu I, Yalvaç S, Tapısız Ö Abstract INTRODUCTION: To evaluate the predictive and clinical utilization of the mean platelet volume (MPV) in severe preeclamptic women. MPV is known as platelet size and associated with platelet activation or new platelet synthesis. Platelet count is decreased by vascular endothelial damage in cases of severe preeclampsia. It leads to increased turnover of platelets. METHODS: The severe preeclamptic women with and without preeclampsia during pregnancy were divided into subgroups depending on the...
Source: Hypertension in Pregnancy - June 19, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Using Doppler ultrasound of the uterine and umbilical arteries and disordered angiogenesis markers (sFlt-1/PlGF) in unified monitoring of ischemic placental syndrome patients.
CONCLUSIONS: A unified method for monitoring the ischemic placental syndrome based on pathogenetic, biophysical (Doppler ultrasound), and biochemical (sFlt-1/PlGF) parameters is feasible and constitutes a valuable supplement to the existing standards, while the high correlations between Doppler ultrasound examinations and both sFlt-1 and PlGF point to a shared pathogenesis of the lesions. Intensity of Doppler changes is connected with time of testing and pregnancy duration. PMID: 27314436 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - June 19, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Reduction of cardiovascular risk after preeclampsia: the role of framing and perceived probability in modifying behavior.
CONCLUSION: Perceived probability influences willingness to modify behavior to reduce cardiovascular risk after preeclampsia; framing and the interaction was not of influence. PMID: 27314519 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - June 19, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Preventing preeclampsia and its fetal complications with low-dose aspirin in East Asians and non-East Asians:A systematic review and meta-analysis.
CONCLUSIONS: Low-dose aspirin is effective in reducing preeclampsia risk in both East Asians and non-East Asians and has differential effects in East Asians and non-East Asians with respect to IUGR. PMID: 27315190 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - June 19, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Etiopathogenesis, prediction, and prevention of preeclampsia.
Authors: Correa PJ, Palmeiro Y, Soto MJ, Ugarte C, Illanes SE Abstract Hypertensive disorders are a major cause of maternal death. Preeclampsia (PE) affects about 5% of pregnancies and is associated to high cardiovascular death risk. Understanding of its origin and cause is difficult and many etiologies have been proposed. So far, little can be done for real prevention and the only treatment is pregnancy interruption, increasing the child's risk for prematurity complications. Early markers of disease are a promising path for understanding the pathogenesis and developing new strategies for prediction and eventually ...
Source: Hypertension in Pregnancy - June 19, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Effect of folic acid supplementation during pregnancy on gestational hypertension/preeclampsia: A systematic review and meta-analysis.
CONCLUSION: Whether folic acid supplementation in pregnancy can prevent the occurrence of gestational hypertension/preeclampsia remains uncertain. PMID: 27315401 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - June 19, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Correlations between complement system's activation factors and anti-angiogenesis factors in plasma of patients with early/late-onset severe preeclampsia.
Authors: He Y, Xu B, Song D, Yu F, Chen Q, Zhao M Abstract OBJECTIVE: To investigate the expression of complement system's activation factors in plasma of patients with severe preeclampsia and their correlations with anti-angiogenesis factors. METHODS: A case-control study was performed. The study group consisted of 30 cases of early-onset severe preeclampsia (EOSPE) and 30 cases of late-onset severe preeclampsia (LOSPE). Thirty cases were selected as the early-onset control group (E-control) and 30 as the late-onset control group (L-control), with the weeks of gestation matched. Enzyme-linked immunosorbent ass...
Source: Hypertension in Pregnancy - June 19, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Clinical assessment of the specificity of an adipsin rapid test for the diagnosis of preeclampsia.
CONCLUSION: Both the adipsin rapid test and the urinary dipstick test are noninvasive and inexpensive rapid tests for the diagnosis of PE. However, the adipsin rapid test was proven more reliable since it had a higher sensitivity, specificity, and accuracy. PMID: 27211512 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - May 24, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research