MiR-140-5p exerts a protective function in pregnancy-induced hypertension via mediating TGF- β/Smad signaling pathway
Hypertens Pregnancy. 2022 Mar 30:1-10. doi: 10.1080/10641955.2022.2056195. Online ahead of print.ABSTRACTAnimal experiments showed that PIH rats had increased mean arterial pressure (MAP), systolic blood pressure (SBP), and diastolic blood pressure (DBP), but decreased litter size, number of viable fetuses, fetal weight, and placental weight. The higher Flt-1 and lower VEGF was observed in PIH rats with elevated TNF-α and IL-6 levels and decreased IL-10 levels. Treatment with agomiR-140-5p improved regarding the above indicators. Cell experiments demonstrated that miR-140-5p mimic increased cell invasion and migration abi...
Source: Hypertension in Pregnancy - March 31, 2022 Category: OBGYN Authors: Ji-Yun Li Yan Jin Yan-Min Cao Gui-Mei Wu Source Type: research

Long non-coding RNA PAXIP-AS1 promotes viability, invasion, and migration of HTR-8/SVneo cells through miR-210-3p/BDNF axis
CONCLUSION: PAXIP-AS1 promoted the viability, migration, and invasion of trophoblast cells by regulating the miR-210-3p/BDNF axis.PMID:35317685 | DOI:10.1080/10641955.2022.2056194 (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - March 23, 2022 Category: OBGYN Authors: Xuejuan Chen Xiang Kong Gang Niu Fengjin Qin Yan Duan Fengjiao Ren Source Type: research

Cardiovascular and hemodynamic consequences of recombinant placental growth factor administration in Guinea pigs
Hypertens Pregnancy. 2022 Mar 7:1-8. doi: 10.1080/10641955.2022.2048390. Online ahead of print.ABSTRACTPlacental growth factor (PlGF), a member of the vascular endothelial growth factor family of proteins regulating angiogenesis, has been shown to have acute vasodilatory effects on human resistance arteries. However, the acute hemodynamic effects of PlGF in vivo are not known. The aim of this study was to report acute cardiovascular changes induced by recombinant human PlGF administered intravenously in male Guinea Pigs with implanted telemeters. PlGF decreased mean arterial blood pressure by 10-20% within minutes. The mag...
Source: Hypertension in Pregnancy - March 7, 2022 Category: OBGYN Authors: Adelene Y Tan Ken Kearney Courtney Jenkins S Ananth Karumanchi Walter Bee Paul Kussie Source Type: research

Subclinical myocardial dysfunction in patients with complete recovery from peripartum cardiomyopathy: a long-term clinical strain-echocardiographic study
CONCLUSION: Subclinical myocardial damage may persist in PPCM patients with full LV systolic recovery. 3D Speckle Tracking strain analysis is a useful method for detecting subtle myocardial dysfunction.PMID:35253556 | DOI:10.1080/10641955.2022.2046049 (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - March 7, 2022 Category: OBGYN Authors: Haldun Akgoz Ufuk Gurkan Source Type: research