Differential expressions of stromal cell-derived factor-1α and vascular endothelial growth factor in the placental bed of pregnancies complicated by preeclampsia.
CONCLUSIONS: This study showed decreased expressions of SDF-1α/CXCR4 and VEGF in the third trimester placental bed of pregnancies with PE. This result suggests that decreased expressions of SDF-1α/CXCR4 and VEGF in the placental bed could be associated with the pathogenesis of PE. PMID: 24354491 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

MicroRNAs: are they the missing link between hypoxia and pre-eclampsia?
Authors: Li JY, Yong TY, Michael MZ, Gleadle JM Abstract Pre-eclampsia is a multisystem disorder that occurs in the second half of pregnancy affecting 5% of pregnancies. It remains the leading cause of maternal and perinatal mortality and morbidity worldwide. Impaired placental implantation, hypoxia, endothelial dysfunction and systemic inflammation are thought to have a role in the pathogenesis of pre-eclampsia. MicroRNAs (miRNAs) are short non-coding RNAs. They are important regulators of gene expression and have been found to affect cell development, proliferation, differentiation and function. Specific patterns...
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Hypoproteinemia in the second trimester among patients with preeclampsia prior to the onset of clinical symptoms.
CONCLUSION: Hypoproteinemia during pregnancy may be a risk factor for this pathophysiology, and the maintenance of sufficient protein in early pregnancy could contribute to prophylaxis for women with uncomplicated PE. PMID: 24354539 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

The association of circulating angiogenic factors and HbA1c with the risk of preeclampsia in women with preexisting diabetes.
CONCLUSIONS: Women with diabetes had a markedly altered anti-angiogenic state late in pregnancy that was further exacerbated in subjects who developed PE. Altered angiogenic factors may be one mechanism for the increased risk of PE in this population. Increased HbA1c in the first trimester of pregnancies in women with diabetes was strongly associated with subsequent PE. PMID: 24354578 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Hypertension, inflammation and T lymphocytes are increased in a rat model of HELLP syndrome.
CONCLUSION: These data support the hypothesis that T cells are associated with hypertension and inflammation. PMID: 24380504 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Correlations between circulating levels of adipokines and anti-angiogenic factors in women with BMI
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

An imbalance in the production of proinflammatory and anti-inflammatory cytokines is observed in whole blood cultures of preeclamptic women in comparison with healthy pregnant women.
Authors: Campos-Cañas J, Romo-Palafox I, Albani-Campanario M, Hernández-Guerrero C Abstract OBJECTIVE: To compare the production of pro- and anti-inflammatory cytokines by whole blood samples stimulated with lipopolysaccharide from normotensive and preeclamptic women. METHODS: The synthesis of tumor necrosis factor-α, interleukyn-1β, interleukin-6 and interleukin-10 were assayed by immunosorbent assays in 56 and 50 preeclamptic and normotensive women, respectively. RESULTS: Preeclamptic women showed a higher synthesis (p 
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

External validation of a model for periconceptional prediction of recurrent early-onset preeclampsia.
CONCLUSIONS: The model's discriminate ability was poor and predictive performance insufficient to classify women into relevant risk groups. PMID: 24392844 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

The relationship between neck circumference and pregnancy-induced hypertension in the third trimester pregnant women.
Authors: Shao JT, Yu J, Qi JQ, Liu XD Abstract OBJECTIVE: The purpose of this study was to evaluate the relationship between neck circumference (NC) and pregnancy-induced hypertension (PIH) in the third trimester pregnant women. METHODS: The study included 126 women who were in the third trimester pregnancy. All subjects completed a standard sleep questionnaire, anthropometric measurements and ultrasonic testing. RESULTS: Pregnant women with NC ≥34.7 cm had significantly higher frequency of PIH than pregnant women with NC
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Serum Follistatin-like-3 was elevated in second trimester of pregnant women who subsequently developed preeclampsia.
CONCLUSION: The elevation of Follistatin-like-3 was demonstrated in late second trimester of pregnancy destined to developing preeclampsia, suggesting its causal role in the pathogenesis and prediction of preeclampsia. PMID: 24475769 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Calcium level during the first trimester of pregnancy as a predictor of preeclampsia.
CONCLUSIONS: Hypocalcemia during the first trimester of pregnancy is not a risk factor for preeclampsia. PMID: 24475770 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Repeatability of SphygmoCor pulse wave analysis in assessing arterial wave reflection in pregnancy using applanation tonometry.
CONCLUSION: AIX-75 can be measured by nurses using PWA in pregnancy with a high level of observer agreement. PMID: 24475771 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Evaluation of the macula, retinal nerve fiber layer and choroid in preeclampsia, healthy pregnant and healthy non-pregnant women using spectral-domain optical coherence tomography.
Authors: Ataş M, Açmaz G, Aksoy H, Demircan S, Ataş F, Gülhan A, Zararsız G Abstract OBJECTIVE: To evaluate the macular, retinal nerve fiber layer (RNFL) and choroidal thickness alterations by using spectral-domain optical coherence tomography (SD-OCT) in preeclampsia and compare with healthy pregnant and healthy non-pregnant controls. METHOD: The study population included healthy pregnant control group (n: 25), healthy non-pregnant control group (n: 26) and study group with preeclampsia (n: 27). Retinal thickness parameters were measured by SD-OCT. RESULTS: There was a statistically signific...
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

The complication and mode of delivery in Chinese women with severe preeclampsia: a retrospective study.
CONCLUSIONS: Our data provide important information on the complication and mode of delivery in Chinese women with severe preeclampsia in the past decades, which may be helpful for clinical management of severe preeclampsia in Chinese women. PMID: 24475773 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Preeclampsia - a risk factor for osteoporosis? Analysis of maternal Sclerostin levels and markers of bone turnover in patients with pre-eclampsia.
Authors: Wild J, Pateisky P, Küssel L, Huf W, Ott J, Haslinger P, Knöfler M, Zeisler H Abstract INTRODUCTION: The role of preeclampsia (PE) in affecting bone metabolism could not be clarified in the past years. Recently Sclerostin, a new marker of bone metabolism which is known to have an inhibitory effect on bone formation causing osteoporosis, was discovered. OBJECTIVE: To investigate serum levels of Sclerostin and markers of bone turnover in women with normotensive pregnancies and pregnancies complicated by PE. METHODS: In this prospective study we enrolled 22 women with PE and 22 healthy pregn...
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

The expression of placental soluble fms-like tyrosine kinase 1 in mouse placenta varies significantly across different litters from normal pregnant mice.
CONCLUSIONS: These findings highlight the importance of adequate sampling from multiple litters in expression studies when using animal models in clinical research. PMID: 24702464 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Maternal, placental and fetal exposure to bisphenol A in women with and without preeclampsia.
CONCLUSIONS: This is the first study to highlight a significant correlation between preeclampsia and a high accumulation of BPA in the placenta. PMID: 24724919 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Urinary lysosomal enzyme excretion in pregnant women with hypertensive disorders.
CONCLUSIONS: The authors conclude that higher values of all the studied enzymes in PE group, in the comparison with the other groups, indicate proximal tubular damage at the cellular level. The lack of correlation between the concentration of lysosomal enzymes and blood pressure suggests that the damage to these parts of kidney is complex. In addition, mechanisms other than hypertension realizing intracellular enzymes may be involved in this process. PMID: 24724946 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Feto-maternal correlation of PTX3, sFlt-1 and PlGF in physiological and pre-eclamptic pregnancies.
CONCLUSION: According to our results, an independent fetal production of the analyzed soluble angiogenic markers can be hypothesized in pregnancies complicated by PE. PMID: 24724970 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

An insertion-deletion polymorphism in interleukin-1α gene associated with susceptibility to preeclampsia.
An insertion-deletion polymorphism in interleukin-1α gene associated with susceptibility to preeclampsia. Hypertens Pregnancy. 2014 Nov;33(4):395-401 Authors: Chen P, Zhou B, Zhang K, Zhang Z, Song Y, Pu Y, Yang Y, Zhang Y, Zhou R, Wang T, Zhang L Abstract OBJECTIVE: To determine whether preeclampsia is associated with polymorphisms in the IL-1α. METHODS: We genotyped a Chinese population (212 women with preeclampsia and 203 controls) for the polymorphism of the interleukin-1α gene (3'-untranslated region). Clinical data were collected from medical records. RESULTS: Significan...
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

The imbalance of circulating angiogenic/antiangiogenic factors is mild or absent in obese women destined to develop preeclampsia.
Authors: Carbillon L PMID: 24842148 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Hemodynamic responses to angiotensin-(1-7) in women in their third trimester of pregnancy.
Authors: Yamaleyeva LM, Merrill DC, Ebert TJ, Smith TL, Mertz HL, Brosnihan KB Abstract BACKGROUND: To understand the role of Angiotensin-(1-7) (Ang-(1-7)) in vasculature of pregnant women, we compared cardiac output (CO), total peripheral resistance (TPR) and forearm blood flow (FBF) responses to Ang-(1-7) infusion between normotensive pregnant women in their third trimester and healthy age matched non-pregnant women. The responses of skin microcirculation to Ang-(1-7) were tested in preeclamptic, normotensive pregnant and non-pregnant women. Responses to Angiotensin II (Ang II) were also determined. METHODS: ...
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Lack of association between matrix metalloproteinase-9 gene-1562C/T polymorphism and preeclampsia: a meta-analysis.
Authors: Gong LL, Liu H, Liu LH Abstract Studies investigating the association between matrix metalloproteinases (MMPs) gene polymorphisms and preeclampsia (PE) reported contradictory or non-conclusive results. We performed a meta-analysis of five studies that examined the relationship between PE and the MMP9-1562C>T polymorphism. The PubMed, Embase, and Google Scholar databases were searched to access the relevant genetic association studies up to September 2013. The meta-analysis revealed that there was no evidence for significant association between MMP9-1562C>T polymorphism and risk of PE. Large, multieth...
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Interaction of parental KIR and fetal HLA-C genotypes with the risk of preeclampsia.
CONCLUSION: Women with KIR AA genotype and fewer C2 genes than their fetuses were at risk for preeclampsia in the Chinese Han population, supporting that maternal-fetal KIR-HLA-C interaction plays an important role in preeclampsia development. PMID: 24911933 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Expression of lipoxin A4, TNFα and IL-1β in maternal peripheral blood, umbilical cord blood and placenta, and their significance in pre-eclampsia.
CONCLUSIONS: The level of lipoxin A4 in maternal peripheral blood may correlate with the expression of FPR2/ALX in placenta. Lipoxin A4 increased to a lesser degree than either TNFα or IL-1β with progression of PE. This may be one of the reasons why oxidative stress and endothelial dysfunction in severe preeclamptic patients are much more serious that in cases of less severe preeclampsia. Moreover, lipoxin A4 does not have any effect on the fetus through the placenta. We conclude that supplementing with lipoxin A4 to ensure adequate levels may be a novel method for the treatment of pre-eclampsia without any effe...
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

The CROWN Initiative: journal editors invite researchers to develop core outcomes in women's health.
Authors: Khan K PMID: 24978187 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Placental Nkx2-5 and target gene expression in early-onset and severe preeclampsia.
CONCLUSIONS: Expression of Nkx2-5 and its target genes may directly influence the genesis and racially disparate severity, and define a mechanistically distinct subclass of EOSPE. PMID: 24987805 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

IMA and IMAR in serum and saliva of preeclampsia--a preliminary study.
Authors: D'souza JM, Pai VR, Harish S, Shriyan C, D'souza N Abstract INTRODUCTION: Oxidative stress could play a role in the development of preeclampsia. Ischemia modified albumin (IMA) is a oxidatively modified form of albumin. OBJECTIVE: To evaluate the levels of salivary and serum IMA and IMA: albumin ratio (IMAR) in preeclampsia and with its severity and investigate their correlation with the fetal birth weight. METHODS: This case control study was conducted on 50 preeclamptic (32 mild and 18 severe cases) and 50 normal pregnant controls. Blood and saliva were obtained to measure albumin, IMA and IMAR w...
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Placental lesions of vascular insufficiency are associated with anti-angiogenic state in women with preeclampsia.
Authors: Baltajian K, Hecht JL, Wenger JB, Salahuddin S, Verlohren S, Perschel FH, Zsengeller ZK, Thadhani R, Karumanchi SA, Rana S Abstract OBJECTIVE: To evaluate if placental histopathological changes of vascular insufficiency correlate with circulating angiogenic factors in patients with preeclampsia. MATERIALS AND METHODS: Subjects were selected from a previous prospective cohort study of preeclampsia based on the availability of plasma anti-angiogenic factor (sFlt1) and pro-angiogenic factor (PlGF) measurements and placental histology specimens. Preeclamptic patients were divided into two groups based on p...
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Measurement of aortic augmentation index in pregnant women with raised blood pressure and subsequent outcomes: a preliminary prospective cohort study.
CONCLUSION: AIX% is associated with time-to-delivery and other outcomes in pregnancy. PMID: 25068523 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Response to Carbillon L et al. letter titled; "The imbalance of circulating angiogenic/anti-angiogenic factors is mild or absent in obese women destined to develop preeclampsia".
Response to Carbillon L et al. letter titled; "The imbalance of circulating angiogenic/anti-angiogenic factors is mild or absent in obese women destined to develop preeclampsia". Hypertens Pregnancy. 2014 Nov;33(4):525 Authors: Rana S, Karumanchi SA PMID: 25068524 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Maternal serum apelin and YKL-40 levels in early and late-onset pre-eclampsia.
CONCLUSION: Circulating levels of apelin are significantly increased in early-onset pre-eclampsia, indicating the role of apelin in the discrimination of the early-onset of pre-eclampsia. On the other hand, maternal serum YKL-40 levels are not elavated significantly, indicating that adipose-derived apelin is primarily involved in the vascular pathogenesis of early-onset pre-eclampsia than macrophage-derived YKL-40. PMID: 25068525 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Maternal exposure to the production of fireworks and reduced rate of new onset hypertension in pregnancy.
CONCLUSION: Maternal exposure to the high density of fireworks factories is associated with reduced risk of developing new onset hypertension in pregnancy. PMID: 25068526 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Increased serum heme oxygenase-1 levels as a diagnostic marker of oxidative stress in preeclampsia.
CONCLUSIONS: Serum HO1 levels were found to be increased in patients with PE compared with normotensive pregnant women. PMID: 25110805 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Maternal lipids in pre-eclampsia: innocent bystander or culprit?
Authors: Barrett HL, Dekker Nitert M, McIntyre HD, Callaway LK Abstract Pre-eclampsia continues to be a challenge--to understand the underlying pathogenesis and to prevent or treat in the clinical setting. One area of potential therapies opening up is treatment of maternal lipids and clinical trials are underway using statins in early pre-eclampsia. At present, most potential therapies to treat lipids cannot be recommended for general use in pregnancy and if we were to target maternal lipids to reduce rates of pre-eclampsia, very large numbers of women may need to be treated. Prior to reaching that point, we first ...
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

A quantitative investigation of hemodynamic adaptation to pregnancy using uterine artery Doppler ultrasonography and finger photoplethysmography.
CONCLUSIONS: The results of this study revealed clear relationship between UtA RI and PPG RI throughout pregnancy which could be exploited to enhance the potential ability in early recognition of pathophysiologic process in maternal adaptation and prediction of complicated pregnancy. PMID: 25121568 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Physical activity, sedentary behavior and risk of hypertensive disorders of pregnancy in Hispanic women.
CONCLUSION: Findings from this prospective study of Hispanic women were consistent with those of prior prospective cohorts indicating that physical activity prior to and during early pregnancy does not significantly reduce risk of hypertensive disorders of pregnancy. PMID: 25121645 [PubMed - in process] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Concentrations of eNOS, VEGF, ACE and PlGF in maternal blood as predictors of impaired fetal growth in pregnancy complicated by gestational hypertension/preeclampsia.
CONCLUSIONS: Circulating levels of VF are not sufficient predictors of SGA in pregnancies complicated by gestational hypertension/preeclampsia. PMID: 25181428 [PubMed - in process] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Low molecular weight heparin improves proteinuria in rats with L-NAME induced preeclampsia by decreasing the expression of nephrin, but not podocin.
CONCLUSION: We demonstrate that down-regulation of nephrin is involved in L-NAME induced proteinuria, and that LMWH reduces proteinuria by up-regulation of neprhin. PMID: 25181538 [PubMed - in process] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Fetal DNA in maternal plasma in preeclamptic pregnancies.
Authors: Vlková B, Turňa J, Celec P Abstract Cell-free fetal DNA present in maternal circulation has revolutionized non-invasive prenatal diagnosis of genetic diseases. In preeclampsia, the quantity of fetal DNA in maternal plasma has been studied and found to be higher in comparison to healthy pregnant women. Whether the quantity of fetal DNA can be used as a reliable predictive biomarker of preeclampsia is currently uncertain. This is a systematic review on studies quantifying fetal DNA in preeclamptic pregnancies. Using a PubMed search 22 studies were identified. In all of them, elevated levels of fetal ...
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Na⁺, K⁺-ATPase and Ca²⁺-ATPase activities in basal and microvillous syncytiotrophoblast membranes from preeclamptic human term placenta.
CONCLUSION: Our findings suggest that the reduction of Ca(2+)- and Na(+), K(+)-ATPase activities during preeclampsia could be at least partially due to an increased level of lipid peroxidation of the syncytiotrophoblast plasma membranes. PMID: 25356531 [PubMed - in process] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Outcomes of expectant management after betamethasone for hypertensive disorders of pregnancy.
CONCLUSIONS: The median latency period between diagnosis and delivery in the setting of HDP is
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Maternal and fetal outcome in de novo preeclampsia in comparison to superimposed preeclampsia: a two-year observational study.
Authors: Rezk M, Gamal A, Emara M Abstract AIM: To assess the maternal and fetal outcome in women with de novo preeclampsia (PE) in comparison to superimposed PE. STUDY DESIGN: This was a prospective 2-year observational study carried out at Menoufia University Hospital, Egypt, in which 164 patients out of 6472 pregnant women were diagnosed with PE (78 with de novo PE and 86 with superimposed PE). Enrolled patients were followed to assess the maternal and fetal outcome. RESULTS: There was a significant higher women with liver impairment and delivery by caesarean section in the de novo PE group (p
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Is the level of maternal serum prohepcidin associated with preeclampsia?
The objective of the study was to compare pro-hepcidin, hemoglobin (Hb) concentration, hematocrit (Hct), C-reactive protein (CRP), IL-6 and iron status parameters in preeclamptic (PE) and healthy pregnant women, and to examine the relationship between serum pro-hepcidin levels and iron parameters of preeclampsia (PE). METHODS: In a prospective controlled study, we collected serum from women with normal pregnancy (n = 37) and from women with PE (n = 30) at the Department of Obstetrics and Gynecology at Turgut Ozal University between February 2010 and January 2013. Pro-hepcidin, hemoglobin (Hb) concentration, hematocrit ...
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Factors associated with vaginal delivery in hypertensive and normotensive pregnant women submitted to labor induction with misoprostol: a cohort study.
Authors: Marques RM, Souza AS, Costa AA, Feitosa FE, Amorim MM Abstract OBJECTIVE: To determine the factors associated with vaginal delivery in hypertensive and normotensive pregnant women submitted to induction of labor with misoprostol. METHODS: A cohort study. RESULTS: The factors associated with vaginal delivery in both normotensive and hypertensive women were, respectively, Bishop score ≥ 4 (OR = 1.87; 95% CI: 1.06-3.29; p = 0.03) and (OR = 2.31; 95% CI: 1.25-4.28; p = 0.008) and parity ≥ 1 (OR = 4.36; 95% CI: 2.16-8.80; p
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Limited evidence for calcium supplementation in preeclampsia prevention: a meta-analysis and systematic review.
CONCLUSION: Some evidence for calcium supplementation exists, but its utility is limited by the possibility of publication bias and a lack of large trials. PMID: 25549172 [PubMed - in process] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Detection of early left ventricular dysfunction in patients with maternal placental syndrome using tissue Doppler and strain rate imaging.
Authors: Attalla W, Gaber R, Bayomy S Abstract BACKGROUND: Maternal placental syndromes (MPS) occur as a consequence of abnormal placental vessel formation and refer to hypertensive pregnancy disorders and related placental abnormalities. The aim of this study is to investigate early alterations in left ventricular function in patients with history of MPS using tissue Doppler and strain rate imaging. METHODS: We enrolled 122 females who were 6 months after delivery. Group 1 included 72 patients who experienced MPS. Group 2 included 50 women with normal pregnancy as control. RESULTS: There was no significant...
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Double notches: association of uterine artery notch forms with pregnancy outcome and severity of preeclampsia.
CONCLUSION: Double notches represent progressive deterioration in the uterine artery and are predictive of adverse maternal outcomes. PMID: 25629902 [PubMed - in process] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Influence of the sFlt-1/PlGF ratio on clinical decision-making in women with suspected preeclampsia--the PreOS study protocol.
CONCLUSION: The PreOS study will provide evidence on how sFlt-1/PlGF ratio testing influences clinical decision-making in women with suspected preeclampsia in real-world clinical practice. PMID: 25629903 [PubMed - in process] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Cardiovascular response to stress and perceived stress is not altered 40 years after hypertensive pregnancies.
CONCLUSION: Response to physical or psychological stress is not affected many years after pregnancy. PMID: 25629904 [PubMed - in process] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research