Translational studies for exercise in high-risk pregnancy: Pre-eclampsia model.
CONCLUSION: There are several animal models to mimic hypertensive disorders in pregnancy; however, clinical studies are still needed for exercise recommendation in pregnant women with hypertensive disorders. PMID: 27159274 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - May 11, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Prediction of preeclampsia with angiogenic biomarkers. Results from the prospective Odense Child Cohort.
CONCLUSION: PlGF and sFlt-1/PlGF had good predictive value for PE at GW20-34 in a population-based unselected cohort, however with low positive predictive value. PMID: 27159383 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - May 11, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Role of maternal factors, PAPP-A, and Doppler in screening for early- and late-onset pregnancy hypertension in Asian population.
CONCLUSION: A combination of variables increased the sensitivity and specificity of the test for hypertension in pregnancy. The markers examined were a predictor of EO hypertension, with a high NPV, making it a good screening test. PMID: 27136371 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - May 3, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Preeclampsia/Eclampsia candidate genes show altered methylation in maternal leukocytes of preeclamptic women at the time of delivery.
CONCLUSION: Differential methylation in four genes associated with PE may represent a potential biomarker or an epigenetic pathophysiologic mechanism altering gene transcription. PMID: 27064514 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - April 12, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Improving the postpartum care of women with a recent history of preeclampsia: a focus group study.
CONCLUSIONS: Solutions offered may improve efforts to modify lifestyle and communication between providers and women about this link. PMID: 27043861 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - April 6, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

A comparison of the diagnostic utility of the sFlt-1/PlGF ratio versus PlGF alone for the detection of preeclampsia/HELLP syndrome.
Authors: Stepan H, Hund M, Gencay M, Denk B, Dinkel C, Kaminski WE, Wieloch P, Semus B, Meloth T, Dröge LA, Verlohren S Abstract OBJECTIVE: The Elecsys(®) immunoassay sFlt-1/PlGF ratio and the Triage(®) PlGF assay were compared (in a prospective, multicenter, case-control study) for diagnosis of preeclampsia/hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome. METHODS: Women in European perinatal care centers with singleton pregnancies were enrolled: 178 cases had confirmed preeclampsia and 391 controls had normal outcome. Patients in the preeclampsia/HELLP syndrome group were matched...
Source: Hypertension in Pregnancy - March 31, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

KRYPTOR-automated angiogenic factor assays and risk of preeclampsia-related adverse outcomes.
Authors: Salahuddin S, Wenger JB, Zhang D, Thadhani R, Karumanchi SA, Rana S Abstract OBJECTIVE: To evaluate KRYPTOR assays for circulating soluble fms-like tyrosine kinase-1 (sFlt1) and placental growth factor (PlGF) in risk assessment of adverse outcomes in women with suspected preeclampsia. METHODS: We studied 412 women carrying a singleton pregnancy from a previous study cohort who were evaluated for suspected preeclampsia. Another 434 nonpreeclamptic patients with plasma samples drawn throughout pregnancy were used to derive normative data. Plasma sFlt1 and PlGF levels were measured on the automated KRYPTO...
Source: Hypertension in Pregnancy - March 31, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Morphometrical analysis of placental functional efficiency in normotensive versus preeclamptic South African black women.
CONCLUSION: This study demonstrates reduced placental morphometrics with impaired placental efficiency in preeclampsia. PMID: 27002286 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - March 25, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Variations of malondialdehyde in pre-eclampsia.
Authors: Khoubnasabjafari M, Ansarin K, Jouyban A Abstract Malondialdehyde, as a biomarker of oxidative stress in pre-eclampsia, is discussed in terms of the determination methods, the validity of the obtained data, and variations in different studies, and it is concluded that there is a need for re-validation of the analytical methods and re-evaluation of its role as a biomarker of oxidative stress. PMID: 27002362 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - March 25, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Serum nitrate and NOx levels in preeclampsia are higher than in normal pregnancy.
CONCLUSION: Increase of NO was observed in preeclampsia women. Failure in the mechanism of action, dependent on cyclic GMP, may justify this finding. PMID: 27003519 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - March 25, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Maternal blood pressures during pregnancy and the risk of delivering a small-for-gestational-age neonate.
Authors: Block-Abraham DM, Adamovich D, Turan OM, Doyle LE, Blitzer MG, Baschat AA Abstract OBJECTIVE: To determine the relationship between maternal blood pressures throughout pregnancy and the risk of delivering a small-for-gestational-age (SGA) neonate. METHODS: Women were prospectively enrolled at 9-14 weeks and had serial blood pressure measurements throughout pregnancy. SGA prevalence was compared to maternal blood pressure at enrollment, average blood pressure during each trimester, and blood pressure trends throughout gestation. Blood pressure was categorized as normotension, prehypertension, or hyperte...
Source: Hypertension in Pregnancy - March 25, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Efficacy of L-arginine for preventing preeclampsia in high-risk pregnancies: A double-blind, randomized, clinical trial.
CONCLUSION: L-arginine is effective for preventing preeclampsia. PMID: 27003763 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - March 25, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Significance of high-normal blood pressure during early second trimester for predicting the onset of hypertensive disorders in pregnancy.
Authors: Mabuchi A, Yamamoto R, Ishii K, Kakubari R, Takaoka S, Muto H, Mitsuda N Abstract OBJECTIVE: The aim of this study was to determine the predictive value of high-normal blood pressure (HNBP) during the early second trimester for hypertensive disorders in pregnancy, including gestational hypertension (GH) and preeclampsia (PE). METHODS: This was a retrospective single-center cohort study of 2143 singleton pregnant women. The association of HNBP, ranging from 130/85 to 139/89 mmHg between 14 and 19 weeks of gestation, with the development of hypertensive disorders was assessed by multivariable logistic re...
Source: Hypertension in Pregnancy - March 6, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Comparison of indications of pregnancy termination and prognosis of mothers and neonates in early- and late-onset preeclampsia.
Authors: Ni Y, Cheng W Abstract OBJECTIVE: To compare the indications of pregnancy termination and prognosis between early-onset preeclampsia (EOP) and late-onset preeclampsia (LOP). METHODS: In total, 100 patients diagnosed early-onset preeclampsia in our hospital from January 1, 2012, to June 30, 2014, were recruited for this retrospective cohort study. At the same time, we randomly chose another 100 late-onset preeclampsia as the contrast group. Criterion distinguishing early versus late was set at week 34 of gestation. Indications for pregnancy termination and prognosis of mothers and neonates were compared...
Source: Hypertension in Pregnancy - March 3, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Association between hypertension and quality of life in pregnancy.
CONCLUSIONS: Pregnancy causes intense changes, both physical and psychological, in women's lives and hypertension was found to be a factor of high interference in pregnant woman's QoL, causing lower scores in all QoL domains of hypertensive pregnant women, compared with pregnant woman without complications. PMID: 26930125 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - March 3, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Preeclampsia and superimposed preeclampsia: The same disease? The role of angiogenic biomarkers.
CONCLUSION: Although angiogenic imbalance is clearly related to preeclampsia, it seems to play a more modest role in superimposed preeclampsia, in which other mechanisms should also be investigated. PMID: 26930132 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - March 3, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Late preterm neonatal morbidity in hypertensive versus normotensive women.
Authors: Fratto VM, Ananth CV, Gyamfi-Bannerman C Abstract OBJECTIVE: We estimated risks of late preterm (LP, 34°(/7)-36(6/7) weeks) delivery and neonatal respiratory and non-respiratory morbidity in women with mild and severe hypertension, in both low-risk and high-risk (history of chronic hypertension, preeclampsia (PE), or insulin-dependent diabetes in current pregnancy) cohorts. STUDY DESIGN: This is a secondary analysis of two Maternal-Fetal Medicine Units Network randomized trials of aspirin to prevent PE. Women with non-anomalous singleton gestations delivered at ≥34 weeks were divided into three ...
Source: Hypertension in Pregnancy - March 3, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Detection of circulating trophoblast particles in maternal blood using density gradient centrifugation in preeclampsia and in normotensive pregnancies.
CONCLUSIONS: The OncoQuick®plus system can be applied to detect TP in both women with PE and in normotensive pregnancies. Longitudinal studies investigating the role of TP as a screening method for patients at risk for PE are warranted. PMID: 26930176 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - March 3, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Attenuation of hyperglycemia-induced apoptotic signaling and anti-angiogenic milieu in cultured cytotrophoblast cells.
In this study, we assess apoptotic and anti-angiogenic signaling in excess glucose-induced CTBs. STUDY DESIGN: Human extravillous CTBs (Sw. 71) were treated with 100, 150, 200, 300, or 400 mg/dL glucose for 48 h. Some cells were pretreated with a p38 inhibitor (SB203580) or a peroxisome proliferator-activated receptor gamma (PPARγ) ligand (rosiglitazone) or with D-mannitol. Cell lysates were utilized to measure p38 MAPK phosphorylation, PPARγ, Bcl-2-associated-X protein (Bax), anti-apoptotic Bcl-2, caspase-9, and cyclooxygenase-2 (Cox-2) expression by western blot. Levels of the vascular endothelial growth ...
Source: Hypertension in Pregnancy - March 3, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Genistein attenuates oxidative damage in preeclamptic placental trophoblast.
CONCLUSION: The study revealed that genistein may play a significant role in controlling oxidative/nitrative stress during preeclampsia. Hence, genistein can be used as an effective dietary supplement for the treatment and management of preeclampsia. PMID: 26930382 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - March 3, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Comparison of serum zinc, calcium, and magnesium concentrations in women with pregnancy-induced hypertension and healthy pregnant women: A meta-analysis.
Authors: He L, Lang L, Li Y, Liu Q, Yao Y Abstract OBJECTIVE: The relationship between serum zinc, magnesium, and calcium levels and pregnancy-induced hypertension (PIH) is controversial. The aim of our study was to determine whether or not serum zinc, magnesium, and calcium levels are associated with PIH. METHODS: In our study, we searched databases, including Wangfang, Chinese National Knowledge Infrastructure, and PubMed, to find literature regarding the relationship between PIH and serum trace elements. Meta-analysis was performed using the Review Manager5.3 software. RESULTS: A total of 14 articles wer...
Source: Hypertension in Pregnancy - March 3, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Analysis of association of clinical aspects and IL1B tagSNPs with severe preeclampsia.
CONCLUSION: We identified an association between clinical variables and preeclampsia. Univariate analysis suggested that inflammatory process-related genes, such as IL1B, may be involved and should be targeted in further studies. The identification of the genetic background involved in preeclampsia host response modulation is mandatory in order to understand the preeclampsia process. PMID: 26909468 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 26, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Management of severe pregnancy-induced hypertension after 34 weeks of gestation: A prospective study to reduce the rate of cesarean section.
CONCLUSIONS: Unnecessary CS may be avoided by defining the limits of safe labor induction. PMID: 26909470 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 26, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Maternal and fetal outcome in women with gestational hypertension in comparison to gestational proteinuria: A 3-year observational study.
CONCLUSIONS: Although gestational hypertension progressed more frequently to PE than gestational proteinuria, poorer fetal outcome was more encountered in women with gestational proteinuria. Larger studies are warranted to confirm these findings. PMID: 26909553 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 26, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Prediction of perinatal outcome in preeclampsia using middle cerebral artery and umbilical artery pulsatility and resistance indices.
Authors: Rani S, Huria A, Kaur R Abstract OBJECTIVE: In preeclampsia, changes in fetal hemodynamics can be detected 2-3 weeks earlier than any changes in cardiotocogram. Thus, these Doppler changes can be used to predict perinatal outcome. The present study is planned to assess the accuracy of the middle cerebral artery to umbilical artery (UA) pulsatility index (PI) and resistance index (RI) in predicting adverse perinatal outcome in pregnancies complicated by preeclampsia. METHODS: Total of 115 and 108 pregnant women were included in preeclampsia and control group, respectively. Weekly Doppler study was done ...
Source: Hypertension in Pregnancy - February 26, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

The effect of loading dose of magnesium sulfate on uterine, umbilical, and fetal middle cerebral arteries Doppler in women with severe preeclampsia: A case control study.
Authors: Maged AM, Hashem AM, Gad Allah SH, Mahy ME, Mostafa WA, Kotb A Abstract SYNOPSIS IV MgSO4 administration in women with severe preeclampsia resulted in a decrease in umbilical artery, uterine artery, and fetal middle cerebral artery Doppler indices. OBJECTIVE: To evaluate Doppler parameters of the umbilical artery (UmA), uterine artery (UA), and fetal middle cerebral artery (MCA) before and after MgSO4 administration in women with severe preeclampsia. METHODS: A case control study included 100 pregnant women with severe preeclampsia. Umbilical artery, uterine artery, and fetal middle cerebral artery...
Source: Hypertension in Pregnancy - February 26, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Effect of regular exercise on blood pressure in normotensive pregnant women. A randomized controlled trial.
CONCLUSIONS: Aerobic exercise reduced resting systolic BP in healthy former inactive pregnant women. PMID: 26909888 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 26, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Comprehensive analysis of DNA methylation and gene expression of placental tissue in preeclampsia patients.
CONCLUSION: Our study is the first study to determine the genome-wide DNA methylation patterns in preeclampsia placenta using microarrays. The results revealed that clusters of DNA methylation were aberrantly altered in preeclampsia placenta compared with controls, which indicated misregulation of DNA methylation. PMID: 26910130 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 26, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Characterization of the down-regulated genes identified in preeclampsia placenta.
CONCLUSION: Preeclampsia may be associated with either: (1) down-regulated expression of genes located in close proximity to known imprinted genes, (2) an imbalance in the maternal-fetal genetic response, or (3) an interaction of the two. PMID: 26910288 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 26, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Risks of parenteral antihypertensive therapy for the treatment of severe maternal hypertension are low.
Authors: Sharma KJ, Rodriguez M, Kilpatrick SJ, Greene N, Aghajanian P Abstract OBJECTIVE: To determine whether the incidence of hypotension or adverse fetal heart tracing (FHT) category change differed following antepartum administration of intravenous (IV) labetalol versus hydralazine. METHODS: Blood pressure and FHT categories were assessed one hour before and after medication administration. Hypotension was defined as ≥30% reduction in baseline systolic blood pressure (SBP) or SBP
Source: Hypertension in Pregnancy - February 26, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Plasma levels of increased miR-195-5p correlates with the sFLT-1 levels in preeclampsia.
In conclusion, our data demonstrate an association of higher levels of sFLT-1 with increased expression of miR-195-5p in preeclampsia pregnant women. PMID: 26910493 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 26, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Preeclampsia and future cardiovascular risk: A point of view from the clearance of plasma vasoactive amines.
CONCLUSION: Preeclampsia is mainly due to decreased excretion of norepinephrine and other vasoactive amines. PMID: 26910507 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 26, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

MYC-induced nuclear antigen (MINA) and preeclampsia.
CONCLUSION: PE and its severity are associated with the underexpression of placental MINA, and the G/G genotype of the MINA rs4857304 variant may modify the risk of severe PE among the PE cases evaluated. PMID: 26910584 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 26, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Counselling and management of cardiovascular risk factors after preeclampsia.
CONCLUSION: Although there is still a considerable scope for improvement, an increasing number of gynaecologists advise women after preeclampsia on preventive interventions to decrease risks of cardiovascular disease. PMID: 26910620 [PubMed - as supplied by publisher] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 26, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

ACE gene in pregnancy complications: Insights into future vascular risk.
Authors: Fatini C, Romagnuolo I, Sticchi E, Rossi L, Cellai AP, Rogolino A, Abbate R Abstract OBJECTIVE: A history of placenta-mediated pregnancy complications (PMPCs) increases the risk of cardiovascular disease later in life, possibly related to the persistence of endothelial dysfunction. We performed this study in order to search for a common genetic background shared by women with a history of PMPC and vascular disorders, due to their common pathophysiologic pathway of endothelial dysfunction. METHODS: We analyzed the prevalence of seven polymorphisms in ACE, AGTR1, AGT, and eNOS genes, endothelial-function...
Source: Hypertension in Pregnancy - February 26, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Risk factors for preeclampsia: a case-control study.
CONCLUSIONS: Health education should be emphasized to encourage women to have children at a relatively younger age and control weight during pregnancy. Special measures should be taken to improve the living condition and prenatal care in the countryside and small towns. PMID: 23957882 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Placental transfer of intravenous nicardipine and disposition into breast milk during the control of hypertension in women with pre-eclampsia.
CONCLUSION: Nicardipine is safe for fetuses and neonates due to its low levels of placental transfer and disposition in BrM. PMID: 24131296 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

LPL Ser447Ter and Asn291Ser variants in Romanians: associations with preeclampsia - implications on lipid profile and prognosis.
CONCLUSIONS: The LPL variants are associated with severe preeclampsia and influence the lipid profile and pregnancy outcome in mild and severe preeclampsia. PMID: 24205968 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

The comparison of endogenous angiogenesis inhibitors in normotensive and preeclamptic placentas: an immunohistochemical study.
CONCLUSION: Our results suggest that thrombospondin-1, angiostatin and vasostatin may play a role in the pathophysiology of preeclampsia. Further molecular studies are required to understand this role. PMID: 24205998 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Expression levels of seven candidate genes in human peripheral blood mononuclear cells and their association with preeclampsia.
Authors: Martinez-Fierro ML, Garza-Veloz I, Carrillo-Sanchez K, Martinez-Gaytan V, Cortes-Flores R, Ochoa-Torres MA, Guerrero GG, Rodriguez-Sanchez IP, Cancela-Murrieta CO, Zamudio-Osuna M, Badillo-Almaraz JI, Castruita-De la Rosa C Abstract OBJECTIVE: To evaluate the peripheral blood mononuclear cell (PBMC) expression levels of hemeoxygenase 1 (HMOX-1), superoxide dismutase 1 (SOD-1), vascular endothelial growth factor A (VEGF-A), transforming growth factor beta 1 (TGF-β1), interleukin (IL)-6, IL-15 and AdipoQ genes to study their association with preeclampsia (PE). METHODS: A total of 177 pregnant women ...
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Development of maternal and neonatal composite outcomes for trials evaluating management of late-onset pre-eclampsia.
CONCLUSION: The composite outcomes developed will enable clinical trials to provide robust estimates on the effectiveness of the interventions in women with mild to moderate late onset pre-eclampsia to inform clinical practice. Caution is needed in the interpretation of composite outcomes due to variation in the importance of individual components. PMID: 24303960 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Placental maturity, hypertensive disorders of pregnancy and birth weight.
We examined placental stained specimens from women with normotensive pregnancies (n = 100), diagnosis of gestational hypertension (n = 38), mild (n = 10), or severe preeclampsia (n = 34) in an optical microscope. Placental Maturity Index (PMI) was calculated as the number of vasculo-syncytial membranes (VSM) in 1 mm(2) divided by VSM thickness (µm). Hypermaturity was defined as>90th percentile of the PMI from placentas of normotensive pregnancies. Newborns were classified as SGA, adequate-for-gestational-age (AGA) or large-for-gestational-age (90th per...
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Association between placental pathology and neonatal outcome in preeclampsia: a large cohort study.
Authors: Vinnars MT, Nasiell J, Holmström G, Norman M, Westgren M, Papadogiannakis N Abstract OBJECTIVE: To study associations between placental histopathology and neonatal outcome in preeclampsia (PE). STUDY DESIGN: The cohort consisted of 544 singleton pregnancies complicated by PE and managed at Karolinska University Hospital, Stockholm, Sweden during 2000-2009. Evaluation of placental histopathology was made by one senior perinatal pathologist, blinded to outcome. Clinical outcome was obtained from prospectively collected medical registry data and medical records. Main outcome measures were intrauterin...
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Ambulatory blood pressure measurements in mid-pregnancy and development of hypertensive pregnancy disorders.
CONCLUSIONS: Women can self-measure BP at home. BP readings show diurnal variation. There are significant differences in BP of women who do and do not develop hypertension later in the pregnancy. Use of home BP monitoring over 24 h of the day in mid-pregnancy is unlikely to add to the use of uterine artery Doppler and a one-off BP reading for future development of hypertension in pregnancy. PMID: 24304043 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Measuring blood pressure in pregnancy and postpartum: assessing the reliability of automated measuring devices.
CONCLUSION: Outpatient automated BP measurement agrees well with mercury sphygmomanometry in hypertensive pregnancies. PMID: 24304096 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Bradykinin B1 receptor-mediated vasodilation is impaired in myometrial arteries from women with pre-eclampsia.
CONCLUSION: Here, we demonstrate a novel B1 receptor-mediated vasodilatation in healthy myometrial vessels that is absent in pre-eclampsia. PMID: 24304135 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

First trimester maternal characteristics, Doppler parameters and serum analytes after preeclampsia.
CONCLUSION: There is a potential role for lifestyle modification and stricter pregnancy blood pressure control in patients with prior preeclampsia. PMID: 24304164 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

miRNA expression profiles determined in maternal sera of patients with HELLP syndrome.
CONCLUSION: In our proof of principle study, we demonstrated that patients with HELLP syndrome showed alterations of serum miRNA expression patterns. Data analysis goes along with the hypothesis that HELLP syndrome is regarded to be a heterogeneous disease. PMID: 24304191 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Relationship between nulliparity and preeclampsia may be explained by altered circulating soluble fms-like tyrosine kinase 1.
CONCLUSIONS: Nulliparous pregnancies had higher circulating sFlt1 levels and sFlt1/PlGF ratios than multiparous pregnancies, suggesting an association with an angiogenic imbalance. Taken together with the pathogenic role of anti-angiogenic factors in preeclampsia, our data may be one explanation for the epidemiological observation that nulliparity is a risk factor for the development of preeclampsia. PMID: 24304210 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Cardiovascular variability before and after delivery: recovery from arterial stiffness in women with preeclampsia 4 days post partum.
CONCLUSION: Four days after delivery, the maternal cardiovascular system is still strongly affected by pregnancy independent of the health status. PMID: 24328785 [PubMed - indexed for MEDLINE] (Source: Hypertension in Pregnancy)
Source: Hypertension in Pregnancy - February 17, 2016 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research