Should women receive luteal support following natural cycle frozen embryo transfer? A systematic review and meta-analysis. Critical assessment of a review and meta-analysis
Dear Sir, (Source: Human Reproduction Update)
Source: Human Reproduction Update - June 4, 2021 Category: OBGYN Source Type: research
Reply: Should women receive luteal support following natural cycle frozen embryo transfer? A systematic review and meta-analysis. Critical assessment of a review and meta-analysis
Dear Sir, (Source: Human Reproduction Update)
Source: Human Reproduction Update - June 4, 2021 Category: OBGYN Source Type: research
Confined placental mosaicism and the association with pregnancy outcome and fetal growth: a review of the literature
The objective of this review is to evaluate the association between CPM and prenatal growth and adverse pregnancy outcomes. All relevant literature has been reviewed in order to achieve an overview on merged results exploring the relation between CPM and FGR and other adverse pregnancy outcomes.SEARCH METHODSThe following Medical Subject Headings (MESH) terms and all their synonyms were used: placental, trophoblast, cytotrophoblast, mosaicism, trisomy, fetal growth, birth weight, small for gestational age and fetal development. A search in Embase, PubMed, Medline Ovid, Web of Science, Cochrane Central Register of Controlle...
Source: Human Reproduction Update - May 13, 2021 Category: OBGYN Source Type: research
A review on the motivations, decision-making factors, attitudes and experiences of couples using pre-implantation genetic testing for inherited conditions
We report that couples find it difficult to consider all of the benefits and costs of PGT, resulting in ambivalence and prolonged indecision. After deciding on PGT use, we found that patients find the process extremely impract ical and psychologically demanding.WIDER IMPLICATIONSThis review aimed to summarize the current knowledge on how patients decide to use and experience PGT and to make suggestions to incorporate the findings into clinical practice. We cannot stress enough the importance of holistic evaluation of patients and thorough counselling prior to and during PGT use from a multidisciplinary team that includes g...
Source: Human Reproduction Update - May 10, 2021 Category: OBGYN Source Type: research
Maternal germline factors associated with aneuploid pregnancy loss: a systematic review
The objective of this review was to appraise critically the existing evidence relating to maternal germline factors associated with pregnancy loss secondary to embryo aneuploidy, identify limitations in the current evidence base and establish areas requiring further research.SEARCH METHODSThe initial literature search was performed in September 2019 and updated in January 2021 using the electronic databases OVID MEDLINE, EMBASE and the Cochrane Library. No time or language restrictions were applied to the searches and only primary research was included. Participants were women who had suffered pregnancy loss secondary to n...
Source: Human Reproduction Update - May 9, 2021 Category: OBGYN Source Type: research
A systematic review and meta-analysis on the association between ICSI and chromosome abnormalities
The objective of this systematic review and meta-analysis was to assess the prevalence of chromosome abnormalities in ICSI pregnancies and children and to examine any potentially increased risk compared to standard IVF and NC.SEARCH METHODSPubmed, Embase, Cochrane Libraries and Web of Science up to October 2020 were searched. Primary outcome measures were overall chromosome abnormalities andde novo abnormalities (including sex chromosome abnormalities and autosomal abnormalities). The secondary outcome was inherited abnormalities. We followed the PRISMA guidelines and relevant meta-analyses were performed.OUTCOMESThe searc...
Source: Human Reproduction Update - May 6, 2021 Category: OBGYN Source Type: research
Novel therapeutic targets to improve IVF outcomes in endometriosis patients: a review and future prospects
AbstractBACKGROUNDPatients with endometriosis often experience infertility and have poor IVF outcomes, with low fertilization and pregnancy rates. Although many theories have tried to explain the mechanisms underlying infertility in these patients, none of them is conclusive.OBJECTIVE AND RATIONALEIn this review, we discuss the pathologic mechanisms through which endometriosis likely leads to infertility along with the therapeutic options used to date to treat endometriosis-related infertility and, thereby, to improve IVF outcomes in patients with endometriosis.SEARCH METHODSWe performed a comprehensive literature search o...
Source: Human Reproduction Update - April 30, 2021 Category: OBGYN Source Type: research
Thank you to our reviewers – 2020
While firmly established as one of the leading journals in the field of reproductive biology and medicine,Human Reproduction Update is not complacent and continually strives for improvement. The journal is acutely aware of the importance of high-quality peer review and its role in maintaining and enhancing the scientific quality and clinical relevance of the articles that we publish. For this reason, the Editorial Team ofHuman Reproduction Update would like to thank all those who have taken the time to review for us in 2020. We greatly appreciate this contribution to the ongoing success of the journal. Thank you. (Source: ...
Source: Human Reproduction Update - April 20, 2021 Category: OBGYN Source Type: research
Should women receive luteal support following natural cycle frozen embryo transfer? A systematic review and meta-analysis
AbstractBACKGROUNDSpontaneous ovulation during a natural menstrual cycle is frequently used for timing frozen embryo transfer (FET). Nevertheless, it remains unclear whether or not women should receive luteal phase support (LPS) following natural cycle frozen embryo transfer (NC-FET).OBJECTIVE AND RATIONALEThe aim of this systematic review and meta-analysis was to study whether the administration of LPS improves the reproductive outcome following NC-FET.SEARCH METHODSWe conducted a systematic search of the literature published in Medline/PubMed, Embase and the Cochrane Library, from January 2000 until December 2020. We inc...
Source: Human Reproduction Update - April 8, 2021 Category: OBGYN Source Type: research
Adipocyte and steroidogenic cell cross-talk in polycystic ovary syndrome
AbstractBACKGROUNDMetabolic and endocrine alterations in women with polycystic ovary syndrome (PCOS) affect adipose tissue mass and distribution. PCOS is characterised by hyperandrogenism, obesity and adipocyte dysfunction. Hyperandrogenism in PCOS drives dysfunctional adipocyte secretion of potentially harmful adipocytokines. Glucocorticoids and sex-steroids modulate adipocyte development and function. For their part, adipocyte products interact with adrenal and ovarian steroidogenic cells. Currently, the relationship between adipocyte and steroidogenic cells is not clear, and for these reasons, it is important to elucida...
Source: Human Reproduction Update - March 25, 2021 Category: OBGYN Source Type: research
Secretory products of the corpus luteum and preeclampsia
AbstractBACKGROUNDDespite significant advances in our understanding of the pathophysiology of preeclampsia (PE), there are still many unknowns and controversies in the field. Women undergoing frozen-thawed embryo transfer (FET) to a hormonally prepared endometrium have been found to have an unexpected increased risk of PE compared to women who receive embryos in a natural FET cycle. The differences in risk have been hypothesized to be related to the absence or presence of a functioning corpus luteum (CL).OBJECTIVE AND RATIONALETo evaluate the literature on secretory products of the CL that could be essential for a healthy ...
Source: Human Reproduction Update - March 22, 2021 Category: OBGYN Source Type: research
Ovarian stimulation for oocyte donation: a systematic review and meta-analysis
AbstractBACKGROUNDSince its introduction in the 1980s, oocyte donation (OD) has been largely integrated into ART. Lately, both demand and the indications for OD have increased greatly. Oocyte donors are healthy and potentially fertile women undergoing voluntarily ovarian stimulation (OS). Selection of the optimal type of stimulation is of paramount importance in order to achieve the most favourable outcomes for the oocyte recipients, but most importantly for the safety of the oocyte donors.OBJECTIVE AND RATIONALEThis is the first systematic review (SR) with the objective to summarize the current evidence on OS in oocyte do...
Source: Human Reproduction Update - March 20, 2021 Category: OBGYN Source Type: research
First trimester mechanisms of gestational sac placental and foetal teratogenicity: a framework for birth cohort studies
AbstractBACKGROUNDThe function of the gestational sac (GS) and the placenta in the closely related processes of embryogenesis and teratogenicity in the first trimester has been minimally described. The prevailing assumption is that direct teratogenic effects are mediated by the critical extraembryonic organ, the placenta, which either blocks or transfers exposures to the foetus. Placental transfer is a dominant mechanism, but there are other paradigms by which the placenta can mediate teratogenic effects. Knowledge of these paradigms and first trimester human developmental biology can be useful to the epidemiologist in the...
Source: Human Reproduction Update - March 1, 2021 Category: OBGYN Source Type: research
Reply: Fertility restoration in azoospermic cancer survivors from testicular VSELs that survive oncotherapy upon transplanting MSCs
Sir, (Source: Human Reproduction Update)
Source: Human Reproduction Update - February 22, 2021 Category: OBGYN Source Type: research
Fertility restoration in azoospermic cancer survivors from testicular VSELs that survive oncotherapy upon transplanting MSCs
Sir (Source: Human Reproduction Update)
Source: Human Reproduction Update - February 22, 2021 Category: OBGYN Source Type: research
