The impact of endometrioma on IVF/ICSI outcomes: a systematic review and meta-analysis
CONCLUSIONS
Women with endometrioma undergoing IVF/ICSI had similar reproductive outcomes compared with those without the disease, although their cycle cancellation rate was significantly higher. Surgical treatment of endometrioma did not alter the outcome of IVF/ICSI treatment compared with those who did not receive surgical intervention. Considering that the reduced ovarian reserve may be attributed to the presence of endometrioma per se, and the potential detrimental impact from surgical intervention, individualization of care for women with endometrioma prior to IVF/ICSI may help optimize their IVF/ICSI results. (Sourc...
Source: Human Reproduction Update - October 6, 2015 Category: OBGYN Authors: Hamdan, M., Dunselman, G., Li, T. C., Cheong, Y. Tags: Reviews Source Type: research
Genetics of primary ovarian insufficiency: new developments and opportunities
CONCLUSION
Taken together, the cytogenetic, cytogenomic (array CGH) and exome sequencing approaches have revealed a genetic causation in ~20–25% of POI cases. Uncovering the remainder of the causative genes will be facilitated not only by whole genome approaches involving larger cohorts in multiple populations but also incorporating environmental exposures and exploring signaling pathways in intragenic and intergenic regions that point to perturbations in regulatory genes and networks. (Source: Human Reproduction Update)
Source: Human Reproduction Update - October 6, 2015 Category: OBGYN Authors: Qin, Y., Jiao, X., Simpson, J. L., Chen, Z.-J. Tags: Reviews Source Type: research
Cellular and molecular regulation of the activation of mammalian primordial follicles: somatic cells initiate follicle activation in adulthood
CONCLUSIONS
In this review, we have provided an updated picture of how mammalian primordial follicles are activated. The functional roles of pfGCs in governing the activation of primordial follicles in adulthood are highlighted. The in-depth understanding of the cellular and molecular mechanisms of primordial follicle activation will hopefully lead to more treatments of female infertility, and the current progress indicates that the use of existing primordial follicles as a source for obtaining fertilizable oocytes as a new treatment for female infertility is just around the corner. (Source: Human Reproduction Update)
Source: Human Reproduction Update - October 6, 2015 Category: OBGYN Authors: Zhang, H., Liu, K. Tags: Reviews Source Type: research
What we know about primary dysmenorrhea today: a critical review
CONCLUSION
Further study is needed to determine whether effectively blocking dysmenorrheic pain ameliorates risk for the development of chronic pain disorders and to explore whether it is possible to prevent the development—and not just treat—severe dysmenorrheic pain in adolescent girls. In conclusion, we demonstrate the extensive multi-factorial impact of dysmenorrhea and we encourage and direct researchers to necessary future studies. (Source: Human Reproduction Update)
Source: Human Reproduction Update - October 6, 2015 Category: OBGYN Authors: Iacovides, S., Avidon, I., Baker, F. C. Tags: Reviews Source Type: research
Menstrual physiology: implications for endometrial pathology and beyond
CONCLUSIONS
The study of menstruation, in both normal and abnormal scenarios, is essential for the production of novel, acceptable medical treatments for common gynaecological complaints. Furthermore, collaboration and communication with specialists in other fields could significantly advance the therapeutic potential of this dynamic tissue. (Source: Human Reproduction Update)
Source: Human Reproduction Update - October 6, 2015 Category: OBGYN Authors: Maybin, J. A., Critchley, H. O. D. Tags: Reviews Source Type: research
