Trends in 'poor responder research: lessons learned from RCTs in assisted conception
CONCLUSIONS
Overall, the majority of published trials on POR suffer from methodological flaws and are, thus, regarded as being high-risk for bias. The same trials have used a variety of definitions for their poor responders and a variety of interventions for their head-to-head comparisons. Not surprisingly, discrepancies are also evident in the findings of trials comparing similar interventions. Based on the identified deficiencies, this novel type of ‘methodology and clinical’ review has introduced custom recommendations on how to improve future experimental research in the ‘poor responder’ populat...
Source: Human Reproduction Update - May 2, 2016 Category: OBGYN Authors: Papathanasiou, A., Searle, B. J., King, N. M. A., Bhattacharya, S. Tags: Review Source Type: research
Assisted reproductive techniques after fertility-sparing treatments in gynaecological cancers
CONCLUSIONS
After fertility-preserving treatment for gynaecological cancers, ART can enable pregnancy to be achieved with apparent oncological safety. The success of such procedures should directly impact clinical practice and management of those patients who require fertility-sparing treatment. (Source: Human Reproduction Update)
Source: Human Reproduction Update - May 2, 2016 Category: OBGYN Authors: Zapardiel, I., Cruz, M., Diestro, M. D., Requena, A., Garcia-Velasco, J. A. Tags: Review Source Type: research
Reply: Metformin for women with hyperandrogenic anovulation
(Source: Human Reproduction Update)
Source: Human Reproduction Update - April 25, 2016 Category: OBGYN Authors: Naderpoor, N., Shorakae, S., de Courten, B., Misso, M. L., Moran, L. J., Teede, H. J. Tags: Letter to the Editor Source Type: research
Metformin for women with hyperandrogenic anovulation
(Source: Human Reproduction Update)
Source: Human Reproduction Update - April 25, 2016 Category: OBGYN Authors: Martins, W. P. Tags: Letter to the Editor Source Type: research
Metformin and lifestyle modification in polycystic ovary syndrome: systematic review and meta-analysis
(Source: Human Reproduction Update)
Source: Human Reproduction Update - April 25, 2016 Category: OBGYN Authors: Naderpoor, N., Shorakae, S., de Courten, B., Misso, M. L., Moran, L. J., Teede, H. J. Tags: Corrigendum Source Type: research
Reply: LNG-IUDs in treating dysmenorrhea
(Source: Human Reproduction Update)
Source: Human Reproduction Update - April 25, 2016 Category: OBGYN Authors: Iacovides, S., Polo-Kantola, P., Baker, F. C. Tags: Letter to the Editor Source Type: research
A frameless LNG-IUD may be preferred over framed LNG-IUD for the treatment of primary dysmenorrhea
(Source: Human Reproduction Update)
Source: Human Reproduction Update - April 25, 2016 Category: OBGYN Authors: Wildemeersch, D. Tags: Letter to the Editor Source Type: research
Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics
CONCLUSIONS
Kinase signalling pathways represent viable targets for endometriosis treatment. At present, however, further improvements in clinical efficacy and the profile of adverse effects are required before these compounds can be useful for long-term endometriosis treatment. A better understanding of the molecular activity of these kinases, including the specific extracellular compounds that lead to their activation in endometriotic cells specifically should facilitate their improvement and could potentially lead to new, non-hormonal treatments of endometriosis. (Source: Human Reproduction Update)
Source: Human Reproduction Update - April 25, 2016 Category: OBGYN Authors: McKinnon, B. D., Kocbek, V., Nirgianakis, K., Bersinger, N. A., Mueller, M. D. Tags: Review Source Type: research
GnRH and GnRH receptors in the pathophysiology of the human female reproductive system
CONCLUSIONS
Increasing knowledge about the regulation of GnRH pulsatile release, as well as the therapeutic use of its analogues, offers interesting new perspectives in the diagnosis, treatment and outcome of female reproductive disorders, including tumoral and iatrogenic diseases. (Source: Human Reproduction Update)
Source: Human Reproduction Update - April 25, 2016 Category: OBGYN Authors: Maggi, R., Cariboni, A. M., Marelli, M. M., Moretti, R. M., Andre, V., Marzagalli, M., Limonta, P. Tags: Review Source Type: research
Activins in reproductive biology and beyond
CONCLUSIONS
The field of activin biology has advanced considerably since its initial discovery as an FSH stimulating agent. Now, activin is well known as a growth factor and cytokine that regulates many aspects of reproductive biology, developmental biology and also inflammation and immunological mechanisms. Current research provides evidence for novel roles of activins in maintaining the structure and function of reproductive and other organ systems. The fact that activin A is elevated both locally as well as systemically in major disorders of the reproductive system makes it an important biomarker. Given the established ...
Source: Human Reproduction Update - April 25, 2016 Category: OBGYN Authors: Wijayarathna, R., de Kretser, D. M. Tags: Review Source Type: research
Leptin and its potential interest in assisted reproduction cycles
CONCLUSION
Leptin regulates energy balance and female reproductive function, mainly through its action on hypothalamic-pituitary-ovarian function, whose molecular and cellular aspects are progressively being deciphered. Preliminary studies evaluating leptin as a biomarker in human IVF seem promising but need further confirmation. (Source: Human Reproduction Update)
Source: Human Reproduction Update - April 25, 2016 Category: OBGYN Authors: Catteau, A., Caillon, H., Barriere, P., Denis, M. G., Masson, D., Freour, T. Tags: Review Source Type: research
Trends in 'poor responder research: lessons learned from RCTs in assisted conception
CONCLUSIONS
Overall, the majority of published trials on POR suffer from methodological flaws and are, thus, regarded as being high-risk for bias. The same trials have used a variety of definitions for their poor responders and a variety of interventions for their head-to-head comparisons. Not surprisingly, discrepancies are also evident in the findings of trials comparing similar interventions. Based on the identified deficiencies, this novel type of ‘methodology and clinical’ review has introduced custom recommendations on how to improve future experimental research in the ‘poor responder’ populat...
Source: Human Reproduction Update - April 25, 2016 Category: OBGYN Authors: Papathanasiou, A., Searle, B. J., King, N. M. A., Bhattacharya, S. Tags: Review Source Type: research
Reply: Polycystic ovary syndrome and pregnancy
(Source: Human Reproduction Update)
Source: Human Reproduction Update - February 16, 2016 Category: OBGYN Authors: Palomba, S., deWilde, M. A., Falbo, A., Koster, M. P. H., La Sala, G. B., Fauser, B. C. J. M. Tags: Letters to the Editor Source Type: research
Polycystic ovary syndrome and pregnancy
(Source: Human Reproduction Update)
Source: Human Reproduction Update - February 16, 2016 Category: OBGYN Authors: Galazis, N. Tags: Letters to the Editor Source Type: research
