Insulin-like growth factor (IGF) performance in ovarian function and applications in reproductive biotechnologies
Growth Horm IGF Res. 2023 Oct-Dec;72-73:101561. doi: 10.1016/j.ghir.2023.101561. Epub 2023 Dec 5.ABSTRACTThe role of the insulin-like growth factor (IGF) system has attracted close attention. The activity of IGF binding proteins (IGFBPs) within the ovary has not been fully elucidated to date. These proteins bind to IGF with an equal, or greater, affinity than to the IGF1 receptor, thus being in the main position to regulate IGF signalling, in addition to extending the half-life of IGFs within the bloodstream and promoting IGF storage in specific tissue niches. IGF1 has an important part in cell proliferation, differentiati...
Source: Growth Hormone and IGF Research - December 9, 2023 Category: Endocrinology Authors: Tathyana Benetis Piau Aline de Queiroz Rodrigues Fernanda Paulini Source Type: research
Insulin-like growth factor (IGF) performance in ovarian function and applications in reproductive biotechnologies
Growth Horm IGF Res. 2023 Oct-Dec;72-73:101561. doi: 10.1016/j.ghir.2023.101561. Epub 2023 Dec 5.ABSTRACTThe role of the insulin-like growth factor (IGF) system has attracted close attention. The activity of IGF binding proteins (IGFBPs) within the ovary has not been fully elucidated to date. These proteins bind to IGF with an equal, or greater, affinity than to the IGF1 receptor, thus being in the main position to regulate IGF signalling, in addition to extending the half-life of IGFs within the bloodstream and promoting IGF storage in specific tissue niches. IGF1 has an important part in cell proliferation, differentiati...
Source: Growth Hormone and IGF Research - December 9, 2023 Category: Endocrinology Authors: Tathyana Benetis Piau Aline de Queiroz Rodrigues Fernanda Paulini Source Type: research
Insulin-like growth factor (IGF) performance in ovarian function and applications in reproductive biotechnologies
Growth Horm IGF Res. 2023 Oct-Dec;72-73:101561. doi: 10.1016/j.ghir.2023.101561. Epub 2023 Dec 5.ABSTRACTThe role of the insulin-like growth factor (IGF) system has attracted close attention. The activity of IGF binding proteins (IGFBPs) within the ovary has not been fully elucidated to date. These proteins bind to IGF with an equal, or greater, affinity than to the IGF1 receptor, thus being in the main position to regulate IGF signalling, in addition to extending the half-life of IGFs within the bloodstream and promoting IGF storage in specific tissue niches. IGF1 has an important part in cell proliferation, differentiati...
Source: Growth Hormone and IGF Research - December 9, 2023 Category: Endocrinology Authors: Tathyana Benetis Piau Aline de Queiroz Rodrigues Fernanda Paulini Source Type: research
Insulin-like growth factor (IGF) performance in ovarian function and applications in reproductive biotechnologies
Growth Horm IGF Res. 2023 Oct-Dec;72-73:101561. doi: 10.1016/j.ghir.2023.101561. Epub 2023 Dec 5.ABSTRACTThe role of the insulin-like growth factor (IGF) system has attracted close attention. The activity of IGF binding proteins (IGFBPs) within the ovary has not been fully elucidated to date. These proteins bind to IGF with an equal, or greater, affinity than to the IGF1 receptor, thus being in the main position to regulate IGF signalling, in addition to extending the half-life of IGFs within the bloodstream and promoting IGF storage in specific tissue niches. IGF1 has an important part in cell proliferation, differentiati...
Source: Growth Hormone and IGF Research - December 9, 2023 Category: Endocrinology Authors: Tathyana Benetis Piau Aline de Queiroz Rodrigues Fernanda Paulini Source Type: research
Insulin-like growth factor (IGF) performance in ovarian function and applications in reproductive biotechnologies
Growth Horm IGF Res. 2023 Dec 5;72-73:101561. doi: 10.1016/j.ghir.2023.101561. Online ahead of print.ABSTRACTThe role of the insulin-like growth factor (IGF) system has attracted close attention. The activity of IGF binding proteins (IGFBPs) within the ovary has not been fully elucidated to date. These proteins bind to IGF with an equal, or greater, affinity than to the IGF1 receptor, thus being in the main position to regulate IGF signalling, in addition to extending the half-life of IGFs within the bloodstream and promoting IGF storage in specific tissue niches. IGF1 has an important part in cell proliferation, different...
Source: Growth Hormone and IGF Research - December 9, 2023 Category: Endocrinology Authors: Tathyana Benetis Piau Aline de Queiroz Rodrigues Fernanda Paulini Source Type: research
Insulin-like growth factor (IGF) performance in ovarian function and applications in reproductive biotechnologies
Growth Horm IGF Res. 2023 Dec 5;72-73:101561. doi: 10.1016/j.ghir.2023.101561. Online ahead of print.ABSTRACTThe role of the insulin-like growth factor (IGF) system has attracted close attention. The activity of IGF binding proteins (IGFBPs) within the ovary has not been fully elucidated to date. These proteins bind to IGF with an equal, or greater, affinity than to the IGF1 receptor, thus being in the main position to regulate IGF signalling, in addition to extending the half-life of IGFs within the bloodstream and promoting IGF storage in specific tissue niches. IGF1 has an important part in cell proliferation, different...
Source: Growth Hormone and IGF Research - December 9, 2023 Category: Endocrinology Authors: Tathyana Benetis Piau Aline de Queiroz Rodrigues Fernanda Paulini Source Type: research
A combined top-down and bottom-up LC-HRMS/MS method for the quantification of human growth hormone in plasma and serum
CONCLUSION: The top-down and bottom-up LC-HRMS/MS method developed here presents a valuable tool for the quantification of GH in plasma/ serum complementary to established LBAs used at present in clinical measurements. Albeit the examination of the GH isoform proportions by the LC-MS method does not yet allow for the assessment of GH abuse, the obtained findings provide an important basis to enable LC-MS-based GH analysis of doping control samples in the future.PMID:37995539 | DOI:10.1016/j.ghir.2023.101560 (Source: Growth Hormone and IGF Research)
Source: Growth Hormone and IGF Research - November 23, 2023 Category: Endocrinology Authors: Sophia Krombholz Andreas Thomas Philippe Delahaut Martin Bidlingmaier Katharina Schilbach Geoffrey Miller Mario Thevis Source Type: research
A combined top-down and bottom-up LC-HRMS/MS method for the quantification of human growth hormone in plasma and serum
CONCLUSION: The top-down and bottom-up LC-HRMS/MS method developed here presents a valuable tool for the quantification of GH in plasma/ serum complementary to established LBAs used at present in clinical measurements. Albeit the examination of the GH isoform proportions by the LC-MS method does not yet allow for the assessment of GH abuse, the obtained findings provide an important basis to enable LC-MS-based GH analysis of doping control samples in the future.PMID:37995539 | DOI:10.1016/j.ghir.2023.101560 (Source: Growth Hormone and IGF Research)
Source: Growth Hormone and IGF Research - November 23, 2023 Category: Endocrinology Authors: Sophia Krombholz Andreas Thomas Philippe Delahaut Martin Bidlingmaier Katharina Schilbach Geoffrey Miller Mario Thevis Source Type: research
A combined top-down and bottom-up LC-HRMS/MS method for the quantification of human growth hormone in plasma and serum
CONCLUSION: The top-down and bottom-up LC-HRMS/MS method developed here presents a valuable tool for the quantification of GH in plasma/ serum complementary to established LBAs used at present in clinical measurements. Albeit the examination of the GH isoform proportions by the LC-MS method does not yet allow for the assessment of GH abuse, the obtained findings provide an important basis to enable LC-MS-based GH analysis of doping control samples in the future.PMID:37995539 | DOI:10.1016/j.ghir.2023.101560 (Source: Growth Hormone and IGF Research)
Source: Growth Hormone and IGF Research - November 23, 2023 Category: Endocrinology Authors: Sophia Krombholz Andreas Thomas Philippe Delahaut Martin Bidlingmaier Katharina Schilbach Geoffrey Miller Mario Thevis Source Type: research
A combined top-down and bottom-up LC-HRMS/MS method for the quantification of human growth hormone in plasma and serum
CONCLUSION: The top-down and bottom-up LC-HRMS/MS method developed here presents a valuable tool for the quantification of GH in plasma/ serum complementary to established LBAs used at present in clinical measurements. Albeit the examination of the GH isoform proportions by the LC-MS method does not yet allow for the assessment of GH abuse, the obtained findings provide an important basis to enable LC-MS-based GH analysis of doping control samples in the future.PMID:37995539 | DOI:10.1016/j.ghir.2023.101560 (Source: Growth Hormone and IGF Research)
Source: Growth Hormone and IGF Research - November 23, 2023 Category: Endocrinology Authors: Sophia Krombholz Andreas Thomas Philippe Delahaut Martin Bidlingmaier Katharina Schilbach Geoffrey Miller Mario Thevis Source Type: research
A combined top-down and bottom-up LC-HRMS/MS method for the quantification of human growth hormone in plasma and serum
CONCLUSION: The top-down and bottom-up LC-HRMS/MS method developed here presents a valuable tool for the quantification of GH in plasma/ serum complementary to established LBAs used at present in clinical measurements. Albeit the examination of the GH isoform proportions by the LC-MS method does not yet allow for the assessment of GH abuse, the obtained findings provide an important basis to enable LC-MS-based GH analysis of doping control samples in the future.PMID:37995539 | DOI:10.1016/j.ghir.2023.101560 (Source: Growth Hormone and IGF Research)
Source: Growth Hormone and IGF Research - November 23, 2023 Category: Endocrinology Authors: Sophia Krombholz Andreas Thomas Philippe Delahaut Martin Bidlingmaier Katharina Schilbach Geoffrey Miller Mario Thevis Source Type: research
A combined top-down and bottom-up LC-HRMS/MS method for the quantification of human growth hormone in plasma and serum
CONCLUSION: The top-down and bottom-up LC-HRMS/MS method developed here presents a valuable tool for the quantification of GH in plasma/ serum complementary to established LBAs used at present in clinical measurements. Albeit the examination of the GH isoform proportions by the LC-MS method does not yet allow for the assessment of GH abuse, the obtained findings provide an important basis to enable LC-MS-based GH analysis of doping control samples in the future.PMID:37995539 | DOI:10.1016/j.ghir.2023.101560 (Source: Growth Hormone and IGF Research)
Source: Growth Hormone and IGF Research - November 23, 2023 Category: Endocrinology Authors: Sophia Krombholz Andreas Thomas Philippe Delahaut Martin Bidlingmaier Katharina Schilbach Geoffrey Miller Mario Thevis Source Type: research
A combined top-down and bottom-up LC-HRMS/MS method for the quantification of human growth hormone in plasma and serum
CONCLUSION: The top-down and bottom-up LC-HRMS/MS method developed here presents a valuable tool for the quantification of GH in plasma/ serum complementary to established LBAs used at present in clinical measurements. Albeit the examination of the GH isoform proportions by the LC-MS method does not yet allow for the assessment of GH abuse, the obtained findings provide an important basis to enable LC-MS-based GH analysis of doping control samples in the future.PMID:37995539 | DOI:10.1016/j.ghir.2023.101560 (Source: Growth Hormone and IGF Research)
Source: Growth Hormone and IGF Research - November 23, 2023 Category: Endocrinology Authors: Sophia Krombholz Andreas Thomas Philippe Delahaut Martin Bidlingmaier Katharina Schilbach Geoffrey Miller Mario Thevis Source Type: research
A combined top-down and bottom-up LC-HRMS/MS method for the quantification of human growth hormone in plasma and serum
CONCLUSION: The top-down and bottom-up LC-HRMS/MS method developed here presents a valuable tool for the quantification of GH in plasma/ serum complementary to established LBAs used at present in clinical measurements. Albeit the examination of the GH isoform proportions by the LC-MS method does not yet allow for the assessment of GH abuse, the obtained findings provide an important basis to enable LC-MS-based GH analysis of doping control samples in the future.PMID:37995539 | DOI:10.1016/j.ghir.2023.101560 (Source: Growth Hormone and IGF Research)
Source: Growth Hormone and IGF Research - November 23, 2023 Category: Endocrinology Authors: Sophia Krombholz Andreas Thomas Philippe Delahaut Martin Bidlingmaier Katharina Schilbach Geoffrey Miller Mario Thevis Source Type: research
A combined top-down and bottom-up LC-HRMS/MS method for the quantification of human growth hormone in plasma and serum
CONCLUSION: The top-down and bottom-up LC-HRMS/MS method developed here presents a valuable tool for the quantification of GH in plasma/ serum complementary to established LBAs used at present in clinical measurements. Albeit the examination of the GH isoform proportions by the LC-MS method does not yet allow for the assessment of GH abuse, the obtained findings provide an important basis to enable LC-MS-based GH analysis of doping control samples in the future.PMID:37995539 | DOI:10.1016/j.ghir.2023.101560 (Source: Growth Hormone and IGF Research)
Source: Growth Hormone and IGF Research - November 23, 2023 Category: Endocrinology Authors: Sophia Krombholz Andreas Thomas Philippe Delahaut Martin Bidlingmaier Katharina Schilbach Geoffrey Miller Mario Thevis Source Type: research
