The effects of the pulsed magnetic field on sepsis-induced liver tissue injury in rats
Gen Physiol Biophys. 2023 Nov;42(6):539-549. doi: 10.4149/gpb_2023026.ABSTRACTSepsis is the host's response to infection and can lead to severe and life-threatening cases. We aimed to investigate the effects of pulsed magnetic field (PMF) on septic liver tissue injury. A total of 28 adult Wistar albino rats were divided equally into four study groups: Sham, PMF-1, PMF-2, and Sepsis, with seven rats in each. Sepsis was performed using the CLP method. PMF-1 and PMF-2 were exposed to 7.5 Hz and 15 Hz PMF, respectively, for 24 hours. After having their livers removed, liver tissues were analysed using histological techniques. ...
Source: General Physiology and Biophysics - November 23, 2023 Category: Physiology Authors: Fikret Gevrek Serkan Yelli Serkan G ürgül Source Type: research
Five glycosylation-related gene signatures predict the prognostic risks of lung adenocarcinoma
This study aimed to identify glycosylation-related genes associated with lung adenocarcinoma (LUAD) prognosis through comprehensive bioinformatic analysis. Glycosylation-related genes were identified from the Human Gene Nomenclature Committee, and LUAD prognostic genes were screened from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO)-GSE68465 datasets. Glycosylation risk score (GLRS) was calculated to predict LUAD prognostic risk. Samples were grouped into GLRS-high and GLRS-low and compared. The Tumor Immune Dysfunction and Exclusion (TIDE) score was computed to assess the antitumor immune escape possibi...
Source: General Physiology and Biophysics - November 23, 2023 Category: Physiology Authors: Xiao-Hui Liu Yi-Ming Yang Ming-Ming Zhang Hao-Yu Fu Source Type: research
Early-life maternal deprivation in rats increases sensitivity to the subsequent stressors: a pilot study
This study underscores the utility of a two-stage PSS model for more accurately reflecting the complexities inherent in stress-related disorders, including PTSD.PMID:37994426 | DOI:10.4149/gpb_2023022 (Source: General Physiology and Biophysics)
Source: General Physiology and Biophysics - November 23, 2023 Category: Physiology Authors: Maria Komelkova Boris Yushkov Stanislav Fedorov Roman Ibragimov Pavel Platkovskiy Desheng Hu Shanshan Luo Alexey Sarapultsev Source Type: research
Effects of novel mRNA-VEGF@USPIO nanoparticles on human brain microvascular endothelial cell injury
This study shows that mRNA-VEGF@USPIO nanoparticles can repair HBMECs injury.PMID:37994427 | DOI:10.4149/gpb_2023032 (Source: General Physiology and Biophysics)
Source: General Physiology and Biophysics - November 23, 2023 Category: Physiology Authors: Jiang Zhao Zhiyuan Qian Source Type: research
Polydatin inhibited TNF- α-induced apoptosis of skeletal muscle cells through AKT-mediated p38 MAPK and NF-κB pathways
This study investigated the effects and mechanism of polydatin on TNF-α-induced skeletal muscle cells. The skeletal muscle cell atrophy model was established by inducing C2C12 cells with TNF-α. Cell viability, IL-1β levels and cell apoptosis were assessed. The mRNA and protein expression levels of apoptosis-related proteins were measured. Meanwhile, the binding of polydatin to AKT was analyzed by molecular docking. TNF-α reduced cell fusion and viability while up-regulated IL-1β level and promoted cell apoptosis. TNF-α activated AKT, NF-κB, and p38 MAPK signaling pathways. Polydatin reversed these effects induced by...
Source: General Physiology and Biophysics - November 23, 2023 Category: Physiology Authors: Yongli Liu Fang Xie Changhuai Lu Zongbo Zhou Shudong Li Jia Zhong Qian Li Xianfang Shao Source Type: research
