Neurogenic Bowel Dysfunction
Spinal cord injury and neurogenic bowel dysfunction (NBD) are life-changing events for affected patients. The clinical manifestations of NBD vary depending on the level and severity of the spinal cord lesion. Managing patients with NBD can be complicated by comorbidities, such as immobility, bladder dysfunction, progressive neurologic decline, psychological factors, loss of independence, and social withdrawal, and ideally involves a multimodal, multidisciplinary approach. Evaluation and management should be individualized, depending on the residual neurologic capabilities of the patient and their predominant gastrointestin...
Source: Gastroenterology Clinics of North America - January 7, 2022 Category: Gastroenterology Authors: Seifeldin Hakim, Tanmay Gaglani, Brooks D. Cash Source Type: research

Opioid-Related Constipation
Opioid-related constipation encompasses constipation directly caused by opioid use (opioid-induced constipation [OIC]) as well as pre-existing constipation worsened by opioid use (opioid-exacerbated constipation [OEC]). Over-the-counter laxatives should be used as first-line agents for both OIC and OEC, given their efficacy, low cost, and high safety profiles. Symptoms of OIC and responses to therapy can be assessed with the Bowel Function Index. Individuals with OIC refractory to laxatives may be responsive to peripherally acting μ-opioid receptor antagonists. Although data supporting the superiority of one prescription ...
Source: Gastroenterology Clinics of North America - January 7, 2022 Category: Gastroenterology Authors: Joy J. Liu, Darren M. Brenner Source Type: research

A Pain in the Butt
Painful and bothersome anorectal syndromes can be a diagnostic and therapeutic challenge for clinicians because structural and functional abnormalities may often coexist and require a multidisciplinary approach to management. Although it is often difficult to attribute all of a patient ’s anorectal symptoms to a singular disorder with definitive intervention and cure, improving quality of life, treating coexistent conditions such as functional constipation and/or defecation disorders, addressing psychological comorbidities if present, and confirming there is no evidence of infla mmatory or malignant conditions are top pr...
Source: Gastroenterology Clinics of North America - January 7, 2022 Category: Gastroenterology Authors: Tisha N. Lunsford, Mary A. Atia, Suaka Kagbo-Kue, Lucinda A. Harris Source Type: research

Psychological and Nutritional Factors in Pelvic Floor Disorders
This article discusses the role of psychological and nutritional factors in gastrointestinal pelvic floor disorders such as dyssynergic defection and explores the use of multidisciplinary strategies to enhance treatment. (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - January 7, 2022 Category: Gastroenterology Authors: Sarah Quinton, Bethany Doerfler Source Type: research

Evaluation and Treatment of Urinary Incontinence in Women
This review focuses on the diagnosis, evaluation, and treatment of urinary incontinence (UI). UI is a common diagnosis that is encountered among women in their lifetime. Stress, urge (overactive bladder), and overflow are the most commonly encountered types of incontinence, but anatomic and neurologic causes are important to rule out. There are many treatment options available for the management of UI, and most patients will benefit from conservative strategies including weight loss, timed voiding, fluid intake reduction, pelvic floor strengthening exercises, and medications. For those who do not achieve adequate improveme...
Source: Gastroenterology Clinics of North America - January 7, 2022 Category: Gastroenterology Authors: Elisa R. Trowbridge, Elizabeth F. Hoover Source Type: research

Pelvic Organ Prolapse
Pelvic organ prolapse (POP) is defined as the descent of one or more of the anterior and posterior vaginal walls, uterus (cervix), or apex of the vagina (vaginal vault or cuff scar after hysterectomy). Although POP can be asymptomatic, if the bulge extends beyond the opening of the vagina, it can have a significant impact on a woman's quality of life. Findings include vaginal bulging toward or through the vaginal introitus that the patient may feel, palpate, or see with a mirror. If a woman is bothered by her prolapse, she should be offered both nonsurgical and surgical treatments. (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - January 7, 2022 Category: Gastroenterology Authors: Sarah Collins, Christina Lewicky-Gaupp Source Type: research

Endometriosis and Pelvic Pain for the Gastroenterologist
Endometriosis, affecting 5-10% of reproductive-age women, is a common contributor to dysmenorrhea and chronic pelvic pain. Diagnosis requires laparoscopic tissue biopsy, but careful pelvic examination, and/or imaging with either ultrasound or MRI, may identify patients who should receive empiric first-line therapy. The presence of dyschezia, particularly with cyclical exacerbation, should raise suspicion for bowel or rectovaginal septum involvement, and a greater need for surgical management. Treatment of dysmenorrhea includes hormonal suppression of the menstrual cycle, and/or analgesics; more severe cases with strong pai...
Source: Gastroenterology Clinics of North America - January 7, 2022 Category: Gastroenterology Authors: Sukhbir S. Singh, Stacey A. Missmer, Frank F. Tu Source Type: research

Scleroderma and the Esophagus
This article highlights esophageal manifestations of scleroderma, focusing on pathogenesis, clinical presentation, diagnostic considerations, and treatment options. In addition, this article briefly reviews the esophageal manifestations of other key connective tissue disorders, including mixed connective tissue disease, myositis, Sjogren syndrome, systemic lupus erythematosus, fibromyalgia, and Ehlers-Danlos syndrome. (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - October 28, 2021 Category: Gastroenterology Authors: Nitin K. Ahuja, John O. Clarke Source Type: research

A Comprehensive Approach to Esophageal Symptoms and Disorders
Esophageal symptoms and disease are highly prevalent and comprise a significant burden to patients and society. Thankfully, our understanding of pathophysiology and treatments continues to expand. As we enter the 2020s, we are better able to diagnose and treat our affected patients (although much remains still to be discovered). (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - October 28, 2021 Category: Gastroenterology Authors: John O. Clarke Tags: Preface Source Type: research

Diseases of the Esophagus
GASTROENTEROLOGY CLINICS OF NORTH AMERICA (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - October 28, 2021 Category: Gastroenterology Authors: John O. Clarke Source Type: research

Copyright
Elsevier (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - October 28, 2021 Category: Gastroenterology Source Type: research

Contributors
ALAN L. BUCHMAN, MD, MSPH, FACP, FACN, FACG, AGAF (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - October 28, 2021 Category: Gastroenterology Source Type: research

Contents
John O. Clarke (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - October 28, 2021 Category: Gastroenterology Source Type: research

Gastroenterology Clinics of North America
Pelvic Floor Disorders (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - October 28, 2021 Category: Gastroenterology Source Type: research

The Art of Endoscopic Dilation
The author offers his approach to esophageal dilation based on 40  years of a practice specializing in swallowing disorders and esophageal disease. He discusses general concepts in the management of esophageal strictures and then provides an approach to dilation of different types of esophageal stenotic lesions. (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - October 7, 2021 Category: Gastroenterology Authors: William J. Ravich Source Type: research