Emerging Endoscopic Interventions in Bariatric Surgery
This article examines the many endoscopic options that have been developed to treat obesity including gastric aspiration devices, incisionless magnetic anastomotic systems, endoluminal bypass barrier sleeves, primary obesity surgery endoluminal, endoscopic sleeve gastroplasty, and duodenal mucosal resurfacing. We review their development, application, efficacy, and the reported literature on their use and results. (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - November 1, 2023 Category: Gastroenterology Authors: Joshua S. Winder, John H. Rodriguez Source Type: research

Surgical Management of Bariatric Complications and Weight Regain
The history and evolution of bariatric/metabolic surgical procedures allows for only a brief introduction to complications and surgical approaches for improved weight loss. Our specialty lacks standardization of our operations such as gastric pouch size, intestinal bypass lengths, and consensus on which procedure is best for each individual patient. Anatomic construct as well as adherence to lifestyle modifications can affect short- and long-term outcomes. (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - November 1, 2023 Category: Gastroenterology Authors: Kelvin Higa Source Type: research

Comprehensive Treatment Approaches To Obesity
This issue of Gastroenterology Clinics of North America provides a comprehensive overview of the spectrum of existing approaches for obesity treatment. Obesity is a complex, chronic disease that is critical to address with a multidisciplinary, bias-free approach. Ideally treatments should begin upstream so as to prevent the numerous weight-related medical conditions, including cardiovascular disease, type 2 diabetes, cancer, and more. While lifestyle modifications remain the foundation for treating obesity, these methods alone have proven insufficient for the majority of patients to improve health through sustained, long-t...
Source: Gastroenterology Clinics of North America - November 1, 2023 Category: Gastroenterology Authors: Amanda Velazquez, Lee M. Kaplan Tags: Preface Source Type: research

Management Of Obesity, Part 2: Treatment Strategies
GASTROENTEROLOGY CLINICS OF NORTH AMERICA (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - November 1, 2023 Category: Gastroenterology Authors: Amanda Velazquez, Lee M. Kaplan Source Type: research

Copyright
Elsevier (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - November 1, 2023 Category: Gastroenterology Source Type: research

Contributors
ALAN L. BUCHMAN, MD, MSPH, FACP, FACN, FACG, AGAF (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - November 1, 2023 Category: Gastroenterology Source Type: research

Contents
Amanda Velazquez and Lee M. Kaplan (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - November 1, 2023 Category: Gastroenterology Source Type: research

Forthcoming Issues
Pathology of Dysplasia in the Gastrointestinal Tract (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - November 1, 2023 Category: Gastroenterology Source Type: research

Squamous Neoplastic Precursor Lesions of the Esophagus
Clinicopathological and molecular studies have demonstrated that dysplasia is a precancerous and/or neoplastic lesion with malignant potential. Further, it is subclassified into two grades: high-grade and low-grade dysplasia. High-grade dysplasia is a clinically significant lesion requiring resection or ablation. Low-grade dysplasia has a much lower risk of carcinoma; thus, it should be followed by endoscopic surveillance. Because squamous dysplasia may progress to squamous cell carcinoma, periodic endoscopy is useful to detect the lesion in patients with risk factors. Squamous dysplasia is diagnosed histopathologically by...
Source: Gastroenterology Clinics of North America - October 23, 2023 Category: Gastroenterology Authors: Tomio Arai, Satoshi Ono, Kaiyo Takubo Source Type: research

Pathology of Gastrointestinal Polyposis Disorders
Gastrointestinal polyposis disorders are a group of syndromes defined by clinicopathologic features that include the predominant histologic type of colorectal polyp and specific inherited gene mutations. Adenomatous polyposis syndromes comprise the prototypical familial adenomatous polyposis syndrome and other recently identified genetic conditions inherited in a dominant or recessive manner. Serrated polyposis syndrome is defined by arbitrary clinical criteria. The diagnosis of hamartomatous polyposis syndromes can be suggested from the histologic characteristics of colorectal polyps and the association with various extra...
Source: Gastroenterology Clinics of North America - October 20, 2023 Category: Gastroenterology Authors: Christophe Rosty, Lodewijk A.A. Brosens Source Type: research

Anal and Perianal Preneoplastic Lesions
Anal cancer, mainly squamous cell carcinoma, is rare but increasing in prevalence, as is its precursor lesion, anal squamous dysplasia. They are both strongly associated with human papillomavirus infection. The 2-tiered Lower Anogenital Squamous Terminology classification, low-grade SIL and high-grade SIL, is preferred to the 3-tiered anal intraepithelial neoplasia classification because of better interobserver agreement and clearer management implications. Immunohistochemistry with p16 is helpful to corroborate the diagnosis of squamous dysplasia. Similarly, immunohistochemistry is helpful to differentiate primary Paget d...
Source: Gastroenterology Clinics of North America - October 16, 2023 Category: Gastroenterology Authors: Maurice B. Loughrey, Neil A. Shepherd Source Type: research

Language Frames and Shapes the Response to Obesity
Because the scientific understanding of obesity has grown, explicit expressions of weight bias have steadily become less acceptable. However, implicit weight bias and stigma remain common impediments to health. Language frames the public perception of obesity. It is problematic when public discourse or scientific publications reflect misinformation or bias against people with obesity because this can promote stigma and barriers to health. Examples of stigmatizing language include descriptions of obesity as an identity rather than a disease, language that describes obesity as a crisis or a cause for panic, and excessive foc...
Source: Gastroenterology Clinics of North America - October 7, 2023 Category: Gastroenterology Authors: Theodore K. Kyle, Scott Kahan, Joe Nadglowski Source Type: research

Management of Medication-Induced Weight Gain
This article reviews the common classes of medications that contribute to weight gain and discusses alternatives to consider. (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - October 3, 2023 Category: Gastroenterology Authors: Sarah R. Barenbaum, Rekha B. Kumar, Louis J. Aronne Source Type: research

Management of Monogenic and Syndromic Obesity
Similar to the general population, lifestyle interventions focused on nutrition and physical activity form the foundation for treating obesity caused by rare genetic disorders. Additional therapies, including metreleptin and setmelanotide, that target defects within the leptin signaling pathway can effectively synergize with lifestyle efforts to treat monogenic disorders of leptin, leptin receptor, proopiomelanocortin (POMC), and proprotein convertase subtilisin/kexin type 1 (PCSK1) and syndromic conditions, such as the ciliopathies Bardet-Biedl and Alstr öm syndromes, whose pathophysiological mechanisms also converge on ...
Source: Gastroenterology Clinics of North America - September 27, 2023 Category: Gastroenterology Authors: Joan C. Han, Marcus C. Rasmussen, Alison R. Forte, Stephanie B. Schrage, Sarah K. Zafar, Andrea M. Haqq Source Type: research

The Effective Use of Anti-obesity Medications
This article reviews the efficacy, safety, prescribing information, and other considerations for all of the currently available AOMs. (Source: Gastroenterology Clinics of North America)
Source: Gastroenterology Clinics of North America - September 21, 2023 Category: Gastroenterology Authors: Sarah H. Schmitz, Louis J. Aronne Source Type: research