METTL14 knockdown inhibits the pyroptosis in the sepsis-induced acute lung injury through regulating the m6A modification of NLRP3
Conclusion: This study demonstrated that METTL14 knockdown inhibited the pyroptosis in the sepsis-induced ALI progression through decreasing the NLRP3 levels dependent on m6A methylation modification.PMID:38047519 | DOI:10.1080/01902148.2023.2288182 (Source: Experimental Lung Research)
Source: Experimental Lung Research - December 4, 2023 Category: Respiratory Medicine Authors: Jianting Gao Huizhen Chen Yong Zhang Sun Yu Yiyi Wu Qiuyan Wang Zhenfei Yu Source Type: research
Stevioside attenuates bleomycin-induced pulmonary fibrosis by activating the Nrf2 pathway and inhibiting the NF- κB and TGF-β1/Smad2/3 pathways
Conclusion: STE may alleviate oxidative stress by activating the Nrf2 pathway, suppress the inflammatory response by downregulating the NF-κB pathway, and inhibit EMT progression by blocking the TGF-β1/Smad2/3 pathway, thereby improving BLM-induced PF.PMID:38044666 | DOI:10.1080/01902148.2023.2286465 (Source: Experimental Lung Research)
Source: Experimental Lung Research - December 4, 2023 Category: Respiratory Medicine Authors: Wei Hao Ting-Ting Yu Dong-Ze Zuo Heng-Zhao Hu Ping-Ping Zhou Source Type: research
METTL14 knockdown inhibits the pyroptosis in the sepsis-induced acute lung injury through regulating the m6A modification of NLRP3
Conclusion: This study demonstrated that METTL14 knockdown inhibited the pyroptosis in the sepsis-induced ALI progression through decreasing the NLRP3 levels dependent on m6A methylation modification.PMID:38047519 | DOI:10.1080/01902148.2023.2288182 (Source: Experimental Lung Research)
Source: Experimental Lung Research - December 4, 2023 Category: Respiratory Medicine Authors: Jianting Gao Huizhen Chen Yong Zhang Sun Yu Yiyi Wu Qiuyan Wang Zhenfei Yu Source Type: research
Stevioside attenuates bleomycin-induced pulmonary fibrosis by activating the Nrf2 pathway and inhibiting the NF- κB and TGF-β1/Smad2/3 pathways
Conclusion: STE may alleviate oxidative stress by activating the Nrf2 pathway, suppress the inflammatory response by downregulating the NF-κB pathway, and inhibit EMT progression by blocking the TGF-β1/Smad2/3 pathway, thereby improving BLM-induced PF.PMID:38044666 | DOI:10.1080/01902148.2023.2286465 (Source: Experimental Lung Research)
Source: Experimental Lung Research - December 4, 2023 Category: Respiratory Medicine Authors: Wei Hao Ting-Ting Yu Dong-Ze Zuo Heng-Zhao Hu Ping-Ping Zhou Source Type: research
METTL14 knockdown inhibits the pyroptosis in the sepsis-induced acute lung injury through regulating the m6A modification of NLRP3
Conclusion: This study demonstrated that METTL14 knockdown inhibited the pyroptosis in the sepsis-induced ALI progression through decreasing the NLRP3 levels dependent on m6A methylation modification.PMID:38047519 | DOI:10.1080/01902148.2023.2288182 (Source: Experimental Lung Research)
Source: Experimental Lung Research - December 4, 2023 Category: Respiratory Medicine Authors: Jianting Gao Huizhen Chen Yong Zhang Sun Yu Yiyi Wu Qiuyan Wang Zhenfei Yu Source Type: research
Impact of lipopolysaccharide-induced acute lung injury in aged mice
Conclusions: Aging may amplify lung damage and inflammatory responses in ALI. This suggests that physicians should exercise increased caution in the clinical management of aged patients with ALI.PMID:38006357 | DOI:10.1080/01902148.2023.2285061 (Source: Experimental Lung Research)
Source: Experimental Lung Research - November 25, 2023 Category: Respiratory Medicine Authors: Sukjin Bae In Kyoung Kim Jeonghyeon Im Heayon Lee Sang Haak Lee Sei Won Kim Source Type: research
Rapamycin attenuates pyroptosis by suppressing mTOR phosphorylation and promoting autophagy in LPS-induced bronchopulmonary dysplasia
CONCLUSIONS: Rapamycin reduces pyroptosis in neonatal rats with LPS-induced BPD by inhibiting mTOR phosphorylation and inducing autophagy; hence, it may represent a potential therapeutic for treating BPD.PMID:37874145 | DOI:10.1080/01902148.2023.2266236 (Source: Experimental Lung Research)
Source: Experimental Lung Research - October 24, 2023 Category: Respiratory Medicine Authors: Feng Zhang Minrong Wang Zhongni Li Jiehong Deng Yang Fan Zhixian Gou Yue Zhou Li Huang Liqun Lu Source Type: research
