Rapamycin attenuates pyroptosis by suppressing mTOR phosphorylation and promoting autophagy in LPS-induced bronchopulmonary dysplasia

CONCLUSIONS: Rapamycin reduces pyroptosis in neonatal rats with LPS-induced BPD by inhibiting mTOR phosphorylation and inducing autophagy; hence, it may represent a potential therapeutic for treating BPD.PMID:37874145 | DOI:10.1080/01902148.2023.2266236

Source: Experimental Lung Research - October 24, 2023 Category: Respiratory Medicine Authors: Feng Zhang Minrong Wang Zhongni Li Jiehong Deng Yang Fan Zhixian Gou Yue Zhou Li Huang Liqun Lu Source Type: research