20th Surgical Research Days, Section of Surgical Research of the German Society of Surgery, September 8-10, 2016, Magdeburg, Germany: Abstracts
Eur Surg Res 2016;57:263-335 (Source: European Surgical Research)
Source: European Surgical Research - September 1, 2016 Category: Surgery Source Type: research
Initial Resistance of Carina Anastomoses with Increasing Tensile Stress: An ex vivo Model Comparing Different Suture Techniques
Conclusion: If tracheal anastomoses can be performed without tension, the suture technique is not important. With increased tension, anastomoses performed in single interrupted suture technique were clearly superior. Thus, in situations, where high tensile stress is to be expected, single interrupted sutures should be preferred.Eur Surg Res 2017;58:20-26 (Source: European Surgical Research)
Source: European Surgical Research - August 30, 2016 Category: Surgery Source Type: research
Uniformity of Chronic Pain Assessment after Inguinal Hernia Repair: A Critical Review of the Literature
Conclusion: The current literature addressing CPIP after inguinal hernia repair has a variable degree of quality and lacks uniformity in outcome measures. Proper comparison of the study results to provide conclusive recommendations for preventive measures against CPIP therefore remains difficult. These findings reaffirm the need for a uniform and validated assessment with uniform reporting of outcomes to improve the burden that CPIP poses to a significant surgical patient population.Eur Surg Res 2017;58:1-19 (Source: European Surgical Research)
Source: European Surgical Research - August 26, 2016 Category: Surgery Source Type: research
Argon Preconditioning Protects Airway Epithelial Cells against Hydrogen Peroxide-Induced Oxidative Stress
Background: Oxidative stress is the predominant pathogenic mechanism of ischaemia-reperfusion (IR) injury. The noble gas argon has been shown to alleviate oxidative stress-related myocardial and cerebral injury. The risk of lung IR injury is increased in some major surgeries, reducing clinical outcome. However, no study has examined the lung-protective efficacy of argon preconditioning. The present study investigated the protective effects of argon preconditioning on airway epithelial cells exposed to hydrogen peroxide (H2O2) to induce oxidative stress.Methods: A549 airway epithelial cells were treated with a cytotoxic con...
Source: European Surgical Research - August 24, 2016 Category: Surgery Source Type: research
Development of a Vascularized Heterotopic Neonatal Rat Heart Transplantation Model
Conclusions: We describe detailed surgical techniques for AHTx and FHTx while addressing neonatal donor-specific issues. Following our recommendations potentially reduces the learning curve to achieve reliable and reproducible results with these challenging animal models.Eur Surg Res 2016;57:240-251 (Source: European Surgical Research)
Source: European Surgical Research - August 19, 2016 Category: Surgery Source Type: research
Bioengineered Livers: A New Tool for Drug Testing and a Promising Solution to Meet the Growing Demand for Donor Organs
< b > < i > Background: < /i > < /b > Organ engineering is a new innovative strategy to cope with two problems: the need for physiological models for pharmacological research and donor organs for transplantation. A functional scaffold is generated from explanted organs by removing all cells (decellularization) by perfusing the organ with ionic or nonionic detergents via the vascular system. Subsequently the acellular scaffold is reseeded with organ-specific cells (repopulation) to generate a functional organ. < b > < i > Summary: < /i > < /b > This review gives an overview of the state of the art describing the decellula...
Source: European Surgical Research - July 26, 2016 Category: Surgery Source Type: research
Antinociceptive Effects of Ginsenoside Rg3 in a Rat Model of Incisional Pain
Conclusions: Ginsenoside Rg3 has an analgesic effect with a curvilinear dose-response relationship. Alpha 2 adrenergic receptor appeared to be related to the analgesic effect of ginsenoside Rg3. Also, the anti-inflammatory effect of ginsenoside Rg3 could be related to its analgesic effect.Eur Surg Res 2016;57:211-223 (Source: European Surgical Research)
Source: European Surgical Research - July 21, 2016 Category: Surgery Source Type: research
Distinct Gene Expression Patterns Defining Human Osteoblasts' Response to BMP2 Treatment: Is the Therapeutic Success All a Matter of Timing?
Conclusions: Our data identified three donor groups profiting from BMP2 treatment either directly via stimulation of osteoblast function or viability and/or indirectly via inhibition of osteoclastogenesis, depending on their expression of BAMBI, SOST, NOG, and RANKL. On the basis of patients' respective expression profiles, the clinical application of BMP2 as well as its timing might be modified in order to better fit the patients' needs to promote bone formation or to inhibit bone resorption.Eur Surg Res 2016;57:197-210 (Source: European Surgical Research)
Source: European Surgical Research - July 21, 2016 Category: Surgery Source Type: research
Immune Architecture of Colorectal Lung Metastases and Implications for Patient Survival
Conclusion: Colorectal lung and liver metastases showed a distinct immunological architecture. A dense cell infiltration of colorectal lung metastases by CD4+ cells was related to prolonged patient survival. Preoperative chemotherapy did not influence cellular immune infiltrates.Eur Surg Res 2016;57:186-196 (Source: European Surgical Research)
Source: European Surgical Research - July 21, 2016 Category: Surgery Source Type: research
Hemodynamic Assessment of a Murine Heterotopic Biventricularly Loaded Cardiac Transplant in vivo Model
Conclusions: These results demonstrate the technical (micro)surgical feasibility of a fully loaded HHT procedure in the murine model without using a combined heart-lung transplantation approach. The acute hemodynamic performance of the HHT grafts approximated the native orthotopic situation. This model may open up new options for the investigation of cellular and molecular questions in the murine cardiovascular in vivo system in the near future.Eur Surg Res 2016;57:171-185 (Source: European Surgical Research)
Source: European Surgical Research - July 19, 2016 Category: Surgery Source Type: research
Limits of and Complications after Embolization of the Hepatic Artery and Portal Vein to Induce Segmental Hypertrophy of the Liver: A Large Mini-Pig Study
Conclusion: PVE is safe and effective to induce segmental hypertrophy. Portal reperfusion by collateral vessels may limit hypertrophy. AE did not increase the segmental hepatic volume but carries the risk of extensive necrotic inflammatory damage.Eur Surg Res 2016;57:155-170 (Source: European Surgical Research)
Source: European Surgical Research - July 19, 2016 Category: Surgery Source Type: research
ESSR News
Eur Surg Res 2016;57:138 (Source: European Surgical Research)
Source: European Surgical Research - July 6, 2016 Category: Surgery Source Type: research
Biographic Characteristics and Factors Perceived as Affecting Female and Male Careers in Academic Surgery: The Tenured Gender Battle to Make It to the Top
Conclusions: Although there are many parallels, female faculty members experience the culture of academic surgery to some extent differently from their male counterparts, especially when impacted by parenthood and childcare. Faculty development programmes need to develop strategies to improve perceived equality in career opportunities by respecting individuals' requirements as well as offering gender-appropriate career guidance.Eur Surg Res 2016;57:139-154 (Source: European Surgical Research)
Source: European Surgical Research - July 4, 2016 Category: Surgery Source Type: research
Intrahepatic Size Regulation in a Surgical Model: Liver Resection-Induced Liver Regeneration Counteracts the Local Atrophy following Simultaneous Portal Vein Ligation
Conclusions: A discontinued portal blood supply does not always result in atrophy of the ligated lobe. The concurrent regenerative stimulus induced by 70% PHx seemed to counteract the local atrophy after a simultaneously performed rPVL, leading to a low but prolonged regenerative response of the portally deprived liver lobe. This observation supports the conclusion that portal flow is not necessary for liver regeneration. The persisting portal hyperperfusion may be crucial for the specific kinetics of prolonged liver regeneration after rPVL + 70% PHx in the portally supplied caudate lobe. Both observations deserve more att...
Source: European Surgical Research - June 16, 2016 Category: Surgery Source Type: research
Protein Kinase CK2 Regulates Leukocyte-Endothelial Cell Interactions during Ischemia and Reperfusion in Striated Skin Muscle
Conclusion: Our findings indicate that CK2 is involved in the regulation of leukocyte-endothelial cell interactions during I/R by mediating the expression of E-selectin and ICAM-1.Eur Surg Res 2016;57:111-124 (Source: European Surgical Research)
Source: European Surgical Research - June 7, 2016 Category: Surgery Source Type: research
