Adenylyl Cyclase (AC) Mediates the Antidepressant-Like Effects of Tropisetron on a Mouse Model of Maternal Separation Stress
Depress Res Treat. 2021 Apr 22;2021:5586119. doi: 10.1155/2021/5586119. eCollection 2021.ABSTRACTThe adenylyl cyclase (AC) pathway is involved in the pathophysiology of depression. Finding new antidepressants with high medicinal properties and low side effects is warranted. Therefore, this study was designed to determine the antidepressant-like effect of tropisetron on a maternal separation (MS) model in mice, considering the possible role of AC. NMRI male mice were divided into eleven groups. The control group was treated with saline and MS groups were treated with saline, tropisetron (a 5-HT3 receptor antagonist) at dose...
Source: Depression Research and Treatment - May 12, 2021 Category: Psychiatry Authors: Ali Hosseinzadeh Shakiba Nasiri Boroujeni Elham Saghaei Zahra Loriooini Saeid Habibian Dehkordi Shima Balali-Dehkordi Mohammad Rahimi-Madiseh Hossein Amini-Khoei Source Type: research

Depressive and Anxiety Symptom Assessment in Adults with Polycystic Ovarian Syndrome
This study is aimed at assessing depression and anxiety symptoms among PCOS patients and their association with different socioeconomic aspects.METHODS: A cross-sectional study was conducted to assess depression and anxiety symptoms on 250 PCOS patients which were selected through consecutive sampling technique. Arabic versions of the HAM-A and HAM-D questionnaires were used alongside a demographic sheet to determine the socioeconomic and fertility status.RESULTS: Prevalence of anxiety symptoms was reported among 100 (40%) of women and was found to be significantly higher in single women with a prevalence of 59 (48%) (χ2 = 5.8, p value
Source: Depression Research and Treatment - May 7, 2021 Category: Psychiatry Authors: Wadha K Almeshari Alanoud K Alsubaie Reham I Alanazi Yara A Almalki Nazish Masud Sami H Mahmoud Source Type: research

The Impact of Different Types of Abuse on Depression
This article, unlike prior research, provides an overview that addresses physical, psychological, and sexual abuse and their psychological impact on the victims. Results show that abuse is a vulnerability factor for a variety of mental and physical health problems and that psychological abuse is strongly associated with depression. More research is needed to understand (a) the role of abuse in the development and maintenance of depression and, in particular, longitudinal studies that also account for the large number of risk and protective factors that influence this relationship and (b) how different types of abuse can in...
Source: Depression Research and Treatment - May 3, 2021 Category: Psychiatry Authors: Milen L Radell Eid G Abo Hamza Wid H Daghustani Asma Perveen Ahmed A Moustafa Source Type: research