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COVID-19 and Gynecologic Oncology: What Have We Learned?
Opinion statementCOVID-19 has transformed the care we provide to gynecologic oncology patients. In addition to directly impacting the diagnosis and treatment of women with gynecologic cancer, it has affected our patient ’s ability to undergo recommended surveillance and has made an impact on every caregiver providing care during this time. Herein we review the current literature on the impact of COVID-19 on gynecologic oncology and highlight new approaches and innovations that have resulted in gynecologic cancer care as a result of the pandemic. The impact of COVID-19 on the field of gynecologic oncology has been profoun...
Source: Current Treatment Options in Oncology - November 23, 2021 Category: Cancer & Oncology Source Type: research

Sequencing of Novel Therapies for Mantle Cell Lymphoma
Opinion statementThere is no standard approach to sequencing novel therapies in mantle cell lymphoma (MCL). For initial treatment, intensive induction chemotherapy followed by autologous stem cell transplant and rituximab maintenance remains our preferred approach in young, fit patients. We consider bendamustine plus rituximab or lenalidomide plus rituximab in patients who are ineligible for intensive chemotherapy-based approaches. Bruton ’s tyrosine kinase inhibitors are our preferred class of agents to use in the second-line setting. When patients inevitably relapse on one of these agents, we proceed with chimeric anti...
Source: Current Treatment Options in Oncology - November 23, 2021 Category: Cancer & Oncology Source Type: research

Treating Chronic Pain with Buprenorphine —The Practical Guide
Opinion statementBuprenorphine has unique and favorable pharmacological properties that make it useful in a variety of clinical scenarios. It has been recommended to consider buprenorphine first-line opioid for chronic pain, especially in the elderly as it may be associated with less cognitive impairment, falls, sexual dysfunction, and sarcopenia when compared with schedule II opioids. It may be useful in patients with comorbid substance use disorder or non-medical opioid use, as there is less risk of misuse, euphoria and it may improve mood. When used to treat opioid use disorder, the training and waiver was recently waiv...
Source: Current Treatment Options in Oncology - November 18, 2021 Category: Cancer & Oncology Source Type: research

Overview and Emerging Trends in the Treatment of  Osteoradionecrosis
Opinion statementOsteoradionecrosis (ORN) of the mandible is a rare but devastating complication which occurs following radiation therapy for head and neck malignancies. Left untreated, ORN often results in pathologic fracture of the mandible leading to pain, trismus, difficulty eating, and overall poor quality of life. Historically, early intervention relied on hyperbaric oxygen and local debridement. Patients whose disease progressed despite therapy required segmental resection of the mandible with osseous free flap reconstruction, a highly invasive operation. Patients that presented with a moderate disease without patho...
Source: Current Treatment Options in Oncology - November 13, 2021 Category: Cancer & Oncology Source Type: research

Options for the Treatment of Mucinous Ovarian Carcinoma
Opinion statementComplete surgical resection is the gold-standard treatment for all mucinous ovarian carcinoma (MOC) cases. Advanced-stage disease is often additionally treated with adjuvant platinum-based chemotherapy; however, these were developed largely against the more common high-grade serous ovarian carcinoma and have low efficacy in treating MOC. More effective therapeutics are needed to treat late-stage and platinum-resistant tumors; however, traditional drug development and clinical trial paradigms are a major challenge for such a rare disease. New approaches to support evidence-based treatment decisions are requ...
Source: Current Treatment Options in Oncology - November 13, 2021 Category: Cancer & Oncology Source Type: research