Loop-Mediated Isothermal Amplification –Based Microfluidic Platforms for the Detection of Viral Infections
Abstract
Purpose of ReviewEasy-to-use, fast, and accurate virus detection method is essential for patient management and epidemic surveillance, especially during severe pandemics. Loop-mediated isothermal amplification (LAMP) on a microfluidic platform is suitable for detecting infectious viruses, regardless of the availability of medical resources. The purpose of this review is to introduce LAMP-based microfluidic devices for virus detection, including their detection principles, methods, and application.Recent FindingsFacing the uncontrolled spread of viruses, the large-scale deployment of LAMP-based microfluidic plat...
Source: Current Infectious Disease Reports - November 2, 2022 Category: Infectious Diseases Source Type: research
Correction to: Nosocomial Extracardiac Infections After Cardiac Surgery
(Source: Current Infectious Disease Reports)
Source: Current Infectious Disease Reports - November 1, 2022 Category: Infectious Diseases Source Type: research
No Crystal Ball? Using Risk Factors and Scoring Systems to Predict Extended-Spectrum Beta-Lactamase Producing Enterobacterales (ESBL-E) and Carbapenem-Resistant Enterobacterales (CRE) Infections
AbstractPurpose of ReviewPredicting whether a hospitalized patient is infected with an ESBL-E or CRE remains challenging and often leads to overutilization of broad-spectrum antibiotics. This review will describe the most common risk factors associated with ESBL-E and CRE infections and how to best apply them to clinical practice. A review of existing risk scoring tools to predict multidrug-resistant gram-negative pathogens (MDR GN) as well as considerations for implementation will be discussed.Recent FindingsPrior use of a fluoroquinolone or broad-spectrum beta-lactam with the past 3 months, history of colonization or i...
Source: Current Infectious Disease Reports - October 6, 2022 Category: Infectious Diseases Source Type: research
Les mis érables: a Parallel Between Antimicrobial Resistance and COVID-19 in Underdeveloped and Developing Countries
AbstractPurpose of ReviewThe COVID-19 pandemic has been responsible for more than 6.3 million deaths worldwide. During the pandemic, the indiscriminate use of antibiotics has increased, contributing to the spread of multidrug-resistant bacteria. In this review, we aim to determine the spread and impact of antibiotic treatments in patients with COVID-19, focusing on underdeveloped and developing countries.Recent FindingsMeta-analysis revealed that bacterial co-infections and secondary infections are relatively rare in COVID-19 patients, corresponding to less than 20% of hospitalized patients. Even so, most of these patients...
Source: Current Infectious Disease Reports - October 4, 2022 Category: Infectious Diseases Source Type: research
Travel in the Time of COVID: A Review of International Travel Health in a Global Pandemic
AbstractPurpose of ReviewThis review critically considers the impact of the COVID-19 pandemic on global travel and the practice of travel medicine, highlights key innovations that have facilitated the resumption of travel, and anticipates how travel medicine providers should prepare for the future of international travel.Recent FindingsSince asymptomatic transmission of the virus was first recognized in March 2020, extensive efforts have been made to characterize the pattern and dynamics of SARS-CoV-2 transmission aboard commercial aircraft, cruise ships, rail and bus transport, and in mass gatherings and quarantine facili...
Source: Current Infectious Disease Reports - October 1, 2022 Category: Infectious Diseases Source Type: research
West Nile virus: another emerging arboviral risk for travelers?
AbstractPurpose of ReviewWest Nile virus (WNV) is an arbovirus transmitted by mosquitos of the genusCulex. Manifestations of WNV infection range from asymptomatic to devastating neuroinvasive disease leading to flaccid paralysis and death. This review examines WNV epidemiology and ecology, with an emphasis on travel-associated infection.Recent FindingsWNV is widespread, including North America and Europe, where its range has expanded in the past decade. Rising temperatures in temperate regions are predicted to lead to an increased abundance ofCulex mosquitoes and an increase in their ability to transmit WNV. Although the e...
Source: Current Infectious Disease Reports - October 1, 2022 Category: Infectious Diseases Source Type: research
Nosocomial Extracardiac Infections After Cardiac Surgery
AbstractPurpose of ReviewNosocomial extracardiac infections after cardiac surgery are a major public health issue affecting 3 –8.2% of patients within 30–60 days following the intervention.Recent FindingsHere, we have considered the most important postoperative infective complications that, in order of frequency, are pneumonia, surgical site infection, urinary tract infection, and bloodstream infection. The overall picture that emerges shows that they cause a greater perioperative morbidity and mortality with a longer hospitalization time and excess costs. Preventive interventions and corrective measures, diminishing ...
Source: Current Infectious Disease Reports - September 24, 2022 Category: Infectious Diseases Source Type: research
Interventions for the Prevention and Treatment of Japanese Encephalitis
AbstractPurpose of ReviewJapanese encephalitis (JE), a clinical indication of JE virus –induced brain inflammation, is the most prevalent cause of viral encephalitis in the world. This review gives a comprehensive update on the epidemiology, clinical features, therapeutic trials and approaches for preventing the spread of JE. It also outlines the different JE vaccines used in variou s countries and recommendations for administration of JE vaccines.Recent FindingsAccording to the WHO, annual incidence of JE is estimated to be approximately 68,000 cases worldwide. It is widespread across Asia –Pacific, with a potential f...
Source: Current Infectious Disease Reports - September 23, 2022 Category: Infectious Diseases Source Type: research
Antifungal Resistance and the Role of New Therapeutic Agents
AbstractPurpose of ReviewAdvances in health care over time have led to an evolution in the epidemiology of invasive fungal infections. There is an increasing concern for antifungal resistance and emergence of less common fungal species for which optimal therapies are not well defined. The purpose of this review is to describe mechanisms of antifungal resistance and to evaluate the modern role of new and investigational antifungals.Recent FindingsIsavuconazole and ibrexafungerp represent the two newest antifungal agents. Evidence from in vivo and in vitro studies has been published recently to help define their place in the...
Source: Current Infectious Disease Reports - September 1, 2022 Category: Infectious Diseases Source Type: research
