The Challenges in the Primary Prevention of Osteoarthritis
In the absence of disease-modifying drugs and small to moderate efficacy of symptom relieving therapies, the primary prevention of osteoarthritis (OA) is important. The current review addresses some of the key challenges for primary OA prevention. Identification of the target group, the design of the intervention, and aspects of the effect evaluation are all discussed from an OA prevention perspective. Although OA prevention is still in its infancy, it holds great potential. Given the enormous burden of OA for patients and society, primary OA prevention should be a high priority in the field of OA research. (Source: Clinic...
Source: Clinics in Geriatric Medicine - April 9, 2022 Category: Geriatrics Authors: Jos Runhaar, Sita M.A. Bierma-Zeinstra Source Type: research
The Genesis of Pain in Osteoarthritis: Inflammation as a Mediator of Osteoarthritis Pain
Chronic pain is a substantial personal and societal burden worldwide. Osteoarthritis (OA) is one of the leading causes of chronic pain and is increasing in prevalence in accordance with a global aging population. In addition to affecting patients ’ physical lives, chronic pain also adversely affects patients’ mental wellbeing. However, there remain no pharmacologic interventions to slow down the progression of OA and pain-alleviating therapies are largely unsuccessful. The presence of low-level inflammation in OA has been recognized for many years as a major pathogenic driver of joint damage. Inflammatory mechanisms ca...
Source: Clinics in Geriatric Medicine - April 9, 2022 Category: Geriatrics Authors: Matthew J. Wood, Rachel E. Miller, Anne-Marie Malfait Source Type: research
Developing a Deeper Understanding of Osteoarthritis: Care to Joint Us?
It gives me great pleasure to introduce this thematic issue for Clinics in Geriatric Medicine with a brief overview of what you can anticipate learning more about by reading further. I have had the enviable privilege of being the Guest Editor for a number of previous themed issues, and I am pleased to say that the content compiled herein is unsurpassed in my experience. All credit for this goes to the authors of the individual articles, who have compiled insightful and critical iterations of complex and important topics. (Source: Clinics in Geriatric Medicine)
Source: Clinics in Geriatric Medicine - April 9, 2022 Category: Geriatrics Authors: David J. Hunter Tags: Preface Source Type: research
Osteoarthritis Pathophysiology
Molecular understanding of osteoarthritis (OA) has greatly increased through careful analysis of tissue samples, preclinical models, and large-scale agnostic “-omic” studies. There is broad acceptance that systemic and biomechanical signals affect multiple tissues of the joint, each of which could potentially be targeted to improve patient outcomes. In this review six experts in different aspects of OA pathogenesis provide their independent view on w hat they believe to be good tractable approaches to OA target discovery. We conclude that molecular discovery has been high but future transformative studies require a mul...
Source: Clinics in Geriatric Medicine - April 9, 2022 Category: Geriatrics Authors: Tonia L. Vincent, Tamara Alliston, Mohit Kapoor, Richard F. Loeser, Linda Troeberg, Christopher B. Little Source Type: research
Osteoarthritis
CLINICS IN GERIATRIC MEDICINE (Source: Clinics in Geriatric Medicine)
Source: Clinics in Geriatric Medicine - April 9, 2022 Category: Geriatrics Authors: DAVID J. HUNTER Source Type: research
Copyright
ELSEVIER (Source: Clinics in Geriatric Medicine)
Source: Clinics in Geriatric Medicine - April 9, 2022 Category: Geriatrics Source Type: research
Contributors
DAVID J. HUNTER, MBBS, MSc (Clin Epi), M SpMed, PhD, FRACP (Rheum) (Source: Clinics in Geriatric Medicine)
Source: Clinics in Geriatric Medicine - April 9, 2022 Category: Geriatrics Source Type: research
Contents
David J. Hunter (Source: Clinics in Geriatric Medicine)
Source: Clinics in Geriatric Medicine - April 9, 2022 Category: Geriatrics Source Type: research
Forthcoming Issues
COVID-19 in the Geriatric Patient (Source: Clinics in Geriatric Medicine)
Source: Clinics in Geriatric Medicine - April 9, 2022 Category: Geriatrics Source Type: research
Coronavirus Disease-2019 in Older People with Cognitive Impairment
Patients with cognitive impairment have paid a heavy price for the coronavirus disease 2019 pandemic. Their clinical characteristics and their place of life made them particularly exposed to being infected and suffering from severe forms. The repercussions of the isolation measures also had significant repercussions on the expression of their neuropsychiatric symptoms and the burden on families and health care professionals. (Source: Clinics in Geriatric Medicine)
Source: Clinics in Geriatric Medicine - March 20, 2022 Category: Geriatrics Authors: Yves Rolland, Marion Baziard, Adelaide De Mauleon, Estelle Dubus, Pascal Saidlitz, Maria Eugenia Soto Source Type: research
Inflammaging at the Time of COVID-19
Severe coronavirus disease 2019 (COVID-19) is associated with overproduction of proinflammatory cytokines. The ensuing cytokine storm contributes to the development of severe pneumonia and, possibly, to long-term symptom persistence (long COVID). The chronic state of low-grade inflammation that accompanies aging (inflammaging) might predispose older adults to severe COVID-19. Inflammaging may also contribute to symptom persistence following acute COVID-19. Antiinflammatory drugs and immunomodulatory agents can achieve significant therapeutic gain during acute COVID-19. Lifestyle interventions (eg, physical activity, diet) ...
Source: Clinics in Geriatric Medicine - March 20, 2022 Category: Geriatrics Authors: Maria Beatrice Zazzara, Andrea Bellieni, Riccardo Calvani, H élio Jose Coelho-Junior, Anna Picca, Emanuele Marzetti Source Type: research
Long COVID-19
Long coronavirus disease 2019 (COVID-19) is characterized by persistent COVID-19 symptoms that last for at least 2 months. In the elderly population, apart from the typical symptoms (fatigue, cough, or dyspnea), unspecific symptoms coexist (functional deterioration, cognitive impairment, or delirium) that can mitigate the prevalence of this syndrome in this age group. Its main consequence is the functional dec line, leading to sarcopenia, frailty, and disability, in addition to the nutritional and cognitive disorders. Thus, a multicomponent and individualized program (exercise, diet, cognitive stimulation) should be desi...
Source: Clinics in Geriatric Medicine - March 20, 2022 Category: Geriatrics Authors: Isabel Rodriguez-Sanchez, Leocadio Rodriguez-Ma ñas, Olga Laosa Source Type: research
COVID-19 Vaccines in Older Adults
This article reviews vaccinations in older adults, compares COVID-19 vaccine platforms, the efficacy and safety of COVID-19 vaccines in frail older people in long-term care settings, and the challenges of COVID-19 vaccine development and policy making for vaccination strategies in older adults. (Source: Clinics in Geriatric Medicine)
Source: Clinics in Geriatric Medicine - March 20, 2022 Category: Geriatrics Authors: Chih-Kuang Liang, Wei-Ju Lee, Li-Ning Peng, Lin-Chieh Meng, Fei-Yuan Hsiao, Liang-Kung Chen Source Type: research
Clinical features of SARS-CoV-2 infection in older adults
The heterogeneity of Covid-19 clinical presentation is extremely diversified, especially in older patients due to possible presence of atypical symptoms at disease onset, such as delirium, hyporexia and falls. Despite this findings, even in older people the typical clinical presentation with fever and respiratory symptoms remains the most probable. The clinical characteristic at Covid-19 onset are influenced by the presence of common health-related conditions in geriatric subjects, such as comorbidity, disability and frailty, and not simply by chronological age. Moreover, few studies investigated the tendency of Covid-19 s...
Source: Clinics in Geriatric Medicine - March 20, 2022 Category: Geriatrics Authors: Francesca Remelli, Stefano Volpato, Caterina Trevisan Source Type: research
COVID-19 in older people with cognitive impairment
Patients with cognitive impairment have paid a heavy price for the COVID-19 pandemic. Their clinical characteristics and their place of life made them particularly exposed to being contaminated and suffering from severe forms. The repercussions of the isolation measures also had significant repercussions on the expression of their neuropsychiatric symptoms and the burden on families and health care professionals. (Source: Clinics in Geriatric Medicine)
Source: Clinics in Geriatric Medicine - March 20, 2022 Category: Geriatrics Authors: Yves Rolland, Marion Baziard, Adelaide De Mauleon, Estelle Dubus, Pascal Saidlitz, Maria Eugenia Soto Source Type: research
