A Visible-Light Regulated ATP Transport in Retinal-modified Pillar[6]arene Layer-by-Layer Self-assembled Sub-nanochannel
Chemistry. 2024 May 1:e202401045. doi: 10.1002/chem.202401045. Online ahead of print.ABSTRACTNatural light-responsive rhodopsins play a critical role in visual conversion, signal transduction, energy transmission, etc., which has aroused extensive interest in the past decade. Inspired by these gorgeous works of living beings, scientists have constructed various biomimetic light-responsive nanochannels to mimic the behaviors of rhodopsins. However, it is still challenging to build stimuli-responsive sub-nanochannels only regulated by visible light as the rhodopsins are always at the sub-nanometer level and regulated by visi...
Source: Chemistry - May 1, 2024 Category: Chemistry Authors: Jiaxin Quan Hewei Yan Govindasami Periyasami Haibing Li Source Type: research
Synthesis of Indolines via Base-Mediated C-H Activation and Defluorinative C-N Coupling, with no Need for Transition-Metals
Chemistry. 2024 May 1:e202401034. doi: 10.1002/chem.202401034. Online ahead of print.ABSTRACTSyntheses of (partially) aromatic nitrogen heterocycles increasingly rely on transition-metal catalyzed C-C- and C-N-cross-coupling reactions. Here we describe a different approach to the synthesis of indolines by a domino C(sp3)-H activation, 1,2-addition, and defluorinative SNAr-cyclization sequence to provide the target 1,2-diarylindolines (1,2-diaryl-2,3-dihydroindoles) from ortho-fluorinated methyl-arenes and N-aryl imines (benzylidene anilines) in a cyclocondensation that is mediated by potassium hexa-methyl-di-silazide (KHMD...
Source: Chemistry - May 1, 2024 Category: Chemistry Authors: Christian Weindl Lukas Hintermann Source Type: research
Modulating the Coordination Chemistry of Co-N-C Catalytic Sites by Ru Species to Accelerate the Polysulfide Conversion Kinetics in Lithium-Sulfur Batteries
Chemistry. 2024 May 1:e202400945. doi: 10.1002/chem.202400945. Online ahead of print.ABSTRACTThe performance of lithium-sulfur batteries is compromised by the loss of sulfur as dissolved polysulfides in the electrolyte and consequently the polysulfide redox shutting effect. Accelerating the conversion kinetics of polysulfide intermediates into sulfur or lithium sulfide through electrocatalysis has emerged as a root-cause solution. Co-N-C composite electrocatalyst is commonly used for this purpose. It is illustrated here that how the effectiveness can be improved by modulating the coordination chemistry of Co-N-C catalytic ...
Source: Chemistry - May 1, 2024 Category: Chemistry Authors: Haoxian Zhu Zhiqian Lin Liyuan Qian Xiaohui Tang Jiangnan Wen Yun Wang Xiaofei Wang Songbai Han Jinlong Zhu Haibin Lin Yusheng Zhao Source Type: research
Polymeric Nanozyme with SOD Activity Capable of Inhibiting Self- and Metal-Induced α-Synuclein Aggregation
Chemistry. 2024 Apr 30:e202401331. doi: 10.1002/chem.202401331. Online ahead of print.ABSTRACTDespite decades of research, Parkinson's disease is still an idiopathic pathology for which no cure has yet been found. This is partly explained by the multifactorial character of most neurodegenerative syndromes, whose generation involves multiple pathogenic factors. Two of the most important ones are the aggregation of α-synuclein and oxidative stress. In this work, we address both issues by synthesizing a multifunctional nanozyme based on grafting a pyridinophane ligand that can strongly coordinate CuII, onto biodegradable PEG...
Source: Chemistry - April 30, 2024 Category: Chemistry Authors: Álvaro Martínez-Camarena Francesco Bellia M Paz Clares Graziella Vecchio Julien Nicolas Enrique Garc ía-España Source Type: research
Insight into the Effect of Methylglyoxal on the Conformation, Function, and Aggregation Propensity of α-Synuclein
Chemistry. 2024 Apr 30:e202400890. doi: 10.1002/chem.202400890. Online ahead of print.ABSTRACTIt is well-known that people suffering from hyperglycemia have a higher propensity to develop Parkinson's disease (PD). One of the most plausible mechanisms linking these two pathologies is the glycation of neuronal proteins and the pathological consequences of it. α-Synuclein, a key component in PD, can be glycated at its fifteen lysine. In fact, the end products of this process have been detected on aggregated α-synuclein isolated from in vivo. However, the consequences of glycation are not entirely clear, which are of crucial...
Source: Chemistry - April 30, 2024 Category: Chemistry Authors: Laura Mari ño Ana Bel én Uceda Francisco Leal Miquel Adrover Source Type: research
Multifunctional Amino Acid Derivative Coordination Compounds: Novel Contrast Agent and Luminescence Materials
Chemistry. 2024 Apr 30:e202304146. doi: 10.1002/chem.202304146. Online ahead of print.ABSTRACTIn this work a family of multidimensional (2-(1H-tetrazol-5-yl)ethyl) amino acid coordination compounds have been synthesized and thoroughly characterized. For this purpose, glycine, valine, phenylalanine and tyrosine have been selected as starting amino acids and Mn2+, Zn2+ and Cd2+ as metallic nodes. From one side, for Mn2+ based dimer magnetic resonance imaging studies have been conducted, prompted by the number and disposition of the coordinated water molecules and taking into consideration the promising future of manganese-ba...
Source: Chemistry - April 30, 2024 Category: Chemistry Authors: Estitxu Echenique-Errandonea Sara Rojas Ana M Ortu ño Javier Cepeda Pedro Ramos-Cabrer Íñigo J Vitórica-Yrezábal Juan M Cuerva Jos é M Seco Antonio Rodr íguez-Diéguez Source Type: research
Defect Engineering in Bi-based Photo/electrocatalysts for Nitrogen Reduction to Ammonia
Chemistry. 2024 Apr 30:e202400342. doi: 10.1002/chem.202400342. Online ahead of print.ABSTRACTMain group Bi-based materials have gained popularity as N2 reduction reaction (NRR) photo/electrocatalysts due to their ability to inhibit competitive H2 evolution reactions (HER) and the unique N2 adsorption activities. The introduction of defects in Bi-based catalysts represents a highly effective strategy for enhancing light absorption, promoting efficient separation of photogenerated carriers, optimizing the activity of free radicals, regulating electronic structure, and improving catalytic performance. In this review, we outl...
Source: Chemistry - April 30, 2024 Category: Chemistry Authors: Shuhua Lv Ying Wang Debao Wang Caixia Song Source Type: research
Impact of Single Acyclic Phosphonate Nucleotide (ZNA) Modifications on DNA Duplex Stability
Chemistry. 2024 Apr 30:e202401254. doi: 10.1002/chem.202401254. Online ahead of print.ABSTRACTAn acyclic phosphonate-linked nucleic acid backbone (ZNA) demonstrated the capability to support duplex formation and propagate genetic information in vivo, unveiling its potential for evolution into a synthetic genetic system (XNA). To determine the structural impact of such modification, modified Dickerson Drew DNA dodecamers (DDDs) were prepared by solid phase synthesis, each containing either an (R) or (S) isomeric form of a cytosine ZNA nucleotide. While the DDD is known to adopt a stable duplex, both duplex and hairpin forms...
Source: Chemistry - April 30, 2024 Category: Chemistry Authors: Xinlu Li Elisabetta Groaz Piet Herdewijn Eveline Lescrinier Source Type: research
Stable CAAC-triazenes: A New Nitrogen Ligand System with Donor and Conformational Flexibility, and with Application in Olefin Activation Catalysis
Chemistry. 2024 Apr 30:e202400400. doi: 10.1002/chem.202400400. Online ahead of print.ABSTRACTN-heterocyclic imines such as pyridylidene amines impart high catalytic activity when coordinated to a transition metal, largely imposed by their electronic flexibility. Here, this donor flexibility has been applied for the first time to CAAC-based systems through the synthesis of CAAC-triazenes. These new ligands offer a larger π-conjugating that extends from the N-heterocyclic carbene through three nitrogens rather than just one, as observed in N-heterocyclic imines. We demonstrate the straightforward synthesis of three new CAA...
Source: Chemistry - April 30, 2024 Category: Chemistry Authors: James J Race Luke A Hudson Martin Albrecht Source Type: research
Control over Anion Coordination on Pd(II), Cu(I), and Ag(I) with Regioisomeric Phosphine-Carboxylate Ligands
Chemistry. 2024 Apr 30:e202401215. doi: 10.1002/chem.202401215. Online ahead of print.ABSTRACTThe coordination of anionic donors is involved at various stages of catalytic cycles in transition-metal catalysis, but control over the spatial positioning of anions around a metal center is a challenge in coordination chemistry. Here we show that regioisomeric phosphine-carboxylate ligands provide spatial anion control on palladium(II) centers by favoring either κ2, cis-κ1, or trans-κ1 coordination of the carboxylate donor. Additionally, the palladium(II) carboxylates, which contain a methyl donor, upon protonation, deliver m...
Source: Chemistry - April 30, 2024 Category: Chemistry Authors: Elisa Gonz ález-Fernández Nittert Marinus Jyoti Dhankhar Anthony Linden Ilija Coric Source Type: research
The Characterization of Multifaceted PREP1 Peptides Provides Insights into Correlations between Spectroscopic and Structural Properties of Amyloid-like Assemblies
Chemistry. 2024 Apr 29:e202400846. doi: 10.1002/chem.202400846. Online ahead of print.ABSTRACTThe widespread ability of proteins and peptides to self-assemble by forming cross-β structure is one of the most significant discoveries in structural biology. Intriguingly, the cross-β association of proteins/peptides may generate intricate supramolecular architectures with uncommon spectroscopic properties. We have recently characterized self-assembled peptides extracted from the PREP1 protein that are endowed with interesting structural/spectroscopic properties. We here demonstrate that the green fluorescence emission of the ...
Source: Chemistry - April 29, 2024 Category: Chemistry Authors: Alessandra Monti Pasqualina Liana Scognamiglio Menotti Ruvo Luigi Vitagliano Nunzianna Doti Source Type: research
Cold Pressing of Perovskite-ZIF Glass Interpenetrating Networks with Stable Photoelectric Response
Chemistry. 2024 Apr 29:e202401172. doi: 10.1002/chem.202401172. Online ahead of print.ABSTRACTThe protection of lead halide perovskite within a stable matrix normally leads to the loss of semiconducting properties. Here, we report the synthesis of perovskite-ZIF glass interpenetrating networks via a cold pressing method, which allows the advantages of bright photoluminescence, high photoconductivity and environmental stability. This hybrid architecture has provided a novel design strategy for the real-world application of perovskite-based devices.PMID:38682408 | DOI:10.1002/chem.202401172 (Source: Chemistry)
Source: Chemistry - April 29, 2024 Category: Chemistry Authors: Zhuhui Xia Yuting Sun Zhanpeng Wei Yu Peng Yu Hou Shuang Yang Source Type: research
KpsS1 Mediates the Glycosylation of Pseudaminic Acid in Acinetobacter Baumannii
This study will provide insights into the further understanding of Pse in bacterial physiology and pathogenesis.PMID:38682414 | DOI:10.1002/chem.202400703 (Source: Chemistry)
Source: Chemistry - April 29, 2024 Category: Chemistry Authors: Yan Chu Cheung Xing Guo Xuemei Yang Ruohan Wei Edward Waichi Chan Xuechen Li Sheng Chen Source Type: research
Plasma-Engraved Lattice-Matched NiO/NiFe2O4 Heterostructure with Ample Oxygen Vacancies for Efficient Water Electrolysis and Zn-Air Batteries
Chemistry. 2024 Apr 29:e202401272. doi: 10.1002/chem.202401272. Online ahead of print.ABSTRACTHeterogeneous interface and defect engineering offer effective pathways to accelerate oxygen evolution reaction (OER) charge transfer kinetics and motivate optimal intrinsic catalytic activity. Herein, we report the lattice-matched NiO/NiFe2O4 heterostructure with ample oxygen vacancies (Vo-NiO/NiFe2O4) induced by a feasible hydrothermal followed by calcination and plasma-engraving assistant technique, which shows the unique porous microflower arrangement of intertwined nanosheets. Benefitting from the synergetic effects between l...
Source: Chemistry - April 29, 2024 Category: Chemistry Authors: Kai Zeng Hongwei Tao Yijia Zhaoshi Jiawen Feng Shuhao Jiang Yanfang Wu Ruizhi Yang Zhengyou He Yibing Li Source Type: research
Advanced Insulin Synthesis by One-pot/Stepwise Disulfide Bond Formation Enabled by S-Protected Cysteine Sulfoxide
Chemistry. 2024 Apr 29:e202401003. doi: 10.1002/chem.202401003. Online ahead of print.ABSTRACTAn advanced insulin synthesis is presented that utilizes one-pot/stepwise disulfide bond formation enabled by acid-activated S-protected cysteine sulfoxides in the presence of chloride anion. S-chlorocysteine generated from cysteine sulfoxides reacts with an S-protected cysteine to afford S-sulfenylsulfonium cation, which then furnishes the disulfide or reversely returns to the starting materials depending on the S-protection employed and the reaction conditions. Use of S-acetamidomethyl cysteine (Cys(Acm)) and its sulfoxide (Cys(...
Source: Chemistry - April 29, 2024 Category: Chemistry Authors: Kota Hidaka Daishiro Kobayashi Junya Hayashi Masaya Denda Akira Otaka Source Type: research
