Near-Infrared-II Nanomaterials for Activatable Photodiagnosis and Phototherapy
Chemistry. 2024 Apr 13:e202400816. doi: 10.1002/chem.202400816. Online ahead of print.ABSTRACTNear-Infrared-II (NIR-II) spans wavelengths between 1,000 to 1,700 nanometers, featuring deep tissue penetration and reduced tissue scattering and absorption characteristics, providing robust support for cancer treatment and tumor imaging research. This review explores the utilization of activatable NIR-II photodiagnosis and phototherapy based on tumor microenvironments (e.g., reactive oxygen species, pH, glutathione, hypoxia) and external stimuli (e.g., laser, ultrasound, photothermal) for precise tumor treatment and imaging. Spe...
Source: Chemistry - April 13, 2024 Category: Chemistry Authors: Wanying Jiang Lisheng Lin Ping Wu Hongxin Lin Jian Sui Source Type: research
Insight into the MOtBu (M = Na, K)-mediated dehydrogenation of dimethylamine-borane and transfer hydrogenation of nitriles to primary amines
Chemistry. 2024 Apr 11:e202400942. doi: 10.1002/chem.202400942. Online ahead of print.ABSTRACTSelective synthesis of primary amines from nitriles is challenging in synthetic chemistry due to the possible en-route generation of various amines and imines. Herein, we report a practical and operationally simple MOtBu-mediated (M = Na, K) transfer hydrogenation of nitriles to the corresponding primary amines with a relatively unexplored sacrificial hydrogen source (dimethylamine borane). The strategy encompasses a broad substrate scope under transition metal-free conditions and does not require any solvent. The mechanistic inve...
Source: Chemistry - April 12, 2024 Category: Chemistry Authors: Deep Chowdhury Rahul Sutradhar Ankan Paul Arup Mukherjee Source Type: research
External Electric Field Control of Exciton Motion in Porphyrin-Based Metal Organic Frameworks
Chemistry. 2024 Apr 12:e202400180. doi: 10.1002/chem.202400180. Online ahead of print.ABSTRACTPorphyrins are excellent light-harvesting complexes. Presently they are unsuitable for photovoltaic applications, as their excellent light absorbance is compensated to a large extent by their poor transport properties, where most excitons are lost by recombination. Arranging porphyrins in regular, strongly bound, lattices of surface-anchored metal-organic frameworks (PP-SURMOFs) may facilitate charge carrier dissociation, but does not significantly enhance the conductive properties. In most cases, photogenerated excitons traverse ...
Source: Chemistry - April 12, 2024 Category: Chemistry Authors: Puja Singhvi Nina Vankova Thomas Heine Source Type: research
Metal-Organic Framework PCN-224 Combined Cobalt Oxide Nanoparticles for Hypoxia Relief and Synergistic Photodynamic / Chemodynamic Therapy
Chemistry. 2024 Apr 12:e202400319. doi: 10.1002/chem.202400319. Online ahead of print.ABSTRACTPhotodynamic therapy (PDT) and chemodynamic therapy (CDT) are promising tumor treatments mediated by reactive oxygen species (ROS), which have the advantages of being minimally invasive. However, the hypoxia of tumor microenvironment and poor target ability often reduce the therapeutic effect. Here we propose a tumor targeted nanoplatform PCN-224@Co3O4-HA for enhanced PDT and synergistic CDT, constructed by hyaluronate-modified Co3O4 nanoparticles decorated metal-organic framework PCN-224. Co3O4 can catalyze the decomposition of h...
Source: Chemistry - April 12, 2024 Category: Chemistry Authors: Haoming Yuan Kaixiu Chen Jing Geng Ziyong Wu Chao Wang Pengfei Shi Source Type: research
Polydentate Amidinato-Silylenes, -Germylenes and -Stannylenes
This article presents schematic descriptions of their structures, the approaches used for their syntheses and a quick overview of their involvement (as ligands) in transition metal-catalysed reactions. The literature is covered up to the end of 2023.PMID:38606572 | DOI:10.1002/chem.202400786 (Source: Chemistry)
Source: Chemistry - April 12, 2024 Category: Chemistry Authors: Javier A Cabeza Pablo Garc ía-Álvarez Source Type: research
Unidentical Twins: Geometrically Similar but Chemically Distinct Metal-free Sites in Boron Oxide for Methane Oxidation to HCHO, CO and CO2
Chemistry. 2024 Apr 12:e202401050. doi: 10.1002/chem.202401050. Online ahead of print.ABSTRACTMetal-free boron-based catalysts such as boron oxide (B2O3) and boron nitride (h-BN) are promising catalysts for the methane oxidation to HCHO and CO. The B2O3 catalyst contains various probable boron sites (B1 to B6), which may be responsible for methane oxidation. In this work, we utilized density functional theory to compare two relevant geometrically identical boron sites (B2 and B4) for their reactivities. The two sites are explored in-detail for the conversion of methane to formaldehyde (M2F), carbon monoxide and carbon diox...
Source: Chemistry - April 12, 2024 Category: Chemistry Authors: Parveen Rawal Puneet Gupta Source Type: research
Silver(i) Perfluoroalcoholates: Synthesis, Structure, and their Use as Transfer Reagents
Chemistry. 2024 Apr 12:e202400861. doi: 10.1002/chem.202400861. Online ahead of print.ABSTRACTHerein we report a general access to silver(i) perfluoroalcoholates, their structure in the solid state and in solution, and their use as transfer reagents. The silver(i) perfluoroalcoholates are prepared by the reaction of AgF with the corresponding perfluorinated carbonyl compounds in acetonitrile and are stable for a prolonged time at -18 °C. X-Ray analysis of single crystals of perfluoroalcoholate species showed that two Ag(i) centers are bridged by the alcoholate ligands. In acetonitrile solution, Ag[OCF3] forms different st...
Source: Chemistry - April 12, 2024 Category: Chemistry Authors: Paul Golz Kamar Shakeri Lilian Maas Marius Balizs Alberto P érez-Bitrián Helen D Kemmler Merlin Kleoff Patrick Vo ßnacker Mathias Christmann Sebastian Hasenstab-Riedel Source Type: research
Continuous Synthesis of a Macrocyclic Sulfite of Polyethylene Glycol by Cascaded Continuous Stirred Tank Reactors (CSTRs)
Chemistry. 2024 Apr 12:e202401026. doi: 10.1002/chem.202401026. Online ahead of print.ABSTRACTInvited for the cover of this issue is the group of Long Pan and co-workers at Asymchem Life Sciences (Tianjin) Co. Ltd. The image depicts a novel continuous process for the synthesis of a macrocyclic poly(ethylene glycol) (PEG) sulfite, the precursor to PEG macrocyclic sulfate, a useful building block in PEG chemistry. Read the full text of the article at 10.1002/chem.202304319.PMID:38607283 | DOI:10.1002/chem.202401026 (Source: Chemistry)
Source: Chemistry - April 12, 2024 Category: Chemistry Authors: Jichang Wei Yinli Liu Yuchen Sun Jun Bai He Gao Zhaojun Yang Long Pan Source Type: research
Trapping an Elusive Phosphanyl-Phosphaalumene
We describe our attempts to access a compound with an Al=P double bond by reaction of Al(Nacnac) towards [H2CN(Dipp)]2PPCO (Nacnac = HC[C(Me)N(Dipp)]2; Dipp = 2,6-iPr2C6H3). Our observations are consistent with the formation of a transient phosphanyl-phosphaalumene at low temperatures (-70 °C), however this species was found to readily undergo intramolecular C-H activation of the β-diketiminato ligand upon warming to room temperature. The reactivity of the transient complex toward small molecules including dihydrogen, carbon dioxide, phosphaketenes, amines and silanes could be explored at low temperatures, showcasing tha...
Source: Chemistry - April 12, 2024 Category: Chemistry Authors: Lilian S Szych Lars Denker Joey Feld Jose Goicoechea Source Type: research
Formation, Selective Encapsulation, and Tautomerization Control of Isoindoleone Utilizing Guanidinium Sulfonate Framework
Chemistry. 2024 Apr 12:e202400957. doi: 10.1002/chem.202400957. Online ahead of print.ABSTRACTHerein we report the use of tetrakis(guanidinium) pyrenetetrasulfonate (G4PYR) and bis(guanidinium) 1,5-napthalene disulfonate (G2NDS) to catalyze the cyclization of 2-cyanobenzamide (1) to isoindolone (2). Moreover, we demonstrate the remarkable selectivity of these guanidinium organosulfonate hosts in encapsulating 2 over 1. By thoroughly investigating the intramolecular cyclization reaction, we determined that guanidinium and the organosulfonate moiety acts as the catalyst in this process. Additionally, 2 is selectively encapsu...
Source: Chemistry - April 12, 2024 Category: Chemistry Authors: Mohammad T Chaudhry Justin A Newman Alfred Y Lee Source Type: research
Total Chemical Synthesis of Aggregation-Prone Disulfide-Rich Starfish Peptides
Chemistry. 2024 Apr 12:e202400933. doi: 10.1002/chem.202400933. Online ahead of print.ABSTRACT: A relaxin-like gonad-stimulating peptide (RGP), Aso-RGP, featuring six cysteine residues, was identified in the Crown-of-Thorns Starfish (COTS, Acanthaster cf. solaris) and initially produced through recombinant yeast expression. This method yielded a single-chain peptide with an uncleaved C-peptide (His Tag) and suboptimal purity. Our objective was to chemically synthesize Aso-RGP in its mature form, comprising two chains (A and B) and three disulfide bridges, omitting the C-peptide. Furthermore, we aimed to synthesize a newly ...
Source: Chemistry - April 12, 2024 Category: Chemistry Authors: Hongkang Wu Praveen Praveen Thomas Ng Handley Chaitra Chandrashekar Scott F Cummins Ross A D Bathgate Mohammed Akhter Hossain Source Type: research
Insight into the MOtBu (M = Na, K)-mediated dehydrogenation of dimethylamine-borane and transfer hydrogenation of nitriles to primary amines
Chemistry. 2024 Apr 11:e202400942. doi: 10.1002/chem.202400942. Online ahead of print.ABSTRACTSelective synthesis of primary amines from nitriles is challenging in synthetic chemistry due to the possible en-route generation of various amines and imines. Herein, we report a practical and operationally simple MOtBu-mediated (M = Na, K) transfer hydrogenation of nitriles to the corresponding primary amines with a relatively unexplored sacrificial hydrogen source (dimethylamine borane). The strategy encompasses a broad substrate scope under transition metal-free conditions and does not require any solvent. The mechanistic inve...
Source: Chemistry - April 12, 2024 Category: Chemistry Authors: Deep Chowdhury Rahul Sutradhar Ankan Paul Arup Mukherjee Source Type: research
External Electric Field Control of Exciton Motion in Porphyrin-Based Metal Organic Frameworks
Chemistry. 2024 Apr 12:e202400180. doi: 10.1002/chem.202400180. Online ahead of print.ABSTRACTPorphyrins are excellent light-harvesting complexes. Presently they are unsuitable for photovoltaic applications, as their excellent light absorbance is compensated to a large extent by their poor transport properties, where most excitons are lost by recombination. Arranging porphyrins in regular, strongly bound, lattices of surface-anchored metal-organic frameworks (PP-SURMOFs) may facilitate charge carrier dissociation, but does not significantly enhance the conductive properties. In most cases, photogenerated excitons traverse ...
Source: Chemistry - April 12, 2024 Category: Chemistry Authors: Puja Singhvi Nina Vankova Thomas Heine Source Type: research
Metal-Organic Framework PCN-224 Combined Cobalt Oxide Nanoparticles for Hypoxia Relief and Synergistic Photodynamic / Chemodynamic Therapy
Chemistry. 2024 Apr 12:e202400319. doi: 10.1002/chem.202400319. Online ahead of print.ABSTRACTPhotodynamic therapy (PDT) and chemodynamic therapy (CDT) are promising tumor treatments mediated by reactive oxygen species (ROS), which have the advantages of being minimally invasive. However, the hypoxia of tumor microenvironment and poor target ability often reduce the therapeutic effect. Here we propose a tumor targeted nanoplatform PCN-224@Co3O4-HA for enhanced PDT and synergistic CDT, constructed by hyaluronate-modified Co3O4 nanoparticles decorated metal-organic framework PCN-224. Co3O4 can catalyze the decomposition of h...
Source: Chemistry - April 12, 2024 Category: Chemistry Authors: Haoming Yuan Kaixiu Chen Jing Geng Ziyong Wu Chao Wang Pengfei Shi Source Type: research
Polydentate Amidinato-Silylenes, -Germylenes and -Stannylenes
This article presents schematic descriptions of their structures, the approaches used for their syntheses and a quick overview of their involvement (as ligands) in transition metal-catalysed reactions. The literature is covered up to the end of 2023.PMID:38606572 | DOI:10.1002/chem.202400786 (Source: Chemistry)
Source: Chemistry - April 12, 2024 Category: Chemistry Authors: Javier A Cabeza Pablo Garc ía-Álvarez Source Type: research
