Highly Efficient Thiolate-Based Ionic Liquid Catalysts for Reduction of CO2: Selective N-Functionalization of Amines to Form Formamides and Methylamines
Chemistry. 2024 Apr 6:e202304315. doi: 10.1002/chem.202304315. Online ahead of print.ABSTRACTDeveloping efficient catalysts to convert CO2 into value-added chemicals is valuable for reducing carbon emissions. Herein, a kind of novel thiolate-based ionic liquid with sulfur as the active site was designed and synthesized, which served as highly efficient catalyst for the reductive functionalization of CO2 by amines and hydrosilane. By adjusting the CO2 pressure, various formamides and methylamines were selectively obtained in high yields. Remarkably, at the catalyst loading of 0.1 mol%, the N-formylation reaction of N-methyl...
Source: Chemistry - April 6, 2024 Category: Chemistry Authors: Jiakai Wu Junping Niu Lu Hou Siliu Cheng Ruijun Xie Ning Zhu Source Type: research
Control of Kinetic Pathways toward Supramolecular Chiral Polymorphs for Tunable Circularly Polarized Luminescence
Chemistry. 2024 Apr 4:e202400899. doi: 10.1002/chem.202400899. Online ahead of print.ABSTRACTAn amphiphilic aza-BODIPY dye (S)-1 bearing two chiral hydrophilic side chains with S-stereogenic centers was synthesized. This dye exhibited kinetic-controlled self-assembly pathways and supramolecular chiral polymorphism properties in MeOH/H2O (9/1, v/v) mixed solvent. The (S)-1 monomers first aggregated into a kinetic controlled, off-pathway species Agg. A, which was spontaneously transformed into an on-pathway metastable aggregate (Agg. B) and subsequently into the thermodynamic Agg. C. The three aggregate polymorphs of dye (S)...
Source: Chemistry - April 5, 2024 Category: Chemistry Authors: Hongfei Pan Baokai Hou Yuanyuan Jiang Mengqi Liu Xiang-Kui Ren Zhijian Chen Source Type: research
Engineered Nanomaterials for Tumor Immune Microenvironment Modulation in Cancer Immunotherapy
Chemistry. 2024 Apr 4:e202400425. doi: 10.1002/chem.202400425. Online ahead of print.ABSTRACTTumor immunotherapy, represented by immune checkpoint blocking and chimeric antigen receptor (CAR) T cell therapy, has achieved promising resutls in clinical applications. However, it faces challenges that hinder its further development, such as limited response rates and poor tumor permeability. The efficiency of tumor immunotherapy is also closely linked to the structure and function of the immune microenvironment where the tumor resides. Recently, nanoparticle-based tumor immune microenvironment (TIME) modulation strategies have...
Source: Chemistry - April 5, 2024 Category: Chemistry Authors: Hao Xing Xiaomin Li Source Type: research
Unraveling Polymorphism Dependent Cytotoxicity, Cellular Uptake, and Live Cell Imaging Using Luminescent Polymorphs
Chemistry. 2024 Apr 5:e202400868. doi: 10.1002/chem.202400868. Online ahead of print.ABSTRACTPolymorphism-dependent cytotoxicity and cellular uptake of drug molecules have been studied for the past two decades. However, visualizing the polymorph-dependent cellular uptake and cytotoxicity using microscopy imaging technique has not been reported yet. The luminescent polymorph is an ideal candidate to validate the above hypothesis. Herein, we report the polymorph-dependent cellular uptake, cytotoxicity, and bio-imaging functions of polymorphs 1Y and 1R of a naphthalimide-phenothiazine dyad. These polymorphs show different lum...
Source: Chemistry - April 5, 2024 Category: Chemistry Authors: Akkarakkaran Thayyil Muhammed Munthasir Poonam Rani Pandi Dhanalakshmi Sambit Pradhan Pakkirisamy Thilagar Source Type: research
Coordination of a Phosphine-Tethered Aminoborane to Group 10 Metals
Chemistry. 2024 Apr 5:e202400666. doi: 10.1002/chem.202400666. Online ahead of print.ABSTRACTWhile π-complexes of C=C bonds are ubiquitous in organometallic chemistry, analogous complexes of the isoelectronic but strongly polarized B=N double bond of aminoboranes are extremely scarce. To address this gap, a diphosphine-aminoborane ligand (PhDPBAiPr) is introduced and its coordination with group 10 metals is investigated. The B=N bond does not coordinate to the metal in Pt(0) and Pd(II) complexes. In contrast, side-on coordination of the B=N bond is observed in the Ni(0) complex [PhDPBAiPr]Ni(NCPh), and the X-ray crystal s...
Source: Chemistry - April 5, 2024 Category: Chemistry Authors: Martine R Tiddens Bram T Kapp é Tom J Smak Martin Lutz Marc-Etienne Moret Source Type: research
Strategies to Design Chemocatalytic Racemization of Tertiary Alcohols: State of the Art & amp; Utilization for Dynamic Kinetic Resolution
Chemistry. 2024 Apr 5:e202304028. doi: 10.1002/chem.202304028. Online ahead of print.ABSTRACTIn this "Concepts"-article, the difficulties in racemizing tertiary alcohols are described as well as a summary of the different chemocatalytic concepts to overcome these hurdles and to pave a way for efficiently racemizing of tertiary alcohols. When combined with the enantioselective enzymatic esterification of tertiary alcohols, the racemization protocols enable a DKR to convert the racemates into enantiomerically pure esters of tertiary alcohols, which are of high interest in the field of pharmaceutically active products. Very r...
Source: Chemistry - April 5, 2024 Category: Chemistry Authors: Harald Gr öger Satoshi Horino Kyohei Kanomata Shuji Akai Source Type: research
Control of Kinetic Pathways toward Supramolecular Chiral Polymorphs for Tunable Circularly Polarized Luminescence
Chemistry. 2024 Apr 4:e202400899. doi: 10.1002/chem.202400899. Online ahead of print.ABSTRACTAn amphiphilic aza-BODIPY dye (S)-1 bearing two chiral hydrophilic side chains with S-stereogenic centers was synthesized. This dye exhibited kinetic-controlled self-assembly pathways and supramolecular chiral polymorphism properties in MeOH/H2O (9/1, v/v) mixed solvent. The (S)-1 monomers first aggregated into a kinetic controlled, off-pathway species Agg. A, which was spontaneously transformed into an on-pathway metastable aggregate (Agg. B) and subsequently into the thermodynamic Agg. C. The three aggregate polymorphs of dye (S)...
Source: Chemistry - April 5, 2024 Category: Chemistry Authors: Hongfei Pan Baokai Hou Yuanyuan Jiang Mengqi Liu Xiang-Kui Ren Zhijian Chen Source Type: research
Engineered Nanomaterials for Tumor Immune Microenvironment Modulation in Cancer Immunotherapy
Chemistry. 2024 Apr 4:e202400425. doi: 10.1002/chem.202400425. Online ahead of print.ABSTRACTTumor immunotherapy, represented by immune checkpoint blocking and chimeric antigen receptor (CAR) T cell therapy, has achieved promising resutls in clinical applications. However, it faces challenges that hinder its further development, such as limited response rates and poor tumor permeability. The efficiency of tumor immunotherapy is also closely linked to the structure and function of the immune microenvironment where the tumor resides. Recently, nanoparticle-based tumor immune microenvironment (TIME) modulation strategies have...
Source: Chemistry - April 5, 2024 Category: Chemistry Authors: Hao Xing Xiaomin Li Source Type: research
Unraveling Polymorphism Dependent Cytotoxicity, Cellular Uptake, and Live Cell Imaging Using Luminescent Polymorphs
Chemistry. 2024 Apr 5:e202400868. doi: 10.1002/chem.202400868. Online ahead of print.ABSTRACTPolymorphism-dependent cytotoxicity and cellular uptake of drug molecules have been studied for the past two decades. However, visualizing the polymorph-dependent cellular uptake and cytotoxicity using microscopy imaging technique has not been reported yet. The luminescent polymorph is an ideal candidate to validate the above hypothesis. Herein, we report the polymorph-dependent cellular uptake, cytotoxicity, and bio-imaging functions of polymorphs 1Y and 1R of a naphthalimide-phenothiazine dyad. These polymorphs show different lum...
Source: Chemistry - April 5, 2024 Category: Chemistry Authors: Akkarakkaran Thayyil Muhammed Munthasir Poonam Rani Pandi Dhanalakshmi Sambit Pradhan Pakkirisamy Thilagar Source Type: research
Coordination of a Phosphine-Tethered Aminoborane to Group 10 Metals
Chemistry. 2024 Apr 5:e202400666. doi: 10.1002/chem.202400666. Online ahead of print.ABSTRACTWhile π-complexes of C=C bonds are ubiquitous in organometallic chemistry, analogous complexes of the isoelectronic but strongly polarized B=N double bond of aminoboranes are extremely scarce. To address this gap, a diphosphine-aminoborane ligand (PhDPBAiPr) is introduced and its coordination with group 10 metals is investigated. The B=N bond does not coordinate to the metal in Pt(0) and Pd(II) complexes. In contrast, side-on coordination of the B=N bond is observed in the Ni(0) complex [PhDPBAiPr]Ni(NCPh), and the X-ray crystal s...
Source: Chemistry - April 5, 2024 Category: Chemistry Authors: Martine R Tiddens Bram T Kapp é Tom J Smak Martin Lutz Marc-Etienne Moret Source Type: research
Structural and Electronic Chirality in Inorganic Crystals: from Construction to Application
Chemistry. 2024 Apr 3:e202400436. doi: 10.1002/chem.202400436. Online ahead of print.ABSTRACTChirality represents a fundamental characteristic inherent in nature, playing a pivotal role in the emergence of homochirality and the origin of life. While the principles of chirality in organic chemistry are well-documented, the exploration of chirality within inorganic crystal structures continues to evolve. This ongoing development is primarily due to the diverse nature of crystal/amorphous structures in inorganic materials, along with the intricate symmetrical and asymmetrical relationships in the geometry of their constituent...
Source: Chemistry - April 4, 2024 Category: Chemistry Authors: Yudi Zhang Yuzhe Ma Wen Sun Wei Li Guowei Li Source Type: research
Selective Mono-Defluorinative Cross-Coupling of Trifluoromethyl arenes via Multiphoton Photoredox Catalysis
Chemistry. 2024 Apr 4:e202302927. doi: 10.1002/chem.202302927. Online ahead of print.ABSTRACTA new cross-coupling of trifluoromethyl arenes has been realized via multiphoton photoredox catalysis. Trifluoromethyl arenes were demonstrated to undergo selective mono-defluorinative alkylation under mild reaction conditions providing access to a series of valuable α,α-difluorobenzylic compounds. The reaction shows broad substrate scope and general functional group tolerance. In addition to the electron-deficient trifluoromethyl arenes that are easily reduced to the corresponding radical anion, more challenging electron-rich su...
Source: Chemistry - April 4, 2024 Category: Chemistry Authors: Jiaqi Jia Serik Zhumagazy Chen Zhu Shao-Chi Lee Salman Alsharif Huifeng Yue Magnus Rueping Source Type: research
Design of Bright Chemogenetic Reporters Based on the Combined Engineering of Fluorogenic Molecular Rotors and of the HaloTag Protein
Chemistry. 2024 Apr 4:e202400641. doi: 10.1002/chem.202400641. Online ahead of print.ABSTRACTThe combination of fluorogenic probes (fluorogens) and self-labeling protein tags represent a promising tool for imaging biological processes with high specificity but it requires the adequation between the fluorogen and its target to ensure a good activation of its fluorescence. In this work, we report a strategy to develop molecular rotors that specifically target HaloTag with a strong enhancement of their fluorescence. The divergent design facilitates the diversification of the structures to tune the photophysical and cellular p...
Source: Chemistry - April 4, 2024 Category: Chemistry Authors: Justine Co ïs Sylvestre P J T Bachollet Louis Sanchez Nicolas Pietrancosta Vincent Vialou Jean-Maurice Mallet Blaise Dumat Source Type: research
Regulation Strategies on Fe-N-C and Co-N-C Catalysts for Oxygen Reduction Reaction: A Review
Chemistry. 2024 Apr 4:e202304003. doi: 10.1002/chem.202304003. Online ahead of print.ABSTRACTProton exchange membrane fuel cells (PEMFCs) and alkaline membrane fuel cells (AEMFCs) have received great attention as the energy device of next generation. Accelerating oxygen reduction reaction (ORR) kinetics is the key to improve PEMFCs and AEMFCs performance. Platinum-based catalysts are the most widely used catalysts for ORR, but their high price and low abundance limit the commercialization of fuel cell. Non-noble metal-nitrogen-carbon (M-N-C) is considered to be the most likely material to replace Pt-based catalysts, among ...
Source: Chemistry - April 4, 2024 Category: Chemistry Authors: Ximing Qu Yani Yan Zeling Zhang Benjun Tian Shuhu Yin Xiaoyang Cheng Rui Huang Yan-Xia Jiang Shigang Sun Source Type: research
Dinuclear Rhenium(I) Tricarbonyl Complexes as Anticancer Drug Candidates
Chemistry. 2024 Apr 4:e202400217. doi: 10.1002/chem.202400217. Online ahead of print.ABSTRACTCancer is one of the deadliest diseases worldwide. Chemotherapy remains one of the most dominant forms for anticancer treatment. Despite their clinical success, the used chemotherapeutic agents are associated with severe side effect and pharmacological limitations. To overcome these drawbacks there is a need for the development of new types of chemotherapeutic agents. Herein, the chemical synthesis and biological evaluation of dinuclear rhenium(I) complexes as potential chemotherapeutic drug candidates are proposed. The metal compl...
Source: Chemistry - April 4, 2024 Category: Chemistry Authors: Nicol ás Montesdeoca Reema L Borkar Malaichamy Sathiyendiran Johannes Karges Source Type: research
