Altered serum levels of platelet-derived growth factor receptor β and cluster of differentiation 13 suggest a role for pericytes in West syndrome
This study aimed to explore the relationship between West syndrome and pericytes. (Source: Brain and Development)
Source: Brain and Development - May 30, 2023 Category: Neurology Authors: Yusuke Watanabe, Gaku Yamanaka, Shinichiro Morichi, Kanako Hayashi, Shinji Suzuki, Mika Takeshita, Natsumi Morishita, Yu Ishida, Shingo Oana, Fuyuko Takata, Hisashi Kawashima Tags: Original article Source Type: research
Myelin oligodendrocyte glycoprotein antibody-associated disease in a patient with symptoms of aseptic meningitis who achieved spontaneous remission: A case report and review of the literature
We report a patient with MOG-Ab-associated disorder (MOGAD) who presented with symptoms of aseptic meningitis and improved without treatment. (Source: Brain and Development)
Source: Brain and Development - May 26, 2023 Category: Neurology Authors: Naomi Hino-Fukuyo, Eiichiro Kawai, Sakiko Itoh, Shuhei Oba, Yukie Sato, Sei Abe, Yukari Ichikawa, Hiroshi Kitazawa, Yuri Atobe, Juichi Fujimori, Ichiro Nakashima, Toshiyuki Takahashi, Tetsuji Morimoto Tags: Case Report Source Type: research
Object identification in cerebral visual impairment characterized by gaze behavior and image saliency analysis
In this study, participants were shown a series of images of ten common objects, each from five possible categories ranging from abstract black& white line drawings to color photographs. Fifty individuals with CVI and 50 neurotypical controls verbally identified each object and success rates and reaction times were collected. Visual gaze behavior was recorded using an eye tracker to quantify the extent of visual search area explored and number of fixations. (Source: Brain and Development)
Source: Brain and Development - May 13, 2023 Category: Neurology Authors: Claire E. Manley, Kerri Walter, Serena Micheletti, Matthew Tietjen, Emily Cantillon, Elisa M. Fazzi, Peter J. Bex, Lotfi B. Merabet Tags: Original article Source Type: research
Developmental delay and non-phenylketonuria (PKU) hyperphenylalaninemia in DNAJC12 deficiency: Case and approach
Hyperphenylalaninemia is a biomarker for several monogenic neurotransmitter disorders where the body cannot metabolise phenylalanine to tyrosine. Biallelic pathogenic variants in DNAJC12, co-chaperone of phenylalanine, tyrosine, and tryptophan hydroxylases, leads to hyperphenylalaninemia and biogenic amines deficiency. (Source: Brain and Development)
Source: Brain and Development - May 6, 2023 Category: Neurology Authors: Rachel Sze Hui Wong, Shekeeb Mohammad, Bindu Parayil Sankaran, Rosie Junek, Won-Tae Kim, Tiffany Wotton, Sushil Bandodkar, Shanti Balasubramaniam Tags: Case Report Source Type: research
Editorial Board
(Source: Brain and Development)
Source: Brain and Development - May 3, 2023 Category: Neurology Source Type: research
Cover
(Source: Brain and Development)
Source: Brain and Development - May 3, 2023 Category: Neurology Source Type: research
Contents
(Source: Brain and Development)
Source: Brain and Development - May 3, 2023 Category: Neurology Source Type: research
The clinical spectrum associated with ATP1A2 variants in Chinese pediatric patients
To evaluate the clinical spectrum associated with ATP1A2 variants in Chinese children with hemiplegia, migraines, encephalopathy or seizures. (Source: Brain and Development)
Source: Brain and Development - May 2, 2023 Category: Neurology Authors: Lifang Dai, Changhong Ding, Xiaojuan Tian, Ming Liu, Yuping Ma, Chunhong Chen, Xiaotun Ren, Hua Li Tags: Original article Source Type: research
Repeated neonatal Needle-pricking stimulation alter neurodevelopment in adolescent rats
To explore the repeated pain stimulation in neonatal rats affects their cognitive and memory abilities during puberty, and the proliferation expression of hippocampal neurons. (Source: Brain and Development)
Source: Brain and Development - April 28, 2023 Category: Neurology Authors: Jing Xu, Youhui Wang, Yu Zuo, Shuai Lv, Dong Li Tags: Original article Source Type: research
Favorable outcome of hematopoietic stem cell transplantation in late-onset Krabbe disease
Late-onset Krabbe disease is a disorder with autosomal recessive inheritance caused by a deficiency in galactocerebrosidase (GALC) activity. Its late-onset form usually shows slow disease progression with atypical symptoms including spastic paresis. The efficacy of hematopoietic stem cell transplantation (HSCT) in late-onset Krabbe disease has not been fully established. (Source: Brain and Development)
Source: Brain and Development - April 18, 2023 Category: Neurology Authors: Akihiko Mitsutake, Takashi Matsukawa, Atsushi Iwata, Hiroyuki Ishiura, Jun Mitsui, Harushi Mori, Takashi Toya, Akira Honda, Mineo Kurokawa, Norio Sakai, Shoji Tsuji, Tatsushi Toda Tags: Case Report Source Type: research
Delayed episodic memory recall after one week is associated with executive functions and divided attention in pediatric epilepsy patients
We assume that executive functions play a crucial role in deep memory encoding, facilitating stronger and more enduring memory traces. Given that approximately 20% of epilepsy patients – compared to a healthy reference sample – had a significantly reduced delayed recall and due to the clinical relevance of long-term memory, age-appropriate standard norms for free memory recall after 1-week are desirable. (Source: Brain and Development)
Source: Brain and Development - April 8, 2023 Category: Neurology Authors: Martina Studer, Stella Schmitt, Kevin Wingeier, Karen Lidzba, Sandra Bigi Tags: Original article Source Type: research
Finger movement functions remain in the ipsilesional hemisphere and compensation by the contralesional hemisphere might not be expected after hemispherotomy -pre- and post-hemispherotomy evaluations in 8 cases-
We hypothesized that fine finger motor functions are controlled by the ipsilesional hemisphere, and that gross motor functions are compensated for by the contralesional hemisphere after brain injury in humans. The purpose of this study was to compare finger movements before and after hemispherotomy that defunctionated the ipsilesional hemisphere for patients with hemispherical lesions. (Source: Brain and Development)
Source: Brain and Development - April 5, 2023 Category: Neurology Authors: Ayataka Fujimoto, Hideo Enoki, Keisuke Hatano, Keishiro Sato, Tohru Okanishi Tags: Original article Source Type: research
Dr. Michael V. Johnston
We regret that Dr. Michael V. Johnston passed away on July 30, 2022. Dr. Johnston was a giant in pediatric neurology, and his contribution to the Japanese Society of Child Neurology was immense. He has been an editorial board member of Brain& Development since 2003. (Source: Brain and Development)
Source: Brain and Development - April 5, 2023 Category: Neurology Tags: Obituary Source Type: research
Treating neurodegenerative disease: Nusinersen and other therapeutic strategies for improved motor function
Intrathecal nusinersen greatly stabilizes motor function by increasing survival motor neuron (SMN) protein production for patients affected by spinal muscular atrophy (SMA). Shimizu-Motohashi et al. investigate the dynamic between muscle impairment and correspondent change in motor function, describing treatment variability to nusinersen in SMA types 2 and 3 [1]. Expanding on this work, it is imperative to investigate additional combinatorial therapies developed to target SMN and other non-SMN targets that affect motor performance. (Source: Brain and Development)
Source: Brain and Development - March 30, 2023 Category: Neurology Authors: Kristine P. Pashin, Tejas C. Sekhar Tags: Letter to the Editor Source Type: research
Editorial Board
(Source: Brain and Development)
Source: Brain and Development - March 27, 2023 Category: Neurology Source Type: research
