Neurological prognostic factors for human herpes virus 6/7-associated acute encephalopathy in children: A single-center study
To identify prognostic factors for severe neurological sequelae and epileptic seizures in children with human herpes virus (HHV) 6/7-associated acute encephalopathy (AE). (Source: Brain and Development)
Source: Brain and Development - October 26, 2022 Category: Neurology Authors: Yoshihiro Watanabe, Mao Odaka, Hirotaka Motoi, Yoshitaka Oyama, Kentaro Shiga, Shuichi Ito Tags: Original article Source Type: research
Validity and prognostic utility of clinical assessment scale for autoimmune encephalitis (CASE) score in children with autoimmune encephalitis
The clinical assessment scale for autoimmune encephalitis (CASE) is a recently developed and validated scale to rate the severity of autoimmune encephalitis (AE) in adults. But it is yet to be validated in pediatric AE cases. (Source: Brain and Development)
Source: Brain and Development - October 14, 2022 Category: Neurology Authors: Prateek Kumar Panda, Indar Kumar Sharawat, Aparna Ramachandran, Aman Elwadhi, Apurva Tomar, Sanjot Bhardwaj, Vignesh Kaniyappan Murugan, Rajkali Rajendiran Tags: Original article Source Type: research
Perinatal lethal Gaucher disease: A case report and review of literature
We report a case of perinatal lethal Gaucher disease treated with enzyme replacement therapy (ERT) who survived for 9 months and present a literature review of perinatal lethal Gaucher disease cases. (Source: Brain and Development)
Source: Brain and Development - October 8, 2022 Category: Neurology Authors: Rie Chida, Masaru Shimura, Yu Ishida, Yusuke Suganami, Gaku Yamanaka Tags: Case Report Source Type: research
Evaluation of cerebrospinal fluid biomarkers in pediatric patients with spinal muscular atrophy
Spinal muscular atrophy (SMA) is a rare neuromuscular disorder characterised by muscle weakness and muscle atrophy and classified into five known subtypes based on clinical features. The recent development of novel drugs to treat SMA has been encouraging, and nusinersen is the first drug approved to treat SMA. (Source: Brain and Development)
Source: Brain and Development - October 6, 2022 Category: Neurology Authors: Yoshiyuki Kobayashi, Nobutsune Ishikawa, Yuichi Tateishi, Hiroki Izumo, Syohei Eto, Yuta Eguchi, Satoshi Okada Source Type: research
Handgrip and finger flexion strength in children: A cross-sectional assessment of age-related normative data and application as a clinical functional marker in paediatric neuromuscular disorders
The aim of this study was to evaluate handgrip and finger flexion strength (HGFS) as functional marker for disease progression in children with neuromuscular disorders (NMD) and present normative data in a paediatric healthy cohort. (Source: Brain and Development)
Source: Brain and Development - October 1, 2022 Category: Neurology Authors: C. Weber, J. Schallner, M. Von Der Hagen Tags: Original article Source Type: research
A novel de novo TET3 loss-of-function variant in a Turkish boy presenting with neurodevelopmental delay and electrical status epilepticus during slow-wave sleep
Beck-Fahrner syndrome is caused by homozygous or heterozygous mutations in TET3 on chromosome 2p13. The general characteristics of this syndrome include behavioral abnormalities such as autistic features, attention-deficit hyperactivity disorder, learning disabilities, and epilepsy. (Source: Brain and Development)
Source: Brain and Development - September 30, 2022 Category: Neurology Authors: Safiye Gunes Sager, Ayberk Turkyilmaz, Hediye P ınar Gunbey, Elif Yuksel Karatoprak, Elif Sibel Aslan, Yasemin Akın Tags: Case Report Source Type: research
Modulation effects of the intact motor skills on the relationship between social skills and motion perceptions in children with autism spectrum disorder: A pilot study
An individual with autism spectrum disorder (ASD) has social skill, motor skill, and motion perception deficits. However, the relationship among them was not clarified. Therefore, this study aimed to evaluate the effects of motor skills on social skills and motion perception. (Source: Brain and Development)
Source: Brain and Development - September 29, 2022 Category: Neurology Authors: Kotoe Sakihara, Yosuke Kita, Kota Suzuki, Masumi Inagaki Tags: Original article Source Type: research
Regarding the impact of maternal dyslipidemia on infant neurodevelopment
We commend Motoki and colleagues for their notable contribution to the growing body of literature through an examination of the possible role of maternal dyslipidemia in pregnancy complications and infant neurodevelopmental disorders. Using scores from the Ages and Stages Questionnaire, third edition (ASQ-3), they concluded that hypercholesterolemia may have a deleterious effect on infant neurodevelopment and age-appropriate acquisition at 12 months [1]. As discussed in the manuscript, limitations of this study included a high participant attrition rate, self-reporting of ASQ-3 data by participants, and variance between ...
Source: Brain and Development - September 27, 2022 Category: Neurology Authors: Tejas C. Sekhar, Sejal C. Sekhar, Miran Bhima, Kristine P. Pashin Tags: Letter to the Editor Source Type: research
First detailed case report of a pediatric patient with neuronal intranuclear inclusion disease diagnosed by NOTCH2NLC genetic testing
Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disease characterized clinically by eosinophilic hyaline intranuclear inclusions in neuronal and other somatic cells. Skin biopsies are reportedly useful in diagnosing NIID, and the genetic cause of NIID was identified as a GGC repeat expansion in NOTCH2NLC in recent years. The number of adult patients diagnosed via genetic testing has increased; however, there have been no detailed reports of pediatric NIID cases with GGC expansions in NOTCH2NLC. (Source: Brain and Development)
Source: Brain and Development - September 20, 2022 Category: Neurology Authors: Yosuke Miyamoto, Tetsuya Okazaki, Keisuke Watanabe, Masami Togawa, Tadashi Adachi, Ayumi Kato, Ryoya Ochiai, Chisato Tamai, Jun Sone, Yoshihiro Maegaki Tags: Case Report Source Type: research
Immediate and progressive neurological damage after electrical injury: A pediatric case report
An electrical injury can cause multiple consequences, especially to the nervous system, both peripheral and central. Such consequences may present immediately as well as later on. (Source: Brain and Development)
Source: Brain and Development - September 17, 2022 Category: Neurology Authors: Alfonso Rubino, Pia Bernardo, Carmela Russo, Celeste Tucci, Luigia D'Amato, Veronica Piccolo, Vincenzo Andreone, Pasquale Striano, Geremia Zito Marinosci, Antonio Varone Tags: Case Report Source Type: research
Weak impacts of neuropsychological measures on symptoms of attention deficit hyperactivity disorder in university students
This study aimed to examine the relationship between ADHD symptoms and neuropsychological measures in university students. (Source: Brain and Development)
Source: Brain and Development - September 15, 2022 Category: Neurology Authors: Kota Suzuki Tags: Original article Source Type: research
Drug-resistant temporal lobe epilepsy due to middle fossa meningoencephalocele in a child: A surgical case report
Meningoencephalocele (ME) of the temporal lobe through a bone defect in the middle cranial fossa is a rare known cause of refractory temporal lobe epilepsy (TLE). ME-induced drug-resistant TLE has been described in adults; however, its incidence in children is very rare. (Source: Brain and Development)
Source: Brain and Development - September 14, 2022 Category: Neurology Authors: Yasuo Sunaga, Yutaro Takayama, Suguru Yokosako, Takahisa Mizuno, Miyuki Kouno, Masahiko Tashiro, Masaki Iwasaki, Masayuki Sasaki Tags: Case Report Source Type: research
ATP1A3-related early childhood onset developmental and epileptic encephalopathy responding to corpus callosotomy: A case report
VariousATP1A3variant-related diseases have been reported, including alternating hemiplegia of childhood; rapid-onset dystonia –parkinsonism; and cerebellar ataxia, areflexia, pes cavus, optic atrophy, and sensorineural hearing loss syndrome. Moreover, a few cases of developmental and epileptic encephalopathy (DEE) with none of these symptoms have been reported. Here, we present a case of DEE with early childhood onset ca used by anATP1A3variant that was effectively treated using corpus callosotomy (CC). (Source: Brain and Development)
Source: Brain and Development - September 14, 2022 Category: Neurology Authors: Kengo Moriyama, Tomoko Mizuno, Tomonori Suzuki, Motoki Inaji, Taketoshi Maehara, Atsushi Fujita, Mitsuhiro Kato, Naomichi Matsumoto Tags: Case Report Source Type: research
An exploratory study to identify neonatal arterial ischemic stroke: A single-center study
Neonatal arterial ischemic stroke (NAIS) presents as seizures, including convulsions, subtle seizures, and apnea, and most patients experience neurological sequelae. Diagnosis is often delayed owing to low test sensitivity. The present study aimed to identify the early clinical diagnostic factors for NAIS in neonates with seizures. (Source: Brain and Development)
Source: Brain and Development - September 2, 2022 Category: Neurology Authors: Takashi Setoue, Shuichi Yatsuga, Kazutoshi Ito, Tatsuro Kodera, Yasuhiro Onda, Hiroyasu Kawano, Toshikazu Niimi, Tatsuki Miyamoto, Eiji Ohta, Shinichiro Nagamitsu Tags: Original article Source Type: research
Corrigendum to: “Detailed clinical course of fatal acute encephalopathy in children” [Brain Dev. 41(8) (2019) 691–698]
The author regrets that the above article lacks information on the legend in Fig. 1. The Fig. 1 legend is updated below. (Source: Brain and Development)
Source: Brain and Development - August 30, 2022 Category: Neurology Authors: Kazumi Tomioka, Masahiro Nishiyama, Hiroaki Nagase, Yusuke Ishida, Tsukasa Tanaka, Shoichi Tokumoto, Hiroshi Yamaguchi, Daisaku Toyoshima, Azusa Maruyama, Kyoko Fujita, Kazunori Aoki, Yusuke Seino, Kandai Nozu, Noriyuki Nishimura, Hiroshi Kurosawa, Kazumo Tags: Corrigendum Source Type: research
