Treating neurodegenerative disease: Nusinersen and other therapeutic strategies for improved motor function

Intrathecal nusinersen greatly stabilizes motor function by increasing survival motor neuron (SMN) protein production for patients affected by spinal muscular atrophy (SMA). Shimizu-Motohashi et al. investigate the dynamic between muscle impairment and correspondent change in motor function, describing treatment variability to nusinersen in SMA types 2 and 3 [1]. Expanding on this work, it is imperative to investigate additional combinatorial therapies developed to target SMN and other non-SMN targets that affect motor performance.
Source: Brain and Development - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research