Biology of Blood and Marrow Transplantation This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Comparison of Outcomes of Hematopoietic Cell Transplantation (HCT) for Asymptomatic Patients with Sickle Cell Disease (SCD) and That of Propensity Matched Symptomatic Patients Undergoing HCT
Improved outcomes has led to some clinicians performing HCT for SCD even in patients without severe manifestations. This raises issues of cost-benefit tradeoff, ethics, and healthcare equity. It is also unknown whether patients who have not suffered complications of SCD would have better outcomes post-HCT compared to propensity-matched symptomatic SCD patients undergoing HCT. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Deeksha Katoch, Vineetha Reddy Nallagatla, Jingchen Liang, Yanhong Deng, Lakshmanan Krishnamurti Tags: 73 Source Type: research

Development of a Prototype Clinical Decision Support Tool for a Machine Learning Based Individualized Prediction of Outcomes of Hematopoietic Cell Transplantation for Sickle Cell Disease
Hematopoietic cell transplantation (HCT) remains the only curative therapy for sickle cell disease (SCD), but the lack of a prediction model that addresses the uncertainty regarding individual outcomes and adverse events is a barrier for shared decision making. Computational machine-learning (ML) has the potential to determine generalizable predictive patterns and quantifying uncertainty in those estimates allowing clinicians to assess the confidence level of the predictions and avoid over-reliance on potentially incorrect results, allow for risk management and mitigation by considering the potential range of outcomes, per...
Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Rajagopalan Subramaniam, Michael Kane, Lakshmanan Krishnamurti Tags: 74 Source Type: research

Monoallelic Germline Pathogenic Variants in DNA Damage Repair Genes and Their Impact on Post-Hematopoietic Cell Transplantation Outcomes in Severe Aplastic Anemia
Recipients of HCT are under significant stressors that may predispose them to DNA damage and unfavorable outcomes. Patients with inherited defects in DNA damage response or repair (DDRR), such as Fanconi anemia, need special conditioning regimens to minimize toxicity. HCT outcomes in patients carrying pathogenic or likely pathogenic (P/LP) variants in DDRR genes is unknown. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Maryam Rafati, Youjin Wang, Lisa J. McReynolds, Kristine Jones, Belynda Hicks, Stephen R. Spellman, Meilun He, Yung-Tsi Bolon, Stephanie J. Lee, Sharon A. Savage, Shahinaz M. Gadalla Tags: 75 Source Type: research

Risk Factors for the Development of Non-Infectious Pulmonary Complications Post-Hematopoietic Cell Transplantation in Sickle Cell Disease
This study aims to assess the impact of various transplant-related risk factors on pulmonary complications post-HCT in patients who underwent transplants between 1990 to 2022 in the US. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Vineetha Reddy Nallagatla, Yanhong Deng, Jingchen Liang, Lakshmanan Krishnamurti Tags: 76 Source Type: research

T-Cell Reconstitution Can be a Predictive Biomarker for Severe Acute GvHD in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation with a Treosulfan/Fludarabine Conditioning Regimen
Immune Reconstitution (IR) following allogeneic HCT is a dynamic and multifaceted process that significantly impacts HCT outcomes and could serve as a predictive biomarker. Treosulfan is being increasingly used in HCT as a safer alternative to busulfan. We have previously reported the pattern of early IR post-HSCT in patients with thalassemia receiving a Treo-containing conditioning regimen (Pai et al. TCT 2023). Here, we studied the immune reconstitution pattern in HCT with treosulfan based conditioning and its correlation with the HCT outcomes. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Rachel Mariam Renji, Aswin Anand Pai, Nayanthara K Bijukumar, Agila Jayaraman, Raveen Stephen Stallon Illangeswaran, Eunice S Edison, Sushil Selvarajan, Fouzia N Aboobacker, Alok Srivastava, Aby Abraham, Vikram Mathews, Biju George, Sujith Karumathil, Aru Tags: 77 Source Type: research

Unrelated and Haploidentical Peripheral Stem Cell Transplant with Tcr αβ/CD19 Depletion for the Treatment of Pediatric Patients with Inborn Errors of Immunity
Hematopoietic stem cell transplant (SCT) is curative therapy for many inborn errors of immunity (IEIs). Yet, only a minority of recipients have a suitable HLA matched related donor. Ex vivo TCR αβ/CD19 depletion allows the use of unrelated or partially matched related donors while reducing the risk of GVHD by removing alloreactive αβ T-cells but retaining γδ T-cells. Here, we present a single institution experience with TCRαβ/CD19 depleted PSCT for treatment of IEIs. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Susan E. McClory, Caitlin W. Elgarten, Kaitlyn N Quijano, Anne Wohlschlaeger, Mrs. Patricia Hankins, Lei Wang, Yongping Wang, Stephan Kadauke, Dimitri Monos, Timothy S. Olson, Stephan A. Grupp, Elisa Ochfeld, Jennifer R. Heimall, Nancy J. Bunin Tags: 78 Source Type: research

Utilization of a CART Pathway: Impact to Length of Stay and Re-Admission Rates
Upon retrospective review of our 2022 Immune Effector Cell (IEC) patients, we identified the opportunity to reduce length of stay (LOS) for the inpatient population. A clinical pathway strategy (Rotter, de Jong RB, Lacko SE, et.al., 2019) was chosen to define a multidisciplinary approach of care for patients admitted to the facility to drive targeted, early discharges after IEC therapy. A multidisciplinary team developed a pathway which spans from referral to discharge back to the referring practice. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Sharon Dillard, Nicole McEntee Tags: 79 Source Type: research

The Scrubbing Olympics
This study evaluates factors involved in NC care including disinfectant, scrubbing material, scrubbing time and human factors. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Kathi Spears, Chelsea S. Goodin, Rachel Meyer, Kaitlyn Kusnier, David Haslam, Dr. Christopher E. Dandoy, Stella M. Davies, Priscila Badia Tags: 80 Source Type: research

Implementation of a Novel Approach to Treating Multiple Sclerosis (MS) Using Autologous Stem Cell Transplantation: Overcoming the Challenges of Educating Bone Marrow Transplant (BMT) Nurses on the Nuances of Caring for Non-Oncology Transplant Recipients
In March of 2023, our program began implementing autologous stem cell therapy for the indication of MS. The program utilized the expertise of a neurological physician group that is well versed in MS patient care and understood the efficacy of stem cell therapy for slowing the demyelination process of the disease. A risk assessment evaluating the education of the BMT nurses was conducted which revealed a need for further education on the disease process, care, and management of patients with MS. As the first patient was scheduled in summer of 2023, the identified educational needs had to be expedited to ensure that approxim...
Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Erin Elgie, Cyndi Ashland, Meagan Enneking Tags: 81 Source Type: research

Autologous Stem Cell Transplant for Multiple Myeloma: Impact of Eliminating Day of Rest on Incidence of Complications and Re-Admission Rate
As part of a length of stay and bed utilization initiative, we eliminated the day of rest for our multiple myeloma patients between administration of their conditioning chemotherapy and autologous stem cell transplant (ASCT) (Ali& Al Hadidi, 2022). Our primary endpoints were rate of complications and rate of re-admission within 30 days of discharge. Our secondary endpoints were time to neutrophil engraftment from ASCT and length of stay. During our quarterly quality meetings, the multidisciplinary team discusses metric and performance improvement projects. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Nicole McEntee, Sharon Dillard Tags: 82 Source Type: research

Developing Practice Guidelines for Preparation and Infusion of Cellular Therapy Products
Cellular therapy staff have historically relied on expert opinion, accreditation standards and manufacturer recommendations, to guide cellular therapy infusion (CTI) practices. The foundation for these practice recommendations were based on the first infusions of cellular therapy products; very little has changed over time, despite improvements in donor selection, product processing, and outcome analysis.Through discussions in the Nursing Track sessions at the American Society for Transplantation and Cellular Therapy (ASTCT) meetings, a lack of evidence surrounding CTI was identified. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Chris Rimkus, Ashley Rumsey, Jessica Miles, Michelle Skinner, Jessica Stiles, Elizabeth Sheldon, Thomas Eunson, Arlen Puti, Mrs. Adelaide van Lier, Mrs. Nicole West, Nicole McEntee, Mrs. Krystal Waldrup, Monica Hente, Robyn Blacken, Emily Roth, Ryan Burke Tags: 83 Source Type: research

Orthostatic Vital Signs to Reduce Falls on the Inpatient BMT Units
Between 700,000 and 1,000,000 patients fall while hospitalized in the nation annually. CMS has deemed inpatient falls as preventable events and stopped reimbursement for fall related injuries. The incidence of falls on both BMT units at the organization intermittently rate above benchmarks. After review of patient falls, orthostatic hypotension (OH) was identified as a contributing factor. This initiative was a nurse-led implementation of an evidence-based intervention to reduce falls on the BMT units. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Lilllian Reilly Tags: 84 Source Type: research

Code Heat: Integrating a New Rapid Response in a Blood and Marrow Transplant (BMT) Unit for Febrile Neutropenia Patients to Decrease Time to Antibiotic Administration
Febrile Neutropenia is an oncologic emergency requiring immediate intervention to decrease the risk for sepsis and mortality. NIH guidelines state that identification of a neutropenic fever requires provider notification, testing, and antibiotic administration to be completed within one hour. After investigating instances where antibiotic treatment was delayed, a process improvement opportunity was identified. The nurse needed a way to get assistance so they would be able to complete all required tasks as quickly as possible. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Nell Mayendia Blanco, Natalia Franco, Jennifer Juarez, Amanda Tapanes, Anna Diaz, Giomara Giron Tags: 85 Source Type: research

Follow up of the Phenotype of a Bone Marrow Transplant Nurse: Survival of the Fittest
This study aimed to investigate factors of resilience and how it pertains to the retention of pediatric BMT nurses. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Chelsea S. Goodin, Dr. Christopher E. Dandoy, Stella M. Davies, Laura Flesch, Brenda Mott, Mark Mueller, Shannon Sarver, Gabby O'Connor, Adam Lane, Aaron Webster, Judith R Ragsdale Tags: 86 Source Type: research

Interactive Education: One Way to Measure Success
Providing standardized professional nursing education to multiple transplant and cellular therapy programs across the United States is critical to the health of patients and their caregivers and the support of specialized nurses. In addition, accreditation by the Commission on Cancer (CoC) requires either oncology-focused certification or a minimum of 36 cancer-related continuing nursing education (CNE) contact hours per 3-year accreditation cycle. Innovative learning methods, such as interactive online modules, are rapidly growing alternatives in delivering standardized nursing education. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Stephanie M. Larson, Tonya Cox, Trista Carelock, Elaine S. DeMeyer Tags: 87 Source Type: research