Frequency of Consumption of Food Groups and Cardio-Metabolic Risk Factors: A Genetically Informative Twin Study in Sri Lanka
Behav Genet. 2023 Dec 22. doi: 10.1007/s10519-023-10165-8. Online ahead of print.ABSTRACTLow- and middle-income countries (LMICs) globally have undergone rapid urbanisation, and changes in demography and health behaviours. In Sri Lanka, cardio-vascular disease and diabetes are now leading causes of mortality. High prevalence of their risk factors, including hypertension, dysglycaemia and obesity have also been observed. Diet is a key modifiable risk factor for both cardio-vascular disease and diabetes as well as their risk factors. Although typically thought of as an environmental risk factor, dietary choice has been shown...
Source: Behavior Genetics - December 22, 2023 Category: Genetics & Stem Cells Authors: Helena M S Zavos Laura Riddleston Kaushalya Jayaweera Lasith Dissanayake Sameeha Jabir Gayani Pannala Matthew Hotopf Sisira Siribaddana Athula Sumathipala Fr ühling V Rijsdijk Source Type: research
Frequency of Consumption of Food Groups and Cardio-Metabolic Risk Factors: A Genetically Informative Twin Study in Sri Lanka
Behav Genet. 2023 Dec 22. doi: 10.1007/s10519-023-10165-8. Online ahead of print.ABSTRACTLow- and middle-income countries (LMICs) globally have undergone rapid urbanisation, and changes in demography and health behaviours. In Sri Lanka, cardio-vascular disease and diabetes are now leading causes of mortality. High prevalence of their risk factors, including hypertension, dysglycaemia and obesity have also been observed. Diet is a key modifiable risk factor for both cardio-vascular disease and diabetes as well as their risk factors. Although typically thought of as an environmental risk factor, dietary choice has been shown...
Source: Behavior Genetics - December 22, 2023 Category: Genetics & Stem Cells Authors: Helena M S Zavos Laura Riddleston Kaushalya Jayaweera Lasith Dissanayake Sameeha Jabir Gayani Pannala Matthew Hotopf Sisira Siribaddana Athula Sumathipala Fr ühling V Rijsdijk Source Type: research
A Developmentally-Informative Genome-wide Association Study of Alcohol Use Frequency
Behav Genet. 2023 Dec 18. doi: 10.1007/s10519-023-10170-x. Online ahead of print.ABSTRACTContemporary genome-wide association study (GWAS) methods typically do not account for variability in genetic effects throughout development. We applied genomic structural equation modeling to combine developmentally-informative phenotype data and GWAS to create polygenic scores (PGS) for alcohol use frequency that are specific to developmental stage. Longitudinal cohort studies targeted for gene-identification analyses include the Collaborative Study on the Genetics of Alcoholism (adolescence n = 1,118, early adulthood n = 2,762, adul...
Source: Behavior Genetics - December 18, 2023 Category: Genetics & Stem Cells Authors: Nathaniel S Thomas Nathan A Gillespie Grace Chan Howard J Edenberg Chella Kamarajan Sally I-Chun Kuo Alex P Miller John I Nurnberger Jay Tischfield Danielle M Dick Jessica E Salvatore Source Type: research
A Developmentally-Informative Genome-wide Association Study of Alcohol Use Frequency
Behav Genet. 2023 Dec 18. doi: 10.1007/s10519-023-10170-x. Online ahead of print.ABSTRACTContemporary genome-wide association study (GWAS) methods typically do not account for variability in genetic effects throughout development. We applied genomic structural equation modeling to combine developmentally-informative phenotype data and GWAS to create polygenic scores (PGS) for alcohol use frequency that are specific to developmental stage. Longitudinal cohort studies targeted for gene-identification analyses include the Collaborative Study on the Genetics of Alcoholism (adolescence n = 1,118, early adulthood n = 2,762, adul...
Source: Behavior Genetics - December 18, 2023 Category: Genetics & Stem Cells Authors: Nathaniel S Thomas Nathan A Gillespie Grace Chan Howard J Edenberg Chella Kamarajan Sally I-Chun Kuo Alex P Miller John I Nurnberger Jay Tischfield Danielle M Dick Jessica E Salvatore Source Type: research
A Developmentally-Informative Genome-wide Association Study of Alcohol Use Frequency
Behav Genet. 2023 Dec 18. doi: 10.1007/s10519-023-10170-x. Online ahead of print.ABSTRACTContemporary genome-wide association study (GWAS) methods typically do not account for variability in genetic effects throughout development. We applied genomic structural equation modeling to combine developmentally-informative phenotype data and GWAS to create polygenic scores (PGS) for alcohol use frequency that are specific to developmental stage. Longitudinal cohort studies targeted for gene-identification analyses include the Collaborative Study on the Genetics of Alcoholism (adolescence n = 1,118, early adulthood n = 2,762, adul...
Source: Behavior Genetics - December 18, 2023 Category: Genetics & Stem Cells Authors: Nathaniel S Thomas Nathan A Gillespie Grace Chan Howard J Edenberg Chella Kamarajan Sally I-Chun Kuo Alex P Miller John I Nurnberger Jay Tischfield Danielle M Dick Jessica E Salvatore Source Type: research
A Developmentally-Informative Genome-wide Association Study of Alcohol Use Frequency
Behav Genet. 2023 Dec 18. doi: 10.1007/s10519-023-10170-x. Online ahead of print.ABSTRACTContemporary genome-wide association study (GWAS) methods typically do not account for variability in genetic effects throughout development. We applied genomic structural equation modeling to combine developmentally-informative phenotype data and GWAS to create polygenic scores (PGS) for alcohol use frequency that are specific to developmental stage. Longitudinal cohort studies targeted for gene-identification analyses include the Collaborative Study on the Genetics of Alcoholism (adolescence n = 1,118, early adulthood n = 2,762, adul...
Source: Behavior Genetics - December 18, 2023 Category: Genetics & Stem Cells Authors: Nathaniel S Thomas Nathan A Gillespie Grace Chan Howard J Edenberg Chella Kamarajan Sally I-Chun Kuo Alex P Miller John I Nurnberger Jay Tischfield Danielle M Dick Jessica E Salvatore Source Type: research
Individual Trajectories of Depressive Symptoms Within Racially-Ethnically Diverse Youth: Associations with Polygenic Risk for Depression and Substance Use Intent and Perceived Harm
We examined racially/ethnically aligned polygenic scores (Dep-PGS) as predictors of trajectories as well as substance use intent and perceived substance use harm as outcomes at age 12-13. Differential trajectories were found in AA, EA, and LX youth but low and high trajectories were represented within each group. In EA youth, greater Dep-PGS were broadly associated with membership in trajectories with greater depressive symptoms. Genetic effects were not significant in AA and LX youth. In AA youth, membership in the low trajectory was associated with greater substance use intent. In EA youth, membership in trajectories wit...
Source: Behavior Genetics - December 14, 2023 Category: Genetics & Stem Cells Authors: Kit K Elam Jinni Su Jodi Kutzner Angel Trevino Source Type: research
Individual Trajectories of Depressive Symptoms Within Racially-Ethnically Diverse Youth: Associations with Polygenic Risk for Depression and Substance Use Intent and Perceived Harm
We examined racially/ethnically aligned polygenic scores (Dep-PGS) as predictors of trajectories as well as substance use intent and perceived substance use harm as outcomes at age 12-13. Differential trajectories were found in AA, EA, and LX youth but low and high trajectories were represented within each group. In EA youth, greater Dep-PGS were broadly associated with membership in trajectories with greater depressive symptoms. Genetic effects were not significant in AA and LX youth. In AA youth, membership in the low trajectory was associated with greater substance use intent. In EA youth, membership in trajectories wit...
Source: Behavior Genetics - December 14, 2023 Category: Genetics & Stem Cells Authors: Kit K Elam Jinni Su Jodi Kutzner Angel Trevino Source Type: research
Individual Trajectories of Depressive Symptoms Within Racially-Ethnically Diverse Youth: Associations with Polygenic Risk for Depression and Substance Use Intent and Perceived Harm
We examined racially/ethnically aligned polygenic scores (Dep-PGS) as predictors of trajectories as well as substance use intent and perceived substance use harm as outcomes at age 12-13. Differential trajectories were found in AA, EA, and LX youth but low and high trajectories were represented within each group. In EA youth, greater Dep-PGS were broadly associated with membership in trajectories with greater depressive symptoms. Genetic effects were not significant in AA and LX youth. In AA youth, membership in the low trajectory was associated with greater substance use intent. In EA youth, membership in trajectories wit...
Source: Behavior Genetics - December 14, 2023 Category: Genetics & Stem Cells Authors: Kit K Elam Jinni Su Jodi Kutzner Angel Trevino Source Type: research
Individual Trajectories of Depressive Symptoms Within Racially-Ethnically Diverse Youth: Associations with Polygenic Risk for Depression and Substance Use Intent and Perceived Harm
We examined racially/ethnically aligned polygenic scores (Dep-PGS) as predictors of trajectories as well as substance use intent and perceived substance use harm as outcomes at age 12-13. Differential trajectories were found in AA, EA, and LX youth but low and high trajectories were represented within each group. In EA youth, greater Dep-PGS were broadly associated with membership in trajectories with greater depressive symptoms. Genetic effects were not significant in AA and LX youth. In AA youth, membership in the low trajectory was associated with greater substance use intent. In EA youth, membership in trajectories wit...
Source: Behavior Genetics - December 14, 2023 Category: Genetics & Stem Cells Authors: Kit K Elam Jinni Su Jodi Kutzner Angel Trevino Source Type: research
Transposons in the Williams-Beuren Syndrome Critical Region are Associated with Social Behavior in Assistance Dogs
Behav Genet. 2023 Dec 13. doi: 10.1007/s10519-023-10166-7. Online ahead of print.ABSTRACTA strong signature of selection in the domestic dog genome is found in a five-megabase region of chromosome six in which four structural variants derived from transposons have previously been associated with human-oriented social behavior, such as attentional bias to social stimuli and social interest in strangers. To explore these genetic associations in more phenotypic detail-as well as their role in training success in a specialized assistance dog program-we genotyped 1001 assistance dogs from Canine Companions for Independence®, i...
Source: Behavior Genetics - December 13, 2023 Category: Genetics & Stem Cells Authors: Gitanjali E Gnanadesikan Dhriti Tandon Emily E Bray Brenda S Kennedy Stavi R Tennenbaum Evan L MacLean Bridgett M vonHoldt Source Type: research
Transposons in the Williams-Beuren Syndrome Critical Region are Associated with Social Behavior in Assistance Dogs
Behav Genet. 2023 Dec 13. doi: 10.1007/s10519-023-10166-7. Online ahead of print.ABSTRACTA strong signature of selection in the domestic dog genome is found in a five-megabase region of chromosome six in which four structural variants derived from transposons have previously been associated with human-oriented social behavior, such as attentional bias to social stimuli and social interest in strangers. To explore these genetic associations in more phenotypic detail-as well as their role in training success in a specialized assistance dog program-we genotyped 1001 assistance dogs from Canine Companions for Independence®, i...
Source: Behavior Genetics - December 13, 2023 Category: Genetics & Stem Cells Authors: Gitanjali E Gnanadesikan Dhriti Tandon Emily E Bray Brenda S Kennedy Stavi R Tennenbaum Evan L MacLean Bridgett M vonHoldt Source Type: research
South Asia: The Missing Diverse in Diversity
Behav Genet. 2023 Nov 2. doi: 10.1007/s10519-023-10161-y. Online ahead of print.ABSTRACTSouth Asia, making up around 25% of the world's population, encompasses a wide range of individuals with tremendous genetic and environmental diversity. This region, which spans eight countries, is home to over 4500 anthropologically defined groups that speak numerous languages and have an array of religious beliefs and cultures, making it one of the most diverse places in the world. Much of the region's rich genetic diversity and structure is the result of a complex combination of population history, migration patterns, and endogamous ...
Source: Behavior Genetics - November 2, 2023 Category: Genetics & Stem Cells Authors: Deepika R Dokuru Tanya B Horwitz Samantha M Freis Michael C Stallings Marissa A Ehringer Source Type: research
South Asia: The Missing Diverse in Diversity
Behav Genet. 2023 Nov 2. doi: 10.1007/s10519-023-10161-y. Online ahead of print.ABSTRACTSouth Asia, making up around 25% of the world's population, encompasses a wide range of individuals with tremendous genetic and environmental diversity. This region, which spans eight countries, is home to over 4500 anthropologically defined groups that speak numerous languages and have an array of religious beliefs and cultures, making it one of the most diverse places in the world. Much of the region's rich genetic diversity and structure is the result of a complex combination of population history, migration patterns, and endogamous ...
Source: Behavior Genetics - November 2, 2023 Category: Genetics & Stem Cells Authors: Deepika R Dokuru Tanya B Horwitz Samantha M Freis Michael C Stallings Marissa A Ehringer Source Type: research
South Asia: The Missing Diverse in Diversity
Behav Genet. 2023 Nov 2. doi: 10.1007/s10519-023-10161-y. Online ahead of print.ABSTRACTSouth Asia, making up around 25% of the world's population, encompasses a wide range of individuals with tremendous genetic and environmental diversity. This region, which spans eight countries, is home to over 4500 anthropologically defined groups that speak numerous languages and have an array of religious beliefs and cultures, making it one of the most diverse places in the world. Much of the region's rich genetic diversity and structure is the result of a complex combination of population history, migration patterns, and endogamous ...
Source: Behavior Genetics - November 2, 2023 Category: Genetics & Stem Cells Authors: Deepika R Dokuru Tanya B Horwitz Samantha M Freis Michael C Stallings Marissa A Ehringer Source Type: research
