Annual Review of Pharmacology and Toxicology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Circulating Biomarkers Instead of Genotyping to Establish Metabolizer Phenotypes
Annu Rev Pharmacol Toxicol. 2023 Aug 16. doi: 10.1146/annurev-pharmtox-032023-121106. Online ahead of print.ABSTRACTPharmacogenomics (PGx) enables personalized treatment for the prediction of drug response and to avoid adverse drug reactions. Currently, PGx mainly relies on the genetic information of absorption, distribution, metabolism, and excretion (ADME) targets such as drug-metabolizing enzymes or transporters to predict differences in the patient's phenotype. However, there is evidence that the phenotype-genotype concordance is limited. Thus, we discuss different phenotyping strategies using exogenous xenobiotics (e....
Source: Annual Review of Pharmacology and Toxicology - August 16, 2023 Category: Drugs & Pharmacology Authors: Roman Tremmel Ute Hofmann Mathias Haag Elke Schaeffeler Matthias Schwab Source Type: research

Targeting Efferocytosis in Inflammaging
Annu Rev Pharmacol Toxicol. 2023 Aug 16. doi: 10.1146/annurev-pharmtox-032723-110507. Online ahead of print.ABSTRACTRapid removal of apoptotic cells by phagocytes, a process known as efferocytosis, is key for the maintenance of tissue homeostasis, the resolution of inflammation, and tissue repair. However, impaired efferocytosis can result in the accumulation of apoptotic cells, subsequently triggering sterile inflammation through the release of endogenous factors such as DNA and nuclear proteins from membrane permeabilized dying cells. Here, we review the molecular basis of the three key phases of efferocytosis, that is, ...
Source: Annual Review of Pharmacology and Toxicology - August 16, 2023 Category: Drugs & Pharmacology Authors: Ivan K H Poon Kodi S Ravichandran Source Type: research

Apathy and Motivation: Biological Basis and Drug Treatment
Annu Rev Pharmacol Toxicol. 2023 Aug 16. doi: 10.1146/annurev-pharmtox-022423-014645. Online ahead of print.ABSTRACTApathy is a disabling syndrome associated with poor functional outcomes that is common across a broad range of neurological and psychiatric conditions. Currently, there are no established therapies specifically for the condition, and safe and effective treatments are urgently needed. Advances in the understanding of motivation and goal-directed behavior in humans and animals have shed light on the cognitive and neurobiological mechanisms contributing to apathy, providing an important foundation for the develo...
Source: Annual Review of Pharmacology and Toxicology - August 16, 2023 Category: Drugs & Pharmacology Authors: Harry Costello Masud Husain Jonathan P Roiser Source Type: research

From Thalidomide to Rational Molecular Glue Design for Targeted Protein Degradation
Annu Rev Pharmacol Toxicol. 2023 Aug 16. doi: 10.1146/annurev-pharmtox-022123-104147. Online ahead of print.ABSTRACTThalidomide and its derivatives are powerful cancer therapeutics that are among the best-understood molecular glue degraders (MGDs). These drugs selectively reprogram the E3 ubiquitin ligase cereblon (CRBN) to commit target proteins for degradation by the ubiquitin-proteasome system. MGDs create novel recognition interfaces on the surface of the E3 ligase that engage in induced protein-protein interactions with neosubstrates. Molecular insight into their mechanism of action opens exciting opportunities to eng...
Source: Annual Review of Pharmacology and Toxicology - August 16, 2023 Category: Drugs & Pharmacology Authors: Vladas Oleinikovas Pablo Gainza Thomas Ryckmans Bernhard Fasching Nicolas H Thom ä Source Type: research

The Nocebo Effect
Annu Rev Pharmacol Toxicol. 2023 Aug 16. doi: 10.1146/annurev-pharmtox-022723-112425. Online ahead of print.ABSTRACTAdverse nocebo responses can cause harm to patients and interfere with treatment adherence and effects in both clinic practice and clinical trials. Nocebo responses refer to negative outcomes to active medical treatments in clinical trials or practice that cannot be explained by the treatment's pharmacologic effects. Negative expectancies and nocebo effects are less known than placebo responses. Nocebo effects can be triggered by verbal suggestions, prior negative experiences, observation of others experienci...
Source: Annual Review of Pharmacology and Toxicology - August 16, 2023 Category: Drugs & Pharmacology Authors: Luana Colloca Source Type: research

Health Digital Twins in life Science and Health Care Innovation
Annu Rev Pharmacol Toxicol. 2023 Aug 10. doi: 10.1146/annurev-pharmtox-022123-022046. Online ahead of print.ABSTRACTHealth digital twins (HDTs) are virtual representations of real individuals that can be used to simulate human physiology, disease, and drug effects. HDTs can be used to improve drug discovery and development by providing a data-driven approach to inform target selection, drug delivery, and design of clinical trials. HDTs also offer new applications into precision therapies and clinical decision making. The deployment of HDTs at scale could bring a precision approach to public health monitoring and interventi...
Source: Annual Review of Pharmacology and Toxicology - August 10, 2023 Category: Drugs & Pharmacology Authors: Kaushik P Venkatesh Gabriel Brito Maged N Kamel Boulos Source Type: research

Hear and Now: Ongoing Clinical Trials to Prevent Drug-Induced Hearing Loss
Annu Rev Pharmacol Toxicol. 2023 Aug 10. doi: 10.1146/annurev-pharmtox-033123-114106. Online ahead of print.ABSTRACTEach year over half a million people experience permanent hearing loss caused by treatment with therapeutic drugs with ototoxic side effects. There is a major unmet clinical need for therapies that protect against this hearing loss without reducing the therapeutic efficacy of these lifesaving drugs. At least 17 clinical trials evaluating 10 therapeutics are currently underway for therapies aimed at preventing aminoglycoside- and/or cisplatin-induced ototoxicity. This review describes the preclinical and clini...
Source: Annual Review of Pharmacology and Toxicology - August 10, 2023 Category: Drugs & Pharmacology Authors: John Lee Katharine Fernandez Lisa L Cunningham Source Type: research