Alcohol Use Disorder Treatment: Problems and Solutions
Annu Rev Pharmacol Toxicol. 2024 Jan 23;64:255-275. doi: 10.1146/annurev-pharmtox-031323-115847.ABSTRACTAlcohol use disorder (AUD) afflicts over 29 million individuals and causes more than 140,000 deaths annually in the United States. A heuristic framework for AUD includes a three-stage cycle-binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation-that provides a starting point for exploring the heterogeneity of AUD with regard to treatment. Effective behavioral health treatments and US Food and Drug Administration-approved medications are available but greatly underutilized, creating a major treatme...
Source: Annual Review of Pharmacology and Toxicology - January 23, 2024 Category: Drugs & Pharmacology Authors: George F Koob Source Type: research

Alcohol Use Disorder Treatment: Problems and Solutions
Annu Rev Pharmacol Toxicol. 2024 Jan 23;64:255-275. doi: 10.1146/annurev-pharmtox-031323-115847.ABSTRACTAlcohol use disorder (AUD) afflicts over 29 million individuals and causes more than 140,000 deaths annually in the United States. A heuristic framework for AUD includes a three-stage cycle-binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation-that provides a starting point for exploring the heterogeneity of AUD with regard to treatment. Effective behavioral health treatments and US Food and Drug Administration-approved medications are available but greatly underutilized, creating a major treatme...
Source: Annual Review of Pharmacology and Toxicology - January 23, 2024 Category: Drugs & Pharmacology Authors: George F Koob Source Type: research

Alcohol Use Disorder Treatment: Problems and Solutions
Annu Rev Pharmacol Toxicol. 2024 Jan 23;64:255-275. doi: 10.1146/annurev-pharmtox-031323-115847.ABSTRACTAlcohol use disorder (AUD) afflicts over 29 million individuals and causes more than 140,000 deaths annually in the United States. A heuristic framework for AUD includes a three-stage cycle-binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation-that provides a starting point for exploring the heterogeneity of AUD with regard to treatment. Effective behavioral health treatments and US Food and Drug Administration-approved medications are available but greatly underutilized, creating a major treatme...
Source: Annual Review of Pharmacology and Toxicology - January 23, 2024 Category: Drugs & Pharmacology Authors: George F Koob Source Type: research

Alcohol Use Disorder Treatment: Problems and Solutions
Annu Rev Pharmacol Toxicol. 2024 Jan 23;64:255-275. doi: 10.1146/annurev-pharmtox-031323-115847.ABSTRACTAlcohol use disorder (AUD) afflicts over 29 million individuals and causes more than 140,000 deaths annually in the United States. A heuristic framework for AUD includes a three-stage cycle-binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation-that provides a starting point for exploring the heterogeneity of AUD with regard to treatment. Effective behavioral health treatments and US Food and Drug Administration-approved medications are available but greatly underutilized, creating a major treatme...
Source: Annual Review of Pharmacology and Toxicology - January 23, 2024 Category: Drugs & Pharmacology Authors: George F Koob Source Type: research

Alcohol Use Disorder Treatment: Problems and Solutions
Annu Rev Pharmacol Toxicol. 2024 Jan 23;64:255-275. doi: 10.1146/annurev-pharmtox-031323-115847.ABSTRACTAlcohol use disorder (AUD) afflicts over 29 million individuals and causes more than 140,000 deaths annually in the United States. A heuristic framework for AUD includes a three-stage cycle-binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation-that provides a starting point for exploring the heterogeneity of AUD with regard to treatment. Effective behavioral health treatments and US Food and Drug Administration-approved medications are available but greatly underutilized, creating a major treatme...
Source: Annual Review of Pharmacology and Toxicology - January 23, 2024 Category: Drugs & Pharmacology Authors: George F Koob Source Type: research

Alcohol Use Disorder Treatment: Problems and Solutions
Annu Rev Pharmacol Toxicol. 2024 Jan 23;64:255-275. doi: 10.1146/annurev-pharmtox-031323-115847.ABSTRACTAlcohol use disorder (AUD) afflicts over 29 million individuals and causes more than 140,000 deaths annually in the United States. A heuristic framework for AUD includes a three-stage cycle-binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation-that provides a starting point for exploring the heterogeneity of AUD with regard to treatment. Effective behavioral health treatments and US Food and Drug Administration-approved medications are available but greatly underutilized, creating a major treatme...
Source: Annual Review of Pharmacology and Toxicology - January 23, 2024 Category: Drugs & Pharmacology Authors: George F Koob Source Type: research

Alcohol Use Disorder Treatment: Problems and Solutions
Annu Rev Pharmacol Toxicol. 2024 Jan 23;64:255-275. doi: 10.1146/annurev-pharmtox-031323-115847.ABSTRACTAlcohol use disorder (AUD) afflicts over 29 million individuals and causes more than 140,000 deaths annually in the United States. A heuristic framework for AUD includes a three-stage cycle-binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation-that provides a starting point for exploring the heterogeneity of AUD with regard to treatment. Effective behavioral health treatments and US Food and Drug Administration-approved medications are available but greatly underutilized, creating a major treatme...
Source: Annual Review of Pharmacology and Toxicology - January 23, 2024 Category: Drugs & Pharmacology Authors: George F Koob Source Type: research

Alcohol Use Disorder Treatment: Problems and Solutions
Annu Rev Pharmacol Toxicol. 2024 Jan 23;64:255-275. doi: 10.1146/annurev-pharmtox-031323-115847.ABSTRACTAlcohol use disorder (AUD) afflicts over 29 million individuals and causes more than 140,000 deaths annually in the United States. A heuristic framework for AUD includes a three-stage cycle-binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation-that provides a starting point for exploring the heterogeneity of AUD with regard to treatment. Effective behavioral health treatments and US Food and Drug Administration-approved medications are available but greatly underutilized, creating a major treatme...
Source: Annual Review of Pharmacology and Toxicology - January 23, 2024 Category: Drugs & Pharmacology Authors: George F Koob Source Type: research

Alcohol Use Disorder Treatment: Problems and Solutions
Annu Rev Pharmacol Toxicol. 2024 Jan 23;64:255-275. doi: 10.1146/annurev-pharmtox-031323-115847.ABSTRACTAlcohol use disorder (AUD) afflicts over 29 million individuals and causes more than 140,000 deaths annually in the United States. A heuristic framework for AUD includes a three-stage cycle-binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation-that provides a starting point for exploring the heterogeneity of AUD with regard to treatment. Effective behavioral health treatments and US Food and Drug Administration-approved medications are available but greatly underutilized, creating a major treatme...
Source: Annual Review of Pharmacology and Toxicology - January 23, 2024 Category: Drugs & Pharmacology Authors: George F Koob Source Type: research

Alcohol Use Disorder Treatment: Problems and Solutions
Annu Rev Pharmacol Toxicol. 2024 Jan 23;64:255-275. doi: 10.1146/annurev-pharmtox-031323-115847.ABSTRACTAlcohol use disorder (AUD) afflicts over 29 million individuals and causes more than 140,000 deaths annually in the United States. A heuristic framework for AUD includes a three-stage cycle-binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation-that provides a starting point for exploring the heterogeneity of AUD with regard to treatment. Effective behavioral health treatments and US Food and Drug Administration-approved medications are available but greatly underutilized, creating a major treatme...
Source: Annual Review of Pharmacology and Toxicology - January 23, 2024 Category: Drugs & Pharmacology Authors: George F Koob Source Type: research

Alcohol Use Disorder Treatment: Problems and Solutions
Annu Rev Pharmacol Toxicol. 2024 Jan 23;64:255-275. doi: 10.1146/annurev-pharmtox-031323-115847.ABSTRACTAlcohol use disorder (AUD) afflicts over 29 million individuals and causes more than 140,000 deaths annually in the United States. A heuristic framework for AUD includes a three-stage cycle-binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation-that provides a starting point for exploring the heterogeneity of AUD with regard to treatment. Effective behavioral health treatments and US Food and Drug Administration-approved medications are available but greatly underutilized, creating a major treatme...
Source: Annual Review of Pharmacology and Toxicology - January 23, 2024 Category: Drugs & Pharmacology Authors: George F Koob Source Type: research

Alcohol Use Disorder Treatment: Problems and Solutions
Annu Rev Pharmacol Toxicol. 2024 Jan 23;64:255-275. doi: 10.1146/annurev-pharmtox-031323-115847.ABSTRACTAlcohol use disorder (AUD) afflicts over 29 million individuals and causes more than 140,000 deaths annually in the United States. A heuristic framework for AUD includes a three-stage cycle-binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation-that provides a starting point for exploring the heterogeneity of AUD with regard to treatment. Effective behavioral health treatments and US Food and Drug Administration-approved medications are available but greatly underutilized, creating a major treatme...
Source: Annual Review of Pharmacology and Toxicology - January 23, 2024 Category: Drugs & Pharmacology Authors: George F Koob Source Type: research

Alcohol Use Disorder Treatment: Problems and Solutions
Annu Rev Pharmacol Toxicol. 2024 Jan 23;64:255-275. doi: 10.1146/annurev-pharmtox-031323-115847.ABSTRACTAlcohol use disorder (AUD) afflicts over 29 million individuals and causes more than 140,000 deaths annually in the United States. A heuristic framework for AUD includes a three-stage cycle-binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation-that provides a starting point for exploring the heterogeneity of AUD with regard to treatment. Effective behavioral health treatments and US Food and Drug Administration-approved medications are available but greatly underutilized, creating a major treatme...
Source: Annual Review of Pharmacology and Toxicology - January 23, 2024 Category: Drugs & Pharmacology Authors: George F Koob Source Type: research

Alcohol Use Disorder Treatment: Problems and Solutions
Annu Rev Pharmacol Toxicol. 2024 Jan 23;64:255-275. doi: 10.1146/annurev-pharmtox-031323-115847.ABSTRACTAlcohol use disorder (AUD) afflicts over 29 million individuals and causes more than 140,000 deaths annually in the United States. A heuristic framework for AUD includes a three-stage cycle-binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation-that provides a starting point for exploring the heterogeneity of AUD with regard to treatment. Effective behavioral health treatments and US Food and Drug Administration-approved medications are available but greatly underutilized, creating a major treatme...
Source: Annual Review of Pharmacology and Toxicology - January 23, 2024 Category: Drugs & Pharmacology Authors: George F Koob Source Type: research

Alcohol Use Disorder Treatment: Problems and Solutions
Annu Rev Pharmacol Toxicol. 2024 Jan 23;64:255-275. doi: 10.1146/annurev-pharmtox-031323-115847.ABSTRACTAlcohol use disorder (AUD) afflicts over 29 million individuals and causes more than 140,000 deaths annually in the United States. A heuristic framework for AUD includes a three-stage cycle-binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation-that provides a starting point for exploring the heterogeneity of AUD with regard to treatment. Effective behavioral health treatments and US Food and Drug Administration-approved medications are available but greatly underutilized, creating a major treatme...
Source: Annual Review of Pharmacology and Toxicology - January 23, 2024 Category: Drugs & Pharmacology Authors: George F Koob Source Type: research