Successful Anesthetic Management of Mitochondrial Myopathy and Hypertrophic Obstructive Cardiomyopathy in a Child With Senger Syndrome
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - November 1, 2022 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research
Aromatherapy and Fermented Fruits for Long COVID: Placebo-Controlled Placebo Trials?
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - November 1, 2022 Category: Drugs & Pharmacology Tags: Editorial Source Type: research
Ivermectin for COVID-19: The 2022 Update
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - November 1, 2022 Category: Drugs & Pharmacology Tags: Editorial Source Type: research
Same-Day Deaths After COVID-19 Vaccinations: Autopsy Findings in 54 Cases
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - November 1, 2022 Category: Drugs & Pharmacology Tags: Editorial Source Type: research
Preventing Vitamin B6–Related Neurotoxicity
Background:
Vitamin B6 is essential for life and plays a critical role in many biochemical and physiological processes in the human body. The term B6 collectively refers to 6 water-soluble vitamers, and only the pyridoxal 5′-phosphate (PLP) serves as the biologically active form. A plasma PLP concentration above 30 nmol/L (7.4 μg/L) is indicative of an adequate vitamin B6 status for all age and sex groups. The currently recommended daily allowance of B6 (1.5–2 mg/d) from dietary sources frequently results in inadequate B6 status (100 nmol/L or 25 μg/L). PLP-based supplements are preferred over pyridoxine suppleme...
Source: American Journal of Therapeutics - November 1, 2022 Category: Drugs & Pharmacology Tags: Therapeutic Opinion Source Type: research
Evaluating the Impact of Glucagon-Like Peptide-1 Receptor Agonists on Metabolic Changes in Patients With Type 2 Diabetes on High-Dose Insulin
Background:
Studies involving the glucagon-like peptide-1 receptor agonist (GLP-1 RA) liraglutide have shown reductions in hemoglobin A1c (HbA1c), weight, and insulin requirements in patients with type 2 diabetes mellitus (DM2) requiring high-dose insulin therapy. The effect of the class of GLP-1 RAs on these parameters is unknown.
Data Sources:
A retrospective cohort analysis was conducted in patients with DM2 where a GLP-1 RA was added to high-dose insulin therapy. The primary composite outcome was the change from baseline to 9 months in HbA1c, weight, and insulin dose.
Results:
GLP-1 RA therapy was ass...
Source: American Journal of Therapeutics - November 1, 2022 Category: Drugs & Pharmacology Tags: Therapeutic Opinion Source Type: research
Pharmacological Management of Pulmonary Tuberculosis: A Century of Expert Opinions in Cecil Textbook of Medicine
Conclusions:
The pharmacological management of tuberculosis has remained archaic until the middle of the 20th century. Fundamental progress occurred in a very short period (1947–1971) and was because of the recognition of the antituberculous effect of many antibiotics and chemotherapy agents. The challenges created by mycobacterial infections resistant to multiple drugs remain and have prompted the addition of new drugs in the past decade. (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - November 1, 2022 Category: Drugs & Pharmacology Tags: Original Investigation Source Type: research
Caregiver Burden Correlates With Complexity of Drug Regimen in Non-oncological Palliative Medicine
Conclusions:
The caregiver's burden is high for nononcological patients. The complexity of the treatment plan (number of drugs and frequency of administration) is significantly correlated with the care burden. Further studies are needed to understand which interventions targeted on family caregivers will minimize the burden of care. (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - November 1, 2022 Category: Drugs & Pharmacology Tags: Original Investigation Source Type: research
Infliximab as Rescue Therapy for Hospitalized Patients With Crohn's Disease Failing Intravenous Corticosteroids
Conclusions:
In our series of hospitalized CD patients failing IV CS, those treated with IFX had low rates of urgent surgery and a generally rapid response to treatment, supporting IFX as an effective rescue therapy. By only including those with prior failure of IV CS, we have likely excluded patients for whom IFX was given in the hospital for reasons other than severe disease. Our results suggest that individuals with severe acute CD flare can be treated with early introduction of IFX, avoiding prolonged CS use, and hospitalization. (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - November 1, 2022 Category: Drugs & Pharmacology Tags: Original Investigation Source Type: research
Large-For-Gestational-Age Neonates in Diabetes Mellitus Type 1 Pregnancy Treated With Continuous Subcutaneous Insulin Infusion: The Impact of Last Trimester A1C
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2022 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research
Comparison of Antiplatelet Effects and Clinical Outcomes Between Ticagrelor Versus Clopidogrel in Chinese Patients With Acute Coronary Syndrome
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2022 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research
Atomoxetine-Associated Angular Cheilitis
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2022 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research
Diffuse Alveolar Hemorrhage Secondary to Hydralazine-Induced Antineutrophilic Cytoplasmic Antibody–Associated Vasculitis
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2022 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research
Lusutrombopag for Thrombocytopenia in Patients With Chronic Liver Disease Undergoing Invasive Procedures: A Systematic Review and Meta-analysis
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2022 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research
Dexmedetomidine-Associated Hypernatremia and Polyuria
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2022 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research
