American Journal of Clinical Dermatology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The Skin and Gut Microbiome in Hidradenitis Suppurativa: Current Understanding and Future Considerations for Research and Treatment
AbstractHidradenitis suppurativa (HS) is a chronic, inflammatory skin disease comprising painful abscesses, deep nodules, fistulas, and scarring predominantly in the axilla and groin. Bacterial colonization of HS lesions has been well characterized and may lead to chronic infection of lesions. While disease pathogenesis of HS is not fully understood, there is increasing evidence that microbial dysbiosis may be occurring in numerous locations, including the skin and gut. The skin –gut microbiome has been proposed as a mechanism by which inflammatory skin disorders, including HS, can be exacerbated. This is evidenced by HS...
Source: American Journal of Clinical Dermatology - November 1, 2022 Category: Dermatology Source Type: research

Classification and Treatment of Angioedema without Wheals: A Spanish Delphi Consensus
ConclusionThe proposed classification of angioedema without wheals was accepted with a high degree of agreement; however, knowledge of available treatments needs to be increased and the definition of angioedema of unknown mechanism needs to be improved. (Source: American Journal of Clinical Dermatology)
Source: American Journal of Clinical Dermatology - October 30, 2022 Category: Dermatology Source Type: research

Cutaneous Small Vessel Vasculitis: A Practical Guide to Diagnosis and Management
AbstractCutaneous vasculitis may be a cutaneous manifestation of systemic vasculitis, a skin-limited variant of systemic vasculitis, or a type of single-organ vasculitis limited to the skin. Careful evaluation is necessary to distinguish these possibilities, differentiate skin-limited from systemic disease, and identify important underlying conditions, if present. Appropriate management depends on disease type and severity. In the case of cutaneous small vessel vasculitis (CSVV), treatment is primarily based on case reports and expert opinion, using a range of immunomodulatory or immunosuppressive therapies. This manuscrip...
Source: American Journal of Clinical Dermatology - October 29, 2022 Category: Dermatology Source Type: research

Patient Care Outcomes in Hospitalized Patients with Acute Generalized Exanthematous Pustulosis: A Cross-Sectional Database Study
ConclusionsAGEP was associated with longer length of hospitalization, higher rates of discharge to long-term care facilities, and higher mortality compared with non-severe cutaneous adverse drug reaction (SCAR) medication reactions. Future research should examine the association between morbid obesity and this particular drug reaction, and the possibility of decreasing hospitalization length given the relatively low risk of mortality among patients with AGEP. (Source: American Journal of Clinical Dermatology)
Source: American Journal of Clinical Dermatology - October 28, 2022 Category: Dermatology Source Type: research

A Patient-Centered Perspective of Molluscum Contagiosum as Reported by B-SIMPLE4 Clinical Trial Patients and Caregivers: Global Impression of Change and Exit Interview Substudy Results
ConclusionsMolluscum contagiosum lesion reductions, with or without complete clearance, may be considered a therapeutic “success” by the patient/caregiver.Clinical Trial RegistrationNCT04535531 (registered 2 September, 2020). (Source: American Journal of Clinical Dermatology)
Source: American Journal of Clinical Dermatology - October 26, 2022 Category: Dermatology Source Type: research

Impact of Ruxolitinib Cream on Work Productivity and Activity Impairment and Associated Indirect Costs in Patients with Atopic Dermatitis: Pooled Results From Two Phase III Studies
ConclusionsRuxolitinib cream therapy is associated with improved work productivity and daily activity compared with vehicle and is estimated to reduce the indirect cost burden on the patient.Clinical trial registrationClinicalTrials.gov identifiers: NCT03745638 (registered 19 November, 2018) and NCT03745651 (registered 19 November, 2018) (Source: American Journal of Clinical Dermatology)
Source: American Journal of Clinical Dermatology - October 20, 2022 Category: Dermatology Source Type: research

Eyebrow and Eyelash Alopecia: A Clinical Review
AbstractMadarosis is characterized by either complete or partial loss of eyebrow or eyelash hair. Etiologies for madarosis are varied, and accurate diagnosis is the first step in clinical management. Many studies have described findings related to specific causes of madarosis, but few have summarized the collective literature. The purpose of this review is to provide an updated overview on the symptomatology, diagnosis, trichoscopy findings, and treatment of eyebrow and eyelash alopecia. (Source: American Journal of Clinical Dermatology)
Source: American Journal of Clinical Dermatology - October 2, 2022 Category: Dermatology Source Type: research

Advances in Topical Treatments of Cutaneous Malignancies
DiscussionWhile surgical intervention remains the standard of care for skin cancer, non-invasive, self-administered topical treatments are highly desirable alternative options. Ultimately, the patient and provider should find a treatment modality that aligns with the patient ’s expectations and maintenance of quality of life. (Source: American Journal of Clinical Dermatology)
Source: American Journal of Clinical Dermatology - September 28, 2022 Category: Dermatology Source Type: research

What ’s New in Therapy for Male Androgenetic Alopecia?
AbstractMale androgenetic alopecia is a common condition and represents a major concern for patients who experience this condition. While there are different treatments to stop hair loss and improve hair density, the 5-alpha reductase inhibitors have demonstrated to be effective in improving androgenetic alopecia in men and can maintain a positive response for many years. Oral finasteride 1  mg is a US FDA-approved option, but dutasteride 0.5 mg has been proven to induce better responses, especially in the frontal area. Both have been shown to be safe in clinical trials but there is widespread concern about sexual adverse...
Source: American Journal of Clinical Dermatology - September 28, 2022 Category: Dermatology Source Type: research

Lactobacillus rhamnosus Used in the Perinatal Period for the Prevention of Atopic Dermatitis in Infants: A Systematic Review and Meta-Analysis of Randomized Trials
ConclusionBased on the meta-analysis and GRADE assessments, the use ofL. rhamnosus with or without other probiotics appears to have a positive effect in reducing the incidence of atopic eczema in pediatric patients at least out to 7 years. Attrition rates temper these findings. (Source: American Journal of Clinical Dermatology)
Source: American Journal of Clinical Dermatology - September 26, 2022 Category: Dermatology Source Type: research

The Skin and Gut Microbiome in Hidradenitis Suppurativa: Current Understanding and Future Considerations for Research and Treatment
AbstractHidradenitis suppurativa (HS) is a chronic, inflammatory skin disease comprising painful abscesses, deep nodules, fistulas, and scarring predominantly in the axilla and groin. Bacterial colonization of HS lesions has been well characterized and may lead to chronic infection of lesions. While disease pathogenesis of HS is not fully understood, there is increasing evidence that microbial dysbiosis may be occurring in numerous locations, including the skin and gut. The skin –gut microbiome has been proposed as a mechanism by which inflammatory skin disorders, including HS, can be exacerbated. This is evidenced by HS...
Source: American Journal of Clinical Dermatology - September 18, 2022 Category: Dermatology Source Type: research