American Journal of Clinical Dermatology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Hypertrophic Scars and Keloids: Advances in Treatment and Review of Established Therapies
AbstractHypertrophic scars and keloids can have significant detrimental effects on patients both psychosocially and functionally. A careful identification of patient risk factors and a comprehensive management plan are necessary to optimize outcomes. Patients with a history of dystrophic scarring should avoid unnecessary procedures and enhance the wound-healing process using various preventive strategies. As there is no single, fully efficacious treatment modality, prevention remains the best approach in reducing aberrant scar formation. When prevention therapies fail, keloids have been shown to be respond to a variety of ...
Source: American Journal of Clinical Dermatology - January 20, 2023 Category: Dermatology Source Type: research

Review of an Anti-CD20 Monoclonal Antibody for the Treatment of Autoimmune Diseases of the Skin
AbstractBiologic therapies targeting B-cells are emerging as an effective strategy to treat a variety of immune-mediated diseases. One of the most studied B-cell-targeted therapies is rituximab, an anti-CD20 monoclonal antibody that exemplifies B-cell depletion therapy and has served as the prototype for other anti-CD20 monoclonal antibodies and the development of biosimilars. While there are multiple studies on the use of rituximab in dermatology, a comprehensive review of rituximab therapy in autoimmune skin conditions is lacking. In this literature review, we summarize indications, treatment efficacy, and safety of ritu...
Source: American Journal of Clinical Dermatology - January 11, 2023 Category: Dermatology Source Type: research

Acknowledgment to Referees
(Source: American Journal of Clinical Dermatology)
Source: American Journal of Clinical Dermatology - January 11, 2023 Category: Dermatology Source Type: research

Development of Cutaneous T-Cell Lymphoma Following Biologic Treatment: A Systematic Review
ConclusionWhile biologic agents may have a role in the development of CTCL, in order to definitively elucidate their role, more methodologically robust studies (such as those that utilize population databases) would need to occur. (Source: American Journal of Clinical Dermatology)
Source: American Journal of Clinical Dermatology - January 10, 2023 Category: Dermatology Source Type: research

The Impact of Hyperhidrosis on Quality of Life: A Review of the Literature
AbstractHyperhidrosis is a condition of excessive sweating, which can have profound physical and mental effects. Hyperhidrosis is a significantly impactful and distressing illness that warrants equal attention as other more well-known dermatologic conditions. However, because of a lack of awareness among the public, stigma, and difficulty with access to treatments (due to cost or insurance coverage), patients are less likely to be diagnosed and treated. In hyperhidrosis, quality-of-life surveys can be useful for determining the magnitude of symptoms and to evaluate treatment outcomes. The purpose of this study was to condu...
Source: American Journal of Clinical Dermatology - January 9, 2023 Category: Dermatology Source Type: research

Impact of Ruxolitinib Cream on Work Productivity and Activity Impairment and Associated Indirect Costs in Patients with Atopic Dermatitis: Pooled Results From Two Phase III Studies
ConclusionsRuxolitinib cream therapy is associated with improved work productivity and daily activity compared with vehicle and is estimated to reduce the indirect cost burden on the patient.Clinical trial registrationClinicalTrials.gov identifiers: NCT03745638 (registered 19 November, 2018) and NCT03745651 (registered 19 November, 2018) (Source: American Journal of Clinical Dermatology)
Source: American Journal of Clinical Dermatology - January 1, 2023 Category: Dermatology Source Type: research

Advances in Topical Treatments of Cutaneous Malignancies
AbstractSurgical excision has been the preferred treatment for cutaneous malignancies, but can be affected by various considerations. Noninvasive, self-administered topical treatments represent an alternative option. The aim of this review was to evaluate and summarize evidence-based recommendations for topical treatments of basal cell carcinoma (BCC), cutaneous squamous cell carcinoma (CSCC), in situ melanoma (MIS), and extramammary Paget ’s disease (EMPD). Studies were reviewed on PubMed. Included studies were summarized, assessed for biases, and assigned a level of evidence to develop treatment recommendations. For t...
Source: American Journal of Clinical Dermatology - January 1, 2023 Category: Dermatology Source Type: research

Ruxolitinib Cream 1.5%: A Review in Mild to Moderate Atopic Dermatitis
AbstractRuxolitinib cream 1.5% (OPZELURA ™) is a topical formulation of ruxolitinib, a potent, selective inhibitor of Janus kinase (JAK)1 and JAK2. The targeting of these kinases is associated with therapeutic benefits in patients with atopic dermatitis (AD). In two identically designed, multinational, phase III studies in patients aged ≥ 12 years with mild to moderate AD, ruxolitinib cream 1.5% improved measures of disease severity, pruritus and sleep disturbance relative to vehicle cream when applied twice daily for 8 weeks. Disease severity was controlled for the next 44 weeks when applied as needed to active les...
Source: American Journal of Clinical Dermatology - January 1, 2023 Category: Dermatology Source Type: research

Eyebrow and Eyelash Alopecia: A Clinical Review
AbstractMadarosis is characterized by either complete or partial loss of eyebrow or eyelash hair. Etiologies for madarosis are varied, and accurate diagnosis is the first step in clinical management. Many studies have described findings related to specific causes of madarosis, but few have summarized the collective literature. The purpose of this review is to provide an updated overview on the symptomatology, diagnosis, trichoscopy findings, and treatment of eyebrow and eyelash alopecia. (Source: American Journal of Clinical Dermatology)
Source: American Journal of Clinical Dermatology - January 1, 2023 Category: Dermatology Source Type: research

Acknowledgment to Referees
(Source: American Journal of Clinical Dermatology)
Source: American Journal of Clinical Dermatology - January 1, 2023 Category: Dermatology Source Type: research

Truncal Acne and Scarring: A Comprehensive Review of Current Medical and Cosmetic Approaches to Treatment and Patient Management
AbstractAcne vulgaris is one of the most common skin disorders worldwide. It typically affects skin areas with a high density of sebaceous glands such as the face, upper arms, chest, and/or back. Historically, the majority of research efforts have focused on facial acne vulgaris, even though approximately half of patients with facial lesions demonstrate truncal involvement. Truncal acne vulgaris is challenging to treat and poses a significant psychosocial burden on patients. Despite these characteristics, studies specifically examining truncal acne vulgaris are limited, with treatment guidelines largely derived from facial...
Source: American Journal of Clinical Dermatology - December 20, 2022 Category: Dermatology Source Type: research