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To Measure or Not to Measure: Direct Oral Anticoagulant Laboratory Assay Monitoring in Clinical Practice
Adv Hematol. 2023 Feb 22;2023:9511499. doi: 10.1155/2023/9511499. eCollection 2023.ABSTRACTThe need for therapeutic drug monitoring of direct oral anticoagulants (DOACs) remains an area of clinical equipoise. Although routine monitoring may be unnecessary given predictable pharmacokinetics in most patients, there may be altered pharmacokinetics in those with end organ dysfunction, such as those with renal impairment, or with concomitant interacting medications, at extremes of body weight or age, or in those with thromboembolic events in atypical locations. We aimed to assess real-world practices in situations in which DOAC...
Source: Advances in Hematology - March 6, 2023 Category: Hematology Authors: Tania Ahuja Veronica Raco Sharonlin Bhardwaj David Green Source Type: research