Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis
CONCLUSIONS: We found that nebulised antibiotics, alone or with oral antibiotics, were better than no treatment for early infection with P aeruginosa. Eradication may be sustained in the short term. There is insufficient evidence to determine whether these antibiotic strategies decrease mortality or morbidity, improve quality of life, or are associated with adverse effects compared to placebo or standard treatment. Four trials comparing two active treatments have failed to show differences in rates of eradication of P aeruginosa. One large trial showed that intravenous ceftazidime with tobramycin is not superior to oral ci...
Source: Cochrane Database of Systematic Reviews - June 2, 2023 Category: General Medicine Authors: Simon C Langton Hewer Sherie Smith Nicola J Rowbotham Alexander Yule Alan R Smyth Source Type: research
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis
CONCLUSIONS: We found that nebulised antibiotics, alone or with oral antibiotics, were better than no treatment for early infection with P aeruginosa. Eradication may be sustained in the short term. There is insufficient evidence to determine whether these antibiotic strategies decrease mortality or morbidity, improve quality of life, or are associated with adverse effects compared to placebo or standard treatment. Four trials comparing two active treatments have failed to show differences in rates of eradication of P aeruginosa. One large trial showed that intravenous ceftazidime with tobramycin is not superior to oral ci...
Source: Cochrane Database of Systematic Reviews - June 2, 2023 Category: General Medicine Authors: Simon C Langton Hewer Sherie Smith Nicola J Rowbotham Alexander Yule Alan R Smyth Source Type: research
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis
CONCLUSIONS: We found that nebulised antibiotics, alone or with oral antibiotics, were better than no treatment for early infection with P aeruginosa. Eradication may be sustained in the short term. There is insufficient evidence to determine whether these antibiotic strategies decrease mortality or morbidity, improve quality of life, or are associated with adverse effects compared to placebo or standard treatment. Four trials comparing two active treatments have failed to show differences in rates of eradication of P aeruginosa. One large trial showed that intravenous ceftazidime with tobramycin is not superior to oral ci...
Source: Cochrane Database of Systematic Reviews - June 2, 2023 Category: General Medicine Authors: Simon C Langton Hewer Sherie Smith Nicola J Rowbotham Alexander Yule Alan R Smyth Source Type: research
Oral-only antibiotics for bone and joint infections in children: study protocol for a nationwide randomised open-label non-inferiority trial
Introduction
Children with bone and joint infections are traditionally treated with intravenous antibiotics for 3–10 days, followed by oral antibiotics. Oral-only treatment has not been tested in randomised trials.
Methods and analysis
Children (3 months to 18 years) will be randomised 1:1 with the experimental group receiving high-dose oral antibiotics and the control group receiving intravenous antibiotics with a shift in both groups to standard oral antibiotics after clinical and paraclinical improvement. Children in need of acute surgery or systemic features requiring intravenous therapy, including septic shock,...
Source: BMJ Open - June 1, 2023 Category: General Medicine Authors: Bybeck Nielsen, A., Borch, L., Damkjaer, M., Glenthoj, J. P., Hartling, U., Hoffmann, T. U., Holm, M., Helleskov Rasmussen, A., Schmidt, L. S., Schmiegelow, K., Stensballe, L. G., Nygaard, U., Local Investigators, Mikkelsen, Petersen, Thaarup, Kristensen, Tags: Open access, Paediatrics Source Type: research
Extravasation of Noncytotoxic Agents: Skin Injury and Risk Classification
Biol Pharm Bull. 2023;46(6):746-755. doi: 10.1248/bpb.b22-00850.ABSTRACTExtravasations are common manifestations of iatrogenic injuries associated with intravenous therapy. Cytotoxic agents are already subject to a relatively well-defined management strategy in healthcare institutions and classified into three groups according to the extent of damage from extravasation: vesicants, irritants, and non-tissue-damaging agents. Therefore, careful monitoring and initial treatment according to the severity of the skin injury decreases the incidence of extravasation injury. In contrast, high osmolarity, acidic or alkaline, and/or ...
Source: Biological and Pharmaceutical Bulletin - May 31, 2023 Category: Drugs & Pharmacology Authors: Yuuka Shibata Takanori Taogoshi Hiroaki Matsuo Source Type: research
Extravasation of Noncytotoxic Agents: Skin Injury and Risk Classification
Biol Pharm Bull. 2023;46(6):746-755. doi: 10.1248/bpb.b22-00850.ABSTRACTExtravasations are common manifestations of iatrogenic injuries associated with intravenous therapy. Cytotoxic agents are already subject to a relatively well-defined management strategy in healthcare institutions and classified into three groups according to the extent of damage from extravasation: vesicants, irritants, and non-tissue-damaging agents. Therefore, careful monitoring and initial treatment according to the severity of the skin injury decreases the incidence of extravasation injury. In contrast, high osmolarity, acidic or alkaline, and/or ...
Source: Biological and Pharmaceutical Bulletin - May 31, 2023 Category: Drugs & Pharmacology Authors: Yuuka Shibata Takanori Taogoshi Hiroaki Matsuo Source Type: research
Extravasation of Noncytotoxic Agents: Skin Injury and Risk Classification
Biol Pharm Bull. 2023;46(6):746-755. doi: 10.1248/bpb.b22-00850.ABSTRACTExtravasations are common manifestations of iatrogenic injuries associated with intravenous therapy. Cytotoxic agents are already subject to a relatively well-defined management strategy in healthcare institutions and classified into three groups according to the extent of damage from extravasation: vesicants, irritants, and non-tissue-damaging agents. Therefore, careful monitoring and initial treatment according to the severity of the skin injury decreases the incidence of extravasation injury. In contrast, high osmolarity, acidic or alkaline, and/or ...
Source: Biological and Pharmaceutical Bulletin - May 31, 2023 Category: Drugs & Pharmacology Authors: Yuuka Shibata Takanori Taogoshi Hiroaki Matsuo Source Type: research
Extravasation of Noncytotoxic Agents: Skin Injury and Risk Classification
Biol Pharm Bull. 2023;46(6):746-755. doi: 10.1248/bpb.b22-00850.ABSTRACTExtravasations are common manifestations of iatrogenic injuries associated with intravenous therapy. Cytotoxic agents are already subject to a relatively well-defined management strategy in healthcare institutions and classified into three groups according to the extent of damage from extravasation: vesicants, irritants, and non-tissue-damaging agents. Therefore, careful monitoring and initial treatment according to the severity of the skin injury decreases the incidence of extravasation injury. In contrast, high osmolarity, acidic or alkaline, and/or ...
Source: Biological and Pharmaceutical Bulletin - May 31, 2023 Category: Drugs & Pharmacology Authors: Yuuka Shibata Takanori Taogoshi Hiroaki Matsuo Source Type: research
Extravasation of Noncytotoxic Agents: Skin Injury and Risk Classification
Biol Pharm Bull. 2023;46(6):746-755. doi: 10.1248/bpb.b22-00850.ABSTRACTExtravasations are common manifestations of iatrogenic injuries associated with intravenous therapy. Cytotoxic agents are already subject to a relatively well-defined management strategy in healthcare institutions and classified into three groups according to the extent of damage from extravasation: vesicants, irritants, and non-tissue-damaging agents. Therefore, careful monitoring and initial treatment according to the severity of the skin injury decreases the incidence of extravasation injury. In contrast, high osmolarity, acidic or alkaline, and/or ...
Source: Biological and Pharmaceutical Bulletin - May 31, 2023 Category: Drugs & Pharmacology Authors: Yuuka Shibata Takanori Taogoshi Hiroaki Matsuo Source Type: research
Extravasation of Noncytotoxic Agents: Skin Injury and Risk Classification
Biol Pharm Bull. 2023;46(6):746-755. doi: 10.1248/bpb.b22-00850.ABSTRACTExtravasations are common manifestations of iatrogenic injuries associated with intravenous therapy. Cytotoxic agents are already subject to a relatively well-defined management strategy in healthcare institutions and classified into three groups according to the extent of damage from extravasation: vesicants, irritants, and non-tissue-damaging agents. Therefore, careful monitoring and initial treatment according to the severity of the skin injury decreases the incidence of extravasation injury. In contrast, high osmolarity, acidic or alkaline, and/or ...
Source: Biological and Pharmaceutical Bulletin - May 31, 2023 Category: Drugs & Pharmacology Authors: Yuuka Shibata Takanori Taogoshi Hiroaki Matsuo Source Type: research
Comparison of Oral and Intravenous Definitive Antibiotic Therapy for Beta-Hemolytic Streptococcus Species Bloodstream Infections from Soft Tissue Sources: a Propensity Score-Matched Analysis
Antimicrob Agents Chemother. 2023 May 16:e0012023. doi: 10.1128/aac.00120-23. Online ahead of print.ABSTRACTBeta-hemolytic streptococci are common causes of bloodstream infection (BSI). There is emerging data regarding oral antibiotics for BSI but limited for beta-hemolytic streptococcal BSI. We conducted a retrospective study of adults with beta-hemolytic streptococcal BSI from a primary skin/soft tissue source from 2015 to 2020. Patients transitioned to oral antibiotics within 7 days of treatment initiation were compared to those who continued intravenous therapy, after propensity score matching. The primary outcome was ...
Source: Antimicrobial Agents and Chemotherapy - May 16, 2023 Category: Microbiology Authors: Zachary A Yetmar Supavit Chesdachai Brian D Lahr Douglas W Challener Kellie N Arensman Hannan Kevin Epps Ryan W Stevens Maria Teresa Seville Aaron J Tande Abinash Virk Source Type: research
Comparison of Oral and Intravenous Definitive Antibiotic Therapy for Beta-Hemolytic Streptococcus Species Bloodstream Infections from Soft Tissue Sources: a Propensity Score-Matched Analysis
Antimicrob Agents Chemother. 2023 May 16:e0012023. doi: 10.1128/aac.00120-23. Online ahead of print.ABSTRACTBeta-hemolytic streptococci are common causes of bloodstream infection (BSI). There is emerging data regarding oral antibiotics for BSI but limited for beta-hemolytic streptococcal BSI. We conducted a retrospective study of adults with beta-hemolytic streptococcal BSI from a primary skin/soft tissue source from 2015 to 2020. Patients transitioned to oral antibiotics within 7 days of treatment initiation were compared to those who continued intravenous therapy, after propensity score matching. The primary outcome was ...
Source: Antimicrobial Agents and Chemotherapy - May 16, 2023 Category: Microbiology Authors: Zachary A Yetmar Supavit Chesdachai Brian D Lahr Douglas W Challener Kellie N Arensman Hannan Kevin Epps Ryan W Stevens Maria Teresa Seville Aaron J Tande Abinash Virk Source Type: research
Durable effect of imatinib and metronomic chemotherapy with capecitabine in pancreatic carcinoma
CONCLUSION: Metronomic chemotherapy, especially capecitabine added to the targeted therapy, imatinib, is a potentially useful treatment for PDC where no other options are available, especially those harbouring no mutation in the dominant four genes. Indeed, the absence of mutation with KIT amplification could be a potential marker for improved outcomes with targeted and metronomic therapy, which deserves further evaluation in a clinical trial setting.PMID:37138969 | PMC:PMC10151079 | DOI:10.3332/ecancer.2023.1535 (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - May 4, 2023 Category: Cancer & Oncology Authors: Sana Al-Sukhun Karim Khalidi Source Type: research
