Association between < em > CNR1 < /em > gene polymorphisms and susceptibility to diabetic nephropathy in Iraqi patients with T2DM
J Med Life. 2023 Nov;16(11):1663-1669. doi: 10.25122/jml-2023-0181.ABSTRACTIn individuals with type 2 diabetes mellitus (T2DM), the cannabinoid receptor 1 (CNR1) gene polymorphism has been linked to diabetic nephropathy (DN). Different renal disorders, including DN, have been found to alter cannabinoid (CB) receptor expression and activation. This cross-sectional study aimed to investigate the relationship between CNR1 rs1776966256 and rs1243008337 genetic variants and the risk of developing DN in Iraqi patients with T2DM. The study included 100 patients with T2DM, divided into two groups: 50 with DN and 50 without DN. Gen...
Source: Journal of Medicine and Life - February 26, 2024 Category: General Medicine Authors: Raghda Hisham Aljorani Eman Saadi Saleh Khalaf Gata Al Mohammadawi Source Type: research
Effects of combined metformin and cabergoline versus metformin alone on ovarian and hormonal activities in Iraqi patients with PCOS and hyperprolactinemia: a randomized clinical trial
J Med Life. 2023 Nov;16(11):1615-1621. doi: 10.25122/jml-2023-0317.ABSTRACTPolycystic ovary syndrome (PCOS) is one of the most prevalent metabolic diseases during female reproductive life, often associated with insulin resistance and hyperprolactinemia. The efficacy of metformin and cabergoline for managing PCOS remains debated in the literature. This three-arm interventional study in Iraq assessed the effects of these drugs on body mass index (BMI), hormonal balance, and uterine artery blood flow in 75 women with PCOS and hyperprolactinemia. Participants were randomized into three groups: metformin (500 mg twice daily), c...
Source: Journal of Medicine and Life - February 26, 2024 Category: General Medicine Authors: Inas Naser Hamad Sinaa Abdul Amir Kadhim Hayder Adnan Fawzi Shoroq Mohammed Al-Temimi Bassim Mohammad Asma Swadi Source Type: research
Epidemiological profile of hemophilia A in Karbala-Iraq
In this study, one-third of patients' presentations started in the first year of life. The most common type was severe hemophilia A (factor VIII activity < 1%). Consequently, more than half of the patients were treated with factor VIII concentrate. Four patients had hepatitis C, while HIV was confirmed in one patient. The epidemiological or clinical parameters of hemophilia A patients in Karbala seem similar to those in other cities in Iraq. By considering this preliminary data, further comprehensive studies for patients with hemophilia and associated complications in other provinces or cities in Iraq are highly suggest...
Source: Journal of Medicine and Life - February 26, 2024 Category: General Medicine Authors: Inas Muayad Mohammed Ali Ashwaq Ali Hussein Israa Mustafa Salih Al-Musawi Sabeeha Sahib Hadi Hillawi Naus Salih Kadhim Abdulkareem Alaiwi Jasim Source Type: research
Association between < em > CNR1 < /em > gene polymorphisms and susceptibility to diabetic nephropathy in Iraqi patients with T2DM
J Med Life. 2023 Nov;16(11):1663-1669. doi: 10.25122/jml-2023-0181.ABSTRACTIn individuals with type 2 diabetes mellitus (T2DM), the cannabinoid receptor 1 (CNR1) gene polymorphism has been linked to diabetic nephropathy (DN). Different renal disorders, including DN, have been found to alter cannabinoid (CB) receptor expression and activation. This cross-sectional study aimed to investigate the relationship between CNR1 rs1776966256 and rs1243008337 genetic variants and the risk of developing DN in Iraqi patients with T2DM. The study included 100 patients with T2DM, divided into two groups: 50 with DN and 50 without DN. Gen...
Source: Journal of Medicine and Life - February 26, 2024 Category: General Medicine Authors: Raghda Hisham Aljorani Eman Saadi Saleh Khalaf Gata Al Mohammadawi Source Type: research
Effects of combined metformin and cabergoline versus metformin alone on ovarian and hormonal activities in Iraqi patients with PCOS and hyperprolactinemia: a randomized clinical trial
J Med Life. 2023 Nov;16(11):1615-1621. doi: 10.25122/jml-2023-0317.ABSTRACTPolycystic ovary syndrome (PCOS) is one of the most prevalent metabolic diseases during female reproductive life, often associated with insulin resistance and hyperprolactinemia. The efficacy of metformin and cabergoline for managing PCOS remains debated in the literature. This three-arm interventional study in Iraq assessed the effects of these drugs on body mass index (BMI), hormonal balance, and uterine artery blood flow in 75 women with PCOS and hyperprolactinemia. Participants were randomized into three groups: metformin (500 mg twice daily), c...
Source: Journal of Medicine and Life - February 26, 2024 Category: General Medicine Authors: Inas Naser Hamad Sinaa Abdul Amir Kadhim Hayder Adnan Fawzi Shoroq Mohammed Al-Temimi Bassim Mohammad Asma Swadi Source Type: research
