Phosphodiesterase 5 inhibitors: preclinical and early phase breakthroughs for impotence treatments
Expert Opin Investig Drugs. 2023 Jul 28. doi: 10.1080/13543784.2023.2242768. Online ahead of print.ABSTRACTINTRODUCTION: Erectile dysfunction (ED) is a condition that affects millions of men worldwide and is characterized by the inability to achieve or maintain an erection for satisfactory sexual performance. There are numerous treatment options for ED, including medications, mechanical assist devices, and surgical management; however, first-line treatment is usually a phosphodiesterase 5 (PDE5) inhibitor. There is a growing interest in developing novel, efficacious PDE5 inhibitors that provide better quality, safety, and ...
Source: Expert Opinion on Investigational Drugs - July 28, 2023 Category: Drugs & Pharmacology Authors: Zachary Melchiode Tivoli Nguyen Omar Dawood Graham A Bobo Wayne J G Hellstrom Source Type: research
Ventral onlay buccal mucosa graft urethroplasty for female urethral stricture improves female sexual functions
International Journal of Impotence Research, Published online: 28 July 2023; doi:10.1038/s41443-023-00743-zVentral onlay buccal mucosa graft urethroplasty for female urethral stricture improves female sexual functions (Source: International Journal of Impotence Research)
Source: International Journal of Impotence Research - July 28, 2023 Category: Urology & Nephrology Authors: Deniz Gul Burak Uysal Yavuz Tarik Atik Anil Erdik Haci Ibrahim Cimen Mehmet Suhha Bostanci Osman Kose Source Type: research
Correction: Foreskin restorers: insights into motivations, successes, challenges, and experiences with medical and mental health professionals – an abridged summary of key findings
International Journal of Impotence Research, Published online: 27 July 2023; doi:10.1038/s41443-023-00741-1Correction: Foreskin restorers: insights into motivations, successes, challenges, and experiences with medical and mental health professionals – an abridged summary of key findings (Source: International Journal of Impotence Research)
Source: International Journal of Impotence Research - July 27, 2023 Category: Urology & Nephrology Authors: Tim Hammond Lauren M. Sardi William A. Jellison Ryan McAllister Ben Snyder Mohamed A. B. Fahmy Source Type: research
Immunotherapies in MuSK-positive Myasthenia Gravis; an IgG4 antibody-mediated disease
Muscle-specific kinase (MuSK) Myasthenia Gravis (MG) represents a prototypical antibody-mediated disease characterized by predominantly focal muscle weakness (neck, facial, and bulbar muscles) and fatigability. The pathogenic antibodies mostly belong to the immunoglobulin subclass (Ig)G4, a feature which attributes them their specific properties and pathogenic profile. On the other hand, acetylcholine receptor (AChR) MG, the most prevalent form of MG, is characterized by immunoglobulin (Ig)G1 and IgG3 antibodies to the AChR. IgG4 class autoantibodies are impotent to fix complement and only weakly bind Fc-receptors expresse...
Source: Frontiers in Immunology - July 26, 2023 Category: Allergy & Immunology Source Type: research
A response to recent penile enlargement industry media report
International Journal of Impotence Research, Published online: 26 July 2023; doi:10.1038/s41443-023-00745-xA response to recent penile enlargement industry media report (Source: International Journal of Impotence Research)
Source: International Journal of Impotence Research - July 26, 2023 Category: Urology & Nephrology Authors: Robert Valenzuela Laurence Levine Kambiz Tajkarimi Edward Gheiler Shawn Blick Edward Karpman Bryan Kansas Steven K. Wilson Source Type: research
Commentary: Value of prolonged scrotal drainage after penile prosthesis implantation: a multicentre prospective nonrandomized pilot study
International Journal of Impotence Research, Published online: 24 July 2023; doi:10.1038/s41443-023-00740-2Commentary: Value of prolonged scrotal drainage after penile prosthesis implantation: a multicentre prospective nonrandomized pilot study (Source: International Journal of Impotence Research)
Source: International Journal of Impotence Research - July 24, 2023 Category: Urology & Nephrology Authors: Wai Gin Lee Philippa Ralph David Ralph Source Type: research
Comparison of the gut microbiome composition between men with Peyronie’s disease and a matched cohort: a pilot study
International Journal of Impotence Research, Published online: 20 July 2023; doi:10.1038/s41443-023-00737-xComparison of the gut microbiome composition between men with Peyronie’s disease and a matched cohort: a pilot study (Source: International Journal of Impotence Research)
Source: International Journal of Impotence Research - July 20, 2023 Category: Urology & Nephrology Authors: Mohamad M. Osman Muhammed A. Hammad David W. Barham Ryan Toma Farouk M. El-Khatib Sharmin Dianatnejad Jeanie Nguyen Maxwell Towe Edward Choi Qiaqia Wu Guruduth Banavar Ying Cai Pedro Moura Nan Shen Momchilo Vuyisich Natalie R. Yafi Faysal A. Yafi Source Type: research
A contemporary assessment of the evaluation and management of patients presenting to a tertiary medical center with Peyronie’s disease
International Journal of Impotence Research, Published online: 19 July 2023; doi:10.1038/s41443-023-00738-wA contemporary assessment of the evaluation and management of patients presenting to a tertiary medical center with Peyronie’s disease (Source: International Journal of Impotence Research)
Source: International Journal of Impotence Research - July 19, 2023 Category: Urology & Nephrology Authors: Daniel Roadman Vinson Wang Adam Beer Laurence Levine Source Type: research
Compulsive sexual behavior and paraphilic interests in adults with chronic tic disorders and Tourette syndrome: a survey-based study
International Journal of Impotence Research, Published online: 19 July 2023; doi:10.1038/s41443-023-00729-xCompulsive sexual behavior and paraphilic interests in adults with chronic tic disorders and Tourette syndrome: a survey-based study (Source: International Journal of Impotence Research)
Source: International Journal of Impotence Research - July 19, 2023 Category: Urology & Nephrology Authors: Lille Kurvits Safiye Tozdan Tina Mainka Alexander M ünchau Kirsten R. M üller-Vahl Andrea E. Cavanna Peer Briken Christos Ganos Source Type: research
Correction: Peyronie’s Disease Questionnaire (PDQ): Spanish translation and validation
International Journal of Impotence Research, Published online: 18 July 2023; doi:10.1038/s41443-023-00734-0Correction: Peyronie’s Disease Questionnaire (PDQ): Spanish translation and validation (Source: International Journal of Impotence Research)
Source: International Journal of Impotence Research - July 18, 2023 Category: Urology & Nephrology Authors: Borja Garc ía-Gómez Juan Ignacio Mart ínez-Salamanca Joaquim Sarquella-Geli Juan Justo-Quintas Esther Garc ía-Rojo Esa ú Fernández-Pascual Eduard Ru íz-Castañé Javier Romero-Otero Source Type: research
Evaluation and characterization of testosterone-related mobile health applications
International Journal of Impotence Research, Published online: 18 July 2023; doi:10.1038/s41443-023-00739-9Evaluation and characterization of testosterone-related mobile health applications (Source: International Journal of Impotence Research)
Source: International Journal of Impotence Research - July 18, 2023 Category: Urology & Nephrology Authors: Jonathan A. Aguiar Joshua A. Halpern Solomon Hayon Robert E. Brannigan Justin M. Dubin Source Type: research
Testosterone replacement therapy is associated with high satisfaction rates: results of a survey study
International Journal of Impotence Research, Published online: 17 July 2023; doi:10.1038/s41443-023-00724-2Testosterone replacement therapy is associated with high satisfaction rates: results of a survey study (Source: International Journal of Impotence Research)
Source: International Journal of Impotence Research - July 17, 2023 Category: Urology & Nephrology Authors: Charles Loeb Jake A. Miller Douglas Schneider Logan Grimaud Muhammed A. Moukhtar Hammad Faysal A. Yafi Source Type: research
Erectile dysfunction drugs are essential and probably life-saving and should be provided to all men who need them just as birth control should be provided to all women who need them
International Journal of Impotence Research, Published online: 13 July 2023; doi:10.1038/s41443-023-00736-yErectile dysfunction drugs are essential and probably life-saving and should be provided to all men who need them just as birth control should be provided to all women who need them (Source: International Journal of Impotence Research)
Source: International Journal of Impotence Research - July 13, 2023 Category: Urology & Nephrology Authors: Luke Curtis Source Type: research
