Study protocol for ACTIVE study: safety and feasibility evaluation of external ventricular drainage with ACTIVE fluid exchange in intraventricular hemorrhage —a phase 2, multi-center, randomized controlled trial
DiscussionWith no standardized treatment for IVH and a poor prognosis, new treatments are needed. IVH patients often need CSF drainage to treat hydrocephalus and to decrease ICP. Standard treatment with passive external ventricular drainage is related to an increased risk of infections which is found in up to 22% of treated cases. The passive VC is known to have a risk of occlusion and is seen in 19 –47% of the cases.We hypothesize that the use of active fluid change using the IRRAflow system will be safe and feasible and will reduce the occlusion and infection rates in patients with IVH.Trial registrationClicalTrials.go...
Source: Trials - December 29, 2022 Category: Research Source Type: clinical trials
Normal Pressure Hydrocephalus Biomarkers Investigation
Conditions: Normal Pressure Hydrocephalus; Cognitive Impairment Intervention: Diagnostic Test: Measurement of oxysterol profile, including 20 molecules, in liquor before and after surgery Sponsors: University of Roma La Sapienza; AUSL Latina Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 3, 2022 Category: Research Source Type: clinical trials
